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How gut microbiota may impact ocular surface homeostasis and related disorders Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-03-08 Marc Labetoulle, Christophe Baudouin, Jose M. Benitez del Castillo, Maurizio Rolando, Maria Rescigno, Elisabeth M. Messmer, Pasquale Aragona
Changes in the bacterial flora in the gut, also described as gut microbiota, are readily acknowledged to be associated with several systemic diseases, especially those with an inflammatory, neuronal, psychological or hormonal factor involved in the pathogenesis and/or the perception of the disease. Maintaining ocular surface homeostasis is also based on all these four factors, and there is accumulating
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Translocator protein (18 kDa) (Tspo) in the retina and implications for ocular diseases Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-03-01 Mandy Hector, Thomas Langmann, Anne Wolf
Translocator protein (18 kDa) (Tspo), formerly known as peripheral benzodiazepine receptor is a highly conserved transmembrane protein primarily located in the outer mitochondrial membrane. In the central nervous system (CNS), especially in glia cells, Tspo is upregulated upon inflammation. Consequently, Tspo was used as a tool for diagnostic imaging of neuroinflammation in the brain and as a potential
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Pluripotent stem cell-derived models of retinal disease: Elucidating pathogenesis, evaluating novel treatments, and estimating toxicity Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-02-16 Marzena Kurzawa-Akanbi, Nik Tzoumas, Julio C. Corral-Serrano, Rosellina Guarascio, David Steel, Michael E. Cheetham, Lyle Armstrong, Majlinda Lako
Blindness poses a growing global challenge, with approximately 26% of cases attributed to degenerative retinal diseases. While gene therapy, optogenetic tools, photosensitive switches, and retinal prostheses offer hope for vision restoration, these high-cost therapies will benefit few patients. Understanding retinal diseases is therefore key to advance effective treatments, requiring models replicating
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Modeling complex age-related eye disease Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-02-15 Silke Becker, Zia L'Ecuyer, Bryan W. Jones, Moussa A. Zouache, Fiona S. McDonnell, Frans Vinberg
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Central serous chorioretinopathy: An evidence-based treatment guideline Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-02-01 Helena M.A. Feenstra, Elon H.C. van Dijk, Chui Ming Gemmy Cheung, Kyoko Ohno-Matsui, Timothy Y.Y. Lai, Hideki Koizumi, Michael Larsen, Giuseppe Querques, Susan M. Downes, Suzanne Yzer, Mark P. Breazzano, Yousif Subhi, Ramin Tadayoni, Siegfried G. Priglinger, Laurenz J.B. Pauleikhoff, Clemens A.K. Lange, Anat Loewenstein, Roselie M.H. Diederen, Reinier O. Schlingemann, Carel B. Hoyng, Jay K. Chhablani
Central serous chorioretinopathy (CSC) is a relatively common disease that causes vision loss due to macular subretinal fluid leakage and is often associated with reduced vision-related quality of life. In CSC, the leakage of subretinal fluid through defects in the retinal pigment epithelial layer's outer blood-retina barrier appears to occur secondary to choroidal abnormalities and dysfunction. The
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Phenotyping and genotyping inherited retinal diseases: Molecular genetics, clinical and imaging features, and therapeutics of macular dystrophies, cone and cone-rod dystrophies, rod-cone dystrophies, leber congenital amaurosis, and cone dysfunction syndromes Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-01-24 Michalis Georgiou, Anthony G. Robson, Kaoru Fujinami, Thales A.C. de Guimarães, Yu Fujinami-Yokokawa, Malena Daich Varela, Nikolas Pontikos, Angelos Kalitzeos, Omar A. Mahroo, Andrew R. Webster, Michel Michaelides
Inherited retinal diseases (IRD) are a leading cause of blindness in the working age population and children. The scope of this review is to familiarise clinicians and scientists with the current landscape of molecular genetics, clinical phenotype, retinal imaging and therapeutic prospects/completed trials in IRD. Herein we present in a comprehensive and concise manner: (i) macular dystrophies (Stargardt
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Optic neuropathy in high myopia: Glaucoma or high myopia or both? Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-01-21 Xiulan Zhang, Jingwen Jiang, Kangjie Kong, Fei Li, Shida Chen, Peiyuan Wang, Yunhe Song, Fengbin Lin, Timothy P.H. Lin, Linda M. Zangwill, Kyoko Ohno-Matsui, Jost B. Jonas, Robert N. Weinreb, Dennis S.C. Lam, Glaucoma Suspects with High Myopia Study Group
Due to the increasing prevalence of high myopia around the world, structural and functional damages to the optic nerve in high myopia has recently attracted much attention. Evidence has shown that high myopia is related to the development of glaucomatous or glaucoma-like optic neuropathy, and that both have many common features. These similarities often pose a diagnostic challenge that will affect
