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  • Multi-platform ’Omics Analysis of Human Ebola Virus Disease Pathogenesis
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-16
    Amie J. Eisfeld, Peter J. Halfmann, Jason P. Wendler, Jennifer E. Kyle, Kristin E. Burnum-Johnson, Zuleyma Peralta, Tadashi Maemura, Kevin B. Walters, Tokiko Watanabe, Satoshi Fukuyama, Makoto Yamashita, Jon M. Jacobs, Young-Mo Kim, Cameron P. Casey, Kelly G. Stratton, Bobbie-Jo M. Webb-Robertson, Marina A. Gritsenko, Matthew E. Monroe, Karl K. Weitz, Anil K. Shukla, Mingyuan Tian, Gabriele Neumann, Jennifer L. Reed, Harm van Bakel, Thomas O. Metz, Richard D. Smith, Katrina M. Waters, Alhaji N'jai, Foday Sahr, Yoshihiro Kawaoka
    更新日期:2017-11-17
  • Mind Your Cs and Gs
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-08
    Oliver I. Fregoso

    How can an innate immune sensor shape viral evolution? In recent work, Takata et al. (2017) determined that the antiviral protein ZAP recognizes CG dinucleotide composition to differentiate self from non-self. This pressure may have driven CG dinucleotide suppression in HIV-1 and other RNA viruses to evade host antiviral defenses.

    更新日期:2017-11-10
  • A Swiss Army Knife to Cut Malaria Transmission
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-08
    Mathilde Gendrin

    The mosquito microbiota is known to naturally limit malaria transmission, acting directly on parasites and via effects on mosquito immunity and fitness. Using genetically modified bacteria and mosquitoes, two studies uncover new potential of this multipotent prospective tool to reduce disease transmission.

    更新日期:2017-11-10
  • Staphylococcus aureus: Master Manipulator of the Skin
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-08
    Michael R. Williams, Teruaki Nakatsuji, Richard L. Gallo

    Skin colonization by Staphylococcus aureus is associated with severity of atopic dermatitis (AD). Two papers in this issue of Cell Host & Microbe by Nakagawa et al. (2017) and Liu et al. (2017) define a pathway by which epicutaneous Staphylococcus aureus promotes skin inflammation and may contribute to AD.

    更新日期:2017-11-10
  • Lipoyl-E2-PDH Gets a Second Job
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-08
    Seth W. Dickey, Michael Otto

    Pyruvate dehydrogenase (PDH) plays a well-known metabolic role inside cells. In this issue of Cell Host & Microbe, Grayczyk et al. (2017) show that the bacterial pathogen Staphylococcus aureus unexpectedly secretes and repurposes the lipoylated E2 subunit of PDH to suppress TLR-mediated activation of host macrophages by bacterial lipoproteins.

    更新日期:2017-11-10
  • Breaking the Barrier: Host Cell Invasion by Lujo Virus
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-08
    Stefan Kunz, Juan Carlos de la Torre

    Lujo virus (LUJV) is an arenavirus that emerged in 2008 associated with a cluster of human cases of severe hemorrhagic fever. In this issue of Cell Host & Microbe, Raaben et al. (2017) identify neuropilin (NRP)-2 as cell surface receptor and the tetraspannin protein CD63 as intracellular entry factor for LUJV.

    更新日期:2017-11-10
  • Getting Your Head around Cerebral Malaria
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-08
    Jeffrey D. Dvorin

    Cerebral malaria is one of the most severe complications of human infection by the Plasmodium falciparum parasite. In this issue of Cell Host & Microbe, Kessler et al. (2017) provide valuable insights into the diagnosis and pathogenesis of this poorly understood manifestation of malaria.

    更新日期:2017-11-10
  • The Human Microbiome and Obesity: Moving beyond Associations
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-08
    Padma Maruvada, Vanessa Leone, Lee M. Kaplan, Eugene B. Chang

    Mounting evidence indicates that the gut microbiome responds to diet, antibiotics, and other external stimuli with speed and high precision and in ways that impact a variety of metabolic conditions including obesity and non-alcoholic fatty liver disease. Despite a decade of research establishing a strong association between the gut microbiota and obesity in humans, a causal relationship and the underlying mechanism remain outstanding. Several technological and methodological limitations in obesity and microbiome research have made it difficult to establish causality in this complex relationship. Additionally, limited collaborative interaction between microbiome and obesity researchers has delayed progress. Here, we discuss the current status of microbiome research as it relates to understanding obesity from the perspective of both communities, outline the underlying research challenges, and suggest directions to advance the obesity-microbiome field as a whole, with particular emphasis on the development of microbiome-targeted therapies for obesity prevention and treatment.

