-
Colorful windows to the dark rhizosphere Trends Microbiol. (IF 15.9) Pub Date : 2024-03-14 Hamed Azarbad
The dynamic and complex interactions between plant and microbiomes in the rhizosphere play a major role in the plant’s health and productivities. Using interdisciplinary approaches, studied how farming practices can influence the rhizosphere process, offering an exciting direction for microbial manipulation to enhance agricultural productivity.
-
Cancer-associated SNPs in bacteria: lessons from Helicobacter pylori Trends Microbiol. (IF 15.9) Pub Date : 2024-03-13 Bodo Linz, Heinrich Sticht, Nicole Tegtmeyer, Steffen Backert
Several single-nucleotide polymorphisms (SNPs) in human chromosomes are known to predispose to cancer. However, cancer-associated SNPs in bacterial pathogens were unknown until discovered in the stomach pathogen . Those include an alanine-threonine polymorphism in the EPIYA-B phosphorylation motif of the injected effector protein CagA that affects cancer risk by modifying inflammatory responses and
-
Targeting gut microbiota to counteract acetaminophen-induced acute liver injury Trends Microbiol. (IF 15.9) Pub Date : 2024-03-11 Peng Chen
Acetaminophen (N-acetyl-p-aminophenol; APAP) overdose-induced acute liver injury (AILI) is a huge threat to public health worldwide. Recent research clearly shows that the intestinal microbiota (IM) is a key modulator in AILI. Herein, I discuss the latest findings on how the IM regulates AILI and the potential interventions to combat AILI by targeting the IM.
-
Diversity and ecology of NrfA-dependent ammonifying microorganisms Trends Microbiol. (IF 15.9) Pub Date : 2024-03-09 Aurélien Saghaï, Sara Hallin
Nitrate ammonifiers are a taxonomically diverse group of microorganisms that reduce nitrate to ammonium, which is released, and thereby contribute to the retention of nitrogen in ecosystems. Despite their importance for understanding the fate of nitrate, they remain a largely overlooked group in the nitrogen cycle. Here, we present the latest advances on free-living microorganisms using NrfA to reduce
-
The macrophage–bacterium mismatch in persister formation Trends Microbiol. (IF 15.9) Pub Date : 2024-03-04 Iris Dadole, Didier Blaha, Nicolas Personnic
Many pathogens are hard to eradicate, even in the absence of genetically detectable antimicrobial resistance mechanisms and despite proven antibiotic susceptibility. The fraction of clonal bacteria that temporarily elude effective antibiotic treatments is commonly known as ‘antibiotic persisters.’ Over the past decade, there has been a growing body of research highlighting the pivotal role played by
-
Antimicrobial susceptibility prediction from genomes: a dream come true? Trends Microbiol. (IF 15.9) Pub Date : 2024-03-03 Guido Werner, Hege Vangstein Aamot, Natacha Couto
Genome-based diagnostics provides relevant information to guide patient treatment and support pathogen and resistance surveillance. Recently, introduced a curated database for predicting antimicrobial resistance (AMR) from genomics data, offering excellent predictive values for susceptibility to important antimicrobials. Challenges to predict resistance to last-resort antimicrobials remain.