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Mechanisms of blood-retinal barrier disruption related to intraocular inflammation and malignancy Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-01-17 Oren Tomkins-Netzer, Rachael Niederer, John Greenwood, Ido Didi Fabian, Yonatan Serlin, Alon Friedman, Sue Lightman
Blood-retinal barrier (BRB) disruption is a common accompaniment of intermediate, posterior and panuveitis causing leakage into the retina and macular oedema resulting in vision loss. It is much less common in anterior uveitis or in patients with intraocular lymphoma who may have marked signs of intraocular inflammation. New drugs used for chemotherapy (cytarabine, immune checkpoint inhibitors, BRAF
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Investing in vision: Innovation in retinal therapeutics and the influence on venture capital investment Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-01-12 Dmitrij Hristodorov, Tim Lohoff, Nanna Luneborg, Geert-Jan Mulder, Simon J. Clark
Since the groundbreaking approval of the first anti-VEGF therapy in 2004, the retinal therapeutics field has undergone a remarkable transformation, witnessing a surge in novel, disease-modifying therapeutics for a broad spectrum of retinal diseases, extending beyond exudative VEGF-driven conditions. The surge in scientific advancement and the pressing, unmet, medical need have captured the attention
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Punctate inner choroidopathy: A review of the current diagnostic and therapeutic approaches Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-01-03 Dimitrios Kalogeropoulos, Najiha Rahman, Farid Afshar, Nigel Hall, Andrew John Lotery
Punctate inner choroidopathy (PIC) is an uncommon idiopathic inflammatory condition characterized by multifocal chorioretinopathy that primarily affects young adults, with a predilection for myopic females. Clinically, it manifests as small, yellowish-white lesions in the inner choroid and outer retina, often associated with inflammatory changes. Accurate diagnosis remains a challenge due to its resemblance
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Squishy matters – Corneal mechanobiology in health and disease Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-01-02 Sara M. Thomasy, Brian C. Leonard, Mark A. Greiner, Jessica M. Skeie, Vijay Krishna Raghunathan
The cornea, as a dynamic and responsive tissue, constantly interacts with mechanical forces in order to maintain its structural integrity, barrier function, transparency and refractive power. Cells within the cornea sense and respond to various mechanical forces that fundamentally regulate their morphology and fate in development, homeostasis and pathophysiology. Corneal cells also dynamically regulate
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UVR and RPE – The good, the bad and the degenerate Macula Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-12-20 Graham Anderson, Shyamanga Borooah, Roly Megaw, Pierre Bagnaninchi, Richard Weller, Andrew McLeod, Baljean Dhillon
Ultraviolet Radiation (UVR) has a well-established causative influence within the aetiology of conditions of the skin and the anterior segment of the eye. However, a grounded assessment of the role of UVR within conditions of the retina has a been hampered by a historical lack of quantitative, and spectrally resolved, assessment of how UVR impacts upon the retina in terms congruent with contemporary
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The endoplasmic reticulum: Homeostasis and crosstalk in retinal health and disease Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-12-12 Sarah X. Zhang, Josh J. Wang, Christopher R. Starr, Eun-Jin Lee, Sophia Park, Assylbek Zhylkibayev, Andy Medina, Jonathan H. Lin, Marina Gorbatyuk
The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad range of important cellular functions including protein biosynthesis, folding, and trafficking, lipid and sterol biosynthesis, carbohydrate metabolism, and calcium storage and gated release. In addition, the ER makes close contact with multiple intracellular organelles such as mitochondria and the plasma membrane
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IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-12-16 Ian Pitha, Liya Du, Thao D. Nguyen, Harry Quigley
There are many unanswered questions on the relation of intraocular pressure to glaucoma development and progression. IOP itself cannot be distilled to a single, unifying value, because IOP level varies over time, differs depending on ocular location, and can be affected by method of measurement. Ultimately, IOP level creates mechanical strain that affects axonal function at the optic nerve head which
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Neonatal sepsis as a cause of retinopathy of prematurity: An etiological explanation Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-11-19 Olaf Dammann, Brian K. Stansfield
