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  • Oseltamivir, amantadine, and ribavirin combination antiviral therapy versus oseltamivir monotherapy for the treatment of influenza: a multicentre, double-blind, randomised phase 2 trial
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-22
    John H Beigel, Yajing Bao, Joy Beeler, Weerawat Manosuthi, Alex Slandzicki, Sadia M Dar, John Panuto, Richard L Beasley, Santiago Perez-Patrigeon, Gompol Suwanpimolkul, Marcelo H Losso, Natalie McClure, Dawn R Bozzolo, Christopher Myers, H Preston Holley, Justin Hoopes, H Clifford Lane, Michael D Hughes, Richard T Davey, Michael Winnie, Dinh V Dinh, Raghu Seethala, Hiram Garcia, Joe Pouzar, Michael Seep, Ernie Riffer, Belinda Bart, Sadia Dar, Melanie Hoppers, John Panuto, Heather Rowe, Alex Slandzicki, Cameron Wolfe, Donna Desantis, Barr Baynton, Richard L Beasley, Norman Markowitz, Zebediah A Stearns, Josalyn Cho, Marcy Goisse, Thomas A Wolf, Jennifer Kay, Nila Dharan, William Fitzgibbons, Mark Woodruff, Todd Bell, Thomas Lenzmeier, Robert Schooley, Marie-Carmelle Elie, Patricia Winokur, Robert Finberg, Christopher Hurt, Pablo Tebas, Fred R Sattler, Madhavi Ampajwala, Donald Batts, Mark Bloch, Richard Moore, Dominic Dwyer, Javier Romo-Garcia, Santiago Perez Patrigeon, Ana Patricia Rodríguez Zulueta, Weerawat Manosuthi, Ploenchan Chetchotisakd, Kiat Ruxrungtham, Anchalee Avihingsanon, Gompol Suwanpimolkul, Winai Ratanasuwan, Sergio Lupo, Liliana Trape, Marcelo H Losso, Laura M Macias, Gustavo Lopardo, Laura Barcelona, Analia Mykietuk, Maria F Alzogaray
    更新日期:2017-09-23
  • Finding the right combination antiviral therapy for influenza
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-22
    Michael G Ison
    更新日期:2017-09-23
  • Scratching the itch: is scabies a truly neglected disease?
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-20
    Olivier Chosidow, L Claire Fuller
    更新日期:2017-09-20
  • The global burden of scabies: a cross-sectional analysis from the Global Burden of Disease Study 2015
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-20
    Chante Karimkhani, Danny V Colombara, Aaron M Drucker, Scott A Norton, Roderick Hay, Daniel Engelman, Andrew Steer, Margot Whitfeld, Mohsen Naghavi, Robert P Dellavalle
    更新日期:2017-09-20
  • Unseen enemy
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Talha Burki
    更新日期:2017-09-20
  • Simon Hay: mapping the world's ills
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Tony Kirby
    更新日期:2017-09-20
  • Research brief
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Dara Mohammadi

    Like smoking a rabbit out of a hole, researchers are testing the ability of an experimental cancer drug to reactivate latent HIV and expose it to antiretroviral treatment. The drug, called JQ1, targets the short form of a viral protein called BRD4, which is involved in virus transcription. JQ1 seems to remove the protein, allowing the transcription machinery to come back into action. Once HIV is transcribed and translated, it can be eliminated with standard antiretroviral therapy. This strategy could be a useful method in the stubborn last yard to effectively eradicate the virus from a patient's body.

    更新日期:2017-09-20
  • Infectious disease surveillance update
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Ruth Zwizwai

    Four cases of locally transmitted chikungunya have been confirmed in Provence-Alpes-Côte d'Azur region of southeastern France as of Aug 23. Eight suspected cases and one probable case have also been reported. Symptoms for the four confirmed cases and one probable case began between Aug 2 and Aug 17. Regional Health Authorities have reported that the 13 patients are aged 3–77 years and live in the commune of Cannet des Maures in Var.

    更新日期:2017-09-20
  • Illnesses of isolation: detention of asylum seekers
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Georgina Kenyon
    更新日期:2017-09-20
  • Counterfeit and substandard malaria drugs in Africa
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Vicki Brower
    更新日期:2017-09-20
  • A case for retraction?
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Lucy Bailey

    In the Editorial in the September issue of The Lancet Infectious Diseases, the editors ask whether the ultimate aim of a call for retraction is “to correct the record” or “to ensure the record does not challenge cherished preconceptions”.1 In the case of the Infectious Diseases Society of America (IDSA) and American Association for the Study of Liver Diseases' (AASLD) critique2 of a recent Cochrane review,3 their aim was clear—to correct the record. Why then, given the subsequent outcry from professional bodies4 and patient organisations5 worldwide, is there any need for further debate on the matter?

