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  • Reproductive endocrinology: Exposure to pesticide residues linked to adverse pregnancy outcomes
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-17
    Alan Morris

    Reproductive endocrinology: Exposure to pesticide residues linked to adverse pregnancy outcomes Reproductive endocrinology: Exposure to pesticide residues linked to adverse pregnancy outcomes, Published online: 17 November 2017; doi:10.1038/nrendo.2017.156

    更新日期:2017-11-17
  • Cardiovascular endocrinology: Long-term safety of growth hormone
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-17
    Conor A. Bradley

    Cardiovascular endocrinology: Long-term safety of growth hormone Cardiovascular endocrinology: Long-term safety of growth hormone, Published online: 17 November 2017; doi:10.1038/nrendo.2017.155

    更新日期:2017-11-17
  • Reproductive endocrinology: Exposure to pesticide residues linked to adverse pregnancy outcomes
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-17
    Alan Morris

    Reproductive endocrinology: Exposure to pesticide residues linked to adverse pregnancy outcomes Reproductive endocrinology: Exposure to pesticide residues linked to adverse pregnancy outcomes, Published online: 17 November 2017; doi:10.1038/nrendo.2017.156

    更新日期:2017-11-17
  • Cardiovascular endocrinology: Long-term safety of growth hormone
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-17
    Conor A. Bradley

    Cardiovascular endocrinology: Long-term safety of growth hormone Cardiovascular endocrinology: Long-term safety of growth hormone, Published online: 17 November 2017; doi:10.1038/nrendo.2017.155

    更新日期:2017-11-17
  • Bone: High-intensity exercise to prevent fractures — risk or gain?
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-10
    Wolfgang Kemmler, Simon von Stengel

    Bone: High-intensity exercise to prevent fractures — risk or gain? Bone: High-intensity exercise to prevent fractures — risk or gain?, Published online: 10 November 2017; doi:10.1038/nrendo.2017.148 NatureArticleSnippet(type=standfirst, markup= Although the favourable effects of high-intensity resistance and impact training (HiRIT) on bone strength have been demonstrated, it is generally considered unsuitable for older adults. A recent study reports that 8 months of HiRIT was efficacious and induced no adverse effects in older postmenopausal women with, or at risk of, osteoporosis. , isJats=true)

    更新日期:2017-11-11
  • Bone: PPARγ controls marrow adiposity
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-10
    Conor A. Bradley

    Bone: PPARγ controls marrow adiposity Bone: PPARγ controls marrow adiposity, Published online: 10 November 2017; doi:10.1038/nrendo.2017.152

    更新日期:2017-11-11
  • Metabolism: Metabolic effects of intermeal fasting
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-10
    Claire Greenhill

    Metabolism: Metabolic effects of intermeal fasting Metabolism: Metabolic effects of intermeal fasting, Published online: 10 November 2017; doi:10.1038/nrendo.2017.153

    更新日期:2017-11-11
  • Bone: High-intensity exercise to prevent fractures — risk or gain?
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-10
    Wolfgang Kemmler, Simon von Stengel

    Bone: High-intensity exercise to prevent fractures — risk or gain? Bone: High-intensity exercise to prevent fractures — risk or gain?, Published online: 10 November 2017; doi:10.1038/nrendo.2017.148 NatureArticleSnippet(type=standfirst, markup= Although the favourable effects of high-intensity resistance and impact training (HiRIT) on bone strength have been demonstrated, it is generally considered unsuitable for older adults. A recent study reports that 8 months of HiRIT was efficacious and induced no adverse effects in older postmenopausal women with, or at risk of, osteoporosis. , isJats=true)

    更新日期:2017-11-11
  • Bone: PPARγ controls marrow adiposity
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-10
    Conor A. Bradley

    Bone: PPARγ controls marrow adiposity Bone: PPARγ controls marrow adiposity, Published online: 10 November 2017; doi:10.1038/nrendo.2017.152

    更新日期:2017-11-11
  • Metabolism: Metabolic effects of intermeal fasting
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-10
    Claire Greenhill

    Metabolism: Metabolic effects of intermeal fasting Metabolism: Metabolic effects of intermeal fasting, Published online: 10 November 2017; doi:10.1038/nrendo.2017.153

    更新日期:2017-11-11
  • Diabetes: Anti-PCSK9 antibodies — beneficial or inducers of diabetes?
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-09
    Rutger Verbeek, G. Kees Hovingh

