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Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia Cell Metab. (IF 29.0) Pub Date : 2024-03-06 Manami Oya, Yoshiki Miyasaka, Yoshiko Nakamura, Miyako Tanaka, Takayoshi Suganami, Tomoji Mashimo, Kazuhiro Nakamura
Obesity is often associated with aging. However, the mechanism of age-related obesity is unknown. The melanocortin-4 receptor (MC4R) mediates leptin-melanocortin anti-obesity signaling in the hypothalamus. Here, we discovered that MC4R-bearing primary cilia of hypothalamic neurons progressively shorten with age in rats, correlating with age-dependent metabolic decline and increased adiposity. This
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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Stanislaw Deja, Justin A. Fletcher, Chai-Wan Kim, Blanka Kucejova, Xiaorong Fu, Monika Mizerska, Morgan Villegas, Natalia Pudelko-Malik, Nicholas Browder, Melissa Inigo-Vollmer, Cameron J. Menezes, Prashant Mishra, Eric D. Berglund, Jeffrey D. Browning, John P. Thyfault, Jamey D. Young, Jay D. Horton, Shawn C. Burgess
Acetyl-CoA carboxylase (ACC) promotes prandial liver metabolism by producing malonyl-CoA, a substrate for lipogenesis and an inhibitor of CPT-1-mediated fat oxidation. We report that inhibition of ACC also produces unexpected secondary effects on metabolism. Liver-specific double ACC1/2 knockout (LDKO) or pharmacologic inhibition of ACC increased anaplerosis, tricarboxylic acid (TCA) cycle intermediates
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Supercharging cancer-fighting T cells with lithium carbonate Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Yue Xu, Kaili Ma, Lianjun Zhang, Guideng Li
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Itaconate boosts malaria via induction of PD-L1 Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Yukun Min, Luke A.J. O’Neill
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Carnosine facilitates lysosomal release of inhibitors of T cell surveillance Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Pawel Swietach, Marja Jäättelä, Shari Pillon-Thomas, Ebbe Boedtkjer
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UCP1 and CKB are parallel players in BAT Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Meng Dong, Ziyu Cheng, Wanzhu Jin
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Transforming the cardiometabolic disease landscape: Multimodal AI-powered approaches in prevention and management Cell Metab. (IF 29.0) Pub Date : 2024-02-29 Evan D. Muse, Eric J. Topol
The rise of artificial intelligence (AI) has revolutionized various scientific fields, particularly in medicine, where it has enabled the modeling of complex relationships from massive datasets. Initially, AI algorithms focused on improved interpretation of diagnostic studies such as chest X-rays and electrocardiograms in addition to predicting patient outcomes and future disease onset. However, AI
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Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1 Cell Metab. (IF 29.0) Pub Date : 2024-02-23 Kan Huang, Zilun Li, Xi He, Jun Dai, Bingding Huang, Yongxia Shi, Dongxiao Fan, Zefeng Zhang, Yunchong Liu, Na Li, Zhongyu Zhang, Jiangyun Peng, Chenshu Liu, Renli Zeng, Zhipeng Cen, Tengyao Wang, Wenchao Yang, Meifeng Cen, Jingyu Li, Shuai Yuan, Lu Zhang, Dandan Hu, Shuxiang Huang, Pin Chen, Peilong Lai, Liyan Lin, Jielu Wen, Zhengde Zhao, Xiuyi Huang, Lining Yuan, Lifang Zhou, Haoliang Wu, Lihua
Thrombosis represents the leading cause of death and disability upon major adverse cardiovascular events (MACEs). Numerous pathological conditions such as COVID-19 and metabolic disorders can lead to a heightened thrombotic risk; however, the underlying mechanisms remain poorly understood. Our study illustrates that 2-methylbutyrylcarnitine (2MBC), a branched-chain acylcarnitine, is accumulated in