    更新日期:2017-11-10
  • Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-05
    Nicholas R. Meyerson, Ligang Zhou, Yusong R. Guo, Chen Zhao, Yizhi J. Tao, Robert M. Krug, Sara L. Sawyer
    更新日期:2017-11-10
  • The Glycolytic Pyruvate Kinase Is Recruited Directly into the Viral Replicase Complex to Generate ATP for RNA Synthesis
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-05
    Chingkai Chuang, K. Reddisiva Prasanth, Peter D. Nagy
    更新日期:2017-11-10
  • Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-08
    Haiyun Liu, Nathan K. Archer, Carly A. Dillen, Yu Wang, Alyssa G. Ashbaugh, Roger V. Ortines, Tracy Kao, Steven K. Lee, Shuting S. Cai, Robert J. Miller, Mark C. Marchitto, Emily Zhang, Daniel P. Riggins, Roger D. Plaut, Scott Stibitz, Raif S. Geha, Lloyd S. Miller
    更新日期:2017-11-10
  • Staphylococcus aureus Virulent PSMα Peptides Induce Keratinocyte Alarmin Release to Orchestrate IL-17-Dependent Skin Inflammation
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-08
    Seitaro Nakagawa, Masanori Matsumoto, Yuki Katayama, Rena Oguma, Seiichiro Wakabayashi, Tyler Nygaard, Shinobu Saijo, Naohiro Inohara, Michael Otto, Hiroyuki Matsue, Gabriel Núñez, Yuumi Nakamura
    更新日期:2017-11-10
  • NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-08
    Matthijs Raaben, Lucas T. Jae, Andrew S. Herbert, Ana I. Kuehne, Sarah H. Stubbs, Yi-ying Chou, Vincent A. Blomen, Tomas Kirchhausen, John M. Dye, Thijn R. Brummelkamp, Sean P. Whelan
    更新日期:2017-11-10
  • Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing Dual TCRs
    Cell Host Microbe (IF 14.946) Pub Date : 2017-11-08
    C. Pierce Bradley, Fei Teng, Krysta M. Felix, Teruyuki Sano, Debdut Naskar, Katharine E. Block, Haochu Huang, Kenneth S. Knox, Dan R. Littman, Hsin-Jung Joyce Wu
    更新日期:2017-11-10
  • Keeping Time in a Relay Race for Fat
    Cell Host Microbe (IF 14.946) Pub Date : 2017-10-11
    Katya Frazier, Vanessa Leone

    Gut microbes impact host metabolism via a multitude of mechanisms, including through host circadian rhythm regulation. How microbes influence host circadian networks remains unclear. Recently, Wang et al. (2017) showed that crosstalk between specific microbial components and innate immune cells tunes epithelial circadian oscillations via Nfil3, modulating lipid uptake and metabolism.

    更新日期:2017-10-12
  • IFN-Lambda: The Key to Norovirus’s Secret Hideaway
    Cell Host Microbe (IF 14.946) Pub Date : 2017-10-11
    Sonja M. Best, Shelly J. Robertson

    The cellular tropism of noroviruses in immune-competent hosts remains enigmatic. In recent studies in Cell Host & Microbe and Immunity, Lee et al. (2017) and Tomov et al. (2017) determine that norovirus innate immune evasion enables infection of intestinal epithelial cells, escape from adaptive immunity, virus persistence, and shedding.

    更新日期:2017-10-12
  • Pla2g1b Places Worms in Peril
    Cell Host Microbe (IF 14.946) Pub Date : 2017-10-11
    Mark Palma, Darine W. El-Naccache, William C. Gause

    The determinants of helminth resistance are not well understood. In this issue of Cell Host & Microbe, Entwistle et al. (2017) provide intriguing evidence that a phospholipase A2 (Pla2gb1) produced by epithelial cells can impair larval development in helminths, providing a novel mechanism contributing to intestinal nematode resistance.