    更新日期:2017-09-20
  • WHO's recommendation for surgical skin antisepsis is premature – Authors' reply
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Benedetta Allegranzi, Matthias Egger, Didier Pittet, Peter Bischoff, Peter Nthumba, Joseph Solomkin

    Matthias Maiwald and Andreas Widmer express concern with the WHO recommendation on surgical site preparation.1,2 WHO guidelines are developed using processes and methods to ensure robust recommendations.3 Specifically, this recommendation was informed by a systematic review and several meta-analyses, including one of six randomised controlled trials comparing alcohol-based chlorhexidine with povidone-iodine-alcohol (PVP-I) preparations that showed a greater reduction in surgical site infections (SSIs) with chlorhexidine (odds ratio [OR] 0·58, 95% CI 0·42–0·80).

    更新日期:2017-09-20
  • WHO's recommendation for surgical skin antisepsis is premature
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Matthias Maiwald, Andreas F Widmer
    更新日期:2017-09-20
  • High mortality in non-Ebola virus disease cases: need to provide timely and effective care
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Robert Colebunders, Shevin T Jacob, Kevin K Ariën, Anja De Weggheleire, Tom Decroo

    In their Article in The Lancet Infectious Diseases, Matthew Waxman and colleagues1 report an overall high (8·1%) mortality in patients without Ebola virus disease (EVD) admitted to three Ebola treatment units (ETU) in Sierra Leone; we report a similarly high (6·4%) mortality in non-EVD cases from a Guinean ETU.2 We agree with the authors that many non-EVD patients succumb to other severe illnesses, probably infectious diseases within a broad differential diagnosis given the high frequency of fever in the context of a negative malaria test.

    更新日期:2017-09-20
  • Combination therapy for bloodstream infections with carbapenemase-producing Enterobacteriaceae – Authors' reply
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Belén Gutiérrez-Gutiérrez, Robert A Bonomo, Yehuda Carmeli, David L Paterson, Alvaro Pascual, Jesús Rodríguez-Baño

    We thank Bernd Salzberger and Gerd Fätkenheuer for their interest in our study.1 They were concerned about the use of Charlson, Pitt, and INCREMENT-CPE scores, as well as the individual variables contained in them in the analyses. Our objective was to provide the best possible estimation of the association of the main exposure (treatment) with the outcome considering the effect of confounders, in accordance with the study hypothesis; we did not intend to provide a model to predict outcome (mortality).

    更新日期:2017-09-20
  • Combination therapy for bloodstream infections with carbapenemase-producing Enterobacteriaceae
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Bernd Salzberger, Gerd Fätkenheuer

    We applaud the authors of the INCREMENT study1 in The Lancet Infectious Diseases for accumulating these impressive data for bloodstream infections with carbapenemase-producing Enterobacteriaceae (CPE). However, we are concerned about several aspects of the study.

    更新日期:2017-09-20
  • Timing of surgical antimicrobial prophylaxis
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Yoshiaki Kanemoto, Tetsuya Tanimoto, Yuto Maeda, Tomohiro Kurokawa, Giichiro Tsurita

    In The Lancet Infectious Diseases, Walter P Weber and colleagues1 found that early administration (approximately 30–75 min before the scheduled incision) of surgical antimicrobial prophylaxis did not significantly reduce the risk of surgical site infection (SSI) compared with late administration (approximately 0–30 min before the scheduled incision). The authors tested cefuroxime, a commonly used cephalosporin with a short half-life, plus metronidazole in colorectal surgery, in patients older than 18 years who underwent inpatients general surgery procedures as well as orthopaedic trauma and vascular procedures at two hospitals in Switzerland from February, 2013, to August, 2015.

    更新日期:2017-09-20
  • Hand, foot, and mouth disease in mainland China before it was listed as category C disease in May, 2008
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    Jie Li, Jinfeng Wang, Chengdong Xu, Qian Yin, Maogui Hu, Zhaojun Sun, Dewang Shao
    更新日期:2017-09-20
  • Vaccine against Zika virus must remain a priority
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-10-01
    The Lancet Infectious Diseases
    更新日期:2017-09-20
  • Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-14
    Nathan C Bahr, Edwin Nuwagira, Emily E Evans, Fiona V Cresswell, Philip V Bystrom, Adolf Byamukama, Sarah C Bridge, Ananta S Bangdiwala, David B Meya, Claudia M Denkinger, Conrad Muzoora, David R Boulware, Darlisha A Williams, Kabanda Taseera, Dan Nyehangane, Mugisha Ivan, Patrick Orikiriza, Joshua Rhein, Kathy Huppler Hullsiek, Abdu Musubire, Katelyn Pastick, Pamela Nabeta, James Mwesigye, Radha Rajasingham
    更新日期:2017-09-15
  • Xpert MTB/RIF Ultra: a gamechanger for tuberculous meningitis?
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-14
    Margaret Khonga, Mark Patrick Nicol
    更新日期:2017-09-15
  • Corrections
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-13