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IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline Cell Metab. (IF 29.0) Pub Date : 2024-02-19 Lexiang Yu, Qianfen Wan, Qiongming Liu, Yong Fan, Qiuzhong Zhou, Alicja A. Skowronski, Summer Wang, Zhengping Shao, Chen-Yu Liao, Lei Ding, Brian K. Kennedy, Shan Zha, Jianwen Que, Charles A. LeDuc, Lei Sun, Liheng Wang, Li Qiang
Aging is underpinned by pronounced metabolic decline; however, the drivers remain obscure. Here, we report that IgG accumulates during aging, particularly in white adipose tissue (WAT), to impair adipose tissue function and metabolic health. Caloric restriction (CR) decreases IgG accumulation in WAT, whereas replenishing IgG counteracts CR’s metabolic benefits. IgG activates macrophages via Ras signaling
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Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma Cell Metab. (IF 29.0) Pub Date : 2024-02-19 ChuanJie Zhang, ZunGuo Du, Yi Gao, Kiat Shenq Lim, WenJie Zhou, Hai Huang, HongChao He, Jun Xiao, DanFeng Xu, QingQuan Li
Here, we identify a subset of vascular pericytes, defined by expression of platelet-derived growth factor receptor beta (PDGFR-β) and G-protein-coupled receptor 91 (GPR91), that promote tumorigenesis and tyrosine kinase inhibitors (TKIs) resistance by functioning as the primary methionine source for cancer stem cells (CSCs) in clear cell renal cell carcinoma (ccRCC). Tumor-cell-derived succinate binds
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Sphingolipid metabolism controls mammalian heart regeneration Cell Metab. (IF 29.0) Pub Date : 2024-02-16 Xiaoqian Ji, Zihao Chen, Qiyuan Wang, Bin Li, Yan Wei, Yun Li, Jianqing Lin, Weisheng Cheng, Yijie Guo, Shilin Wu, Longkun Mao, Yuzhou Xiang, Tian Lan, Shanshan Gu, Meng Wei, Joe Z. Zhang, Lan Jiang, Jia Wang, Jin Xu, Nan Cao
Utilization of lipids as energy substrates after birth causes cardiomyocyte (CM) cell-cycle arrest and loss of regenerative capacity in mammalian hearts. Beyond energy provision, proper management of lipid composition is crucial for cellular and organismal health, but its role in heart regeneration remains unclear. Here, we demonstrate widespread sphingolipid metabolism remodeling in neonatal hearts
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SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells Cell Metab. (IF 29.0) Pub Date : 2024-02-14 Mu-Jie Lu, Jonathan Busquets, Valeria Impedovo, Crystal N. Wilson, Hsin-Ru Chan, Yu-Tai Chang, William Matsui, Stefano Tiziani, Xiaolu A. Cambronne
SLC25A51 selectively imports oxidized NAD into the mitochondrial matrix and is required for sustaining cell respiration. We observed elevated expression of SLC25A51 that correlated with poorer outcomes in patients with acute myeloid leukemia (AML), and we sought to determine the role SLC25A51 may serve in this disease. We found that lowering SLC25A51 levels led to increased apoptosis and prolonged
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Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5 Cell Metab. (IF 29.0) Pub Date : 2024-02-12 Yongfeng Lai, Yuan Gao, Junhong Lin, Fangfang Liu, Liguo Yang, Jie Zhou, Ying Xue, Yan Li, Zhenzhen Chang, Jing Li, Tengfei Chao, Jing Chen, Xiang Cheng, Xianfu Gao, Xiong Li, Fujia Lu, Qian Chu, Weimin Wang
Immunomodulatory effects of long-chain fatty acids (LCFAs) and their activating enzyme, acyl-coenzyme A (CoA) synthetase long-chain family (ACSL), in the tumor microenvironment remain largely unknown. Here, we find that ACSL5 functions as an immune-dependent tumor suppressor. ACSL5 expression sensitizes tumors to PD-1 blockade therapy and the cytotoxicity mediated by CD8 T cells via regulation of major