    更新日期:2017-10-12
  • Shigella Stays on the Move
    Cell Host Microbe (IF 14.946) Pub Date : 2017-10-11
    Noelia Lopez-Montero, Jost Enninga

    Guanylate-binding proteins (GBPs) confer protection against intracellular pathogens. In this issue of Cell Host & Microbe, Wandel et al. (2017) report that cytosolic Shigella becomes trapped within a GBP coat that prevents bacterial cell-to-cell spread. However, this defense mechanism is counteracted by the bacterial E3 ubiquitin ligase IpaH9.8.

    更新日期:2017-10-12
  • Helicobacter pylori Makes a Molecular Incision to Gain Epithelial Entry
    Cell Host Microbe (IF 14.946) Pub Date : 2017-10-11
    Jennifer M. Noto, Richard M. Peek Jr.

    Helicobacter pylori type IV secretion system injects the oncoprotein CagA into epithelial cells to drive carcinogenesis. In this issue of Cell Host & Microbe, Tegtmeyer et al. (2017) show that a secreted bacterial protease disrupts apical-junctional complexes, paving the way for H. pylori to access the basolateral compartment and trigger pathogenesis.

    更新日期:2017-10-12
  • Sociovirology: Conflict, Cooperation, and Communication among Viruses
    Cell Host Microbe (IF 14.946) Pub Date : 2017-10-11
    Samuel L. Díaz-Muñoz, Rafael Sanjuán, Stuart West

    Viruses are involved in various interactions both within and between infected cells. Social evolution theory offers a conceptual framework for how virus-virus interactions, ranging from conflict to cooperation, have evolved. A critical examination of these interactions could expand our understanding of viruses and be exploited for epidemiological and medical interventions.