-
Adaptive strategies and ecological roles of phages in habitats under physicochemical stress Trends Microbiol. (IF 15.9) Pub Date : 2024-03-02 Dan Huang, Rong Xia, Chengyi Chen, Jingqiu Liao, Linxing Chen, Dongsheng Wang, Pedro J.J. Alvarez, Pingfeng Yu
Bacteriophages (phages) play a vital role in ecosystem functions by influencing the composition, genetic exchange, metabolism, and environmental adaptation of microbial communities. With recent advances in sequencing technologies and bioinformatics, our understanding of the ecology and evolution of phages in stressful environments has substantially expanded. Here, we review the impact of physicochemical
-
Engineering agricultural soil microbiomes and predicting plant phenotypes Trends Microbiol. (IF 15.9) Pub Date : 2024-02-29 Chiara A. Berruto, Gozde S. Demirer
Plant growth-promoting rhizobacteria (PGPR) can improve crop yields, nutrient use efficiency, plant tolerance to stressors, and confer benefits to future generations of crops grown in the same soil. Unlocking the potential of microbial communities in the rhizosphere and endosphere is therefore of great interest for sustainable agriculture advancements. Before plant microbiomes can be engineered to
-
Recent advances in modelling Shigella infection Trends Microbiol. (IF 15.9) Pub Date : 2024-02-28 Sydney L. Miles, Kathryn E. Holt, Serge Mostowy
is an important human-adapted pathogen which contributes to a large global burden of diarrhoeal disease. Together with the increasing threat of antimicrobial resistance and lack of an effective vaccine, there is great urgency to identify novel therapeutics and preventatives to combat infection. In this review, we discuss the development of innovative technologies and animal models to study mechanisms
-
Micronutrient–microbiome interplay: a critical regulator of soil–plant health Trends Microbiol. (IF 15.9) Pub Date : 2024-02-22 Muhammad Noman, Temoor Ahmed, Jiaoyu Wang, Jason C. White
The delicate balance between soil micronutrients and the phytobeneficial microbiome is crucial for maintaining soil–plant health. Recently, established a correlation between elemental micronutrients and the soil microbiome that regulates plant quality and productivity, offering innovative and sustainable solutions to increase agricultural production in a changing climate.
-
Chemosynthesis: a neglected foundation of marine ecology and biogeochemistry Trends Microbiol. (IF 15.9) Pub Date : 2024-02-21 Francesco Ricci, Chris Greening
-
Harnessing human microbiomes for disease prediction Trends Microbiol. (IF 15.9) Pub Date : 2024-02-20 Yang Liu, Muhamad Fachrul, Michael Inouye, Guillaume Méric
-
Deciphering Fc-effector functions against SARS-CoV-2 Trends Microbiol. (IF 15.9) Pub Date : 2024-02-15 Guillaume Beaudoin-Bussières, Andrés Finzi
Major efforts were deployed to study the antibody response against SARS-CoV-2. Antibodies neutralizing SARS-CoV-2 have been extensively studied in the context of infections, vaccinations, and breakthrough infections. Antibodies, however, are pleiotropic proteins that have many functions in addition to neutralization. These include Fc-effector functions such as antibody-dependent cellular cytotoxicity
-
How does evolution work in superabundant microbes? Trends Microbiol. (IF 15.9) Pub Date : 2024-02-14 Dmitry A. Filatov, Mark Kirkpatrick
Marine phytoplankton play crucial roles in the Earth’s ecological, chemical, and geological processes. They are responsible for about half of global primary production and drive the ocean biological carbon pump. Understanding how plankton species may adapt to the Earth’s rapidly changing environments is evidently an urgent priority. This problem requires evolutionary genetic approaches as evolution
-
Exploiting cAMP signaling in Mycobacterium tuberculosis for drug discovery Trends Microbiol. (IF 15.9) Pub Date : 2024-02-14 Dipak Kathayat, Brian C. VanderVen
(Mtb) replicates within host macrophages by adapting to the stressful and nutritionally constrained environments in these cells. Exploiting these adaptations for drug discovery has revealed that perturbing cAMP signaling can restrict Mtb growth in macrophages. Specifically, compounds that agonize or stimulate the bacterial enzyme, Rv1625c/Cya, induce cAMP synthesis and this interferes with the ability
-
-
Subscription and Copyright Information Trends Microbiol. (IF 15.9) Pub Date : 2024-02-06
Abstract not available
-
Broadening oncological boundaries: the intratumoral microbiota Trends Microbiol. (IF 15.9) Pub Date : 2024-02-03 Ying-Qi Lu, Han Qiao, Xi-Rong Tan, Na Liu
The microbiota of solid tumors was identified >100 years ago; however, heterogeneous composition and diversity have been revealed only recently. Growing evidence has suggested that several functional mechanisms of the intratumoral microbiota affect tumorigenesis and progression, suggesting that the intratumoral microbiota is a promising biomarker for multiple cancers. The low biomass of the intratumoral
-
The energetic costs of cellular complexity in evolution Trends Microbiol. (IF 15.9) Pub Date : 2024-02-01 Sergio A. Muñoz-Gómez