    Saunders MJ, Wingfield T, Tovar MA, et al. A score to predict and stratify risk of tuberculosis in adult contacts of tuberculosis index cases: a prospective derivation and external validation cohort study. Lancet Infect Dis 2017; published online Aug 18. http://dx.doi.org/10.1016/S1473-3099(17)30447-4—The support and grants in the Acknowledgments section should have been assigned as follows: This study was supported by Wellcome Trust awards 057434/Z/99/B (MAT, KZ, RM, TRV, JSF, RHG, and CAE), Z070005/Z/02/Z (MAT, TRV, JSF, RHG, and CAE), 078340/Z/05/Z (MAT, KZ, RM, TRV, JSF, and RHG, CAE), 105788/Z/14/Z (SD, RHG, and CAE), 201251/Z/16/Z (MJS, RHG, and CAE), the Department for International Development Civil Society Challenge Fund (MAT, KZ, RM, TRV, CAE), the Joint Global Health Trials consortium (Medical Research Council, Department for International Development, and Wellcome Trust award MR/K007467/1 [TW, MAT, KZ, RM, TRV, RHG, and CAE]), the Bill & Melinda Gates Foundation (award OPP1118545 [TW, MAT, RM, TRV, and CAE]), Imperial College National Institutes of Health Research Biomedical Research Centre (JAF and CAE), the Foundation for Innovative New Diagnostics (MAT, KZ, TRV, and CAE), the Sir Halley Stewart Trust (CAE), WHO (CAE), the STOP TB partnership's TB REACH initiative funded by the Government of Canada (W5_PER_CDT1_PRISMA [MAT, RM, and CAE]), and Innovation For Health And Development (MJS, TW, and CAE).

    更新日期:2017-09-14
  • Treating malaria: new drugs for a new era
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-12
    G Dennis Shanks, Jörg J Möhrle
    更新日期:2017-09-13
  • Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomised, controlled, single-blinded, non-inferiority trial
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-29
    Wendelin Moser, Jean T Coulibaly, Said M Ali, Shaali M Ame, Amour K Amour, Richard B Yapi, Marco Albonico, Maxim Puchkov, Jörg Huwyler, Jan Hattendorf, Jennifer Keiser
    更新日期:2017-08-30
  • Global deworming: moving past albendazole and mebendazole
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-29
    Peter J Hotez
    更新日期:2017-08-30
  • CRP: tell-tale biomarker or common denominator?
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-25
    Annemieke Geluk, Paul Corstjens
    更新日期:2017-08-26
  • Point-of-care C-reactive protein-based tuberculosis screening for people living with HIV: a diagnostic accuracy study
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-25
    Christina Yoon, Fred C Semitala, Elly Atuhumuza, Jane Katende, Sandra Mwebe, Lucy Asege, Derek T Armstrong, Alfred O Andama, David W Dowdy, J Luke Davis, Laurence Huang, Moses Kamya, Adithya Cattamanchi
    更新日期:2017-08-26
  • Measuring progress on preventing pneumonia deaths: are we there yet?
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-23
    Cynthia G Whitney
    更新日期:2017-08-24
  • Effect of HSV-2 infection on subsequent HIV acquisition: an updated systematic review and meta-analysis
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-23
    Katharine J Looker, Jocelyn A R Elmes, Sami L Gottlieb, Joshua T Schiffer, Peter Vickerman, Katherine M E Turner, Marie-Claude Boily
    更新日期:2017-08-24
  • A fresh look at an old problem
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-23
    Thomas M Zydowsky
    更新日期:2017-08-24
  • Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the Global Burden of Disease Study 2015
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-23
    Christopher Troeger, Mohammad Forouzanfar, Puja C Rao, Ibrahim Khalil, Alexandria Brown, Scott Swartz, Nancy Fullman, Jonathan Mosser, Robert L Thompson, Robert C Reiner, Amanuel Abajobir, Noore Alam, Mulubirhan Assefa Alemayohu, Azmeraw T Amare, Carl Abelardo Antonio, Hamid Asayesh, Euripide Avokpaho, Aleksandra Barac, Muktar A Beshir, Dube Jara Boneya, Michael Brauer, Lalit Dandona, Rakhi Dandona, Joseph R A Fitchett, Tsegaye Tewelde Gebrehiwot, Gessessew Buggsa Hailu, Peter J Hotez, Amir Kasaeian, Tawfik Khoja, Niranjan Kissoon, Luke Knibbs, G Anil Kumar, Rajesh Kumar Rai, Hassan Magdy Abd El Razek, Muktar S K Mohammed, Katie Nielson, Eyal Oren, Abdalla Osman, George Patton, Mostafa Qorbani, Hirbo Shore Roba, Benn Sartorius, Miloje Savic, Mika Shigematsu, Bryan Sykes, Soumya Swaminathan, Roman Topor-Madry, Kingsley Ukwaja, Andrea Werdecker, Naohiro Yonemoto, Maysaa El Sayed Zaki, Stephen S Lim, Mohsen Naghavi, Theo Vos, Simon I Hay, Christopher J L Murray, Ali H Mokdad
    更新日期:2017-08-24
  • Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006–12: a matched case-control study
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Enny S Paixão, Maria da Conceição N Costa, Maria Glória Teixeira, Katie Harron, Marcia Furquim de Almeida, Mauricio L Barreto, Laura C Rodrigues
    更新日期:2017-08-24
  • PK-PD Compass, a novel computerized decision support system
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Glenn Tillotson
    更新日期:2017-08-24
  • African American women surviving HIV/AIDS
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Kimberly Parker
    更新日期:2017-08-24
  • Research brief
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Dara Mohammadi