    Diabetes: Anti-PCSK9 antibodies — beneficial or inducers of diabetes?Diabetes: Anti-PCSK9 antibodies — beneficial or inducers of diabetes?, Published online: 09 November 2017; doi:10.1038/nrendo.2017.145NatureArticleSnippet(type=standfirst, markup=A recent study has shown that evolocumab, an injectable monoclonal antibody directed against proprotein convertase subtilisin/kexin type 9 (PCSK9), robustly reduces levels of LDL cholesterol and decreases the risk of cardiovascular disease in patients with and without diabetes mellitus. When given on top of statins, evolocumab does not induce diabetes mellitus., isJats=true)

    更新日期:2017-11-10
  • Thyroid cancer: Lenvatinib — beyond trials
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-09
    Claire Greenhill

    Thyroid cancer: Lenvatinib — beyond trialsThyroid cancer: Lenvatinib — beyond trials, Published online: 09 November 2017; doi:10.1038/nrendo.2017.149

    更新日期:2017-11-10
  • Ageing: Improvement in age-related cognitive functions and life expectancy by ketogenic diets
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-09
    Arne Astrup, Mads Fiil Hjorth

    Ageing: Improvement in age-related cognitive functions and life expectancy by ketogenic dietsAgeing: Improvement in age-related cognitive functions and life expectancy by ketogenic diets, Published online: 09 November 2017; doi:10.1038/nrendo.2017.142NatureArticleSnippet(type=standfirst, markup=Rodent studies have indicated that low-carbohydrate diets prevent age-related cognitive decline and extend lifespan due to increased circulating levels of ketone bodies. A possible physiological mechanism for how ketone bodies exert this effect might be by improving central nervous system insulin resistance, which makes this finding interesting with regards to the prevention of cognitive decline and dementia in patients with type 2 diabetes mellitus., isJats=true)

    更新日期:2017-11-10
  • Obesity: The myth of innocent obesity
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-09
    Matthias Blüher

    Obesity: The myth of innocent obesityObesity: The myth of innocent obesity, Published online: 09 November 2017; doi:10.1038/nrendo.2017.146NatureArticleSnippet(type=standfirst, markup=The concept of metabolically healthy obesity (MHO) suggests that obesity might be a benign condition. This view has been challenged by a recent study demonstrating that, among 3.5 million individuals, those with MHO still have a higher risk of cardiovascular diseases than individuals who are metabolically healthy and normal weight., isJats=true)

    更新日期:2017-11-10
  • Diabetes: A new hope for insulin-sensitizing drugs
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-09
    Alan Morris

    Diabetes: A new hope for insulin-sensitizing drugsDiabetes: A new hope for insulin-sensitizing drugs, Published online: 09 November 2017; doi:10.1038/nrendo.2017.150

    更新日期:2017-11-10
  • Diabetes: Anti-PCSK9 antibodies — beneficial or inducers of diabetes?
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-09
    Rutger Verbeek, G. Kees Hovingh

    Diabetes: Anti-PCSK9 antibodies — beneficial or inducers of diabetes?Diabetes: Anti-PCSK9 antibodies — beneficial or inducers of diabetes?, Published online: 09 November 2017; doi:10.1038/nrendo.2017.145NatureArticleSnippet(type=standfirst, markup=A recent study has shown that evolocumab, an injectable monoclonal antibody directed against proprotein convertase subtilisin/kexin type 9 (PCSK9), robustly reduces levels of LDL cholesterol and decreases the risk of cardiovascular disease in patients with and without diabetes mellitus. When given on top of statins, evolocumab does not induce diabetes mellitus., isJats=true)

    更新日期:2017-11-10
  • Thyroid cancer: Lenvatinib — beyond trials
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-09
    Claire Greenhill

    Thyroid cancer: Lenvatinib — beyond trialsThyroid cancer: Lenvatinib — beyond trials, Published online: 09 November 2017; doi:10.1038/nrendo.2017.149

    更新日期:2017-11-10
  • Ageing: Improvement in age-related cognitive functions and life expectancy by ketogenic diets
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-09
    Arne Astrup, Mads Fiil Hjorth