The evolutionary history of cells has been marked by drastic increases in complexity. Some hypothesize that such cellular complexification requires a massive energy flux as the origin of new features is hypothetically more energetically costly than their evolutionary maintenance. However, it remains unclear how increases in cellular complexity demand more energy. I propose that the early evolution
-
Chemosynthesis: a neglected foundation of marine ecology and biogeochemistry Trends Microbiol. (IF 15.9) Pub Date : 2024-01-30 Francesco Ricci, Chris Greening
Chemosynthesis is a metabolic process that transfers carbon to the biosphere using reduced compounds. It is well recognised that chemosynthesis occurs in much of the ocean, but it is often thought to be a negligible process compared to photosynthesis. Here we propose that chemosynthesis is the underlying process governing primary production in much of the ocean and suggest that it extends to a much
-
Deep-sea microbial genetic resources: new frontiers for bioprospecting Trends Microbiol. (IF 15.9) Pub Date : 2024-01-29 Chuwen Zhang, Yongyi Peng, Xinyue Liu, Jieni Wang, Xiyang Dong
Deep-sea ecosystems are home to a diverse community of microorganisms. These microbes are not only fundamental to ecological processes but also a treasure trove of natural products and enzymes with significant scientific and industrial applications. This forum focuses on the vast diversity of deep-sea microbes and their potential for bioprospecting. It also discusses threats posed by climate change
-
Starvation helps transition to abundance – a ferrosome story Trends Microbiol. (IF 15.9) Pub Date : 2024-01-28 Subham Mridha, Michael C. Abt
Iron is an essential nutrient for bacterial pathogenesis. In their study, Skaar and colleagues (Pi et al.) discovered and determined the detailed structure of ferrosomes within Clostridioides difficile, the iron-storage organelles that form under iron-limited conditions in anticipation of future iron overload.
-
Breaking bad nucleotides: understanding the regulatory mechanisms of bacterial small alarmone hydrolases Trends Microbiol. (IF 15.9) Pub Date : 2024-01-22 Adriana Chrenková, Francesco Bisiak, Ditlev E. Brodersen
Guanosine tetra- and pentaphosphate nucleotides, (p)ppGpp, function as central secondary messengers and alarmones in bacterial cell biology, signalling a range of stress conditions, including nutrient starvation and exposure to cell-wall-targeting antibiotics, and are critical for survival. While activation of the stringent response and alarmone synthesis on starved ribosomes by members of the RSH
-
HIV-1-induced translocation of CPSF6 to biomolecular condensates Trends Microbiol. (IF 15.9) Pub Date : 2024-01-23 Katarzyna Bialas, Felipe Diaz-Griffero
Cleavage and polyadenylation specificity factor subunit 6 (CPSF6, also known as CFIm68) is a 68 kDa component of the mammalian cleavage factor I (CFIm) complex that modulates mRNA alternative polyadenylation (APA) and determines 3′ untranslated region (UTR) length, an important gene expression control mechanism. CPSF6 directly interacts with the HIV-1 core during infection, suggesting involvement in
-
Projecting global biological N2 fixation under climate warming across land and ocean Trends Microbiol. (IF 15.9) Pub Date : 2024-01-22 Curtis Deutsch, Keisuke Inomura, Ya-Wei Luo, Ying-Ping Wang
Biological N2 fixation sustains the global inventory of nitrogenous nutrients essential for the productivity of terrestrial and marine ecosystems. Like most metabolic processes, rates of biological N2 fixation vary strongly with temperature, making it sensitive to climate change, but a global projection across land and ocean is lacking. Here we use compilations of field and laboratory measurements
-
Harnessing human microbiomes for disease prediction Trends Microbiol. (IF 15.9) Pub Date : 2024-01-20 Yang Liu, Muhamad Fachrul, Michael Inouye, Guillaume Méric
The human microbiome has been increasingly recognized as having potential use for disease prediction. Predicting the risk, progression, and severity of diseases holds promise to transform clinical practice, empower patient decisions, and reduce the burden of various common diseases, as has been demonstrated for cardiovascular disease or breast cancer. Combining multiple modifiable and non-modifiable
-
Forecasting antimicrobial resistance evolution Trends Microbiol. (IF 15.9) Pub Date : 2024-01-18 Jens Rolff, Sebastian Bonhoeffer, Charlotte Kloft, Rasmus Leistner, Roland Regoes, Michael E. Hochberg
Antimicrobial resistance (AMR) is a major global health issue. Current measures for tackling it comprise mainly the prudent use of drugs, the development of new drugs, and rapid diagnostics. Relatively little attention has been given to forecasting the evolution of resistance. Here, we argue that forecasting has the potential to be a great asset in our arsenal of measures to tackle AMR. We argue that
-
Latex – a potential plant defense against microbes Trends Microbiol. (IF 15.9) Pub Date : 2024-01-13 Meret Huber
Laticifers – among the most common defensive reservoirs in plants – are hypothesized to benefit plant fitness by preventing microbes from entering wounds. I argue that while latex seals wounds, and can suppress microbial growth, direct evidence that these processes benefit plant fitness is scarce. I outline a roadmap for filling this knowledge gap.