    The global incidence of dengue fever is on the rise, especially in southeast Asia and the Americas. New research suggests much of this spread is caused by aeroplane travel. Researchers did a phylogenetic analysis of 2202 viral sequences from dengue virus samples collected in 20 countries between 1956 and 2015. They also assessed air travel, maritime mobility, migration, and socioeconomic factors for associated trends. Spread of dengue serotypes 1, 2, and 3 was associated with air travel more than any other factor.

    更新日期:2017-08-24
  • Infectious disease surveillance update
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Ruth Zwizwai

    Health authorities in Sri Lanka reported more than 35 651 suspected cases of dengue fever during July. 10 715 cases were reported for the same period in 2016. The total number of suspected cases reported in 2017 as of Aug 4 is 122 384, including an estimated 300 deaths. 44% of the cases have been reported in the Western Province, which includes the capital Colombo.

    更新日期:2017-08-24
  • Essential medicines for hepatitis C: at what price?
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Vijay Shankar Balakrishnan

    Effective new hepatitis C drugs have been added to WHO's Essential Medicines List, but governments are struggling to afford them. Vijay Shankar Balakrishnan reports.

    更新日期:2017-08-24
  • No jab, no play: Australia and compulsory vaccination
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Tony Kirby

    Public health concerns have prompted several Australian states to propose laws imposing heavy fines on kindergartens that enrol unvaccinated children. Tony Kirby reports.

    更新日期:2017-08-24
  • Highlights from the 9th International AIDS Society meeting
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Peter Hayward

    Held in Paris, France (July 23–26), the conference lacked major breakthroughs but developments in treatment and prevention provided hope in turbulent times. Peter Hayward reports.

    更新日期:2017-08-24
  • Changing trends of neglected tropical diseases in China
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Shi-Zhu Li, Men-Bao Qian, Li-Juan Zhang, Xiao-Nong Zhou
    更新日期:2017-08-24
  • Divergent policy responses to increasing vaccine scepticism in southern Europe
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Jonathan Kennedy, Domna Michailidou

    In the last month, the Greek1 and Italian2 Ministries of Health have expressed concern about increasing numbers of parents refusing to vaccinate their children against preventable infectious diseases. But their policy responses have been very different. Greece moved from a paternalist approach to child vaccinations to a more laissez faire one. Child vaccination has been mandatory since 1999 and children were only allowed to avoid vaccination for certified medical reasons. But at the end of May, 2017, the left-wing Syriza-led government proposed that parents be able to opt out of vaccinating their children.

    更新日期:2017-08-24
  • Combination therapy for carbapenemase-producing Entero-bacteriaceae: INCREMENT-al effect on resistance remains unclear
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Sara E Boyd, Luke S P Moore, Timothy M Rawson, William W Hope, Alison H Holmes

    Belén Gutiérrez-Gutiérrez and colleagues1 investigated the effect of appropriate combination therapy versus monotherapy on the mortality of patients with bloodstream infections (BSIs) due to carbapenemase-producing Enterobacteriaceae (CPE) in The Lancet Infectious Diseases. In stratified analyses, appropriate combination therapy was associated with a significantly lower mortality than was appropriate monotherapy in the high-mortality-score stratum (adjusted hazard ratio 0·56, 95% CI 0·34–0·91; p=0·02), yet the low-mortality-score stratum showed no benefit (adjusted odds ratio 1·21, 0·56–2·56; p=0·62).

    更新日期:2017-08-24
  • Successful cure of extensively drug-resistant pulmonary tuberculosis in a young child
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Nicole Salazar-Austin, Ibukunoluwa Akinboyo, Sanjay K Jain

    In The Lancet Infectious Diseases,1 we described a 2-year-old child from the USA who developed extensively drug-resistant pulmonary tuberculosis after a 3 month visit to India. She has been closely followed for 2 years after completing 18 months of directly observed therapy with an individualised drug regimen, including streptomycin (first 6 months), linezolid, para-aminosalicylic acid, cycloserine, and clofazimine. In the absence of clinical or microbiological markers, low-radiation exposure CT was used as a rapid biomarker to guide treatment.

