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Exploring rhodanine linked enamine–carbohydrazide derivatives as mycobacterial carbonic anhydrase inhibitors: Design, synthesis, biological evaluation, and molecular docking studies Arch. Pharm. (IF 5.1) Pub Date : 2024-03-18 Sarvan Maddipatla, Bulti Bakchi, Rutuja Rama Gadhave, Andrea Ammara, Shashikanta Sau, Bandela Rani, Srinivas Nanduri, Nitin Pal Kalia, Claudiu T. Supuran, Venkata Madhavi Yaddanapudi
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Sulfonamide-incorporated bis(α-aminophosphonates) as promising carbonic anhydrase inhibitors: Design, synthesis, biological evaluation, and X-ray crystallographic studies Arch. Pharm. (IF 5.1) Pub Date : 2024-03-18 Marjan Sobati, Morteza Abdoli, Andrea Angeli, Alessandro Bonardi, Marta Ferraroni, Claudiu T. Supuran, Raivis Žalubovskis
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Morpholinodiazenyl chalcone blocks influenza A virus capsid uncoating by perturbing the clathrin‐mediated vesicular trafficking pathway Arch. Pharm. (IF 5.1) Pub Date : 2024-03-16 Ahammed A. Thottasseri, Gaganpreet Kaur, Deepthi Ramesh, Indranil Banerjee, Tharanikkarasu Kannan
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N1‐Benzoylated 5‐(4‐pyridinyl)indazole‐based kinase inhibitors: Attaining haspin and Clk4 selectivity via modulation of the benzoyl substituents Arch. Pharm. (IF 5.1) Pub Date : 2024-03-13 Habiba G. Aboelfotouh, Mennatallah Abdallah, Hend Khalifa, Youssef Aboushady, Ashraf H. Abadi, Matthias Engel, Mohammad Abdel‐Halim
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Design, synthesis, structure elucidation, antimicrobial, molecular docking, and SAR studies of novel urea derivatives bearing tricyclic aromatic hydrocarbon rings Arch. Pharm. (IF 5.1) Pub Date : 2024-03-11 Farid M. Sroor, Ahmed F. El‐Sayed, Mohamed Abdelraof
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Design, synthesis, and biological evaluation of 3‐benzenesulfonamide‐linked 3‐hydrazinoisatin derivatives as carbonic anhydrase inhibitors Arch. Pharm. (IF 5.1) Pub Date : 2024-03-11 Baijayantimala Swain, Vaibhav S. Marde, Priti Singh, Andrea Angeli, Abrar Khan, Venkata M. Yaddanapudi, Qasim Ullah, Claudiu T. Supuran, Mohammed Arifuddin
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Design and synthesis of highly selective Janus kinase 3 covalent inhibitors for the treatment of rheumatoid arthritis Arch. Pharm. (IF 5.1) Pub Date : 2024-03-05 Hualiang Yao, Jie Zhang, Qisheng Zheng, Xianxia Zeng, Huaizheng Huang, Zhen Ling, Minghai Tang, Zhiquan Chen, Wenchu Wang, Linhong He
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4‐{3‐[(Pyridin‐4‐ylmethyl)amino]‐[1,2,4]triazolo[4,3‐b][1,2,4]triazin‐6‐yl}phenol: An improved anticancer agent in hepatocellular carcinoma and a selective MDR1/MRP modulator Arch. Pharm. (IF 5.1) Pub Date : 2024-03-05 Zahra Zakeri Khatir, Antonella Di Sotto, Ester Percaccio, Tuba Tuylu Kucukkilinc, Ayse Ercan, Ann M. Chippindale, Mehdi Valipour, Hamid Irannejad
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A decade's overview of 2‐aminothiophenes and their fused analogs as promising anticancer agents Arch. Pharm. (IF 5.1) Pub Date : 2024-03-05 Donia G. Darwish, Hany A. M. El‐Sherief, Salah A. Abdel‐Aziz, Gamal El‐Din A. Abuo‐Rahma