    更新日期:2017-10-12
  • Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread
    Cell Host Microbe (IF 14.946) Pub Date : 2017-10-11
    H.-Heinrich Hoffmann, William M. Schneider, Vincent A. Blomen, Margaret A. Scull, Alain Hovnanian, Thijn R. Brummelkamp, Charles M. Rice
    更新日期:2017-10-12
  • Epithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic
    Cell Host Microbe (IF 14.946) Pub Date : 2017-10-11
    Lewis J. Entwistle, Victoria S. Pelly, Stephanie M. Coomes, Yashaswini Kannan, Jimena Perez-Lloret, Stephanie Czieso, Mariana Silva dos Santos, James I. MacRae, Lucy Collinson, Abdul Sesay, Nikolay Nikolov, Amina Metidji, Helena Helmby, David Y. Hui, Mark S. Wilson
    更新日期:2017-10-12
  • GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8
    Cell Host Microbe (IF 14.946) Pub Date : 2017-10-11
    Michal P. Wandel, Claudio Pathe, Emma I. Werner, Cara J. Ellison, Keith B. Boyle, Alexander von der Malsburg, John Rohde, Felix Randow
    更新日期:2017-10-12
  • M. tuberculosis-Induced Necrosis of Infected Neutrophils Promotes Bacterial Growth Following Phagocytosis by Macrophages
    Cell Host Microbe (IF 14.946) Pub Date : 2017-10-11
    Tobias Dallenga, Urska Repnik, Björn Corleis, Jacqueline Eich, Rudolph Reimer, Gareth W. Griffiths, Ulrich E. Schaible
    更新日期:2017-10-12
  • Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery
    Cell Host Microbe (IF 14.946) Pub Date : 2017-10-11
    Nicole Tegtmeyer, Silja Wessler, Vittorio Necchi, Manfred Rohde, Aileen Harrer, Tilman T. Rau, Carmen Isabell Asche, Manja Boehm, Holger Loessner, Ceu Figueiredo, Michael Naumann, Ralf Palmisano, Enrico Solcia, Vittorio Ricci, Steffen Backert
    更新日期:2017-10-12
  • The Epstein-Barr Virus Regulome in Lymphoblastoid Cells
    Cell Host Microbe (IF 14.946) Pub Date : 2017-10-11
    Sizun Jiang, Hufeng Zhou, Jun Liang, Catherine Gerdt, Chong Wang, Liangru Ke, Stefanie C.S. Schmidt, Yohei Narita, Yijie Ma, Shuangqi Wang, Tyler Colson, Benjamin Gewurz, Guoliang Li, Elliott Kieff, Bo Zhao
    更新日期:2017-10-12
  • A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-28
    Fei Yu, He Song, Yanling Wu, So Young Chang, Lili Wang, Wei Li, Binbin Hong, Shuai Xia, Chunyu Wang, Surender Khurana, Yang Feng, Yanping Wang, Zhiwu Sun, Biao He, Dongni Hou, Jody Manischewitz, Lisa R. King, Yuanlin Song, Ji-Young Min, Hana Golding, Xinhua Ji, Lu Lu, Shibo Jiang, Dimiter S. Dimitrov, Tianlei Ying
    更新日期:2017-09-29
  • Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-28
    Sanghyun Lee, Craig B. Wilen, Anthony Orvedahl, Broc T. McCune, Ki-Wook Kim, Robert C. Orchard, Stefan T. Peterson, Timothy J. Nice, Megan T. Baldridge, Herbert W. Virgin
    更新日期:2017-09-29
  • A Subset of Polysaccharide Capsules in the Human Symbiont Bacteroides thetaiotaomicron Promote Increased Competitive Fitness in the Mouse Gut
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-28
    Nathan T. Porter, Pablo Canales, Daniel A. Peterson, Eric C. Martens
    更新日期:2017-09-29
  • A Two-Component System Regulates Bacteroides fragilis Toxin to Maintain Intestinal Homeostasis and Prevent Lethal Disease
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-21
    Aaron L. Hecht, Benjamin W. Casterline, Vivian M. Choi, Juliane Bubeck Wardenburg
    更新日期:2017-09-29
  • O-Acetylation of Peptidoglycan Limits Helper T Cell Priming and Permits Staphylococcus aureus Reinfection
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-21
    Marisel Sanchez, Stacey L. Kolar, Sabrina Müller, Christopher N. Reyes, Andrea J. Wolf, Chihiro Ogawa, Rajat Singhania, Daniel D. De Carvalho, Moshe Arditi, David M. Underhill, Gislâine A. Martins, George Y. Liu
    更新日期:2017-09-29
  • Dietary Manganese Promotes Staphylococcal Infection of the Heart
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-21
    Lillian J. Juttukonda, Evelien T.M. Berends, Joseph P. Zackular, Jessica L. Moore, Matthew T. Stier, Yaofang Zhang, Jonathan E. Schmitz, William N. Beavers, Christiaan D. Wijers, Benjamin A. Gilston, Thomas E. Kehl-Fie, James Atkinson, Mary K. Washington, R. Stokes Peebles, Walter J. Chazin, Victor J. Torres, Richard M. Caprioli, Eric P. Skaar
    更新日期:2017-09-29
  • Dancing with the Stars: Phenolic Glycolipids Partners with Macrophages
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Micah D. Dunlap, Shabaana A. Khader

    How Mycobacterium leprae infection causes demyelination to mediate leprosy pathogenesis has been a long-standing question. In a recent Cell paper, Madigan et al. (2017) use a zebrafish model of M. leprae infection to show that infected macrophages patrol axons to trigger mitochondrial damage and induce demyelination of nerve cells.

    更新日期:2017-09-14
  • Tooth Be Told, Genetics Influences Oral Microbiome
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Emily R. Davenport

    The mix of bacteria that coat our teeth impact oral health, but it remains unclear what factors govern their composition. In this issue of Cell Host & Microbe, Gomez et al. (2017) examine the relationship between host genetics and the oral microbiome in the context of health and disease.

    更新日期:2017-09-14
  • Choline Theft—An Inside Job
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Marina Mora-Ortiz, Sandrine Paule Claus

    Choline is a crucial methyl donor necessary for epigenetic regulation. In this issue of Cell Host & Microbe, Romano et al. (2017) demonstrate that choline-utilizing gut bacteria compete with their host for this essential resource, calling for a systematic consideration of gut microbial composition for personalized diet recommendations.