    更新日期:2017-08-24
  • Multidrug-resistant tuberculosis: pharmacokinetic and pharmacodynamic science
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Jan-Willem C Alffenaar, Giovanni Battista Migliori, Tawanda Gumbo

    Despite all efforts, the burden of disease caused by multidrug-resistant (MDR) tuberculosis is worrisome. In The Lancet Infectious Diseases, Aditya Sharma and colleagues1 estimated an increase in MDR and extensively drug-resistant tuberculosis and a shift from acquired drug resistance to transmission of resistance.1 In the accompanying Comment, Andrei Mariandyshev and Platon Eliseev2 emphasised implementation of the short-course regimen as the most important measure to prevent the spread of MDR tuberculosis.

    更新日期:2017-08-24
  • International Surviving Sepsis Campaign guidelines 2016: the perspective from low-income and middle-income countries
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Gentle S Shrestha, Arthur Kwizera, Ganbold Lundeg, John I Baelani, Luciano C P Azevedo, Rajyabardhan Pattnaik, Rashan Haniffa, Srdjan Gavrilovic, Nguyen Thi Hoang Mai, Niranjan Kissoon, Rakesh Lodha, David Misango, Ary Serpa Neto, Marcus J Schultz, Arjen M Dondorp, Jonarthan Thevanayagam, Martin W Dünser, A K M Shamsul Alam, Ahmed M Mukhtar, Madiha Hashmi, Suchitra Ranjit, Akaninyene Otu, Charles Gomersall, Jacinta Amito, Nicolas Nin Vaeza, Jane Nakibuuka, Pierre Mujyarugamba, Elisa Estenssoro, Gustavo A Ospina-Tascón, Sanjib Mohanty, Mervyn Mer

    In the most recent international Surviving Sepsis Campaign guidelines, Rhodes and colleagues1 excellently outline evidence-based management of patients with sepsis and septic shock. Of note, however, is that most of the world's population resides in low-income and middle-income countries (LMICs), where the burden of sepsis is enormous, outcomes are often poor, and socioeconomic consequences are dire.2 Of the 655 references supporting the new sepsis guidelines, only a few pertain to studies in LMICs (about 10%).