-
Frenemies on the reef? Resolving the coral–Endozoicomonas association Trends Microbiol. (IF 15.9) Pub Date : 2024-01-11 Claudia Pogoreutz, Maren Ziegler
Stony corals are poster child holobionts due to their intimate association with diverse microorganisms from all domains of life. We are only beginning to understand the diverse functions of most of these microbial associates, including potential main contributors to holobiont health and resilience. Among these, bacteria of the elusive genus Endozoicomonas are widely perceived as beneficial symbionts
-
Swimming towards each other: the role of chemotaxis in bacterial interactions Trends Microbiol. (IF 15.9) Pub Date : 2024-01-11 Justin R. Seymour, Douglas R. Brumley, Roman Stocker, Jean-Baptiste Raina
Chemotaxis allows microorganisms to direct movement in response to chemical stimuli. Bacteria use this behaviour to develop spatial associations with animals and plants, and even larger microbes. However, current theory suggests that constraints imposed by the limits of chemotactic sensory systems will prevent sensing of chemical gradients emanating from cells smaller than a few micrometres, precluding
-
Enhancing microbiome research in sub-Saharan Africa Trends Microbiol. (IF 15.9) Pub Date : 2024-01-10 Kolawole I. Ayeni, David Berry, Chibundu N. Ezekiel, Benedikt Warth
While there are lighthouse examples of microbiome research in sub-Saharan Africa (SSA), a significant proportion of local researchers face several challenges. Here, we highlight prevailing issues limiting microbiome research in SSA and suggest potential technological, societal, and research-based solutions. We emphasize the need for considerable investment in infrastructures, training, and appropriate
-
Interplay between Staphylococcus aureus and the vaginal microbiota Trends Microbiol. (IF 15.9) Pub Date : 2024-01-04 Carla S. Maduta, Stephen W. Tuffs, John K. McCormick, Karine Dufresne
Staphylococcus aureus is a proficient colonizer and opportunistic pathogen which can lead to vaginal dysbiosis, aerobic vaginitis, or life-threatening menstrual toxic shock syndrome. Here we explore the complex but underappreciated interactions that S. aureus may impose on the vaginal environment leading to additional disease outcomes.
-
Advisory Board and Contents Trends Microbiol. (IF 15.9) Pub Date : 2024-01-02
Abstract not available
-
Subscription and Copyright Information Trends Microbiol. (IF 15.9) Pub Date : 2024-01-02
Abstract not available
-
Microbial warfare: B. subtilis antagonizes E. coli biofilm formation Trends Microbiol. (IF 15.9) Pub Date : 2023-12-28 Kailyn Jessel, Matthew R. Chapman
Biofilm formation helps bacteria to survive environmental challenges. Biofilm development often involves multiple genetic pathways that can be regulated by external signals. Diego Serra and his team (Cordisco et al.) explore how Bacillus subtilis can antagonize Escherichia coli macrocolony biofilm formation via the metabolite bacillaene.