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DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER Cell Metab. (IF 29.0) Pub Date : 2024-02-09 Shunxing Rong, Mingfeng Xia, Goncalo Vale, Simeng Wang, Chai-Wan Kim, Shili Li, Jeffrey G. McDonald, Arun Radhakrishnan, Jay D. Horton
Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the final step of triglyceride (TG) synthesis. DGAT2 deletion in mice lowers liver TGs, and DGAT2 inhibitors are under investigation for the treatment of fatty liver disease. Here, we show that DGAT2 inhibition also suppressed SREBP-1 cleavage, reduced fatty acid synthesis, and lowered TG accumulation and secretion from liver. DGAT2 inhibition increased
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Interorgan rhythmicity as a feature of healthful metabolism Cell Metab. (IF 29.0) Pub Date : 2024-02-08 J, o, s, e, p, h, , B, a, s, s
The finding that animals with circadian gene mutations exhibit diet-induced obesity and metabolic syndrome with hypoinsulinemia revealed a distinct role for the clock in the brain and peripheral tissues. Obesogenic diets disrupt rhythmic sleep/wake patterns, feeding behavior, and transcriptional networks, showing that metabolic signals reciprocally control the clock. Providing access to high-fat diet
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Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus Cell Metab. (IF 29.0) Pub Date : 2024-02-06 Ying Lei, Xian Liang, Yunong Sun, Ting Yao, Hongyu Gong, Zhenhua Chen, Yuanqing Gao, Hui Wang, Ru Wang, Yunqi Huang, Tao Yang, Miao Yu, Longqi Liu, Chun-Xia Yi, Qing-Feng Wu, Xingxing Kong, Xun Xu, Shiping Liu, Zhi Zhang, Tiemin Liu
The hypothalamus plays a crucial role in the progression of obesity and diabetes; however, its structural complexity and cellular heterogeneity impede targeted treatments. Here, we profiled the single-cell and spatial transcriptome of the hypothalamus in obese and sporadic type 2 diabetic macaques, revealing primate-specific distributions of clusters and genes as well as spatial region, cell-type-
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Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding Cell Metab. (IF 29.0) Pub Date : 2024-02-06 Ashley S. Williams, Scott B. Crown, Scott P. Lyons, Timothy R. Koves, Rebecca J. Wilson, Jordan M. Johnson, Dorothy H. Slentz, Daniel P. Kelly, Paul A. Grimsrud, Guo-Fang Zhang, Deborah M. Muoio
Time-restricted feeding (TRF) has gained attention as a dietary regimen that promotes metabolic health. This study questioned if the health benefits of an intermittent TRF (iTRF) schedule require ketone flux specifically in skeletal and cardiac muscles. Notably, we found that the ketolytic enzyme beta-hydroxybutyrate dehydrogenase 1 (BDH1) is uniquely enriched in isolated mitochondria derived from
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Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells Cell Metab. (IF 29.0) Pub Date : 2024-02-06 Theresa Ramalho, Patricia A. Assis, Ogooluwa Ojelabi, Lin Tan, Brener Carvalho, Luiz Gardinassi, Osvaldo Campos, Philip L. Lorenzi, Katherine A. Fitzgerald, Cole Haynes, Douglas T. Golenbock, Ricardo T. Gazzinelli
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Preventing metabolic disease: Part I Cell Metab. (IF 29.0) Pub Date : 2024-02-06 T, h, e, , C, e, l, l, , M, e, t, a, b, o, l, i, s, m, , e, d, i, t, o, r, i, a, l, , t, e, a, m
Abstract not available
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Inequalities in life expectancy and cardiometabolic disease mortality across and within high-income countries Cell Metab. (IF 29.0) Pub Date : 2024-02-06 Jessica Y. Ho, Arun S. Hendi
Cardiometabolic disease is a leading cause of death and plays a key role in recent life expectancy trends worldwide. We highlight inequalities in cardiometabolic disease mortality across sex, race/ethnicity, geographic region, and urbanicity within the United States, as well as across high-income countries.