    更新日期:2017-09-14
  • Fragment and Conquer
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Vera Kozjak-Pavlovic, Suvagata Roy Chowdhury, Thomas Rudel

    The replication vacuole of Legionella pneumophila makes contact with host mitochondria. In this issue of Cell Host & Microbe, Escoll et al. (2017) dissect the mechanisms of this interaction, the effect of the T4SS effector MitF on mitochondrial function, and the resultant metabolic reprogramming of infected cells to benefit the bacteria.

    更新日期:2017-09-14
  • Specialized Weaponry: How a Type III-A CRISPR-Cas System Excels at Combating Phages
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Ole Niewoehner, Martin Jinek

    CRISPR-Cas-mediated defense against phage invaders usually requires recognition of short sequences, termed protospacer-adjacent motifs (PAMs), in phage DNA. In this issue of Cell Host & Microbe, Pyenson et al. (2017) show that the lack of a PAM requirement in some CRISPR-Cas systems prevents interference evasion and facilitates phage extinction.

    更新日期:2017-09-14
  • Drivers of Dengue Intrahost Evolution
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Etienne Simon-Lorière, Marco Vignuzzi

    RNA viruses circulate as rapidly evolving swarms of related variants, and their evolutionary dynamics within hosts may be key to understanding virus emergence. In this issue of Cell Host & Microbe, Parameswaran et al. (2017) combine next-generation sequencing and functional studies to characterize viral populations in acute dengue infections.

    更新日期:2017-09-14
  • Host Genetic Control of the Oral Microbiome in Health and Disease
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Andres Gomez, Josh L. Espinoza, Derek M. Harkins, Pamela Leong, Richard Saffery, Michelle Bockmann, Manolito Torralba, Claire Kuelbs, Rohith Kodukula, Jason Inman, Toby Hughes, Jeffrey M. Craig, Sarah K. Highlander, Marcus B. Jones, Chris L. Dupont, Karen E. Nelson
    更新日期:2017-09-14
  • Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Yuxuan Miao, Pradeep Bist, Jianxuan Wu, Qing Zhao, Qi-jing Li, Ying Wan, Soman N. Abraham
    更新日期:2017-09-14
  • Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Brett W. Jagger, Jonathan J. Miner, Bin Cao, Nitin Arora, Amber M. Smith, Attila Kovacs, Indira U. Mysorekar, Carolyn B. Coyne, Michael S. Diamond
    更新日期:2017-09-14
  • Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    David G. Courtney, Edward M. Kennedy, Rebekah E. Dumm, Hal P. Bogerd, Kevin Tsai, Nicholas S. Heaton, Bryan R. Cullen
    更新日期:2017-09-14
  • Intrahost Selection Pressures Drive Rapid Dengue Virus Microevolution in Acute Human Infections
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Poornima Parameswaran, Chunling Wang, Surbhi Bharat Trivedi, Meghana Eswarappa, Magelda Montoya, Angel Balmaseda, Eva Harris
    更新日期:2017-09-14
  • The Landscape of Type VI Secretion across Human Gut Microbiomes Reveals Its Role in Community Composition
    Cell Host Microbe (IF 14.946) Pub Date : 2017-09-13
    Adrian J. Verster, Benjamin D. Ross, Matthew C. Radey, Yiqiao Bao, Andrew L. Goodman, Joseph D. Mougous, Elhanan Borenstein
    更新日期:2017-09-14
  • Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-31
    Pedro Escoll, Ok-Ryul Song, Flávia Viana, Bernhard Steiner, Thibault Lagache, Jean-Christophe Olivo-Marin, Francis Impens, Priscille Brodin, Hubert Hilbi, Carmen Buchrieser
    更新日期:2017-09-04
  • Using Engineered Bacteria to Characterize Infection Dynamics and Antibiotic Effects In Vivo
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-31
    Laura K. Certain, Jeffrey C. Way, Matthew J. Pezone, James J. Collins
    更新日期:2017-09-04
  • Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-31
    Chris Lauber, Stefan Seitz, Simone Mattei, Alexander Suh, Jürgen Beck, Jennifer Herstein, Jacob Börold, Walter Salzburger, Lars Kaderali, John A.G. Briggs, Ralf Bartenschlager
    更新日期:2017-09-04
  • A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-24
    Cheryl N. Miller, Erin P. Smith, Jennifer A. Cundiff, Leigh A. Knodler, Jessica Bailey Blackburn, Vladimir Lupashin, Jean Celli
    更新日期:2017-08-28
  • Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-24
    Kymberleigh A. Romano, Ana Martinez-del Campo, Kazuyuki Kasahara, Carina L. Chittim, Eugenio I. Vivas, Daniel Amador-Noguez, Emily P. Balskus, Federico E. Rey
    更新日期:2017-08-28
  • An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-24
    Luisella Spiga, Maria G. Winter, Tatiane Furtado de Carvalho, Wenhan Zhu, Elizabeth R. Hughes, Caroline C. Gillis, Cassie L. Behrendt, Jiwoong Kim, Daniela Chessa, Helene L. Andrews-Polymenis, Daniel P. Beiting, Renato L. Santos, Lora V. Hooper, Sebastian E. Winter
    更新日期:2017-08-28
  • Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-17
    Melissa M. Remy, Mehmet Sahin, Lukas Flatz, Tommy Regen, Lifen Xu, Mario Kreutzfeldt, Benedict Fallet, Camille Doras, Toni Rieger, Lukas Bestmann, Uwe-Karsten Hanisch, Beat A. Kaufmann, Doron Merkler, Daniel D. Pinschewer
    更新日期:2017-08-24
  • Broad Targeting Specificity during Bacterial Type III CRISPR-Cas Immunity Constrains Viral Escape
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-17
    Nora C. Pyenson, Kaitlyn Gayvert, Andrew Varble, Olivier Elemento, Luciano A. Marraffini
    更新日期:2017-08-24
  • Reflections on a Decade
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09