Retinopathy of prematurity (ROP) is a complex neonatal disorder with multiple contributing factors. In this paper we have mounted the evidence in support of the proposal that neonatal sepsis meets all requirements for being a cause of ROP (not a condition, mechanism, or even innocent bystander) by means of initiating the early stages of the pathomechanism of ROP occurrence, systemic inflammation. We
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Optical coherence tomography in the management of diabetic macular oedema Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-11-07 Simon KH. Szeto, Timothy YY. Lai, Stela Vujosevic, Jennifer K. Sun, SriniVas R. Sadda, Gavin Tan, Sobha Sivaprasad, Tien Y. Wong, Carol Y. Cheung
Diabetic macular oedema (DMO) is the major cause of visual impairment in people with diabetes. Optical coherence tomography (OCT) is now the most widely used modality to assess presence and severity of DMO. DMO is currently broadly classified based on the involvement to the central 1 mm of the macula into non-centre or centre involved DMO (CI-DMO) and DMO can occur with or without visual acuity (VA)
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Assessment of angle closure disease in the age of artificial intelligence: A review Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-11-03 Zhi Da Soh, Mingrui Tan, Monisha Esther Nongpiur, Benjamin Yixing Xu, David Friedman, Xiulan Zhang, Christopher Leung, Yong Liu, Victor Koh, Tin Aung, Ching-Yu Cheng
Primary angle closure glaucoma is a visually debilitating disease that is under-detected worldwide. Many of the challenges in managing primary angle closure disease (PACD) are related to the lack of convenient and precise tools for clinic-based disease assessment and monitoring. Artificial intelligence (AI)- assisted tools to detect and assess PACD have proliferated in recent years with encouraging
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From randomised controlled trials to real-world data: Clinical evidence to guide management of diabetic macular oedema Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-10-26 Pierre-Henry Gabrielle, Hemal Mehta, Daniel Barthelmes, Vincent Daien, Vuong Nguyen, Mark C. Gillies, Catherine P. Creuzot-Garcher
Randomised clinical trials (RCTs) are generally considered the gold-standard for providing scientific evidence for treatments' effectiveness and safety but their findings may not always be generalisable to the broader population treated in routine clinical practice. RCTs include highly selected patient populations that fit specific inclusion and exclusion criteria. Although they may have a lower level
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Consensus and controversies in the science of endophthalmitis management: Basic research and clinical perspectives Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-10-12 Taraprasad Das, Joveeta Joseph, Matthew P. Simunovic, Andrzej Grzybowski, Kuan-Jen Chen, Vivek Pravin Dave, Savitri Sharma, Patrick Staropoli, Harry Flynn
Infectious endophthalmitis is a severe intraocular infection caused by bacteria, or less commonly by fungi. It can occur after penetrating eye procedures, trauma, or the spread of infection from contiguous structures or via emboli from distant organs. Because of the time-critical nature of the treatment, endophthalmitis is treated with the clinical diagnosis and modified by the microbiological report
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Neurovascular dysfunction in glaucoma Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-09-30 Luis Alarcon-Martinez, Yukihiro Shiga, Deborah Villafranca-Baughman, Jorge L. Cueva Vargas, Isaac A. Vidal Paredes, Heberto Quintero, Brad Fortune, Helen Danesh-Meyer, Adriana Di Polo
Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The timely regulation of blood flow is, therefore, essential to supply firing neurons in active areas with the oxygen and glucose they need for energy. Many glaucoma patients suffer from vascular deficits including reduced blood
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Risk factors, clinical features and treatment of Behçet's disease uveitis Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-09-19 Zhenyu Zhong, Guannan Su, Peizeng Yang
Behçet's disease is a systemic vasculitis frequently associated with intraocular inflammation. Recent findings identified independent clinical clusters in Behçet's disease, each involving distinct combinations of affected organs. Ocular Behçet's disease, mainly manifested as uveitis, is characterized as an independent cluster with a low likelihood of association with other system involvements, such
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Identification of novel biomarkers for retinopathy of prematurity in preterm infants by use of innovative technologies and artificial intelligence Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-08-21 Sandra Hoyek, Natasha F.S. da Cruz, Nimesh A. Patel, Hasenin Al-Khersan, Kenneth C. Fan, Audina M. Berrocal
Retinopathy of prematurity (ROP) is a leading cause of preventable vision loss in preterm infants. While appropriate screening is crucial for early identification and treatment of ROP, current screening guidelines remain limited by inter-examiner variability in screening modalities, absence of local protocol for ROP screening in some settings, a paucity of resources and an increased survival of younger
