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  • Dancing with the Stars: Phenolic Glycolipids Partners with Macrophages
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Micah D. Dunlap, Shabaana A. Khader

    How Mycobacterium leprae infection causes demyelination to mediate leprosy pathogenesis has been a long-standing question. In a recent Cell paper, Madigan et al. (2017) use a zebrafish model of M. leprae infection to show that infected macrophages patrol axons to trigger mitochondrial damage and induce demyelination of nerve cells.

    更新日期:2017-09-14
  • Tooth Be Told, Genetics Influences Oral Microbiome
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Emily R. Davenport

    The mix of bacteria that coat our teeth impact oral health, but it remains unclear what factors govern their composition. In this issue of Cell Host & Microbe, Gomez et al. (2017) examine the relationship between host genetics and the oral microbiome in the context of health and disease.

    更新日期:2017-09-14
  • Choline Theft—An Inside Job
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Marina Mora-Ortiz, Sandrine Paule Claus

    Choline is a crucial methyl donor necessary for epigenetic regulation. In this issue of Cell Host & Microbe, Romano et al. (2017) demonstrate that choline-utilizing gut bacteria compete with their host for this essential resource, calling for a systematic consideration of gut microbial composition for personalized diet recommendations.

    更新日期:2017-09-14
  • Fragment and Conquer
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Vera Kozjak-Pavlovic, Suvagata Roy Chowdhury, Thomas Rudel

    The replication vacuole of Legionella pneumophila makes contact with host mitochondria. In this issue of Cell Host & Microbe, Escoll et al. (2017) dissect the mechanisms of this interaction, the effect of the T4SS effector MitF on mitochondrial function, and the resultant metabolic reprogramming of infected cells to benefit the bacteria.

    更新日期:2017-09-14
  • Specialized Weaponry: How a Type III-A CRISPR-Cas System Excels at Combating Phages
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Ole Niewoehner, Martin Jinek

    CRISPR-Cas-mediated defense against phage invaders usually requires recognition of short sequences, termed protospacer-adjacent motifs (PAMs), in phage DNA. In this issue of Cell Host & Microbe, Pyenson et al. (2017) show that the lack of a PAM requirement in some CRISPR-Cas systems prevents interference evasion and facilitates phage extinction.

    更新日期:2017-09-14
  • Drivers of Dengue Intrahost Evolution
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Etienne Simon-Lorière, Marco Vignuzzi

    RNA viruses circulate as rapidly evolving swarms of related variants, and their evolutionary dynamics within hosts may be key to understanding virus emergence. In this issue of Cell Host & Microbe, Parameswaran et al. (2017) combine next-generation sequencing and functional studies to characterize viral populations in acute dengue infections.