-
Host factor KAP1 coordinates temporal control between transcription and replication Trends Microbiol. (IF 15.9) Pub Date : 2023-12-29 Sarah Preston-Alp, Italo Tempera
Temporal control of transcription and replication is necessary for efficient Epstein–Barr virus reactivation. Xu et al. identified the KAP1/EA-D/ATM axis as a critical regulator of these processes. This discovery illuminates the collaboration between host and viral factors as an essential interaction for viral reactivation.
-
Cable bacteria: widespread filamentous electroactive microorganisms protecting environments Trends Microbiol. (IF 15.9) Pub Date : 2023-12-26 Meijun Dong, Lars Peter Nielsen, Shan Yang, Lasse Hyldgaard Klausen, Meiying Xu
Cable bacteria have been identified and detected worldwide since their discovery in marine sediments in Aarhus Bay, Denmark. Their activity can account for the majority of oxygen consumption and sulfide depletion in sediments, and they induce sulfate accumulation, pH excursions, and the generation of electric fields. In addition, they can affect the fluxes of other elements such as calcium, iron, manganese
-
Diagnosing arthropod-borne flaviviruses: non-structural protein 1 (NS1) as a biomarker Trends Microbiol. (IF 15.9) Pub Date : 2023-12-21 Martina Ceconi, Kevin K. Ariën, Peter Delputte
In recent decades, the presence of flaviviruses of concern for human health in Europe has drastically increased,exacerbated by the effects of climate change – which has allowed the vectors of these viruses to expand into new territories. Co-circulation of West Nile virus (WNV), Usutu virus (USUV), and tick-borne encephalitis virus (TBEV) represents a threat to the European continent, and this is further
-
Modeling nontuberculous mycobacterial infections in zebrafish Trends Microbiol. (IF 15.9) Pub Date : 2023-12-21 Matt D. Johansen, Herman P. Spaink, Stefan H. Oehlers, Laurent Kremer
The incidence of infections due to nontuberculous mycobacteria (NTM) has increased rapidly in recent years, surpassing tuberculosis in developed countries. Due to inherent antimicrobial resistance, NTM infections are particularly difficult to treat with low cure rates. There is an urgent need to understand NTM pathogenesis and to develop novel therapeutic approaches for the treatment of NTM diseases
-
Microbial life in slow and stopped lanes Trends Microbiol. (IF 15.9) Pub Date : 2023-12-19 Rachel M. Walker, Valeria C. Sanabria, Hyun Youk
Microbes in nature often lack nutrients and face extreme or widely fluctuating temperatures, unlike microbes in growth-optimized settings in laboratories that much of the literature examines. Slowed or suspended lives are the norm for microbes. Studying them is important for understanding the consequences of climate change and for addressing fundamental questions about life: are there limits to how
-
A brief history of metal recruitment in protozoan predation Trends Microbiol. (IF 15.9) Pub Date : 2023-12-15 Yanshuang Yu, Yuan-Ping Li, Kexin Ren, Xiuli Hao, Ernest Chi Fru, Regin Rønn, Windell L. Rivera, Karsten Becker, Renwei Feng, Jun Yang, Christopher Rensing
Metals and metalloids are used as weapons for predatory feeding by unicellular eukaryotes on prokaryotes. This review emphasizes the role of metal(loid) bioavailability over the course of Earth’s history, coupled with eukaryogenesis and the evolution of the mitochondrion to trace the emergence and use of the metal(loid) prey-killing phagosome as a feeding strategy. Members of the genera Acanthamoeba
-
Exploring the antibiotic potential of cultured ‘unculturable’ bacteria Trends Microbiol. (IF 15.9) Pub Date : 2023-12-14 Xiaozhao Wang, Zixin Deng, Jiangtao Gao
In response to the severe global antibiotic resistance crisis, this forum delves into ‘unculturable’ bacteria, believed to be a promising source of novel antibiotics. We propose remarkable drug discovery strategies that leverage these bacteria’s diversity, aspiring to transform resistance management. The urgent call for new antibiotics accentuates the essentiality of further research.