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Latest advances in white spot syndromes: New findings and interpretations Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-08-12 Maria Vittoria Cicinelli, Prithvi Ramtohul, Alessandro Marchese, Francesco Bandello, K. Bailey Freund, Elisabetta Miserocchi, Lee M. Jampol
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Optical coherence tomography angiography in diabetic retinopathy Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-07-26 Nadia K. Waheed, Richard B. Rosen, Yali Jia, Marion R. Munk, David Huang, Amani Fawzi, Victor Chong, Quan Dong Nguyen, Yasir Sepah, Elizabeth Pearce
There remain many unanswered questions on how to assess and treat the pathology and complications that arise from diabetic retinopathy (DR). Optical coherence tomography angiography (OCTA) is a novel and non-invasive three-dimensional imaging method that can visualize capillaries in all retinal layers. Numerous studies have confirmed that OCTA can identify early evidence of microvascular changes and
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Mitophagy in the retina: Viewing mitochondrial homeostasis through a new lens Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-07-15
Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ that has one of the highest metabolic rates body-wide and is constantly exposed to photooxidative damage and external stressors. Mitophagy is the selective autophagic degradation of mitochondria within lysosomes, and can be triggered by distinct stimuli such as mitochondrial damage or hypoxia. Here, we review
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Neville Osborne - Editor-in-Chief of Progress in Retinal and Eye Research for 40 years Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-07-19
Abstract not available
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Female carriers of X-linked inherited retinal diseases – Genetics, diagnosis, and potential therapies Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-07-03 Sena A. Gocuk, Jasleen K. Jolly, Thomas L. Edwards, Lauren N. Ayton
Inherited retinal diseases (IRDs) are a group of heterogeneous conditions that cause progressive vision loss, typically due to monogenic mutations. Female carriers of X-linked IRDs have a single copy of the disease-causing gene, and therefore, may exhibit variable clinical signs that vary from near normal retina to severe disease and vision loss. The relationships between individual genetic mutations
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Etiopathogenesis of primary acquired nasolacrimal duct obstruction (PANDO) Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-07-01 Mohammad Javed Ali
Primary acquired nasolacrimal duct obstruction, or PANDO, is a common adult lacrimal drainage disorder. The current treatment modality of dacryocystorhinostomy to bypass the obstructed nasolacrimal duct has excellent outcomes. However, the understanding of the disease etiopathogenesis needs to be revisited. There are not many studies that specifically assessed any hypothesis or ones that convincingly
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Posterior corneoscleral limbus: Architecture, stem cells, and clinical implications Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-06-29 Gary Hin-Fai Yam, Shaohua Pi, Yiqin Du, Jodhbir S. Mehta
The limbus is a transition from the cornea to conjunctiva and sclera. In human eyes, this thin strip has a rich variation of tissue structures and composition, typifying a change from scleral irregularity and opacity to corneal regularity and transparency; a variation from richly vascularized conjunctiva and sclera to avascular cornea; the neural passage and drainage of aqueous humor. The limbal stroma
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Familial normal tension glaucoma genetics Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-06-22 Austin R. Fox, John H. Fingert
Glaucoma is defined by characteristic optic nerve damage and corresponding visual field defects and is the leading cause of irreversible blindness in the world. Elevated intraocular pressure (IOP) is a strong risk factor for developing glaucoma. However, glaucoma can occur at any IOP. Normal tension glaucoma (NTG) arises with IOPs that are within what has been defined as a normal range, i.e., 21 mm
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The immune response in tubercular uveitis and its implications for treatment: From anti-tubercular treatment to host-directed therapies Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-05-25 Ikhwanuliman Putera, Benjamin Schrijver, Josianne C.E.M. ten Berge, Vishali Gupta, Rina La Distia Nora, Rupesh Agrawal, P. Martin van Hagen, Saskia M. Rombach, Willem A. Dik
Tubercular uveitis (TB-uveitis) remains a conundrum in the uveitis field, which is mainly related to the diverse clinical phenotypes of TB-uveitis. Moreover, it remains difficult to differentiate whether Mycobacterium tuberculosis (Mtb) is present in the ocular tissues, elicits a heightened immune response without Mtb invasion in ocular tissues, or even induces an anti-retinal autoimmune response.