    更新日期:2017-09-14
  • Host Genetic Control of the Oral Microbiome in Health and Disease
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Andres Gomez, Josh L. Espinoza, Derek M. Harkins, Pamela Leong, Richard Saffery, Michelle Bockmann, Manolito Torralba, Claire Kuelbs, Rohith Kodukula, Jason Inman, Toby Hughes, Jeffrey M. Craig, Sarah K. Highlander, Marcus B. Jones, Chris L. Dupont, Karen E. Nelson
    更新日期:2017-09-14
  • Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Yuxuan Miao, Pradeep Bist, Jianxuan Wu, Qing Zhao, Qi-jing Li, Ying Wan, Soman N. Abraham
    更新日期:2017-09-14
  • Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Brett W. Jagger, Jonathan J. Miner, Bin Cao, Nitin Arora, Amber M. Smith, Attila Kovacs, Indira U. Mysorekar, Carolyn B. Coyne, Michael S. Diamond
    更新日期:2017-09-14
  • Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    David G. Courtney, Edward M. Kennedy, Rebekah E. Dumm, Hal P. Bogerd, Kevin Tsai, Nicholas S. Heaton, Bryan R. Cullen
    更新日期:2017-09-14
  • Intrahost Selection Pressures Drive Rapid Dengue Virus Microevolution in Acute Human Infections
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Poornima Parameswaran, Chunling Wang, Surbhi Bharat Trivedi, Meghana Eswarappa, Magelda Montoya, Angel Balmaseda, Eva Harris
    更新日期:2017-09-14
  • The Landscape of Type VI Secretion across Human Gut Microbiomes Reveals Its Role in Community Composition
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Adrian J. Verster, Benjamin D. Ross, Matthew C. Radey, Yiqiao Bao, Andrew L. Goodman, Joseph D. Mougous, Elhanan Borenstein
    更新日期:2017-09-14
  • Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-31
    Pedro Escoll, Ok-Ryul Song, Flávia Viana, Bernhard Steiner, Thibault Lagache, Jean-Christophe Olivo-Marin, Francis Impens, Priscille Brodin, Hubert Hilbi, Carmen Buchrieser
    更新日期:2017-09-04
  • Using Engineered Bacteria to Characterize Infection Dynamics and Antibiotic Effects In Vivo
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-31
    Laura K. Certain, Jeffrey C. Way, Matthew J. Pezone, James J. Collins
    更新日期:2017-09-04
  • Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-31
    Chris Lauber, Stefan Seitz, Simone Mattei, Alexander Suh, Jürgen Beck, Jennifer Herstein, Jacob Börold, Walter Salzburger, Lars Kaderali, John A.G. Briggs, Ralf Bartenschlager
    更新日期:2017-09-04
  • A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-24
    Cheryl N. Miller, Erin P. Smith, Jennifer A. Cundiff, Leigh A. Knodler, Jessica Bailey Blackburn, Vladimir Lupashin, Jean Celli
    更新日期:2017-08-28
  • Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-24
    Kymberleigh A. Romano, Ana Martinez-del Campo, Kazuyuki Kasahara, Carina L. Chittim, Eugenio I. Vivas, Daniel Amador-Noguez, Emily P. Balskus, Federico E. Rey
    更新日期:2017-08-28
  • An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-24
    Luisella Spiga, Maria G. Winter, Tatiane Furtado de Carvalho, Wenhan Zhu, Elizabeth R. Hughes, Caroline C. Gillis, Cassie L. Behrendt, Jiwoong Kim, Daniela Chessa, Helene L. Andrews-Polymenis, Daniel P. Beiting, Renato L. Santos, Lora V. Hooper, Sebastian E. Winter
    更新日期:2017-08-28
  • Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-17
    Melissa M. Remy, Mehmet Sahin, Lukas Flatz, Tommy Regen, Lifen Xu, Mario Kreutzfeldt, Benedict Fallet, Camille Doras, Toni Rieger, Lukas Bestmann, Uwe-Karsten Hanisch, Beat A. Kaufmann, Doron Merkler, Daniel D. Pinschewer
    更新日期:2017-08-24
  • Broad Targeting Specificity during Bacterial Type III CRISPR-Cas Immunity Constrains Viral Escape
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-17
    Nora C. Pyenson, Kaitlyn Gayvert, Andrew Varble, Olivier Elemento, Luciano A. Marraffini
    更新日期:2017-08-24
  • Reflections on a Decade
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09

    We invited ten Cell Host & Microbe authors, who are experts in their field, to join us in celebrating our anniversary by highlighting an area of host-microbe research that the journal has contributed to advancing.

    更新日期:2017-08-24
  • The Gut Microbiota, Food Science, and Human Nutrition: A Timely Marriage
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Michael J. Barratt, Carlito Lebrilla, Howard-Yana Shapiro, Jeffrey I. Gordon

    Analytic advances are enabling more precise definitions of the molecular composition of key food staples incorporated into contemporary diets and how the nutrient landscapes of these staples vary as a function of cultivar and food processing methods. This knowledge, combined with insights about the interrelationship between consumer microbiota configurations and biotransformation of food ingredients, should have a number of effects on agriculture, food production, and strategies for improving the nutritional value of foods and health status. These effects include decision-making about which cultivars of current or future food staples to incorporate into existing and future food systems, and which components of waste streams from current or future food manufacturing processes have nutritional value that is worth capturing. They can also guide which technologies should be applied, or need to be developed, to produce foods that support efficient microbial biotransformation of their ingredients into metabolic products that sustain health.

    更新日期:2017-08-24
  • Establishing Causality: Opportunities of Synthetic Communities for Plant Microbiome Research
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Julia A. Vorholt, Christine Vogel, Charlotte I. Carlström, Daniel B. Müller

    Plant microbiome research highlights the importance of indigenous microbial communities for host phenotypes such as growth and health. It aims to discover the molecular basis by which host-microbe and microbe-microbe interactions shape and maintain microbial communities and to understand the role of individual microorganisms, as well as their collective ecosystem function. Here, we discuss reductionist approaches to disentangle the inherent complexity of interactions in situ. Experimentally tractable, synthetic communities enable testing of hypotheses by targeted manipulation in gnotobiotic systems. Modifications of microbial, host, and environmental parameters allow for the quantitative assessment of host and microbe characteristics with dynamic and spatial resolution. We summarize first insights from this emerging field and discuss current challenges and limitations. Using multifaceted approaches to detect interactions and functions will provide new insights into the fundamental biology of plant-microbe interactions and help to harness the power of the microbiome.