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Novel benzene sulfonamides with acetylcholinesterase and carbonic anhydrase inhibitory actions Arch. Pharm. (IF 5.1) Pub Date : 2024-03-01 Rafika El Ati, Necla Öztaşkın, Ahmet Çağan, Akın Akıncıoğlu, Yeliz Demir, Süleyman Göksu, Rachid Touzani, İlhami Gülçin
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A comparative untargeted metabolomic analysis and assessment of antiplasmodial potential of nine Albizia species Arch. Pharm. (IF 5.1) Pub Date : 2024-02-27 Yosra A. El Khodary, Iriny M. Ayoub, Pierre Pério, Sandra Bourgeade‐Delmas, Nehal Ibrahim, Sherweit H. El‐Ahmady
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Targeting Lewy body dementia with neflamapimod‐rasagiline hybrids Arch. Pharm. (IF 5.1) Pub Date : 2024-02-27 Claudia Albertini, Sabrina Petralla, Francesca Massenzio, Barbara Monti, Nicola Rizzardi, Christian Bergamini, Elisa Uliassi, Fernanda Borges, Daniel Chavarria, Gert Fricker, Marcia Goettert, Thales Kronenberger, Matthias Gehringer, Stefan Laufer, Maria L. Bolognesi
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Chemical composition and biological activities of Cucurbita okeechobeensis extracts from its aerial parts, seeds, and fruit shells Arch. Pharm. (IF 5.1) Pub Date : 2024-02-26 Eulogio J. Llorent‐Martínez, Antonio Ruiz‐Medina, Milena Terzic, Kouadio Ibrahime Sinan, Ismail Koyuncu, Kadir Egi, Nilofar Nilofar, Gokhan Zengin
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Quinoa as phytopharmaceutical? Urinary elimination of ecdysterone after consumption of quinoa alone and in combination with spinach Arch. Pharm. (IF 5.1) Pub Date : 2024-02-24 Eduard Isenmann, Tasha Yuliandra, Konstantina Touvleliou, Matthias Broekmann, Xavier de la Torre, Francesco Botrè, Patrick Diel, Maria Kristina Parr
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Ligandability assessment of the C‐terminal Rel‐homology domain of NFAT1 Arch. Pharm. (IF 5.1) Pub Date : 2024-02-24 Jark Böttcher, Julian E. Fuchs, Moriz Mayer, Jan Kahmann, Krzysztof M. Zak, Tobias Wunberg, Simon Woehrle, Dirk Kessler
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Novel quinoline derivatives with broad‐spectrum antiprotozoal activities Arch. Pharm. (IF 5.1) Pub Date : 2024-02-24 Carla B. Hartman, Phelelisiwe S. Dube, Lesetja J. Legoabe, Natascha Van Pelt, An Matheeussen, Guy Caljon, Richard M. Beteck
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Rational design and synthesis of 2,4‐dichloro‐6‐methyl pyrimidine derivatives as potential selective EGFRT790M/L858R inhibitors for the treatment of non‐small cell lung cancer Arch. Pharm. (IF 5.1) Pub Date : 2024-02-21 Lei Duan, Cilong Chu, Xiaoling Huang, Huizhi Yao, Jie Wen, Rui Chen, Caolin Wang, Yuanbiao Tu, Qiaoli Lv, Qingshan Pan, Shan Xu
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Novel N-pyrocatechoyl and N-pyrogalloyl hydrazone antioxidants endowed with cytotoxic and antibacterial activity Arch. Pharm. (IF 5.1) Pub Date : 2024-02-12 Jovica Branković, Vesna Matejić, Dušica Simijonović, Milena D. Vukić, Miroslava Kačaniova, Marko Živanović, Ana Mirić, Jelena Košarić, Marija Branković, Vladimir P. Petrović
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Synthesis of novel benzylamine antimycotics and evaluation of their antimycotic potency Arch. Pharm. (IF 5.1) Pub Date : 2024-02-12 Monika Klimt, Martina Stadler, Ulrike Binder, Jürgen Krauss