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The multifunctional human ocular melanocortin system Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-05-20 Chieh-Lin (Stanley) Wu, Adrian V. Cioanca, Maria C. Gelmi, Li Wen, Nick Di Girolamo, Ling Zhu, Riccardo Natoli, R Max Conway, Constantinos Petsoglou, Martine J. Jager, Peter J. McCluskey, Michele C. Madigan
Immune privilege in the eye involves physical barriers, immune regulation and secreted proteins that together limit the damaging effects of intraocular immune responses and inflammation. The neuropeptide alpha-melanocyte stimulating hormone (α-MSH) normally circulates in the aqueous humour of the anterior chamber and the vitreous fluid, secreted by iris and ciliary epithelium, and retinal pigment epithelium
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Myocilin misfolding and glaucoma: A 20-year update Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-05-20 Emily G. Saccuzzo, Hannah A. Youngblood, Raquel L. Lieberman
Mutations in the gene MYOC account for approximately 5% of cases of primary open angle glaucoma (POAG). MYOC encodes for the protein myocilin, a multimeric secreted glycoprotein composed of N-terminal coiled-coil (CC) and leucine zipper (LZ) domains that are connected via a disordered linker to a 30 kDa olfactomedin (OLF) domain. More than 90% of glaucoma-causing mutations are localized to the OLF
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Elucidating glial responses to products of diabetes-associated systemic dyshomeostasis Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-04-05 Dolly Ann Padovani-Claudio, Carla J. Ramos, Megan E. Capozzi, John S. Penn
Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. DR has non-proliferative stages, characterized in part by retinal neuroinflammation and ischemia, and proliferative stages, characterized by retinal angiogenesis. Several systemic factors, including poor glycemic control, hypertension, and hyperlipidemia, increase the risk of DR progression to vision-threatening stages
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From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-02-12 Grazyna Palczewska, Maciej Wojtkowski, Krzysztof Palczewski
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The novel role of lymphatic vessels in the pathogenesis of ocular diseases Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-02-08 Thomas Clahsen, Karina Hadrian, Maria Notara, Simona L. Schlereth, Antonia Howaldt, Verena Prokosch, Thomas Volatier, Deniz Hos, Falk Schroedl, Alexandra Kaser-Eichberger, Ludwig M. Heindl, Philipp Steven, Jacobus J. Bosch, Alexander Steinkasserer, Alexander C. Rokohl, Hanhan Liu, Mert Mestanoglu, Hamid Kashkar, Björn Schumacher, Friedemann Kiefer, Claus Cursiefen
Historically, the eye has been considered as an organ free of lymphatic vessels. In recent years, however, it became evident, that lymphatic vessels or lymphatic-like vessels contribute to several ocular pathologies at various peri- and intraocular locations. The aim of this review is to outline the pathogenetic role of ocular lymphatics, the respective molecular mechanisms and to discuss current and
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Amblyopia and the whole child Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-02-01
Amblyopia is a disorder of neurodevelopment that occurs when there is discordant binocular visual experience during the first years of life. While treatments are effective in improving visual acuity, there are significant individual differences in response to treatment that cannot be attributed solely to difference in adherence. In this considerable variability in response to treatment, we argue that
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Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-02-01
Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons, are well involved into retinal ganglion cell (RGC) degeneration in experimental glaucoma animal models generated by elevated IOP. In response to elevated IOP, mGluR I is first activated and Kir4.1 channels are subsequently
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Shedding light on myopia by studying complete congenital stationary night blindness Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-01-19 Christina Zeitz, Jérome E. Roger, Isabelle Audo, Christelle Michiels, Nuria Sánchez-Farías, Juliette Varin, Helen Frederiksen, Baptiste Wilmet, Jacques Callebert, Marie-Laure Gimenez, Nassima Bouzidi, Frederic Blond, Xavier Guilllonneau, Stéphane Fouquet, Thierry Léveillard, Vasily Smirnov, Ajoy Vincent, Elise Héon, José-Alain Sahel, Barbara Kloeckener-Gruissem, Serge Picaud
Myopia is the most common eye disorder, caused by heterogeneous genetic and environmental factors. Rare progressive and stationary inherited retinal disorders are often associated with high myopia. Genes implicated in myopia encode proteins involved in a variety of biological processes including eye morphogenesis, extracellular matrix organization, visual perception, circadian rhythms, and retinal