    Ageing: Improvement in age-related cognitive functions and life expectancy by ketogenic dietsAgeing: Improvement in age-related cognitive functions and life expectancy by ketogenic diets, Published online: 09 November 2017; doi:10.1038/nrendo.2017.142NatureArticleSnippet(type=standfirst, markup=Rodent studies have indicated that low-carbohydrate diets prevent age-related cognitive decline and extend lifespan due to increased circulating levels of ketone bodies. A possible physiological mechanism for how ketone bodies exert this effect might be by improving central nervous system insulin resistance, which makes this finding interesting with regards to the prevention of cognitive decline and dementia in patients with type 2 diabetes mellitus., isJats=true)

    更新日期:2017-11-10
  • Obesity: The myth of innocent obesity
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-09
    Matthias Blüher

    Obesity: The myth of innocent obesityObesity: The myth of innocent obesity, Published online: 09 November 2017; doi:10.1038/nrendo.2017.146NatureArticleSnippet(type=standfirst, markup=The concept of metabolically healthy obesity (MHO) suggests that obesity might be a benign condition. This view has been challenged by a recent study demonstrating that, among 3.5 million individuals, those with MHO still have a higher risk of cardiovascular diseases than individuals who are metabolically healthy and normal weight., isJats=true)

    更新日期:2017-11-10
  • Diabetes: A new hope for insulin-sensitizing drugs
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-11-09
    Alan Morris

    Diabetes: A new hope for insulin-sensitizing drugsDiabetes: A new hope for insulin-sensitizing drugs, Published online: 09 November 2017; doi:10.1038/nrendo.2017.150

    更新日期:2017-11-10
  • Obesity: Pharmacological actions of FGF19 and FGF21 revealed
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-27
    Alan Morris

    Obesity: Pharmacological actions of FGF19 and FGF21 revealed Nature Reviews Endocrinology, Published online: 27 October 2017; doi:10.1038/nrendo.2017.144

    更新日期:2017-10-30
  • Therapy: SGLT inhibition in T1DM — definite benefit with manageable risk
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-27
    Ele Ferrannini, Anna Solini

    Therapy: SGLT inhibition in T1DM — definite benefit with manageable risk Nature Reviews Endocrinology, Published online: 27 October 2017; doi:10.1038/nrendo.2017.139 Two phase III trials using the selective SGLT2 inhibitor dapagliflozin or the dual SGLT2/SGLT1 inhibitor sotagliflozin in patients with type 1 diabetes mellitus show similar clinical benefit (reduction of HbA1c, body weight, blood pressure and insulin dose). The risk of hypoglycaemia and diabetic ketoacidosis with these inhibitors can be managed by careful adjustment of insulin therapy.

    更新日期:2017-10-30
  • Diabetes: Omega-6 PUFAs and T2DM
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-27
    Conor A. Bradley

    Diabetes: Omega-6 PUFAs and T2DM Nature Reviews Endocrinology, Published online: 27 October 2017; doi:10.1038/nrendo.2017.143

    更新日期:2017-10-30
  • The special relationship: glia–neuron interactions in the neuroendocrine hypothalamus
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-27
    Jerome Clasadonte, Vincent Prevot

    The special relationship: glia–neuron interactions in the neuroendocrine hypothalamus Nature Reviews Endocrinology, Published online: 27 October 2017; doi:10.1038/nrendo.2017.124 The hypothalamus is the main integrator of endocrine regulation. Glia–neuron interactions contribute to physiological processes such as puberty, the maintenance of bodily homeostasis and ageing. Here, Vincent Prevot and Jerome Clasadonte discuss glia–neuron interactions in the control of hypothalamic neuroendocrine function.

    更新日期:2017-10-30
  • Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-23
    Matthias J. Betz, Sven Enerbäck

    Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease Nature Reviews Endocrinology, Published online: 23 October 2017; doi:10.1038/nrendo.2017.132 Targeting thermogenesis in brown fat and skeletal muscle to expend energy and reduce fat mass is a promising therapeutic strategy for treating obesity and related metabolic diseases. Here, Betz and Enerbäck discuss the different molecular pathways regulating thermogenesis in these organs and discuss how they can be therapeutically exploited.