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SiteMine: Large-scale binding site similarity searching in protein structure databases Arch. Pharm. (IF 5.1) Pub Date : 2024-02-09 Thorben Reim, Christiane Ehrt, Joel Graef, Sebastian Günther, Alke Meents, Matthias Rarey
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Advances in sample preparation methods for pesticide residue analysis in medicinal plants: A focus on Nepal Arch. Pharm. (IF 5.1) Pub Date : 2024-02-08 Sudip Pandey, Poonam Pant, Stefano Dall'Acqua
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A virtual library of small molecules mimicking dipeptides Arch. Pharm. (IF 5.1) Pub Date : 2024-02-08 Victor Jun Yu Lim, Hans-Dieter Gerber, Hannes Schihada, Van Tuan Trinh, Daniel Hilger, Olalla Vázquez, Peter Kolb
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Design, synthesis, and evaluation of dual-target inhibitors for the treatment of Alzheimer's disease Arch. Pharm. (IF 5.1) Pub Date : 2024-02-08 Jingfang Zhai, Canhua Hao, Xiaojing Wang, Yuexing Cao, Yinbo Pan, Min Zhou, Jie Sun, Chuanyou Li
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Sulfonyl thioureas with a benzo[d]thiazole ring as dual acetylcholinesterase/butyrylcholinesterase and human monoamine oxidase A and B inhibitors: An in vitro and in silico study Arch. Pharm. (IF 5.1) Pub Date : 2024-02-06 Nguyen Dinh Thanh, Do Son Hai, Vu Ngoc Toan, Hoang Thi Kim Van, Nguyen Thi Kim Giang, Nguyen Minh Tri
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Extracting binding energies and binding modes from biomolecular simulations of fragment binding to endothiapepsin Arch. Pharm. (IF 5.1) Pub Date : 2024-02-06 Birte Schmitz, Benedikt Frieg, Nadine Homeyer, Gisela Jessen, Holger Gohlke
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Dual COX-2 and 15-LOX inhibition study of novel 4-arylidine-2-mercapto-1-phenyl-1H-imidazolidin-5(4H)-ones: Design, synthesis, docking, and anti-inflammatory activity Arch. Pharm. (IF 5.1) Pub Date : 2024-02-05 Nermine A. Osman, Mostafa K. Soltan, Samar Rezq, Joseph Flaherty, Damian G. Romero, Ahmed S. Abdelkhalek
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UHPLC-ESI-QTOF-MS metabolite profiles of different extracts from Pelargonium endlicherianum parts and their biological properties based on network pharmacological approaches Arch. Pharm. (IF 5.1) Pub Date : 2024-02-05 Gokhan Zengin, Francisco Javier Leyva-Jiménez, Álvaro Fernández-Ochoa, Abdelhakim Bouyahya, Evren Yildiztugay, Antonio Segura Carretero, Mohamad Fawzi Mahomoodally, Sathish Kumar M Ponniya, Nilofar, Ismail Koyuncu, Özgür Yüksekdağ, María de la Luz Cádiz-Gurrea
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Multipathway regulation induced by 4-(phenylsulfonyl)morpholine derivatives against triple-negative breast cancer Arch. Pharm. (IF 5.1) Pub Date : 2024-02-05 Fan-Wei Yang, Te-Lun Mai, Ying-Chung Jimmy Lin, Yu-Chen Chen, Shang-Che Kuo, Chia-Ming Lin, Meng-Hsuan Lee, Jung-Chen Su
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Quinazoline-chalcone hybrids as HDAC/EGFR dual inhibitors: Design, synthesis, mechanistic, and in-silico studies of potential anticancer activity against multiple myeloma Arch. Pharm. (IF 5.1) Pub Date : 2024-01-31 Mostafa A. Mansour, Asmaa M. AboulMagd, Samar H. Abbas, Mohamed Abdel-Aziz, Hamdy M. Abdel-Rahman