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Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner Cell Metab. (IF 29.0) Pub Date : 2024-02-06 Jianqing She, Gulinigaer Tuerhongjiang, Manyun Guo, Junhui Liu, Xiang Hao, Liangan Guo, Nairong Liu, Wen Xi, Tao Zheng, Bin Du, Bowen Lou, Xiyu Gao, Xiao Yuan, Yue Yu, Yi Zhang, Fan Gao, Xiaozhen Zhuo, Ying Xiong, Xiang Zhang, Jun Yu, Zuyi Yuan, Yue Wu
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GDF15 is a major determinant of ketogenic diet-induced weight loss Cell Metab. (IF 29.0) Pub Date : 2024-02-06 Jun Feng Lu, Meng Qing Zhu, Bo Xia, Na Na Zhang, Xiao Peng Liu, Huan Liu, Rui Xin Zhang, Jun Ying Xiao, Hui Yang, Ying Qi Zhang, Xiao Miao Li, Jiang Wei Wu
Abstract not available
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PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression Cell Metab. (IF 29.0) Pub Date : 2024-02-02 Xin Yang, Zhe Wang, Svetlana N. Samovich, Alexander A. Kapralov, Andrew A. Amoscato, Vladimir A. Tyurin, Haider H. Dar, Zhiming Li, Shoufu Duan, Ning Kon, Delin Chen, Benjamin Tycko, Zhiguo Zhang, Xuejun Jiang, Hülya Bayir, Brent R. Stockwell, Valerian E. Kagan, Wei Gu
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Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells Cell Metab. (IF 29.0) Pub Date : 2024-02-02 Cegui Hu, Wen Qiao, Xiang Li, Zhi-kun Ning, Jiang Liu, Sumiya Dalangood, Hanjun Li, Xiang Yu, Zhen Zong, Zhenke Wen, Jun Gui
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Reproductive risk factors across the female lifecourse and later metabolic health Cell Metab. (IF 29.0) Pub Date : 2024-01-26 Amy R. Nichols, Jorge E. Chavarro, Emily Oken
Metabolic health is characterized by optimal blood glucose, lipids, cholesterol, blood pressure, and adiposity. Alterations in these characteristics may lead to the development of type 2 diabetes mellitus or dyslipidemia. Recent evidence suggests that female reproductive characteristics may be overlooked as risk factors that contribute to later metabolic dysfunction. These reproductive traits include
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Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB Cell Metab. (IF 29.0) Pub Date : 2024-01-24 Janane F. Rahbani, Jakub Bunk, Damien Lagarde, Bozena Samborska, Anna Roesler, Haopeng Xiao, Abhirup Shaw, Zafir Kaiser, Jessica L. Braun, Mia S. Geromella, Val A. Fajardo, Robert A. Koza, Lawrence Kazak
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Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment Cell Metab. (IF 29.0) Pub Date : 2024-01-23 Wei Wei, Yali Liu, Yuanlong Hou, Shuqi Cao, Zhuo Chen, Youying Zhang, Xiaoying Cai, Qingyuan Yan, Ziguang Li, Yonggui Yuan, Guangji Wang, Xiao Zheng, Haiping Hao
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Understanding the variation in exercise responses to guide personalized physical activity prescriptions Cell Metab. (IF 29.0) Pub Date : 2024-01-22 John Noone, Justine M. Mucinski, James P. DeLany, Lauren M. Sparks, Bret H. Goodpaster
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Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating Cell Metab. (IF 29.0) Pub Date : 2024-01-18 Molly McDougle, Alan de Araujo, Arashdeep Singh, Mingxin Yang, Isadora Braga, Vincent Paille, Rebeca Mendez-Hernandez, Macarena Vergara, Lauren N. Woodie, Abhishek Gour, Abhisheak Sharma, Nikhil Urs, Brandon Warren, Guillaume de Lartigue
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Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity Cell Metab. (IF 29.0) Pub Date : 2024-01-17 Jia-Yao Fu, Shi-Jia Huang, Bao-Li Wang, Jun-Hao Yin, Chang-Yu Chen, Jia-Bao Xu, Yan-Lin Chen, Shuo Xu, Ting Dong, Hao-Nan Zhou, Xin-Yi Ma, Yi-Ping Pu, Hui Li, Xiu-Juan Yang, Li-Song Xie, Zhi-Jun Wang, Qi Luo, Yan-Xiong Shao, Lei Ye, Zi-Rui Zong, Xin-Di Wei, Wan-Wen Xiao, Shu-Tong Niu, Yi-Ming Liu, He-Ping Xu, Chuang-Qi Yu, Sheng-Zhong Duan, Ling-Yan Zheng
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Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease Cell Metab. (IF 29.0) Pub Date : 2024-01-17 May-Yun Wang, Zhuzhen Zhang, Shangang Zhao, Toshiharu Onodera, Xue-Nan Sun, Qingzhang Zhu, Chao Li, Na Li, Shiuhwei Chen, Megan Paredes, Laurent Gautron, Maureen J. Charron, Denise K. Marciano, Ruth Gordillo, Daniel J. Drucker, Philipp E. Scherer
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Augmentation of scleral glycolysis promotes myopia through histone lactylation Cell Metab. (IF 29.0) Pub Date : 2024-01-16 Xiaolei Lin, Yi Lei, Miaozhen Pan, Changxi Hu, Bintao Xie, Wenjing Wu, Jianzhong Su, Yating Li, Yuhan Tan, Xiaohuan Wei, Zhengbo Xue, Ruiyan Xu, Mengqi Di, Hanyu Deng, Shengcong Liu, Xingxing Yang, Jia Qu, Wei Chen, Xiangtian Zhou, Fei Zhao
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Targeting Erbin-mitochondria axis in platelets/megakaryocytes promotes B cell-mediated antitumor immunity Cell Metab. (IF 29.0) Pub Date : 2024-01-16 Zilong Zhang, Xu Xu, Di Zhang, Songsong Zhao, Chuyi Wang, Guilin Zhang, Wenshu Chen, Jinglin Liu, Huimin Gong, Youlutuziayi Rixiati, Shi Li, Tong Shen, Jianming Li