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The pre-Descemet's layer (Dua's layer, also known as the Dua-Fine layer and the pre-posterior limiting lamina layer): Discovery, characterisation, clinical and surgical applications, and the controversy Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-01-14 Harminder S. Dua, Rui Freitas, Imran Mohammed, Darren S.J. Ting, Dalia G. Said
The pre-Descemet's layer/Dua's layer, also termed the Dua-Fine layer and the pre-posterior limiting lamina layer, lies anterior to the Descemet's membrane in the cornea, is 10 μm (range 6–16) thick, made predominantly of type I and some type VI collagen with abundant elastin, more than any other layer of the cornea. It has high tensile strength (bursting pressure up to 700 mm of Hg), is impervious
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The genetics and disease mechanisms of rhegmatogenous retinal detachment Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-01-06 Birgit M. Govers, Ramon A.C. van Huet, Susanne Roosing, Sander Keijser, Leonoor I. Los, Anneke I. den Hollander, B. Jeroen Klevering
Rhegmatogenous retinal detachment (RRD) is a sight threatening condition that warrants immediate surgical intervention. To date, 29 genes have been associated with monogenic disorders involving RRD. In addition, RRD can occur as a multifactorial disease through a combined effect of multiple genetic variants and non-genetic risk factors. In this review, we provide a comprehensive overview of the spectrum
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Endpoints for clinical trials in ophthalmology Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-01-02 Leopold Schmetterer, Hendrik Scholl, Gerhard Garhöfer, Lucas Janeschitz-Kriegl, Federico Corvi, SriniVas R. Sadda, Felipe A. Medeiros
With the identification of novel targets, the number of interventional clinical trials in ophthalmology has increased. Visual acuity has for a long time been considered the gold standard endpoint for clinical trials, but in the recent years it became evident that other endpoints are required for many indications including geographic atrophy and inherited retinal disease. In glaucoma the currently available
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Myopia: Histology, clinical features, and potential implications for the etiology of axial elongation Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-28 Jost B. Jonas, Rahul A. Jonas, Mukharram M. Bikbov, Ya Xing Wang, Songhomitra Panda-Jonas
Myopic axial elongation is associated with various non-pathological changes. These include a decrease in photoreceptor cell and retinal pigment epithelium (RPE) cell density and retinal layer thickness, mainly in the retro-equatorial to equatorial regions; choroidal and scleral thinning pronounced at the posterior pole and least marked at the ora serrata; and a shift in Bruch's membrane opening (BMO)
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Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-28 Yang Pan, Yingbin Fu, Paul N. Baird, Robyn H. Guymer, Taraprasad Das, Takeshi Iwata
Age-related macular degeneration (AMD) is the leading cause of severe irreversible central vision loss in individuals over 65 years old. Genome-wide association studies (GWASs) have shown that the region at chromosome 10q26, where the age-related maculopathy susceptibility (ARMS2/LOC387715) and HtrA serine peptidase 1 (HTRA1) genes are located, represents one of the strongest associated loci for AMD
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10q26 – The enigma in age-related macular degeneration Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-10 David A. Merle, Merve Sen, Angela Armento, Chloe M. Stanton, Eric F. Thee, Magda A. Meester-Smoor, Markus Kaiser, Simon J. Clark, Caroline C.W. Klaver, Pearse A. Keane, Alan F. Wright, Michael Ehrmann, Marius Ueffing
Despite comprehensive research efforts over the last decades, the pathomechanisms of age-related macular degeneration (AMD) remain far from being understood. Large-scale genome wide association studies (GWAS) were able to provide a defined set of genetic aberrations which contribute to disease risk, with the strongest contributors mapping to distinct regions on chromosome 1 and 10. While the chromosome
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Cellular and subcellular optogenetic approaches towards neuroprotection and vision restoration Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-08 Edward H. Wood, Alexander Kreymerman, Tia Kowal, David Buickians, Yang Sun, Stephanie Muscat, Mark Mercola, Darius M. Moshfeghi, Jeffrey L. Goldberg
Optogenetics is defined as the combination of genetic and optical methods to induce or inhibit well-defined events in isolated cells, tissues, or animals. While optogenetics within ophthalmology has been primarily applied towards treating inherited retinal disease, there are a myriad of other applications that hold great promise for a variety of eye diseases including cellular regeneration, modulation