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Design, synthesis, and biological evaluation of naphthoylamide derivatives as inhibitors of STAT3 phosphorylation Arch. Pharm. (IF 5.1) Pub Date : 2024-01-31 JiaHao Lu, XiuYang Yan, WuJi Lai, Li-He Jiang, Li-Qun Shen, Ai-Qun Wu, Chengguang Zhao
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Valorization of Citrus peels: GC/MS-based metabolites profiling, multivariate analysis, and antiaging potential Arch. Pharm. (IF 5.1) Pub Date : 2024-01-30 Wafaa M. El Kady, Iriny M. Ayoub, Ahmed K. El Mehrate, Mohamed Emad, Mohamed Tarek, Ahmed El Gdeily, El-Romisaa Mohamed, Rana Medhat, Omar Mahmoud, Amira M. Gad, Alaa M. Danderawy, Ola L. Breaka, Nada E. Mosad, Safaa M. Gemeaha, Noha Fathallah
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Design, synthesis, and activity evaluation of novel multitargeted l-tryptophan derivatives with powerful antioxidant activity against Alzheimer's disease Arch. Pharm. (IF 5.1) Pub Date : 2024-01-30 Xianghao Zeng, Shaobing Cheng, Huilan Li, Haiyang Yu, Yushun Cui, Yuanying Fang, Shilin Yang, Yulin Feng
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On the hunt for metalloenzyme inhibitors: Investigating the presence of metal-coordinating compounds in screening libraries and chemical spaces Arch. Pharm. (IF 5.1) Pub Date : 2024-01-26 Bruna Schuck, Ruth Brenk
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Identification and assessment of new PIM2 inhibitors for treating hematologic cancers: A combined approach of energy-based virtual screening and machine learning evaluation Arch. Pharm. (IF 5.1) Pub Date : 2024-01-23 Xi Chen, Jingyi Zhao, Roufen Chen, Liteng Shen, Jialiang Lu, Yu Guo, Xinglong Chi, Shuangshuang Geng, Qingnan Zhang, Zhichao Pan, Xinjun He, Lei Xu, Zheyuan Shen, Haiyan Yang, Tao Lei
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Immunomodulatory activities and biomedical applications of melittin and its recent advances Arch. Pharm. (IF 5.1) Pub Date : 2024-01-22 Zohreh Jafari, Sahar Sadeghi, Mahsa Mirzarazi Dehaghi, Ashkan Bigham, Shokouh Honarmand, Afsaneh Tavasoli, Mostafa Haji Molla Hoseini, Rajender S. Varma
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Biaryl carboxamide-based peptidomimetics analogs as potential pancreatic lipase inhibitors for treating obesity Arch. Pharm. (IF 5.1) Pub Date : 2024-01-22 Vikash K. Yadav, Patil A. Adhikrao, Gudle M. Motiram, Nisha Yadav, Utkarsh Jagtap, Gautam Kumar, Atish Paul
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Exosomal miR-122, miR-128, miR-200, miR-298, and miR-342 as novel diagnostic biomarkers in NAFL/NASH: Impact of LPS/TLR-4/FoxO3 pathway Arch. Pharm. (IF 5.1) Pub Date : 2024-01-22 Ahmed M. Samy, Mohamed A. Kandeil, Dina Sabry, A. A. Abdel-Ghany, Mohamed O. Mahmoud
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Indole clubbed 2,4-thiazolidinedione linked 1,2,3-triazole as a potent antimalarial and antibacterial agent against drug-resistant strain and molecular modeling studies Arch. Pharm. (IF 5.1) Pub Date : 2024-01-21 Dipti B. Upadhyay, Jaydeep A. Mokariya, Paras J. Patel, Subham G. Patel, Anwesha Das, Arijit Nandi, Joaquina Nogales, Nachiket More, Amit Kumar, Dhanji P. Rajani, Mahesh Narayan, Jyotish Kumar, Sourav Banerjee, Suban K. Sahoo, Hitendra M. Patel