    更新日期:2017-10-30
  • Genetics: Towards β-cell regeneration
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-23
    Claire Greenhill

    Genetics: Towards β-cell regeneration Nature Reviews Endocrinology, Published online: 23 October 2017; doi:10.1038/nrendo.2017.140

    更新日期:2017-10-30
  • Diabetes: Predicting severe hypoglycaemia — a step forward
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-23
    Francesco Zaccardi, Kamlesh Khunti

    Diabetes: Predicting severe hypoglycaemia — a step forward Nature Reviews Endocrinology, Published online: 23 October 2017; doi:10.1038/nrendo.2017.138 The patient-centred approach to the management of hyperglycaemia, encouraged by current guidelines, requires the availability of tools to quantify the benefits and harms of intensive glucose control. Although several scores enable estimation of the long-term risk of developing diabetes-related complications, there are very few validated models to predict the risk of severe hypoglycaemia.

    更新日期:2017-10-30
  • Reversing the tide — diagnosis and prevention of T2DM in populations of African descent
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-23
    Jean N. Utumatwishima, Stephanie T. Chung, Amy R. Bentley, Margaret Udahogora, Anne E. Sumner

    Reversing the tide — diagnosis and prevention of T2DM in populations of African descent Nature Reviews Endocrinology, Published online: 23 October 2017; doi:10.1038/nrendo.2017.127 Populations of African descent are at the forefront of the worldwide epidemic of type 2 diabetes mellitus (T2DM). Here, Anne Sumner and colleagues discuss issues related to the diagnosis and prevention of T2DM in these populations, including screening test efficacy, prevention strategies and the relative paucity of genomic data.

    更新日期:2017-10-30
  • Obesity: Pharmacological actions of FGF19 and FGF21 revealed
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-27
    Alan Morris

    Obesity: Pharmacological actions of FGF19 and FGF21 revealed Nature Reviews Endocrinology, Published online: 27 October 2017; doi:10.1038/nrendo.2017.144

    更新日期:2017-10-30
  • Therapy: SGLT inhibition in T1DM — definite benefit with manageable risk
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-27
    Ele Ferrannini, Anna Solini

    Therapy: SGLT inhibition in T1DM — definite benefit with manageable risk Nature Reviews Endocrinology, Published online: 27 October 2017; doi:10.1038/nrendo.2017.139 Two phase III trials using the selective SGLT2 inhibitor dapagliflozin or the dual SGLT2/SGLT1 inhibitor sotagliflozin in patients with type 1 diabetes mellitus show similar clinical benefit (reduction of HbA1c, body weight, blood pressure and insulin dose). The risk of hypoglycaemia and diabetic ketoacidosis with these inhibitors can be managed by careful adjustment of insulin therapy.

    更新日期:2017-10-30
  • Diabetes: Omega-6 PUFAs and T2DM
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-27
    Conor A. Bradley

    Diabetes: Omega-6 PUFAs and T2DM Nature Reviews Endocrinology, Published online: 27 October 2017; doi:10.1038/nrendo.2017.143

    更新日期:2017-10-30
  • The special relationship: glia–neuron interactions in the neuroendocrine hypothalamus
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-27
    Jerome Clasadonte, Vincent Prevot

    The special relationship: glia–neuron interactions in the neuroendocrine hypothalamus Nature Reviews Endocrinology, Published online: 27 October 2017; doi:10.1038/nrendo.2017.124 The hypothalamus is the main integrator of endocrine regulation. Glia–neuron interactions contribute to physiological processes such as puberty, the maintenance of bodily homeostasis and ageing. Here, Vincent Prevot and Jerome Clasadonte discuss glia–neuron interactions in the control of hypothalamic neuroendocrine function.

    更新日期:2017-10-30
  • Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-23
    Matthias J. Betz, Sven Enerbäck

    Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease Nature Reviews Endocrinology, Published online: 23 October 2017; doi:10.1038/nrendo.2017.132 Targeting thermogenesis in brown fat and skeletal muscle to expend energy and reduce fat mass is a promising therapeutic strategy for treating obesity and related metabolic diseases. Here, Betz and Enerbäck discuss the different molecular pathways regulating thermogenesis in these organs and discuss how they can be therapeutically exploited.

    更新日期:2017-10-30
  • Genetics: Towards β-cell regeneration
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-23
    Claire Greenhill

    Genetics: Towards β-cell regeneration Nature Reviews Endocrinology, Published online: 23 October 2017; doi:10.1038/nrendo.2017.140

    更新日期:2017-10-30
  • Diabetes: Predicting severe hypoglycaemia — a step forward
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-23
    Francesco Zaccardi, Kamlesh Khunti

    Diabetes: Predicting severe hypoglycaemia — a step forward Nature Reviews Endocrinology, Published online: 23 October 2017; doi:10.1038/nrendo.2017.138 The patient-centred approach to the management of hyperglycaemia, encouraged by current guidelines, requires the availability of tools to quantify the benefits and harms of intensive glucose control. Although several scores enable estimation of the long-term risk of developing diabetes-related complications, there are very few validated models to predict the risk of severe hypoglycaemia.