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Niche-specific control of tissue function by regulatory T cells—Current challenges and perspectives for targeting metabolic disease Cell Metab. (IF 29.0) Pub Date : 2024-01-12 Maike Becker, Sandra M. Dirschl, Martin G. Scherm, Isabelle Serr, Carolin Daniel
Tissue regulatory T cells (Tregs) exert pivotal functions in both immune and metabolic regulation, maintaining local tissue homeostasis, integrity, and function. Accordingly, Tregs play a crucial role in controlling obesity-induced inflammation and supporting efficient muscle function and repair. Depending on the tissue context, Tregs are characterized by unique transcriptomes, growth, and survival
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The hormesis principle of neuroplasticity and neuroprotection Cell Metab. (IF 29.0) Pub Date : 2024-01-10 Mark P. Mattson, Rehana K. Leak
Animals live in habitats fraught with a range of environmental challenges to their bodies and brains. Accordingly, cells and organ systems have evolved stress-responsive signaling pathways that enable them to not only withstand environmental challenges but also to prepare for future challenges and function more efficiently. These phylogenetically conserved processes are the foundation of the hormesis
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Prevention of cardiorenal complications in people with type 2 diabetes and obesity Cell Metab. (IF 29.0) Pub Date : 2024-01-09 D, a, n, i, e, l, , J, o, s, h, u, a, , D, r, u, c, k, e, r
Traditional approaches to prevention of the complications of type 2 diabetes (T2D) and obesity have focused on reduction of blood glucose and body weight. The development of new classes of medications, together with evidence from dietary weight loss and bariatric surgery trials, provides new options for prevention of heart failure, chronic kidney disease, myocardial infarction, stroke, metabolic liver
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DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication Cell Metab. (IF 29.0) Pub Date : 2024-01-08 Kyohei Tokizane, Cynthia S. Brace, Shin-ichiro Imai
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Exercise induces tissue-specific adaptations to enhance cardiometabolic health Cell Metab. (IF 29.0) Pub Date : 2024-01-05 Stephen P. Ashcroft, Ben Stocks, Brendan Egan, Juleen R. Zierath
The risk associated with multiple cancers, cardiovascular disease, diabetes, and all-cause mortality is decreased in individuals who meet the current recommendations for physical activity. Therefore, regular exercise remains a cornerstone in the prevention and treatment of non-communicable diseases. An acute bout of exercise results in the coordinated interaction between multiple tissues to meet the
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ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis Cell Metab. (IF 29.0) Pub Date : 2024-01-04 Chao Chen, Zhenxing Zhang, Caiyun Liu, Pengkai Sun, Ping Liu, Xinjian Li
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Human trials exploring anti-aging medicines Cell Metab. (IF 29.0) Pub Date : 2024-01-04 Leonard Guarente, David A. Sinclair, Guido Kroemer
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatories. Multiple clinical trials have commenced to evaluate the efficacy of such agents against age-associated diseases including diabetes
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Time-restricted eating: Watching the clock to treat obesity Cell Metab. (IF 29.0) Pub Date : 2024-01-03 Mark Ezpeleta, Sofia Cienfuegos, Shuhao Lin, Vasiliki Pavlou, Kelsey Gabel, Lisa Tussing-Humphreys, Krista A. Varady
Time-restricted eating (TRE) has become a popular strategy to treat obesity. TRE involves confining the eating window to 4–10 h per day and fasting for the remaining hours (14–20 h fast). During the eating window, individuals are not required to monitor food intake. The sudden rise in popularity of TRE is most likely due to its simplicity and the fact that it does not require individuals to count calories
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Epigenetic biomarkers for disease susceptibility and preventative medicine Cell Metab. (IF 29.0) Pub Date : 2024-01-03 M, i, c, h, a, e, l, , K, ., , S, k, i, n, n, e, r
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Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer Cell Metab. (IF 29.0) Pub Date : 2024-01-02 Yingsheng Zhang, Meng-Ju Wu, Wan-Chi Lu, Yi-Chuan Li, Chun Ju Chang, Jer-Yen Yang
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TAMC-derived creatine sustains glioblastoma growth Cell Metab. (IF 29.0) Pub Date : 2024-01-02 Huiwen Yan, Pengcheng Bu
Tumor-associated myeloid cells (TAMCs) are the predominant immune population in glioblastoma (GBM), but the definite role of TAMCs in GBM tumorigenicity remains uncertain. In this issue of Cell Metabolism, Rashidi et al. identify a specific population of TAMCs surrounding hypoxic regions of GBM. These TAMCs provide creatine to nearby tumor cells to promote GBM progression.