    更新日期:2017-08-24
  • Dengue and stillbirth
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    Robert L Goldenberg, Elizabeth M McClure
    更新日期:2017-08-24
  • A proper place for retraction
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-09-01
    The Lancet Infectious Diseases
    更新日期:2017-08-24
  • Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-22
    Delan Devakumar, Alasdair Bamford, Marcelo U Ferreira, Jonathan Broad, Richard E Rosch, Nora Groce, Judith Breuer, Marly A Cardoso, Andrew J Copp, Paula Alexandre, Laura C Rodrigues, Ibrahim Abubakar
    更新日期:2017-08-23
  • Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-21
    Guillaume Joguet, Jean-Michel Mansuy, Giulia Matusali, Safouane Hamdi, Marie Walschaerts, Lynda Pavili, Stefanie Guyomard, Nadia Prisant, Pierre Lamarre, Nathalie Dejucq-Rainsford, Christophe Pasquier, Louis Bujan
    更新日期:2017-08-22
  • Zika virus infection in semen: effect on human reproduction
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-21
    Luisa Barzon, Enrico Lavezzo, Giorgio Palù
    更新日期:2017-08-22
  • 更新日期:2017-08-19
  • A score to predict and stratify risk of tuberculosis in adult contacts of tuberculosis index cases: a prospective derivation and external validation cohort study
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-18
    Matthew J Saunders, Tom Wingfield, Marco A Tovar, Matthew R Baldwin, Sumona Datta, Karine Zevallos, Rosario Montoya, Teresa R Valencia, Jon S Friedland, Larry H Moulton, Robert H Gilman, Carlton A Evans
    更新日期:2017-08-19
  • Tuberculosis—making predictions, especially about the future
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-18
    Anna M Mandalakas, Frank Cobelens
    更新日期:2017-08-19
  • The epidemiology of sepsis in Brazilian intensive care units (the Sepsis PREvalence Assessment Database, SPREAD): an observational study
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-17
    Flavia R Machado, Alexandre Biasi Cavalcanti, Fernando Augusto Bozza, Elaine M Ferreira, Fernanda Sousa Angotti Carrara, Juliana Lubarino Sousa, Noemi Caixeta, Reinaldo Salomao, Derek C Angus, Luciano Cesar Pontes Azevedo, S R Zajac, M V Bley, M V Bley, A Scazufca, P Rosateli, T Reis, A Nogueira Junior, P A Nunes Neto, I L S Filho, H Lima, M Vieira, M Zanchet, I Ferreira, R Miguita, G M Petisco, G A Westphal, J R P Santos, V Damasceno, J T dos Santos, F Fernandes, EP Almeida, M Lemos, M F A Lima, R Camacho, A Ribeiro, M O G Douglas, G A Mattei, E A Junior, P Ferreira, H R M P Rabelo, S P S Pinto, L E Fontes, D Machado, M Guitzel, M Lucio, C N P Conceição, A Barros, D Salgado, V C Veiga, S S O Rojas, V C Veiga, S S O Rojas, KM de Paula, R Hatum, L Fraenkel, W N Viana, A P G Santos, L Rabello, L Tanaka, M Uchoa, M D Moura, H Gneco, M F Buarque, K Monteiro, A P Nassar, E Koterba, M J Teixeira, A L E Falcão, V G S Pinto, J M M Junior, A L Gut, L M Stefano, M Damasceno, M V Lontra, C Cozzani, E B Sobrinho, S G Lage, L Kopel, N C M Youssef, L C Sanches, C P Amendola, C Kmohan, C B Silva, L Schifelbain, E Bellotto, P Viecili, L Azevedo, L Monteiro, S Vieira, A M Abrão, A P Moraes, H Insaurrale, M Gadelha, D Marisa, R N Diniz, E R Romano, S Luzzi, E Rezende, M C Filho, R H F C Martins, F B Carvalho, G C Moreira, J Paula, F Fernandes, F Haag, FS Lucena, R S Machado, W O Filho, L O Cavalcante, H Carvalho Filho, G S Lima, J N Trombka, E C Machado, M P Bainy, C H Ramos, C Hoppe, G D Luckmeyer, C Vogas, M M Thompson, R K Sousa, R Fernandes, E Lourenço, G L Peixoto, A Mocelin, M M L Silva, J S A Neto, C Villela, S L Mendonça, S C Prado, R Goulart, J J L Duarte, H A O Junior, J N Andrade, L F Souza, L Fernandes, M L Neto, S S Fernandes, F Amâncio, J C Versiani, F Pitanga, M B Alcantara, C C Reiff, R Rosenblat, M S Nobrega, M L F S Nobrega, G Costa, N Assunção, E P Almeida, L Neder, R Almeida, J Fuck, R M Souza, A G Ribeiro, A A G Alves, S H C Carvalho, M Arbex, E C Oliveira, F B Carvalho, R S Melo, K Conde, N Q Abreu, C L T Melo, A A Carvalho, M C Filho, R Lannes, H Missaka, A H Furtado, A A Peixoto, I Maia, M P Pincelli, R Camacho, M P Yunes, A N Pessoa, S Figueiredo, F A Botoni, C T Cunha, F A Olson, R Franco, A F Bemfica, M S Nobrega, A D F Junior, E L A Ferreira, O Messeder, R Passos, J A Lira, C A Vilela, S M D Junior, C S Ferreira, O P J A Muller, R Perreira dos Santos, P Rubini, D Monteiro, L E Rodrigues, G F Ruivo, M C Gomes, E Egito, M G Assef, M A M Lima, A F Borges, M Gadelha, S Jezler, C Mendes, P C Gottardo, R Lima, C M F Filho, V P Campagnucci, I Solino, A P Lorca, A P Lorca, G M Rodrigues, K B Gerent, O Barbosa, G T Henriques Filho, E Troncoso, A Ventura, M A Silva, J G Houly, J P M Pimentel, R A Ramos, F Gianini, B Casemiro, E M Pinto, G A Silva, M Sebold, E Vieira, R Ferreira, L A Gomes, W J Lovato, W Dantas, L Ishy, W Dantas, L Ishy, J Moreira, I Gagliardi, L O Goes, L S Vendrame, H P Guimarães, A Gois, F R Machado, M Rodrigues, P C B Vieira, W Bittencourt, E Melnick, M Schneider, L Rezegue, N J M Nogueira, L Azevedo, E P Godinho, B F Mazza, L E Paciencia, S Ferraz, C R A Imamura, J Tavares, J C Santos, E Vale, J Mugait Filho, L A Tannous, P G D João, C T I Geral, D Salgado, A P Matera, M Matsui, E Eberhart Neto, B V Pinheiro, E V Carvalho, H Matos, M Lippi, A L Campos, D C Albuquerque, D Monteiro, D Castiglioni, G S Silva, S Cunha, E Novello, M E B Silva, C Grion, J Festti, C Grion, J Festti, C R A Souza, G C Mecatti, E B Junqueira, R S Dutra, G B Mirachi, D A Mendes, E M F Moura, I F Silva, M G P Mota, T Carneiro, A Celso, A Réa-Neto, M C Oliveira, A Japiassú, P P Castro, H J M Costa, A V Rolim, D Rocha, C Righy, C Righy, V Santos, B Fernandino, A L Pereira, V L D Rego, M M L Silva, L A Melo, L Guilherme, H Chagas Ferro, F J L Silva, H V C J Carrasco, S El-Fakouri, J Alvarez, D de Castro, P M Shiavetto, S R Gallate, E Thomé Filho, S G Veneziano, W O Filho, P Antoniazzi, W H Filho, P Sadala, C Balbino, G Moreno, M