    更新日期:2017-08-24
  • Commensal Fungi in Health and Disease
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Jose J. Limon, Joseph H. Skalski, David M. Underhill

    Fungi are increasingly being recognized as common members of the microbiomes found on nearly all mucosal surfaces, and interest is growing in understanding how these organisms may contribute to health and disease. In this review, we investigate recent developments in our understanding of the fungal microbiota or “mycobiota” including challenges faced in characterizing it, where these organisms are found, their diversity, and how they interact with host immunity. Growing evidence indicates that, like the bacterial microbiota, the fungal microbiota is often altered in disease states, and increasingly studies are being designed to probe the functional consequences of such fungal dysbiosis on health and disease.

    更新日期:2017-08-24
  • Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Gabriel Mitchell, Ralph R. Isberg

    Recent excitement regarding immune clearance of intracellular microorganisms has focused on two systems that maintain cellular homeostasis. One system includes cellular autophagy components that mediate degradation of pathogens in membrane-bound compartments, in a process termed xenophagy. The second system is driven by interferon-regulated GTPases that promote rupture of pathogen-containing vacuoles and microbial degradation. In the case of xenophagy, pathogen sequestration and compartmentalization suppress inflammation. In contrast, interferon-driven events can lead to exposure of pathogen-associated molecular patterns to the host cytosol with consequent inflammasome activation. Paradoxically, signals and factors involved in xenophagy also mobilize interferon-regulated GTPases, which drive the inflammatory response, indicating considerable cross-talk between these pathways. How these responses are prioritized remains to be understood. In this review, we describe mechanisms of intracellular pathogen clearance that rely on the autophagy machinery and interferon-regulated GTPases, and speculate how these pathways engage each other to balance pathogen elimination with inflammation.

    更新日期:2017-08-24
  • Ten Strategies of Interferon Evasion by Viruses
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Adolfo García-Sastre

    Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral response to replicate and propagate to new hosts. The complex regulation of the IFN response allows viruses to antagonize IFN at multiple levels. However, no single strategy appears to be the golden ticket, and viruses have adopted multiple means to dampen this host defense. This Review does not exhaustively cover all mechanisms of viral IFN antagonism. Rather it examines the ten most common strategies that viruses use to subvert the IFN response with examples from publications appearing in the last 10 years of Cell Host & Microbe. The virus-host interactions involved in induction and evasion of IFN represent a fertile area of research due to the significant large number of host and viral products that regulate this response, resulting in an intricate dance between hosts and their pathogens to achieve an optimal balance between virus replication, host disease, and survival.

    更新日期:2017-08-24
  • Circadian Coordination of Antimicrobial Responses
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Paola Tognini, Christoph A. Thaiss, Eran Elinav, Paolo Sassone-Corsi

    Microbial infection poses a threat to organismal homeostasis and therefore must be efficiently counteracted by host defense mechanisms. It has been recently demonstrated that the immune system may anticipate an emerging pathogenic exposure through a heightened inflammatory state. Such anticipatory responses to fluctuating environmental conditions are typically orchestrated by the circadian clock, an intrinsic time-keeping system that adapts tissue physiology to diurnal variations in external influences. Here, we review current knowledge about the interplay between the circadian clock and antimicrobial responses. We summarize the molecular strategies employed by the circadian system against specific pathogens, the core-clock proteins as well as cells in which they are expressed that mediate host defense, and the consequences of circadian variations on immune function. Furthermore, we highlight the possible implications of such circadian gating in immune reactions against pathogenic infections for the chronopharmacology of antibacterial and antiviral therapies.