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Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD Cell Metab. (IF 29.0) Pub Date : 2024-01-02 Alia Ghrayeb, Alexandra C. Finney, Bella Agranovich, Daniel Peled, Sumit Kumar Anand, M. Peyton McKinney, Mahasen Sarji, Dongshan Yang, Natan Weissman, Shani Drucker, Sara Isabel Fernandes, Jonatan Fernández-García, Kyle Mahan, Zaid Abassi, Lin Tan, Philip L. Lorenzi, James Traylor, Jifeng Zhang, Ifat Abramovich, Y. Eugene Chen, Oren Rom, Inbal Mor, Eyal Gottlieb
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The DEAD Box Protein Mrh4 Functions in the Assembly of the Mitochondrial Large Ribosomal Subunit Cell Metab. (IF 29.0) Pub Date : 2024-01-02 Dasmanthie De Silva, Flavia Fontanesi, Antoni Barrientos
Abstract not available
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H2S serves as the immunoregulatory essence of apoptotic cell death Cell Metab. (IF 29.0) Pub Date : 2024-01-02 Christopher Hine, András K. Ponti, María Ángeles Cáliz-Molina, Alejandro Martín-Montalvo
Apoptosis supports tissue homeostasis and prevents immune disorders by removing damaged and functionally aberrant cells. Here, Ou et al. utilized genetic, pharmacological, and proteomic approaches focused on sulfur amino acid catabolism to discover that hydrogen sulfide (H2S) release during apoptosis suppresses Th17 cell differentiation, thus providing therapeutic targets for autoimmune diseases.
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Show MERCI on mobile mitochondria Cell Metab. (IF 29.0) Pub Date : 2024-01-02 Jelle van den Ameele, Patrick F. Chinnery
There is emerging evidence that mitochondria can move between cells, particularly from immune cells into cancers. Recent work from Zhang et al. in Cancer Cell employs single-cell RNA- and mitochondrial DNA-sequencing in co-culture experiments and patient tumor samples to detect mitochondrial transfer. However, the mechanisms, scale, and implications remain uncertain.
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What we talk about when we talk about spinal cord aging Cell Metab. (IF 29.0) Pub Date : 2024-01-02 Xianhong Ji, Jiajia Zhang, Xiaoqiang Tang, Hou-Zao Chen
Spinal cord-associated disorders are common in the elderly population; however, the mechanisms underlying spinal aging remain elusive. In a recent Nature paper, Sun et al. systemically analyzed aged spines in nonhuman primates and identified a new cluster of CHIT1-positive microglia that drives motor neuron senescence and subsequent spine aging.
