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  • Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
    Lancet Neurol. (IF 26.284) Pub Date : 2017-09-17
    Valery L Feigin, Amanuel Alemu Abajobir, Kalkidan Hassen Abate, Foad Abd-Allah, Abdishakur M Abdulle, Semaw Ferede Abera, Gebre Yitayih Abyu, Muktar Beshir Ahmed, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, Rufus Olusola Akinyemi, Samer Alabed, Rajaa Al-Raddadi, Nelson Alvis-Guzman, Azmeraw T. Amare, Hossein Ansari, Palwasha Anwari, Johan Ärnlöv, Hamid Asayesh, Solomon Weldegebreal Asgedom, Tesfay Mehari Atey, Leticia Avila-Burgos, Euripide Frinel, G. Arthur Avokpaho, Aleksandra Barac, Miguel Barboza, Suzanne L Barker-Collo, Till Bärnighausen, Neeraj Bedi, Ettore Beghi, Derrick A Bennett, Isabela M Bensenor, Adugnaw Berhane, Balem Demtsu Betsu, Soumyadeep Bhaumik, Sait Mentes Birlik, Stan Biryukov, Dube Jara Boneya, Lemma Negesa Bulto Bulto, Hélène Carabin, Daniel Casey, Carlos A. Castañeda-Orjuela, Ferrán Catalá-López, Honglei Chen, Abdulaal A Chitheer, Rajiv Chowdhury, Hanne Christensen, Lalit Dandona, Rakhi Dandona, Gabrielle A de Veber, Samath D Dharmaratne, Huyen Phuc Do, Klara Dokova, E Ray Dorsey, Richard G Ellenbogen, Sharareh Eskandarieh, Maryam S Farvid, Seyed-Mohammad Fereshtehnejad, Florian Fischer, Kyle J Foreman, Johanna M Geleijnse, Richard F Gillum, Giorgia Giussani, Philimon N Gona, Alessandra Carvalho Goulart, Harish Chander Gugnani, Rahul Gupta, Rajeev Gupta, Randah Ribhi Hamadeh, Mitiku Hambisa, Graeme J Hankey, Habtamu Abera Hareri, Rasmus Havmoeller, Simon I Hay, Pouria Heydarpour, Peter J Hotez, Mihajlo (Michael) B Jakovljevic, Mehdi Javanbakht, Panniyammakal Jeemon, Jost B Jonas, Yogeshwar Kalkonde, Amit Kandel, André Karch, Amir Kasaeian, Anshul Kastor, Peter Njenga Keiyoro, Yousef Saleh Khader, Ibrahim A Khalil, Ejaz Ahmad Khan, Young-Ho Khang, Abdullah Tawfih, Abdullah Khoja, Jagdish Khubchandani, Daniel Kim, Yun Jin Kim, Mika Kivimaki, Yoshihiro Kokubo, Soewarta Kosen, Michael Kravchenko, Rita Vanmala Krishnamurthi, Barthelemy Kuate Defo, G Anil Kumar, Rashmi Kumar, Hmwe H Kyu, Anders Larsson, Pablo M Lavados, Yongmei Li, Xiaofeng Liang, Misgan Legesse Liben, Warren D Lo, Giancarlo Logroscino, Paulo A Lotufo, Clement T Loy, Mark T Mackay, Hassan Magdy Abd El Razek, Mohammed Magdy Abd El Razek, Azeem Majeed, Reza Malekzadeh, Treh Manhertz, Lorenzo G Mantovani, João Massano, Mohsen Mazidi, Colm McAlinden, Suresh Mehata, Man Mohan Mehndiratta, Ziad A Memish, Walter Mendoza, Mubarek Abera Mengistie, George A Mensah, Atte Meretoja, Haftay Berhane Mezgebe, Ted R Miller, Shiva Raj Mishra, Norlinah Mohamed Ibrahim, Alireza Mohammadi, Kedir Endris Mohammed, Shafiu Mohammed, Ali H Mokdad, Maziar Moradi-Lakeh, Ilais Moreno Velasquez, Kamarul Imran Musa, Mohsen Naghavi, Josephine Wanjiku Ngunjiri, Cuong Tat Nguyen, Grant Nguyen, Quyen Le Nguyen, Trang Huyen Nguyen, Emma Nichols, Dina Nur Anggraini Ningrum, Vuong Minh Nong, Bo Norrving, Jean Jacques N Noubiap, Felix Akpojene Ogbo, Mayowa O Owolabi, Jeyaraj D. Pandian, Max Petzold, Michael Robert Phillips, Michael A Piradov, Richie G. Poulton, Farshad Pourmalek, Mostafa Qorbani, Anwar Rafay, Mahfuzar Rahman, Mohammad HifzUr Rahman, Rajesh Kumar Rai, Sasa Rajsic, Annemarei Ranta, Salman Rawaf, Andre M.N. Renzaho, Mohammad Sadegh Rezai, Gholamreza Roshandel, Enrico Rubagotti, Perminder Sachdev, Saeid Safiri, Ramesh Sahathevan, Mohammad Ali Sahraian, Abdallah M. Samy, Paula Santalucia, Itamar S Santos, Benn Sartorius, Maheswar Satpathy, Monika Sawhney, Mete I Saylan, Sadaf G Sepanlou, Masood Ali Shaikh, Raad Shakir, Morteza Shamsizadeh, Kevin N Sheth, Mika Shigematsu, Haitham Shoman, Diego Augusto Santos Silva, Mari Smith, Eugene Sobngwi, Luciano A Sposato, Dan J Stein, Timothy J Steiner, Lars Jacob Stovner, Rizwan Suliankatchi Abdulkader, Cassandra EI Szoeke, Rafael Tabarés-Seisdedos, David Tanne, Alice M Theadom, Amanda G Thrift, David L Tirschwell, Roman Topor-Madry, Bach Xuan Tran, Thomas Truelsen, Kald Beshir Tuem, Kingsley Nnanna Ukwaja, Olalekan A Uthman, Yuri Y Varakin, Tommi Vasankari, Narayanaswamy Venketasubramanian, Vasiliy Victorovich Vlassov, Fiseha Wadilo, Tolassa Wakayo, Mitchell T Wallin, Elisabete Weiderpass, Ronny Westerman, Tissa Wijeratne, Charles Shey Wiysonge, Minyahil Alebachew Woldu, Charles D A Wolfe, Denis Xavier, Gelin Xu, Yuichiro Yano, Hassen Hamid Yimam, Naohiro Yonemoto, Chuanhua Yu, Zoubida Zaidi, Maysaa El Sayed Zaki, Joseph R Zunt, Christopher J L Murray, Theo Vos
    更新日期:2017-09-18
  • Global burden of neurological disease: what's in a name?
    Lancet Neurol. (IF 26.284) Pub Date : 2017-09-17
    James J Sejvar