    更新日期:2017-08-24
  • Principles of Broad and Potent Antiviral Human Antibodies: Insights for Vaccine Design
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    James E. Crowe

    Antibodies are the principal immune effectors that mediate protection against reinfection following viral infection or vaccination. Robust techniques for human mAb isolation have been developed in the last decade. The study of human mAbs isolated from subjects with prior immunity has become a mainstay for rational structure-based, next-generation vaccine development. The plethora of detailed molecular and genetic studies coupling the structure of antigen-antibody complexes with their antiviral function has begun to reveal common principles of critical interactions on which we can build better vaccines and therapeutic antibodies. This review outlines the approaches to isolating and studying human antiviral mAbs and discusses the common principles underlying the basis for their activity. This review also examines progress toward the goal of achieving a comprehensive understanding of the chemical and physical basis for molecular recognition of viral surface proteins in order to build predictive molecular models that can be used for vaccine design.

    更新日期:2017-08-24
  • Of Mice, Macaques, and Men: Broadly Neutralizing Antibody Immunotherapy for HIV-1
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Yoshiaki Nishimura, Malcolm A. Martin

    The neutralizing antibodies targeting the HIV-1 envelope protein have been a major focus for HIV therapy. Early studies with anti-HIV-1 neutralizing monoclonal antibodies (mAbs) administered to infected individuals showed some promise, as they resulted in transient reductions in plasma viremia in some recipients. However, resistant viral variants rapidly emerged. A major development during the past 6 to 7 years has been the isolation and characterization of highly potent and broadly neutralizing mAbs (bNAbs) from infected individuals known as “elite neutralizers.” These “next-generation” bNAbs have been tested in animal model systems and shown to effectively control virus replication, particularly following combination immunotherapy. The success of these preclinical animal studies has led to human clinical trials using an individual bNAb for therapy. This review examines recent findings from animal models and human clinical trials and discusses the future use of bNAbs for HIV-1 treatment.

    更新日期:2017-08-24
  • Salmonella SPI-2 Type III Secretion System Effectors: Molecular Mechanisms And Physiological Consequences
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Elliott Jennings, Teresa L.M. Thurston, David W. Holden

    Serovars of Salmonella enterica cause both gastrointestinal and systemic diseases in a broad range of mammalian hosts, including humans. Salmonella virulence depends in part on its pathogenicity island 2 type III secretion system (SPI-2 T3SS), which is required to translocate at least 28 effector proteins from vacuolar-resident bacteria into host cells. Comparative genomic analysis reveals that all serovars encode a subset of “core” effectors, suggesting that they are critical for virulence in different hosts. An additional subset of effectors is found sporadically throughout different serovars, and several inhibit activation of the innate immune system. In this Review, we summarize the biochemical activities, host cell interaction partners, and physiological functions of SPI-2 T3SS effectors in the context of the selective pressures encountered by S. enterica in vivo. We also consider some of the remaining challenges to achieve a unified understanding of how effector activities work together to promote Salmonella virulence.

    更新日期:2017-08-24
  • The Molecular Basis of Erythrocyte Invasion by Malaria Parasites
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Alan F. Cowman, Christopher J. Tonkin, Wai-Hong Tham, Manoj T. Duraisingh

    Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of immunologically privileged erythrocytes provides a relatively protective niche as well as access to a rich source of nutrients. Plasmodium spp. target erythrocytes of different ages, but share a common mechanism of invasion. Specific engagement of erythrocyte receptors defines target cell tropism, activating downstream events and resulting in the physical penetration of the erythrocyte, powered by the parasite's actinomyosin-based motor. Here we review the latest in our understanding of the molecular composition of this highly complex and fascinating biological process.

    更新日期:2017-08-24
  • Skin Dysbiosis Goes “Off-Leish”
    Cell Host Microbe (IF 14.946) Pub Date : 2017-07-12
    Tiffany C. Scharschmidt

    There is increasing interest in the contribution of microbes to skin disease. In this issue of Cell Host & Microbe, Gimblet et al. (2017) demonstrate that cutaneous leishmaniasis alters the human skin microbiota. In mice, this dysbiosis is transferable to naive animals, where it augments skin inflammation and disease severity.

    更新日期:2017-08-24
  • Bacteria Tell Us How to Protect Our Intestine
    Cell Host Microbe (IF 14.946) Pub Date : 2017-07-12
    George Birchenough, Gunnar C. Hansson

    The inner colon mucus layer capacity to separate bacteria from the epithelium is dependent on bacterial colonizers signaling to the host epithelium. In this issue of Cell Host & Microbe, Wlodarska et al. (2017) demonstrate that the mucin-utilizing Peptostreptococcus russellii protects the host from inflammatory disease via metabolite signals.