-
Pseudomonas aeruginosa’s adaptive trajectory: diverse origins, convergent paths Trends Microbiol. (IF 15.9) Pub Date : 2023-12-14 Tiffany B. Taylor, Matthew J. Shepherd, James S. Horton
Does genetic background contribute to populations following the same or divergent adaptive trajectories? A recent study by Filipow et al. evolved multiple genetically distinct Pseudomonas aeruginosa strains to an artificial cystic fibrosis lung sputum media. The strains adapted at different rates but converged on similar phenotypes despite their initial diversity.
-
The protist cultural renaissance Trends Microbiol. (IF 15.9) Pub Date : 2023-12-14 Javier del Campo, Maria Carlos-Oliveira, Ivan Čepička, Elisabeth Hehenberger, Aleš Horák, Anna Karnkowska, Martin Kolisko, Enrique Lara, Julius Lukeš, Tomáš Pánek, Kasia Piwosz, Daniel J. Richter, Pavel Škaloud, Robert Sutak, Jan Tachezy, Vladimír Hampl
Protists are key players in the biosphere. Here, we provide a perspective on integrating protist culturing with omics approaches, imaging, and high-throughput single-cell manipulation strategies, concluding with actions required for a successful return of the golden age of protist culturing.
-
Crosslink cleaving enzymes: the smart autolysins that remodel the bacterial cell wall Trends Microbiol. (IF 15.9) Pub Date : 2023-12-09 Vaidehi Rajguru, Stuti Chatterjee, Shambhavi Garde, Manjula Reddy
Peptidoglycan (PG) is a protective mesh-like polymer in bacterial cell walls that enables their survival in almost every ecological niche. PG is formed by crosslinking of several glycan strands through short peptides, conferring a characteristic structure and elasticity, distinguishing it from other polymeric exoskeletons. The significance of PG crosslink formation has been known for decades, as some
-
A review on the use of prebiotics in ulcerative colitis Trends Microbiol. (IF 15.9) Pub Date : 2023-12-07 James M. Kennedy, Aminda De Silva, Gemma E. Walton, Glenn R. Gibson
The gut microbiome in the inflammatory bowel disease, ulcerative colitis (UC), is different to that of healthy controls. Patients with UC have relative reductions in abundance of Firmicutes and Bifidobacterium in the colon, and an increase in sulfate-reducing bacteria. Prebiotics are dietary substrates which are selectively metabolised by the human colonic microbiota to confer health benefits to the
-
Human milk oligosaccharides and Bifidobacterium species Trends Microbiol. (IF 15.9) Pub Date : 2023-12-11 Cassie R. Bakshani, Lucy I. Crouch
Several bacterial species initially colonise the infant gut, but are outcompeted. Human milk oligosaccharides (HMOs) in breast milk create an environment for Bifidobacterium to flourish. Laursen and Roager recently showed a clear link between breast milk and the dominance of Bifidobacterium longum subsp. infantis in the infant gut.
-
Microbes guide corals looking to find a home Trends Microbiol. (IF 15.9) Pub Date : 2023-12-08 David G. Bourne, Yui Sato, Hillary A. Smith
Coral reefs are facing unprecedented anthropogenic pressures impacting critical processes such as recruitment of juvenile corals. Through larval choice assays and co-occurrence network analyses, a recent study by Turnlund et al. identified microbial taxa within reef biofilms that positively correlate and therefore have potential key roles in inducing coral settlement.
-
Pseudomonas aeruginosa Trends Microbiol. (IF 15.9) Pub Date : 2023-12-07 Tino Krell, Miguel A. Matilla
Abstract not available
-
Unveiling strain-level dynamics in probiotic activity Trends Microbiol. (IF 15.9) Pub Date : 2023-12-05 Jiang Chang, Yuwei Wu, Hao Wu
Divergent gene content among distinct probiotic strains contributes to varied or conflicting clinical efficacies. Zhang et al. unveils a novel bacterial gene signature, particularly the abfA gene cluster, offering a promising avenue for screening probiotics and advancing our understanding of strain-level activities in the context of gastrointestinal health.