    We are living in a rapidly changing landscape in terms of global public health. On one hand, the immense increase in and ageing of the world's population, mass migration of people from rural to urban areas, and unhealthy lifestyles—either by choice or by circumstance—are negatively affecting the overall health of the planet. On the other hand, medical advances such as vaccines, antibiotics, and new medications, and renewed emphasis on workplace safety, have benefitted global health. These balancing influences perhaps have the most effect on neurological diseases, which affect many different daily functions and therefore have a disproportionately large effect on global health.

    更新日期:2017-09-18
  • Sarah Tabrizi: timed to perfection
    Lancet Neurol. (IF 26.284) Pub Date : 2017-09-12
    Adrian Burton
    更新日期:2017-09-13
  • Exercise in patients with multiple sclerosis
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Robert W Motl, Brian M Sandroff, Gert Kwakkel, Ulrik Dalgas, Anthony Feinstein, Christoph Heesen, Peter Feys, Alan J Thompson

    Exercise can be a beneficial rehabilitation strategy for people with multiple sclerosis to manage symptoms, restore function, optimise quality of life, promote wellness, and boost participation in activities of daily living. However, this population typically engages in low levels of health-promoting physical activity compared with adults from the general population, a fact which has not changed in the past 25 years despite growing evidence of the benefits of exercise. To overcome this challenge, the main limitations to promoting exercise through the patient–clinician interaction must be addressed. These limitations are the inadequate quality and scope of existing evidence, incomplete understanding of the mechanisms underlying the beneficial effects of exercise in people with multiple sclerosis, and the absence of a conceptual framework and toolkit for translating the evidence into practice. Future research to address those limitations will be essential to inform decisions about the inclusion of exercise in the clinical care of people with multiple sclerosis.