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Mitochondrial-derived vesicles in metabolism, disease, and aging Cell Metab. (IF 29.0) Pub Date : 2024-01-02 Tim König, Heidi M. McBride
Mitochondria are central hubs of cellular metabolism and are tightly connected to signaling pathways. The dynamic plasticity of mitochondria to fuse, divide, and contact other organelles to flux metabolites is central to their function. To ensure functionality and signaling interconnectivity, diverse molecular mechanisms evolved. An ancient and long-overlooked mechanism is the generation of mitochondrial-derived
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Repression of latent NF-κB enhancers by PDX1 regulates β cell functional heterogeneity Cell Metab. (IF 29.0) Pub Date : 2024-01-02 Benjamin J. Weidemann, Biliana Marcheva, Mikoto Kobayashi, Chiaki Omura, Marsha V. Newman, Yumiko Kobayashi, Nathan J. Waldeck, Mark Perelis, Louise Lantier, Owen P. McGuinness, Kathryn Moynihan Ramsey, Roland W. Stein, Joseph Bass
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Glycine homeostasis requires reverse SHMT flux Cell Metab. (IF 29.0) Pub Date : 2024-01-02 Matthew J. McBride, Craig J. Hunter, Zhaoyue Zhang, Tara TeSlaa, Xincheng Xu, Gregory S. Ducker, Joshua D. Rabinowitz
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Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation Cell Metab. (IF 29.0) Pub Date : 2024-01-02 Xiaohui Si, Mi Shao, Xinyi Teng, Yue Huang, Ye Meng, Longyuan Wu, Jieping Wei, Lianxuan Liu, Tianning Gu, Junzhe Song, Ruirui Jing, Xingyuan Zhai, Xin Guo, Delin Kong, Xiujian Wang, Bohan Cai, Ying Shen, Zhaoru Zhang, Dongrui Wang, Yongxian Hu, Pengxu Qian, Gang Xiao, He Huang
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Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution Cell Metab. (IF 29.0) Pub Date : 2024-01-02 Jing Cao, Qi Jason Yao, Jiao Wu, Xiaonan Chen, Lin Huang, Wanshan Liu, Kun Qian, Jing-Jing Wan, Bo O. Zhou
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Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth Cell Metab. (IF 29.0) Pub Date : 2023-12-21 Aida Rashidi, Leah K. Billingham, Andrew Zolp, Tzu-yi Chia, Caylee Silvers, Joshua L. Katz, Cheol H. Park, Suzi Delay, Lauren Boland, Yuheng Geng, Steven M. Markwell, Crismita Dmello, Victor A. Arrieta, Kaylee Zilinger, Irene M. Jacob, Aurora Lopez-Rosas, David Hou, Brandyn Castro, Alicia M. Steffens, Kathleen McCortney, Jordain P. Walshon, Mariah S. Flowers, Hanchen Lin, Hanxiang Wang, Junfei Zhao
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Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism Cell Metab. (IF 29.0) Pub Date : 2023-12-20 Riley J. Wedan, Jacob Z. Longenecker, Sara M. Nowinski
Contrary to their well-known functions in nutrient breakdown, mitochondria are also important biosynthetic hubs and express an evolutionarily conserved mitochondrial fatty acid synthesis (mtFAS) pathway. mtFAS builds lipoic acid and longer saturated fatty acids, but its exact products, their ultimate destination in cells, and the cellular significance of the pathway are all active research questions
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Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes Cell Metab. (IF 29.0) Pub Date : 2023-12-20 Udi Ehud Knebel, Shani Peleg, Chunhua Dai, Roni Cohen-Fultheim, Sara Jonsson, Karin Poznyak, Maya Israeli, Liza Zamashanski, Benjamin Glaser, Erez Y. Levanon, Alvin C. Powers, Agnes Klochendler, Yuval Dor
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Nutrient inputs and social metabolic control of T cell fate Cell Metab. (IF 29.0) Pub Date : 2023-12-19 Zachary A. Bacigalupa, Madelyn D. Landis, Jeffrey C. Rathmell
Cells in multicellular organisms experience diverse neighbors, signals, and evolving physical environments that drive functional and metabolic demands. To maintain proper development and homeostasis while avoiding inappropriate cell proliferation or death, individual cells interact with their neighbors via “social” cues to share and partition available nutrients. Metabolic signals also contribute to
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Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation Cell Metab. (IF 29.0) Pub Date : 2023-12-18 Chi Kin Wong, Brent A. McLean, Laurie L. Baggio, Jacqueline A. Koehler, Rola Hammoud, Nikolaj Rittig, Julian M. Yabut, Randy J. Seeley, Theodore J. Brown, Daniel J. Drucker
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Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation Cell Metab. (IF 29.0) Pub Date : 2023-12-18 Qianmin Ou, Xinhua Qiao, Zhengshi Li, Luhan Niu, Fangcao Lei, Ruifeng Cheng, Ting Xie, Ning Yang, Yao Liu, Ling Fu, Jing Yang, Xueli Mao, Xiaoxing Kou, Chang Chen, Songtao Shi