S F Dias, R P Lopez, M L Rodrigues, J Terceiro, M F Serpa, L Santos, W O Filho, M M Lippi, S R Zajac, M V Bley, M V Bley, A Scazufca, P Rosateli, T Reis, A Nogueira Junior, P A Nunes Neto, I L S Filho, H Lima, M Vieira, M Zanchet, I Ferreira, R Miguita, G M Petisco, G A Westphal, J R P Santos, V Damasceno, J T dos Santos, F Fernandes, EP Almeida, M Lemos, M F A Lima, R Camacho, A Ribeiro, M O G Douglas, G A Mattei, E A Junior, P Ferreira, H R M P Rabelo, S P S Pinto, L E Fontes, D Machado, M Guitzel, M Lucio, C N P Conceição, A Barros, D Salgado, V C Veiga, S S O Rojas, V C Veiga, S S O Rojas, KM de Paula, R Hatum, L Fraenkel, W N Viana, A P G Santos, L Rabello, L Tanaka, M Uchoa, M D Moura, H Gneco, M F Buarque, K Monteiro, A P Nassar, E Koterba, M J Teixeira, A L E Falcão, V G S Pinto, J M M Junior, A L Gut, L M Stefano, M Damasceno, M V Lontra, C Cozzani, E B Sobrinho, S G Lage, L Kopel, N C M Youssef, L C Sanches, C P Amendola, C Kmohan, C B Silva, L Schifelbain, E Bellotto, P Viecili, L Azevedo, L Monteiro, S Vieira, A M Abrão, A P Moraes, H Insaurrale, M Gadelha, D Marisa, R N Diniz, E R Romano, S Luzzi, E Rezende, M C Filho, R H F C Martins, F B Carvalho, G C Moreira, J Paula, F Fernandes, F Haag, FS Lucena, R S Machado, W O Filho, L O Cavalcante, H Carvalho Filho, G S Lima, J N Trombka, E C Machado, M P Bainy, C H Ramos, C Hoppe, G D Luckmeyer, C Vogas, M M Thompson, R K Sousa, R Fernandes, E Lourenço, G L Peixoto, A Mocelin, M M L Silva, J S A Neto, C Villela, S L Mendonça, S C Prado, R Goulart, J J L Duarte, H A O Junior, J N Andrade, L F Souza, L Fernandes, M L Neto, S S Fernandes, F Amâncio, J C Versiani, F Pitanga, M B Alcantara, C C Reiff, R Rosenblat, M S Nobrega, M L F S Nobrega, G Costa, N Assunção, E P Almeida, L Neder, R Almeida, J Fuck, R M Souza, A G Ribeiro, A A G Alves, S H C Carvalho, M Arbex, E C Oliveira, F B Carvalho, R S Melo, K Conde, N Q Abreu, C L T Melo, A A Carvalho, M C Filho, R Lannes, H Missaka, A H Furtado, A A Peixoto, I Maia, M P Pincelli, R Camacho, M P Yunes, A N Pessoa, S Figueiredo, F A Botoni, C T Cunha, F A Olson, R Franco, A F Bemfica, M S Nobrega, A D F Junior, E L A Ferreira, O Messeder, R Passos, J A Lira, C A Vilela, S M D Junior, C S Ferreira, O P J A Muller, R Perreira dos Santos, P Rubini, D Monteiro, L E Rodrigues, G F Ruivo, M C Gomes, E Egito, M G Assef, M A M Lima, A F Borges, M Gadelha, S Jezler, C Mendes, P C Gottardo, R Lima, C M F Filho, V P Campagnucci, I Solino, A P Lorca, A P Lorca, G M Rodrigues, K B Gerent, O Barbosa, G T Henriques Filho, E Troncoso, A Ventura, M A Silva, J G Houly, J P M Pimentel, R A Ramos, F Gianini, B Casemiro, E M Pinto, G A Silva, M Sebold, E Vieira, R Ferreira, L A Gomes, W J Lovato, W Dantas, L Ishy, W Dantas, L Ishy, J Moreira, I Gagliardi, L O Goes, L S Vendrame, H P Guimarães, A Gois, F R Machado, M Rodrigues, P C B Vieira, W Bittencourt, E Melnick, M Schneider, L Rezegue, N J M Nogueira, L Azevedo, E P Godinho, B F Mazza, L E Paciencia, S Ferraz, C R A Imamura, J Tavares, J C Santos, E Vale, J Mugait Filho, L A Tannous, P G D João, C T I Geral, D Salgado, A P Matera, M Matsui, E Eberhart Neto, B V Pinheiro, E V Carvalho, H Matos, M Lippi, A L Campos, D C Albuquerque, D Monteiro, D Castiglioni, G S Silva, S Cunha, E Novello, M E B Silva, C Grion, J Festti, C Grion, J Festti, C R A Souza, G C Mecatti, E B Junqueira, R S Dutra, G B Mirachi, D A Mendes, E M F Moura, I F Silva, M G P Mota, T Carneiro, A Celso, A Réa-Neto, M C Oliveira, A Japiassú, P P Castro, H J M Costa, A V Rolim, D Rocha, C Righy, C Righy, V Santos, B Fernandino, A L Pereira, V L D Rego, M M L Silva, L A Melo, L Guilherme, H Chagas Ferro, F J L Silva, H V C J Carrasco, S El-Fakouri, J Alvarez, D de Castro, P M Shiavetto, S R Gallate, E Thomé Filho, S G Veneziano, W O Filho, P Antoniazzi, W H Filho, P Sadala, C Balbino, G Moreno, M S F Dias, R P Lopez, M L Rodrigues, J Terceiro, M F Serpa, L Santos, W O Filho, M M Lippi
    更新日期:2017-08-17
  • Spreading the knowledge on the epidemiology of sepsis
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-17
    Jorge I F Salluh, Marcio Soares, Mervyn Singer
    更新日期:2017-08-17
  • Inpatient versus outpatient parenteral antibiotic therapy at home for acute infections in children: a systematic review
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-16
    Penelope A Bryant, Naomi T Katz
    更新日期:2017-08-16
  • Global yellow fever vaccination coverage from 1970 to 2016: an adjusted retrospective analysis
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-16
    Freya M Shearer, Catherine L Moyes, David M Pigott, Oliver J Brady, Fatima Marinho, Aniruddha Deshpande, Joshua Longbottom, Annie J Browne, Moritz U G Kraemer, Kathleen M O'Reilly, Joachim Hombach, Sergio Yactayo, Valdelaine E M de Araújo, Aglaêr A da Nóbrega, Jonathan F Mosser, Jeffrey D Stanaway, Stephen S Lim, Simon I Hay, Nick Golding, Robert C Reiner
    更新日期:2017-08-16
  • Yellow fever vaccination: estimating coverage
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-16
    Annelies Wilder-Smith
    更新日期:2017-08-16
  • Trends in antimicrobial resistance in bloodstream infection isolates at a large urban hospital in Malawi (1998–2016): a surveillance study
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-14
    Patrick Musicha, Jennifer E Cornick, Naor Bar-Zeev, Neil French, Clemens Masesa, Brigitte Denis, Neil Kennedy, Jane Mallewa, Melita A Gordon, Chisomo L Msefula, Robert S Heyderman, Dean B Everett, Nicholas A Feasey
    更新日期:2017-08-15
  • Understanding threats to polio vaccine commitment among caregivers in high-priority areas of Afghanistan: a polling study
    Lancet Infect. Dis. (IF 19.864) Pub Date : 2017-08-14
    Gillian K SteelFisher, Robert J Blendon, Sherine Guirguis, William Lodge, Hannah Caporello, Vincent Petit, Michael Coleman, Matthew R Williams, Sardar Mohammad Parwiz, Melissa Corkum, Scott Gardner, Eran N Ben-Porath