    We invited ten Cell Host & Microbe authors, who are experts in their field, to join us in celebrating our anniversary by highlighting an area of host-microbe research that the journal has contributed to advancing.

    更新日期:2017-08-24
  • The Gut Microbiota, Food Science, and Human Nutrition: A Timely Marriage
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Michael J. Barratt, Carlito Lebrilla, Howard-Yana Shapiro, Jeffrey I. Gordon

    Analytic advances are enabling more precise definitions of the molecular composition of key food staples incorporated into contemporary diets and how the nutrient landscapes of these staples vary as a function of cultivar and food processing methods. This knowledge, combined with insights about the interrelationship between consumer microbiota configurations and biotransformation of food ingredients, should have a number of effects on agriculture, food production, and strategies for improving the nutritional value of foods and health status. These effects include decision-making about which cultivars of current or future food staples to incorporate into existing and future food systems, and which components of waste streams from current or future food manufacturing processes have nutritional value that is worth capturing. They can also guide which technologies should be applied, or need to be developed, to produce foods that support efficient microbial biotransformation of their ingredients into metabolic products that sustain health.

    更新日期:2017-08-24
  • Establishing Causality: Opportunities of Synthetic Communities for Plant Microbiome Research
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Julia A. Vorholt, Christine Vogel, Charlotte I. Carlström, Daniel B. Müller

    Plant microbiome research highlights the importance of indigenous microbial communities for host phenotypes such as growth and health. It aims to discover the molecular basis by which host-microbe and microbe-microbe interactions shape and maintain microbial communities and to understand the role of individual microorganisms, as well as their collective ecosystem function. Here, we discuss reductionist approaches to disentangle the inherent complexity of interactions in situ. Experimentally tractable, synthetic communities enable testing of hypotheses by targeted manipulation in gnotobiotic systems. Modifications of microbial, host, and environmental parameters allow for the quantitative assessment of host and microbe characteristics with dynamic and spatial resolution. We summarize first insights from this emerging field and discuss current challenges and limitations. Using multifaceted approaches to detect interactions and functions will provide new insights into the fundamental biology of plant-microbe interactions and help to harness the power of the microbiome.

    更新日期:2017-08-24
  • Commensal Fungi in Health and Disease
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Jose J. Limon, Joseph H. Skalski, David M. Underhill

    Fungi are increasingly being recognized as common members of the microbiomes found on nearly all mucosal surfaces, and interest is growing in understanding how these organisms may contribute to health and disease. In this review, we investigate recent developments in our understanding of the fungal microbiota or “mycobiota” including challenges faced in characterizing it, where these organisms are found, their diversity, and how they interact with host immunity. Growing evidence indicates that, like the bacterial microbiota, the fungal microbiota is often altered in disease states, and increasingly studies are being designed to probe the functional consequences of such fungal dysbiosis on health and disease.