    更新日期:2017-08-24
  • Double the Trouble When Herpesviruses Join Hands
    Cell Host Microbe (IF 14.946) Pub Date : 2017-07-12
    Un Yung Choi, Angela Park, Jae U. Jung

    KSHV is the etiologic agent of PEL—an aggressive lymphoma. Interestingly, EBV concurrently exists in nearly 70% of PEL cases. In this issue of Cell Host & Microbe, McHugh et al. (2017) develop humanized mouse models for EBV/KSHV co-infection and identify their complementary effect on in vivo tumor formation.

    更新日期:2017-08-24
  • War on Viruses: LC3 Recruits GTPases
    Cell Host Microbe (IF 14.946) Pub Date : 2017-07-12
    Teneema Kuriakose, Thirumala-Devi Kanneganti

    Interferon effector functions and autophagy are evolutionarily conserved arms of cell-autonomous immunity that restrict replication of intracellular pathogens. In this issue of Cell Host and Microbe, Biering et al., (2017) demonstrate how host cells co-opt sequential action of autophagy proteins and IFN-inducible GTPases to inhibit replication of positive-sense RNA viruses.

    更新日期:2017-08-24
  • Dual Blades: The Role of Musashi 1 in Zika Replication and Microcephaly
    Cell Host Microbe (IF 14.946) Pub Date : 2017-07-12
    Robyn S. Klein

    Infection with Zika virus (ZIKV) during pregnancy may cause severe developmental defects in the human brain via unknown mechanisms. In a recent issue of Science, Chavali et al. (2017) identified a neural progenitor cell (NPC)-specific RNA binding protein that may underlie the high levels of ZIKV replication and apoptosis observed in these cells during congenital infections.

    更新日期:2017-08-24
  • Cutaneous Leishmaniasis Induces a Transmissible Dysbiotic Skin Microbiota that Promotes Skin Inflammation
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-29
    Ciara Gimblet, Jacquelyn S. Meisel, Michael A. Loesche, Stephen D. Cole, Joseph Horwinski, Fernanda O. Novais, Ana M. Misic, Charles W. Bradley, Daniel P. Beiting, Shelley C. Rankin, Lucas P. Carvalho, Edgar M. Carvalho, Phillip Scott, Elizabeth A. Grice
    更新日期:2017-08-24
  • Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation
    Cell Host Microbe (IF 14.946) Pub Date : 2017-07-12
    Marta Wlodarska, Chengwei Luo, Raivo Kolde, Eva d’Hennezel, John W. Annand, Cortney E. Heim, Philipp Krastel, Esther K. Schmitt, Abdifatah S. Omar, Elizabeth A. Creasey, Ashley L. Garner, Sina Mohammadi, Daniel J. O’Connell, Sahar Abubucker, Timothy D. Arthur, Eric A. Franzosa, Curtis Huttenhower, Leon O. Murphy, Henry J. Haiser, Hera Vlamakis, Jeffrey A. Porter, Ramnik J. Xavier
    更新日期:2017-08-24
  • Synergy between the Host Immune System and Bacteriophage Is Essential for Successful Phage Therapy against an Acute Respiratory Pathogen
    Cell Host Microbe (IF 14.946) Pub Date : 2017-07-12
    Dwayne R. Roach, Chung Yin Leung, Marine Henry, Eric Morello, Devika Singh, James P. Di Santo, Joshua S. Weitz, Laurent Debarbieux
    更新日期:2017-08-24
  • Environmental Stress Causes Lethal Neuro-Trauma during Asymptomatic Viral Infections
    Cell Host Microbe (IF 14.946) Pub Date : 2017-07-12
    Jonathan Chow, Zsuzsa Márka, Imre Bartos, Szabolcs Márka, Jonathan C. Kagan
    更新日期:2017-08-24
  • Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression
    Cell Host Microbe (IF 14.946) Pub Date : 2017-07-12
    Donal McHugh, Nicole Caduff, Mario Henrique M. Barros, Patrick C. Rämer, Ana Raykova, Anita Murer, Vanessa Landtwing, Isaak Quast, Christine T. Styles, Michael Spohn, Adeola Fowotade, Henri-Jacques Delecluse, Alexandra Papoudou-Bai, Yong-Moon Lee, Jin-Man Kim, Jaap Middeldorp, Thomas F. Schulz, Ethel Cesarman, Andrea Zbinden, Riccarda Capaul, Robert E. White, Martin J. Allday, Gerald Niedobitek, David J. Blackbourn, Adam Grundhoff, Christian Münz
    更新日期:2017-08-24
  • Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-29
    Scott B. Biering, Jayoung Choi, Rachel A. Halstrom, Hailey M. Brown, Wandy L. Beatty, Sanghyun Lee, Broc T. McCune, Erin Dominici, Lelia E. Williams, Robert C. Orchard, Craig B. Wilen, Masahiro Yamamoto, Jörn Coers, Gregory A. Taylor, Seungmin Hwang
    更新日期:2017-08-24
  • Induction of INKIT by Viral Infection Negatively Regulates Antiviral Responses through Inhibiting Phosphorylation of p65 and IRF3
    Cell Host Microbe (IF 14.946) Pub Date : 2017-07-12
    Bin Lu, Yujie Ren, Xueqin Sun, Cuijuan Han, Hongyan Wang, Yuxuan Chen, Qianqian Peng, Yongbo Cheng, Xiaoliang Cheng, Qiyun Zhu, Wenxin Li, Hong-Liang Li, Hai-Ning Du, Bo Zhong, Zan Huang
    更新日期:2017-08-24
  • Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine
    Cell Host Microbe (IF 14.946) Pub Date : 2017-07-12
    Elena Zaitseva, Eugene Zaitsev, Kamran Melikov, Anush Arakelyan, Mariana Marin, Rafael Villasmil, Leonid B. Margolis, Gregory B. Melikyan, Leonid V. Chernomordik
    更新日期:2017-08-24
  • HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells
    Cell Host Microbe (IF 14.946) Pub Date : 2017-07-12
    Christian Körner, Camille R. Simoneau, Philipp Schommers, Mitchell Granoff, Maja Ziegler, Angelique Hölzemer, Sebastian Lunemann, Janet Chukwukelu, Björn Corleis, Vivek Naranbhai, Douglas S. Kwon, Eileen P. Scully, Stephanie Jost, Frank Kirchhoff, Mary Carrington, Marcus Altfeld
    更新日期:2017-08-24
  • Diabetes Enhances IL-17 Expression and Alters the Oral Microbiome to Increase Its Pathogenicity
    Cell Host Microbe (IF 14.946) Pub Date : 2017-07-12
    E Xiao, Marcelo Mattos, Gustavo Henrique Apolinário Vieira, Shanshan Chen, Jôice Dias Corrêa, Yingying Wu, Mayra Laino Albiero, Kyle Bittinger, Dana T. Graves
    更新日期:2017-08-24
  • Protectors of the Neonatal Gut: Clostridia Send Pathogens Packing
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-14
    Judith Behnsen