    Background Eradication of poliovirus from endemic countries relies on vaccination of children with oral polio vaccine (OPV) many times a year until the age of 5 years. We aimed to determine caregivers' commitment to OPV in districts of Afghanistan at high risk for polio transmission and to examine what knowledge, attitudes, or experiences could threaten commitment. Methods We designed and analysed a poll using face-to-face interviews among caregivers of children under 5 years of age. The sample was drawn via a stratified multistage cluster design with random route household selection. We calculated the percentage of committed and uncommitted caregivers. All percentages were weighted. We then compared percentages of uncommitted caregivers among those with varying knowledge, attitudes, and experiences, using logistic regression to control for possible demographic confounders. Findings Between Dec 19, 2014, and Jan 5, 2015, we interviewed 1980 caregivers, 21% of whom were “uncommitted” to accepting OPV. Multiple measures of knowledge, attitudes, and experiences are associated with lack of commitment. For example, compared with their relevant counterparts, caregivers are more likely to be uncommitted if they did not trust vaccinators “a great deal” (54% vs 9%), if they do not know that polio spreads through contaminated water (41% vs 14%), or if they believe rumours that OPV is not halal (50% vs 21%). Interpretation To enhance OPV commitment, it might be useful to consider a multifactorial approach that highlights building trust in vaccinators, providing facts about transmission, sharing positive messages to overcome key rumours, and strengthening community support for vaccination. Funding Harvard T H Chan School of Public Health and UNICEF.

    更新日期:2017-08-15
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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