    更新日期:2017-09-12
  • Therapies targeting DNA and RNA in Huntington's disease
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Edward J Wild, Sarah J Tabrizi
    更新日期:2017-09-12
  • Prediction of motor recovery after stroke: advances in biomarkers
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Cathy M Stinear
    更新日期:2017-09-12
  • The chronic and evolving neurological consequences of traumatic brain injury
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Lindsay Wilson, William Stewart, Kristen Dams-O'Connor, Ramon Diaz-Arrastia, Lindsay Horton, David K Menon, Suzanne Polinder
    更新日期:2017-09-12
  • Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Axel Petzold, Laura J Balcer, Peter A Calabresi, Fiona Costello, Teresa C Frohman, Elliot M Frohman, Elena H Martinez-Lapiscina, Ari J Green, Randy Kardon, Olivier Outteryck, Friedemann Paul, Sven Schippling, Patrik Vermersch, Pablo Villoslada, Lisanne J Balk, Orhan Aktas, Philipp Albrecht, Jane Ashworth, Nasrin Asgari, Laura Balcer, Lisanne Balk, Graeme Black, Daniel Boehringer, Raed Behbehani, Leslie Benson, Robert Bermel, Jacqueline Bernard, Alexander Brandt, Jodie Burton, Peter Calabresi, Jonathan Calkwood, Christian Cordano, Fiona Costello, Ardith Courtney, Andrés Cruz-Herranz, Ricarda Diem, Avril Daly, Helene Dollfus, Christina Fasser, Carsten Finke, Jette Frederiksen, Elliot Frohman, Teresa Frohman, Elenaw Garcia-Martin, Inés González Suárez, Gorm Pihl-Jensen, Jennifer Graves, Ari Green, Joachim Havla, Bernhard Hemmer, Su-Chun Huang, Jaime Imitola, Hong Jiang, David Keegan, Eric Kildebeck, Alexander Klistorner, Benjamin Knier, Scott Kolbe, Thomas Korn, Bart LeRoy, Letizia Leocani, Dorothee Leroux, Netta Levin, Petra Liskova, Birgit Lorenz, Jana Lizrova Preiningerova, Elena Hernández Martínez-Lapiscina, Janine Mikolajczak, Xavier Montalban, Mark Morrow, Rachel Nolan, Timm Oberwahrenbrock, Frederike Cosima Oertel, Celia Oreja-Guevara, Benjamin Osborne, Olivier Outteryck, Athina Papadopoulou, Friedemann Paul, Axel Petzold, Marius Ringelstein, Shiv Saidha, Bernardo Sanchez-Dalmau, Jaume Sastre-Garriga, Sven Schippling, Robert Shin, Neil Shuey, Kerstin Soelberg, Ahmed Toosy, Rubén Torres, Angela Vidal-Jordana, Pablo Villoslada, Amy Waldman, Owen White, Ann Yeh, Sui Wong, Hanna Zimmermann
    更新日期:2017-09-12
  • Biomarkers, bioprediction, and ethics
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Henrik Zetterberg
    更新日期:2017-09-12
  • Gian Lorenzo Bernini's 17th century white noise machine
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Michele Augusto Riva, Vincenzo Cimino, Stefano Sanchirico

    For centuries, people have sought relief from insomnia through a wide assortment of methods. Studies in young adults and children, which investigated non-pharmacological approaches in sleep induction, found that white noise triggered sleep and reduced night-waking behaviours.1–2 Nowadays, different kinds of white noise devices are available for insomnia relief, which can sound like rushing waterfalls or wind blowing through trees. It is less well known that one of the most ancient insomnia treatment machines—which used the principles of white noise—was invented in the 17th century by the illustrious architect and sculptor Gian Lorenzo Bernini (1598–1680), known for designing the Fountain of the Four Rivers (Rome, Italy), and the colonnades of St.

    更新日期:2017-09-12
  • Ed Wild
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    更新日期:2017-09-12
  • David Menon: the incredible, incurable, clinical rationalist
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Jules Morgan
    更新日期:2017-09-12
  • Obesity and the nervous system: more questions – Authors' reply
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Brian C Callaghan, Phillipe D O'Brien, Lucy M Hinder, Eva L Feldman

    We appreciate the insightful comments pertaining to our Review1 on the neurological consequences of obesity. Our Review focused on the increasing medical literature supporting an association between obesity and CNS and peripheral nervous system (PNS) injury. Several observational and intervention studies have provided consistent evidence substantiating a potential causal link. The two letters raise important issues pertaining to the strength of the current evidence for other associations involving obesity and CNS outcomes.

    更新日期:2017-09-12
  • Obesity and the nervous system: more questions
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Ane Mínguez-Olaondo, Pablo Irimia, Gema Frühbeck

    In their excellent Review, Phillipe O'Brien and colleagues1 describe the neurological consequences of obesity. However, the authors did not mention migraine, which is a common, chronic, disabling neurological disorder.2 Epidemiological research shows a link between migraine and obesity that is further substantiated by putative pathophysiological mechanisms.3 A body of evidence supports a role for adipokines (such as leptin, adiponectin, interleukin 6, and TNF-α, among others), which are mediators of inflammatory processes, in the onset, persistence, and progression of migraines.