    Commensal bacteria are known to provide colonization resistance in the gut. But exactly which ones provide this function? In a recent paper in Science, Kim et al. (2017) revealed that Clostridia added to mouse infant gut microbiota are sufficient to limit colonization of pathogenic Enterobacteriaceae.

    更新日期:2017-08-24
  • The Making of a Pathogen
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-14
    Kim Lewis, Mariaelena Caboni

    Enterococci are opportunistic pathogens, hard to eradicate because of their unusually robust resistance to antibiotics, disinfectants, and desiccation. In recent work, Lebreton et al. (2017) show that traits promoting survival in hospitals were acquired upon adaptation to terrestrial life when Enterococci split from marine ancestors 400 million years ago.

    更新日期:2017-08-24
  • The Helper T Cell’s Dilemma in Tuberculosis
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-14
    Daniel L. Barber

    Vaccination approaches eliciting strong CD4 T cell responses provide only weak protection from tuberculosis. In this issue of Cell Host & Microbe, Moguche et al. (2017) show that T cells specific for different immunodominant vaccine antigens can fail to protect for opposite reasons, highlighting a major challenge in tuberculosis vaccine design.

    更新日期:2017-08-24
  • Relish the Thought and Channel Your Chloride, for Bacterial Clearance Depends on It
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-14
    Amanda J. Monahan, Neal Silverman

    Macrophage-mediated bacterial clearance relies on phagocytic uptake of the pathogen, subsequent phagolysosomal maturation, and microbial degradation. In this issue of Cell Host & Microbe, Wong et al. (2017) report that a chloride transporter couples phagocytosis and bacterial clearance in an NF-κB-mediated feedforward loop, which is required for sustained pathogen uptake.