    更新日期:2017-08-24
  • Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Gabriel Mitchell, Ralph R. Isberg

    Recent excitement regarding immune clearance of intracellular microorganisms has focused on two systems that maintain cellular homeostasis. One system includes cellular autophagy components that mediate degradation of pathogens in membrane-bound compartments, in a process termed xenophagy. The second system is driven by interferon-regulated GTPases that promote rupture of pathogen-containing vacuoles and microbial degradation. In the case of xenophagy, pathogen sequestration and compartmentalization suppress inflammation. In contrast, interferon-driven events can lead to exposure of pathogen-associated molecular patterns to the host cytosol with consequent inflammasome activation. Paradoxically, signals and factors involved in xenophagy also mobilize interferon-regulated GTPases, which drive the inflammatory response, indicating considerable cross-talk between these pathways. How these responses are prioritized remains to be understood. In this review, we describe mechanisms of intracellular pathogen clearance that rely on the autophagy machinery and interferon-regulated GTPases, and speculate how these pathways engage each other to balance pathogen elimination with inflammation.

    更新日期:2017-08-24
  • Ten Strategies of Interferon Evasion by Viruses
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Adolfo García-Sastre

    Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral response to replicate and propagate to new hosts. The complex regulation of the IFN response allows viruses to antagonize IFN at multiple levels. However, no single strategy appears to be the golden ticket, and viruses have adopted multiple means to dampen this host defense. This Review does not exhaustively cover all mechanisms of viral IFN antagonism. Rather it examines the ten most common strategies that viruses use to subvert the IFN response with examples from publications appearing in the last 10 years of Cell Host & Microbe. The virus-host interactions involved in induction and evasion of IFN represent a fertile area of research due to the significant large number of host and viral products that regulate this response, resulting in an intricate dance between hosts and their pathogens to achieve an optimal balance between virus replication, host disease, and survival.

    更新日期:2017-08-24
  • Circadian Coordination of Antimicrobial Responses
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    Paola Tognini, Christoph A. Thaiss, Eran Elinav, Paolo Sassone-Corsi

    Microbial infection poses a threat to organismal homeostasis and therefore must be efficiently counteracted by host defense mechanisms. It has been recently demonstrated that the immune system may anticipate an emerging pathogenic exposure through a heightened inflammatory state. Such anticipatory responses to fluctuating environmental conditions are typically orchestrated by the circadian clock, an intrinsic time-keeping system that adapts tissue physiology to diurnal variations in external influences. Here, we review current knowledge about the interplay between the circadian clock and antimicrobial responses. We summarize the molecular strategies employed by the circadian system against specific pathogens, the core-clock proteins as well as cells in which they are expressed that mediate host defense, and the consequences of circadian variations on immune function. Furthermore, we highlight the possible implications of such circadian gating in immune reactions against pathogenic infections for the chronopharmacology of antibacterial and antiviral therapies.

    更新日期:2017-08-24
  • Principles of Broad and Potent Antiviral Human Antibodies: Insights for Vaccine Design
    Cell Host Microbe (IF 14.946) Pub Date : 2017-08-09
    James E. Crowe

    Antibodies are the principal immune effectors that mediate protection against reinfection following viral infection or vaccination. Robust techniques for human mAb isolation have been developed in the last decade. The study of human mAbs isolated from subjects with prior immunity has become a mainstay for rational structure-based, next-generation vaccine development. The plethora of detailed molecular and genetic studies coupling the structure of antigen-antibody complexes with their antiviral function has begun to reveal common principles of critical interactions on which we can build better vaccines and therapeutic antibodies. This review outlines the approaches to isolating and studying human antiviral mAbs and discusses the common principles underlying the basis for their activity. This review also examines progress toward the goal of achieving a comprehensive understanding of the chemical and physical basis for molecular recognition of viral surface proteins in order to build predictive molecular models that can be used for vaccine design.

    更新日期:2017-08-24
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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