-
Colonization factors of human and animal-specific enterotoxigenic Escherichia coli (ETEC) Trends Microbiol. (IF 15.9) Pub Date : 2023-12-04 Astrid von Mentzer, Ann-Mari Svennerholm
Colonization factors (CFs) are major virulence factors of enterotoxigenic Escherichia coli (ETEC). This pathogen is among the most common causes of bacterial diarrhea in children in low- and middle-income countries, travelers, and livestock. CFs are major candidate antigens in vaccines under development as preventive measures against ETEC infections in humans and livestock. Recent molecular studies
-
SNAREs: a double-edged sword for intravacuolar bacterial pathogens within host cells Trends Microbiol. (IF 15.9) Pub Date : 2023-11-30 Ritika Chatterjee, Subba Rao Gangi Setty, Dipshikha Chakravortty
In the tug-of-war between host and pathogen, both evolve to combat each other's defence arsenals. Intracellular phagosomal bacteria have developed strategies to modify the vacuolar niche to suit their requirements best. Conversely, the host tries to target the pathogen-containing vacuoles towards the degradative pathways. The host cells use a robust system through intracellular trafficking to maintain
-
Plasmid-mediated colistin-resistance genes: mcr Trends Microbiol. (IF 15.9) Pub Date : 2023-11-25 Jian-Hua Liu, Yi-Yun Liu, Ying-Bo Shen, Jun Yang, Timothy R. Walsh, Yang Wang, Jianzhong Shen
Colistin is regarded as a last-line drug against serious infections caused by multidrug-resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin resistance (mcr) genes has attracted global concern and led to policy changes for the use of colistin in food animals across many countries. Currently, the distribution, function, mechanism of action, transmission vehicles,
-
Convergent evolution of innate immune-modulating effectors in invasive fungal pathogens Trends Microbiol. (IF 15.9) Pub Date : 2023-11-18 Michael J. Boucher, Hiten D. Madhani
Invasive fungal infections pose a major threat to human health. Bacterial and protozoan pathogens secrete protein effectors that overcome innate immune barriers to promote microbial colonization, yet few such molecules have been identified in human fungal pathogens. Recent studies have begun to reveal these long-sought effectors and have illuminated how they subvert key cellular pathways, including
-
Enhancing agroecosystem nitrogen management: microbial insights for improved nitrification inhibition Trends Microbiol. (IF 15.9) Pub Date : 2023-11-15 Fabian Beeckman, Laure Annetta, Mario Corrochano-Monsalve, Tom Beeckman, Hans Motte
Nitrification is a key microbial process in the nitrogen (N) cycle that converts ammonia to nitrate. Excessive nitrification, typically occurring in agroecosystems, has negative environmental impacts, including eutrophication and greenhouse gas emissions. Nitrification inhibitors (NIs) are widely used to manage N in agricultural systems by reducing nitrification rates and improving N use efficiency
-
Advisory Board and Contents Trends Microbiol. (IF 15.9) Pub Date : 2023-11-13
Abstract not available
-
Focus on the pathogen defense arsenal Trends Microbiol. (IF 15.9) Pub Date : 2023-11-10 Shankar Iyer
Abstract not available
-
Subscription and Copyright Information Trends Microbiol. (IF 15.9) Pub Date : 2023-11-13
Abstract not available
-
Exploiting predatory bacteria as biocontrol agents across ecosystems Trends Microbiol. (IF 15.9) Pub Date : 2023-11-09 Lu Zhang, Lingyun Guo, Zhongli Cui, Feng Ju
Predatory bacteria have been increasingly known for their ubiquity in environments and great functional potentials in controlling unwanted microorganisms. Fundamental understanding of the predation mechanisms, population dynamics, and interaction patterns underlying bacterial predation is required for wise exploitation of predatory bacteria for enhancing ecoenvironmental, animal, and human health.
-
Policy implications of the microbiota–gut–brain axis Trends Microbiol. (IF 15.9) Pub Date : 2023-11-10 Jake M. Robinson, Emily F. Wissel, Martin F. Breed
The microbiota–gut–brain axis facilitates communication between the gut microbiota and the brain. It has implications for health and environmental policy. Microbiota are linked to neurological and metabolic disorders, and our exposure to health-promoting microbiota depends on environmental quality. Microbiota–gut–brain axis interventions could inform policy initiatives to address systemic health issues