    更新日期:2017-08-24
  • Unconventional Interrogation Yields HIV’s Escape Plan
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-14
    Thomas B. Kepler

    Chasing HIV-1 across the genotype landscape, unequipped to anticipate its maneuvers, the antibody variable-region genes pursue the virus in futility. In this issue of Cell Host & Microbe, Dingens et al. (2017) exhibit a powerful technology that reveals the escape pathways of HIV-1 and may enable its capture.

    更新日期:2017-08-24
  • Making the Mark: The Role of Adenosine Modifications in the Life Cycle of RNA Viruses
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-14
    Sarah R. Gonzales-van Horn, Peter Sarnow

    Viral epitranscriptomics is a newly emerging field that has identified unique roles for RNA modifications in modulating life cycles of RNA viruses. Despite the observation of a handful of modified viral RNAs five decades ago, very little was known about how these modifications regulate viral life cycles, until recently. Here we review the pro- and anti-viral effects of methyl-6-adenosine in distinct viral life cycles, the role of 2′ O-methyl modifications in RNA stability and innate immune sensing, and functions of adenosine to inosine modifications in retroviral life cycles. With roles for over 100 modifications in RNA still unknown, this is a rapidly emerging field that is destined to suggest novel antiviral therapies.

    更新日期:2017-08-24
  • IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-14
    Pei-Yun Tsai, Bingkun Zhang, Wei-Qi He, Juan-Min Zha, Matthew A. Odenwald, Gurminder Singh, Atsushi Tamura, Le Shen, Anne Sailer, Sunil Yeruva, Wei-Ting Kuo, Yang-Xin Fu, Sachiko Tsukita, Jerrold R. Turner
    更新日期:2017-08-24
  • Enhancement of IFNγ Production by Distinct Commensals Ameliorates Salmonella-Induced Disease
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-14
    Sophie Thiemann, Nathiana Smit, Urmi Roy, Till Robin Lesker, Eric J.C. Gálvez, Julia Helmecke, Marijana Basic, Andre Bleich, Andrew L. Goodman, Ulrich Kalinke, Richard A. Flavell, Marc Erhardt, Till Strowig
    更新日期:2017-08-24
  • Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-14
    Albanus O. Moguche, Munyaradzi Musvosvi, Adam Penn-Nicholson, Courtney R. Plumlee, Helen Mearns, Hennie Geldenhuys, Erica Smit, Deborah Abrahams, Virginie Rozot, One Dintwe, Søren T. Hoff, Ingrid Kromann, Morten Ruhwald, Peter Bang, Ryan P. Larson, Shahin Shafiani, Shuyi Ma, David R. Sherman, Kevin B. Urdahl
    更新日期:2017-08-24
  • β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections
    Cell Host Microbe (IF 14.946) Pub Date : 2017-05-25
    Heike Grassmé, Brian Henry, Regan Ziobro, Katrin Anne Becker, Joachim Riethmüller, Aaron Gardner, Aaron P. Seitz, Joerg Steinmann, Stephan Lang, Christopher Ward, Edward H. Schuchman, Charles C. Caldwell, Markus Kamler, Michael J. Edwards, Malcolm Brodlie, Erich Gulbins
    更新日期:2017-08-24
  • Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-01
    Ching-On Wong, Steven Gregory, Hongxiang Hu, Yufang Chao, Victoria E. Sepúlveda, Yuchun He, David Li-Kroeger, William E. Goldman, Hugo J. Bellen, Kartik Venkatachalam
    更新日期:2017-08-24
  • Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-14
    Joana Mendonca Santos, Gabrielle Josling, Philipp Ross, Preeti Joshi, Lindsey Orchard, Tracey Campbell, Ariel Schieler, Ileana M. Cristea, Manuel Llinás
    更新日期:2017-08-24
  • Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-14
    Nicholas C. Wu, Jia Xie, Tianqing Zheng, Corwin M. Nycholat, Geramie Grande, James C. Paulson, Richard A. Lerner, Ian A. Wilson
    更新日期:2017-08-24
  • Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses
    Cell Host Microbe (IF 14.946) Pub Date : 2017-06-14
    Shengduo Liu, Shasha Chen, Xinran Li, Shiying Wu, Qian Zhang, Qiuheng Jin, Lin Hu, Ruyuan Zhou, Zhengyang Yu, Fansen Meng, Siwen Wang, Yaowei Huang, Sheng Ye, Li Shen, Zongping Xia, Jian Zou, Xin-Hua Feng, Pinglong Xu
    更新日期:2017-08-24
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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