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Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-08 Jacob D. Bhoi, Manvi Goel, Christophe P. Ribelayga, Stuart C. Mangel
Circadian (24-h) clocks are cell-autonomous biological oscillators that orchestrate many aspects of our physiology on a daily basis. Numerous circadian rhythms in mammalian and non-mammalian retinas have been observed and the presence of an endogenous circadian clock has been demonstrated. However, how the clock and associated rhythms assemble into pathways that support and control retina function
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Secondary outcomes of lens and cataract surgery: More than just “best-corrected visual acuity” Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-05 Idan Hecht, Piotr Kanclerz, Raimo Tuuminen
Most studies evaluating cataract surgery focus on the primary outcome of early, central, best-corrected visual acuity. However, cataract surgery and intraocular lens (IOL) design have other secondary visual outcomes as well as impacts on various ocular tissues, the visual function, and quality of life. Some of these aspects are more difficult to quantify, or are historically neglected, but might be
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Regulation of lens water content: Effects on the physiological optics of the lens Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-05 Paul J. Donaldson, Yadi Chen, Rosica S. Petrova, Angus C. Grey, Julie C. Lim
The lens is an important determinant of overall vision quality whose refractive and transparent properties change throughout life. Alterations to the refractive properties of the lens contribute to the process of emmetropisation in early childhood, and then the gradual loss in lens power that occurs throughout adulthood. In parallel to these changes to lens refractive power, age-dependent increases
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Non-canonical Wnt signaling in the eye Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-11-25 Ruchi Shah, Cynthia Amador, Steven T. Chun, Sean Ghiam, Mehrnoosh Saghizadeh, Andrei A. Kramerov, Alexander V. Ljubimov
Wnt signaling comprises a group of complex signal transduction pathways that play critical roles in cell proliferation, differentiation, and apoptosis during development, as well as in stem cell maintenance and adult tissue homeostasis. Wnt pathways are classified into two major groups, canonical (β-catenin-dependent) or non-canonical (β-catenin-independent). Most previous studies in the eye have focused
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Cell identity changes in ocular surface Epithelia Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-11-20 Nick Di Girolamo, Mijeong Park
Corneal and conjunctival epithelia arise from a common ancestral ectoderm cell, then diverge into distinct lineages. The former develops into a multilayered stratified squamous epithelium, the latter into an expansive mucous membrane that stretches the eyelid margin to the cornea's outskirts. The limbus, which intersects these epithelia, is purported to harbor corneal stem cells. Intrinsic programs
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Retinal dystrophins and the retinopathy of Duchenne muscular dystrophy Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-11-18 Mirella Telles Salgueiro Barboni, Anneka Joachimsthaler, Michel J. Roux, Zoltán Zsolt Nagy, Dora Fix Ventura, Alvaro Rendon, Jan Kremers, Cyrille Vaillend
Duchenne muscular dystrophy (DMD) is caused by X-linked inherited or de novo DMD gene mutations predominantly affecting males who develop early-onset muscle degeneration, severely affecting their quality of life and leading to reduced life expectancy. DMD patients may also develop proliferative retinopathy, cataract, ERG abnormalities, altered contrast sensitivity, color vision losses, and elevated
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Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-11-16 Won-Kyu Ju, Guy A. Perkins, Keun-Young Kim, Tonking Bastola, Woo-Young Choi, Soo-Ho Choi
Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their axons, resulting in vision loss. Despite its high prevalence in individuals 60 years of age and older, the causing factors contributing to glaucoma progression are currently not well characterized. Intraocular pressure
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Advances in understanding the molecular structure of retinoschisin while questions remain of biological function Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-11-16 J Bernard Heymann, Camasamudram Vijayasarathy, Robert N. Fariss, Paul A. Sieving
Retinoschisin (RS1) is a secreted protein that is essential for maintaining integrity of the retina. Numerous mutations in RS1 cause X-linked retinoschisis (XLRS), a progressive degeneration of the retina that leads to vision loss in young males. A key manifestation of XLRS is the formation of cavities (cysts) in the retina and separation of the layers (schisis), disrupting synaptic transmission. There
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