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Synthesis of 2-(pyridylvinyl)chromen-4-ones and their N-oxide analogs for assessment of their biological activities as anticancer agents Arch. Pharm. (IF 5.1) Pub Date : 2024-01-16 Yu Chun Ding, Yi-Cheng Chu, Chuan-Hsin Chang, Jia-Hua Liang, Jih-Jung Chen, Tzenge-Lien Shih
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Inhibitory effect of galantamine and donepezil combination against cholinesterase: An in silico and in vitro study Arch. Pharm. (IF 5.1) Pub Date : 2024-01-16 Camila W. Adarvez-Feresin, Javier E. Ortiz, Mauricio D. Piñeiro, Oscar Parravicini, Ricardo D. Enriz, Adriana D. Garro, Gabriela E. Feresin
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Current scenario of chalcone hybrids with antibreast cancer therapeutic applications Arch. Pharm. (IF 5.1) Pub Date : 2024-01-16 Huan Wang, Juanying Zhu, Qianru Zhang, Jie Tang, Xufeng Huang
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Synthesis and evaluation of febrifugine derivatives as anticoccidial agents Arch. Pharm. (IF 5.1) Pub Date : 2024-01-12 Da Tang, Xiao-Hu Chen, Yuan-Di Yu, Yu Deng
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Benzothiazole-based apoptosis inducers: A comprehensive overview and future prospective Arch. Pharm. (IF 5.1) Pub Date : 2024-01-11 Payal Kamboj, Anjali Mahore, Asif Husain, Mohammad Amir
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Triazole derivatives as potential xanthine oxidase inhibitors: Design, enzyme inhibition potential, and docking studies Arch. Pharm. (IF 5.1) Pub Date : 2024-01-09 Harmandeep Kaur Gulati, Aanchal Khanna, Nitish Kumar, Anchal Sharma, Rupali, Jyoti, Jatindervir Singh, Kavita Bhagat, Preet Mohinder Singh Bedi
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Structure-guided design of potent JAK1-selective inhibitors based on 4-amino-7H-pyrrolo[2,3-d]pyrimidine with anti-inflammatory efficacy Arch. Pharm. (IF 5.1) Pub Date : 2024-01-07 Jiahao Zhang, Shuming Xing, Jianming Cui, Xiujian Wei, Zhi Cao, Bin Shao, Nan Jiang, Xin Zhai
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Novel radioiodinated desvenlafaxine-loaded lipid nanocapsule for brain delivery Arch. Pharm. (IF 5.1) Pub Date : 2023-12-31 Veronia R. Ayoub, Mona M. A. Abdel-Mottaleb, Ismail T. Ibrahem, Mohamed A. Motaleb, Ahmed S. Geneidi
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Radiosynthesis and whole-body distribution in mice of a 18F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease Arch. Pharm. (IF 5.1) Pub Date : 2023-12-29 Sang Hee Lee, Rosa Purgatorio, Francesco Samarelli, Marco Catto, Nunzio Denora, Maria Grazia Morgese, Paolo Tucci, Luigia Trabace, Hye Won Kim, Hyun Soo Park, Sang Eun Kim, Byung Chul Lee, Modesto de Candia, Cosimo D. Altomare
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Synthesis and biological evaluation of novel benzenesulfonamide incorporated thiazole–triazole hybrids as antimicrobial and antioxidant agents Arch. Pharm. (IF 5.1) Pub Date : 2023-12-28 Monika, Chander, Deepansh Sharma, Pawan K. Sharma, Sita Ram
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Developments in the chemistry and biology of 1,2,3-triazolyl-C-nucleosides Arch. Pharm. (IF 5.1) Pub Date : 2023-12-27 Sarah Moreira Rodrigues do Nascimento, Angélique Ferry, Florian Gallier, Nadège Lubin-Germain, Jacques Uziel, Simon Gonzales, Leandro Soter de Mariz e Miranda