    更新日期:2017-10-30
  • Reversing the tide — diagnosis and prevention of T2DM in populations of African descent
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-10-23
    Jean N. Utumatwishima, Stephanie T. Chung, Amy R. Bentley, Margaret Udahogora, Anne E. Sumner

    Reversing the tide — diagnosis and prevention of T2DM in populations of African descent Nature Reviews Endocrinology, Published online: 23 October 2017; doi:10.1038/nrendo.2017.127 Populations of African descent are at the forefront of the worldwide epidemic of type 2 diabetes mellitus (T2DM). Here, Anne Sumner and colleagues discuss issues related to the diagnosis and prevention of T2DM in these populations, including screening test efficacy, prevention strategies and the relative paucity of genomic data.

    更新日期:2017-10-30
  • Bone diseases: Romosozumab — on track or derailed?
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    Sundeep Khosla

    Bone diseases: Romosozumab — on track or derailed? Nature Reviews Endocrinology, Published online: 13 October 2017; doi:10.1038/nrendo.2017.136 Romosozumab, a recently developed sclerostin inhibitor, stimulates bone formation and inhibits bone resorption, thereby markedly increasing bone mass and reducing fracture risk. But will a red flag regarding possible adverse cardiovascular events derail this promising new drug for osteoporosis?

    更新日期:2017-10-13
  • Microbiota: FMT transiently improves insulin sensitivity
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    Claire Greenhill

    Microbiota: FMT transiently improves insulin sensitivity Nature Reviews Endocrinology, Published online: 13 October 2017; doi:10.1038/nrendo.2017.137

    更新日期:2017-10-13
  • Current pharmacotherapy for obesity
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    Gitanjali Srivastava, Caroline M. Apovian

    Current pharmacotherapy for obesity Nature Reviews Endocrinology, Published online: 13 October 2017; doi:10.1038/nrendo.2017.122 As not all individuals with obesity respond to lifestyle modification, pharmacotherapy has a key role in tackling the obesity epidemic. Here, Gitanjali Srivastava and Caroline Apovian review the six currently available FDA-approved anti-obesity drugs in terms of safety, efficacy and clinical utility.

    更新日期:2017-10-13
  • Paediatric endocrinology: Can niacin supplementation protect against congenital malformations?
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    Melanie Penke, Wieland Kiess

    Paediatric endocrinology: Can niacin supplementation protect against congenital malformations? Nature Reviews Endocrinology, Published online: 11 October 2017; doi:10.1038/nrendo.2017.133 A recent report found mutations in the de novo kynurenine pathway and reduced plasma levels of NAD in patients with congenital malformations. In a mouse model, the mutation not only altered the phenotype of the litters but the combination of a homozygous mutation and a niacin-free diet resulted in miscarriages.

    更新日期:2017-10-11
  • Pituitary gland: Gamma Knife for Cushing disease — time for a reappraisal?
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    Frederic Castinetti, Thierry Brue

    Pituitary gland: Gamma Knife for Cushing disease — time for a reappraisal? Nature Reviews Endocrinology, Published online: 11 October 2017; doi:10.1038/nrendo.2017.130 The first large-scale, multicentric analysis of long-term results with Gamma Knife (Elekta) radiosurgery in the therapeutically challenging area of Cushing disease shows that, in selected patients, this radiation technique enables hormonal control to be achieved in most patients with relatively few adverse effects but with a significant risk of disease recurrence.

    更新日期:2017-10-11
  • Diabetes: Risk of kidney disease in T1DM
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    Claire Greenhill

    Diabetes: Risk of kidney disease in T1DM Nature Reviews Endocrinology, Published online: 6 October 2017; doi:10.1038/nrendo.2017.134

    更新日期:2017-10-11
  • Angiopoietin-like 3 in lipoprotein metabolism
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    Sander Kersten