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Microwave-induced one-pot synthesis of 3-imidazolyl indole clubbed 1,2,3-triazole hybrids as antiproliferative agents and density functional theory study Arch. Pharm. (IF 5.1) Pub Date : 2023-12-27 Dipakkumar D. Chudasama, Chetan V. Rajput, Manan S. Patel, Jaydeepkumar N. Parekh, Harsh C. Patel, Navin P. Chikhaliya, Adrián Puerta, José M. Padrón, Kesur R. Ram
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Carbonylbis(hydrazine-1-carbothioamide) derivatives as a new class of α-glucosidase inhibitors and their mechanistic insights via molecular docking and dynamic simulations Arch. Pharm. (IF 5.1) Pub Date : 2023-12-26 Saira Naseem, Shamool Fatima, Saeed Ullah, Ajmal Khan, Suraj N. Mali, Rahul D. Jawarkar, Asad Syed, Abdallah M. Elgorban, Ahmed Al-Harrasi, Zahid Shafiq
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Synthesis of novel pyrimido[4,5-b]quinoline derivatives as dual EGFR/HER2 inhibitors as anticancer agents Arch. Pharm. (IF 5.1) Pub Date : 2023-12-26 Nahla Said M. Ibrahim, Hanan H. Kadry, Ashraf F. Zaher, Khaled O. Mohamed
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Liposomes modified with a multivalent glutamic hexapeptide: A novel and effective way to promote bone targeting Arch. Pharm. (IF 5.1) Pub Date : 2023-12-22 Yi Zhao, Yang Yang, Yamin Cui, Ze Zhao, Xing Chen
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Nascent pharmacological advancement in adamantane derivatives Arch. Pharm. (IF 5.1) Pub Date : 2023-12-21 Aman Ragshaniya, Vijay Kumar, Ram Kumar Tittal, Kashmiri Lal
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Identification of novel sulfathiazole-triazolo-chalcone hybrids as VEGFR-2/EGFR dual inhibitors with antiangiogenic activity and apoptotic induction Arch. Pharm. (IF 5.1) Pub Date : 2023-12-20 Mohamed A. Zeidan, Dina I. A. Othman, Fatma E. Goda, Amany S. Mostafa
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A combined approach of structure-based virtual screening and NMR to interrupt the PD-1/PD-L1 axis: Biphenyl-benzimidazole containing compounds as novel PD-L1 inhibitors Arch. Pharm. (IF 5.1) Pub Date : 2023-12-18 Greta Donati, Monica Viviano, Vincenzo Maria D'Amore, Alessandra Cipriano, Isidora Diakogiannaki, Jussara Amato, Stefano Tomassi, Diego Brancaccio, Pasquale Russomanno, Francesco Saverio Di Leva, Daniela Arosio, Pierfausto Seneci, Sabrina Taliani, Katarzyna Magiera-Mularz, Bogdan Musielak, Lukasz Skalniak, Tad A. Holak, Sabrina Castellano, Valeria La Pietra, Luciana Marinelli
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The anti-breast cancer therapeutic potential of 1,2,3-triazole-containing hybrids Arch. Pharm. (IF 5.1) Pub Date : 2023-12-18 Juntao Song, Shuai Zhang, Bo Zhang, Junwei Ma
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Phthalimide-tethered isatins as novel poly(ADP-ribose) polymerase inhibitors: Design, synthesis, biological evaluations, and molecular modeling investigations Arch. Pharm. (IF 5.1) Pub Date : 2023-12-15 Mahmoud A. El Hassab, Amer Ali Abd El-Hafeez, Hadia Almahli, Zainab M. Elsayed, Wagdy M. Eldehna, Ghaneya S. Hassan, Sahar M. Abou-Seri