    Triglycerides and cholesterol circulate in the bloodstream as part of various lipoprotein particles. Three members of the angiopoietin-like (ANGPTL) protein family — ANGPTL3, ANGPTL4 and ANGPTL8 — have emerged as important regulators of plasma lipoprotein levels by inhibiting the enzyme lipoprotein lipase. Here, I review the role of ANGPTL3 in lipoprotein metabolism. In contrast to ANGPTL4 and ANGPTL8, ANGPTL3 is exclusively produced in the liver and can therefore be classified as a true hepatokine. ANGPTL3 cooperates with ANGPTL8 to inhibit lipoprotein lipase and is mostly active after feeding, whereas ANGPTL4 is mostly active after fasting. Inactivation of ANGPTL3 in mice reduces plasma triglyceride and free fatty acid levels and suppresses atherosclerosis. In humans, homozygous loss-of-function mutations in ANGPTL3 lead to low plasma levels of low-density lipoproteins, high-density lipoproteins and triglycerides, a condition referred to as familial combined hypolipidaemia. Heterozygous carriers of loss-of-function mutations in ANGPTL3 have a lower risk of coronary artery disease than non-carriers. At present, researchers are investigating antisense oligonucleotide and monoclonal antibody-based inactivation of ANGPTL3 in human clinical trials for the therapeutic management of dyslipidaemia and atherosclerosis. Thus, ANGPTL3 is an important liver-derived regulator of lipoprotein metabolism that holds considerable promise as a target for atherosclerosis.

    更新日期:2017-10-11
  • Pharmacotherapy: A smarter way to treat obesity
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    David Holmes

    Pharmacotherapy: A smarter way to treat obesity Nature Reviews Endocrinology, Published online: 6 October 2017; doi:10.1038/nrendo.2017.135

    更新日期:2017-10-11
  • The effects of oxytocin on eating behaviour and metabolism in humans
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    Elizabeth A. Lawson

    Oxytocin, a hypothalamic hormone that is secreted directly into the brain and enters the peripheral circulation through the posterior pituitary gland, regulates a range of physiologic processes, including eating behaviour and metabolism. In rodents and nonhuman primates, chronic oxytocin administration leads to sustained weight reduction by reducing food intake, increasing energy expenditure and inducing lipolysis. Oxytocin might improve glucose homeostasis, independently of its effects on weight. Clinical studies are beginning to translate these important preclinical findings to humans. This Review describes key data linking oxytocin to eating behaviour and metabolism in humans. For example, a single intranasal dose of oxytocin can reduce caloric intake, increase fat oxidation and improve insulin sensitivity in men. Furthermore, a pilot study of 8 weeks of oxytocin treatment in adults with obesity or overweight led to substantial weight loss. Together, these data support further investigation of interventions that target pathways involving oxytocin as potential therapeutics in metabolic disorders, including obesity and diabetes mellitus. Therapeutic considerations and areas for further research are also discussed.

    更新日期:2017-10-11
  • Obesity: Fasting every other day promotes beiging of white adipose tissue
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    David Holmes

    Obesity: Fasting every other day promotes beiging of white adipose tissue Nature Reviews Endocrinology, Published online: 29 September 2017; doi:10.1038/nrendo.2017.131

    更新日期:2017-10-11
  • Diabetes: New marker to predict risk of T2DM
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    David Holmes

    Diabetes: New marker to predict risk of T2DM Nature Reviews Endocrinology, Published online: 22 September 2017; doi:10.1038/nrendo.2017.128

    更新日期:2017-09-22
  • Endocrine disruptors: Flame retardants and increased risk of thyroid cancer
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    Bilal B. Mughal, Barbara A. Demeneix

    Endocrine disruptors: Flame retardants and increased risk of thyroid cancer Nature Reviews Endocrinology, Published online: 22 September 2017; doi:10.1038/nrendo.2017.123 Household dust contaminated with common flame retardants used in everyday household items has been found to be associated with increased risk of developing smaller, as well as more aggressive forms of papillary thyroid cancer in humans. These findings emphasize the need to consider the exposome when evaluating the increased incidence of thyroid cancer.

    更新日期:2017-09-22
  • Metabolism: Ketogenic diet rewires circadian clock
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    Claire Greenhill

    Metabolism: Ketogenic diet rewires circadian clock Nature Reviews Endocrinology, Published online: 22 September 2017; doi:10.1038/nrendo.2017.129

    更新日期:2017-09-22
  • Transplantation: CXCL10 linked to poor outcomes
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    David Holmes

    Transplantation: CXCL10 linked to poor outcomes Nature Reviews Endocrinology, Published online: 15 September 2017; doi:10.1038/nrendo.2017.126

    更新日期:2017-09-15
  • Surgery: Postprandial hypoglycaemia following bariatric surgery
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    Alan Morris

    Surgery: Postprandial hypoglycaemia following bariatric surgery Nature Reviews Endocrinology, Published online: 15 September 2017; doi:10.1038/nrendo.2017.125

    更新日期:2017-09-15
  • Diabetes: Cardiovascular benefits of metformin in T1DM
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    Janet K. Snell-Bergeon

    Diabetes: Cardiovascular benefits of metformin in T1DM Nature Reviews Endocrinology, Published online: 12 September 2017; doi:10.1038/nrendo.2017.116 Results from the Reducing with Metformin Vascular Adverse Lesions (REMOVAL) study show for the first time that metformin has a cardiovascular benefit in patients with type 1 diabetes mellitus (T1DM), although the benefit was limited to tertiary outcomes and was modest. Additional measures are therefore needed to reduce cardiovascular disease in patients with T1DM.

    更新日期:2017-09-13
  • Diabetes: The diabetic brain
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 
    John E. Morley

    Diabetes: The diabetic brain Nature Reviews Endocrinology, Published online: 12 September 2017; doi:10.1038/nrendo.2017.111 Dementia is a complication associated with diabetes mellitus. Evidence suggests that patients with diabetes mellitus who have dementia have a unique form of the disease, albeit with similarities to vascular dementia. A recent study by Juraj Secnik and colleagues confirms this suggestion and provides insights into the clinical characteristics and treatment of the disorder.

    更新日期:2017-09-13
  • Diabetes: Risk of T2DM in children — influence of sleep duration
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-09-01
    Claire Greenhill

    In adults, short sleep duration is known to be associated with an increased risk of type 2 diabetes mellitus (T2DM), but whether this association is also present in children is unclear. A new study published in Pediatrics has begun to answer this question.The

    更新日期:2017-09-12
  • Obesity: New insights into BAT activity
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-08-11
    Alan Morris

    In humans, brown adipose tissue (BAT) activity can contribute to changes in energy expenditure and increased levels of BAT can improve insulin sensitivity. The overall effect of BAT on human metabolism, however, remains contested. Now, new data show that previous studies could have underestimated the

    更新日期:2017-09-12
  • Diabetes: Systemic effects of metformin revealed
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-08-18
    Alan Morris

    Metformin is widely prescribed to treat patients with type 2 diabetes mellitus, but the whole-body systemic responses to the drug remain unclear. Now, new research conducted by Michaela Reagan and colleagues reveals the effects of metformin in lean and obese mice on bone, bone marrow

    更新日期:2017-09-12
  • Thyroid function: Thyroid hypofunction in pregnancy
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-08-11
    Claire Greenhill

    The 2017 Guidelines of the American Thyroid Association (ATA) for the diagnosis and management of thyroid disease during pregnancy and postpartum recommend that pregnant women requiring treatment for thyroid dysfunction are identified using a case-finding method that takes account of their history of thyroid dysfunction

    更新日期:2017-09-12
  • Diabetes: Falling insulin requirements — a red flag for pre-eclampsia
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-08-29
    David Holmes

    Women with pre-existing diabetes mellitus whose insulin requirements fall during pregnancy have a markedly increased risk of developing pre-eclampsia and other adverse obstetric outcomes, according to new research. As the fall in insulin requirement seems to precede the onset of pre-eclampsia, clinicians should be alert

    更新日期:2017-09-12
  • Gut microbiota: Gas-induced GLP1 release
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-08-18
    David Holmes

    New research shows that hydrogen sulphide (H2S), a microbial gas produced in the colon by sulphate-reducing bacteria (SRB), can directly stimulate the release of glucagon-like peptide 1 (GLP1; an incretin hormone involved in glucose homeostasis and appetite regulation) from enteroendocrine L cells in

    更新日期:2017-09-12
  • Diabetes: Peripheral Aβ linked to pathogenesis of T2DM
    Nat. Rev. Endocrinol. (IF 18.318) Pub Date : 2017-09-01
    Alan Morris

    Epidemiological studies suggest that patients with type 2 diabetes mellitus (T2DM) are at increased risk of developing Alzheimer disease, but the mechanistic underpinnings of this relationship remain unclear. In a new study, Nadeeja Wijesekara and colleagues investigated the link between these two diseases in a

    更新日期:2017-09-12
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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