    更新日期:2017-09-12
  • Obesity and the nervous system: more questions
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Jannis Kountouras, Stergios A Polyzos, Panagiotis Katsinelos, Georgios Kotronis, Michael Doulberis

    In their Review, Phillipe O'Brien and colleagues1 concluded that, although extensive data exist to indicate that obesity—a component of the metabolic syndrome—is a mediator of CNS and peripheral nervous system (PNS) injury, the ideal intervention to prevent the associated cognitive impairment, autonomic neuropathy, and polyneuropathy is not yet known.

    更新日期:2017-09-12
  • Edaravone for treatment of early-stage ALS – Authors' reply
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Makoto Akimoto, Kazue Nakamura

    We thank Jesús Mora for allowing us to provide clarifications on our study.1 The protocol2 required all investigators to receive ALSFRS-R video training and to be certified to meet the same evaluation standards. One patient's ALSFRS-R score at cycle 2 was evaluated by an investigator who did not meet this standard, and this cycle 2 score was therefore excluded from analyses. Nonetheless, since the cycle 6 endpoint data were available and adequate, this exclusion did not affect our primary analysis.

    更新日期:2017-09-12
  • Edaravone for treatment of early-stage ALS
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Jesús S Mora

    The Edaravone (MCI-186) ALS 19 Study Group1 reported on the safety and efficacy of edaravone in a phase 3 study of patients with early-stage amyotrophic lateral sclerosis. The primary endpoint was change in the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) scores from baseline to 24 weeks after randomisation. Before randomisation, patients entered a 12-week observation period, and those patients with a decrease in ALSFRS-R score of 1–4 points were randomly assigned to receive edaravone or placebo.

    更新日期:2017-09-12
  • Corrections
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01

    Pointing the way to primary prevention of dementia. Lancet Neurol 2017; 16: 677. In this Editorial, the website for World Wide FINGERS was incorrect and should have been http://wwfingers.com/. This correction has been made to the online version as of Sept 12, 2017.

    更新日期:2017-09-12
  • A new era of multiple sclerosis rehabilitation: lessons from stroke
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Michelle Ploughman
    更新日期:2017-09-12
  • Traumatic brain injury: an enduring challenge
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Ross D Zafonte

    The outcomes of traumatic brain injury (TBI) can vary widely from no lasting effects to devastating and persistent consequences. Detailed understanding of the sequelae of TBI has been limited by the heterogeneity of this disorder and, until recently, there have been few studies of long-term outcomes in particular. However, recent progress in characterising specific consequences and the availability of longitudinal studies of outcomes are providing the basis for improved understanding of TBI sequelae, as highlighted in two Series papers on TBI in The Lancet Neurology.

    更新日期:2017-09-12
  • Unravelling neurodegeneration in multiple sclerosis
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    Robert A Bermel

    Neurodegeneration is postulated to be a major contributor to neurological disability in multiple sclerosis and might be the dominant process underlying progressive multiple sclerosis. Whether neurodegeneration is an independent process in patients with multiple sclerosis or its occurrence is secondary to inflammation remains unknown.1 Current therapies, focused on immune modulation, are generally less effective in the progressive forms than in the relapsing remitting forms of the disease. Therefore, understanding neurodegeneration might be fundamental to determining how to prevent neurological disability in all patients with multiple sclerosis, but especially in those in whom a progressive disease course dominates.

    更新日期:2017-09-12
  • Treating rare disorders: time to act on unfair prices
    Lancet Neurol. (IF 26.284) Pub Date : 2017-10-01
    The Lancet Neurology
    更新日期:2017-09-12
  • Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study
    Lancet Neurol. (IF 26.284) Pub Date : 2017-09-11
    Keith A Josephs, Dennis W Dickson, Nirubol Tosakulwong, Stephen D Weigand, Melissa E Murray, Leonard Petrucelli, Amanda M Liesinger, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Joseph E Parisi, Ronald C Petersen, Clifford R Jack, Jennifer L Whitwell
    更新日期:2017-09-12
  • Corrections
    Lancet Neurol. (IF 26.284) Pub Date : 2017-08-23

    Lai C. Flashing lights and poor funding: more than a headache. Lancet Neurol 2017; published online Aug 16. http://dx.doi.org/10.1016/S1474-4422(17)30285-5—In this Radio review, the affiliation for Peter Goadsby should have been King's College London. This correction has been made to the online version as of Aug 23, 2017.

    更新日期:2017-08-24
  • Phillip Low: the autonomic expert
    Lancet Neurol. (IF 26.284) Pub Date : 2017-08-18
    Jules Morgan
    更新日期:2017-08-19
  • Flashing lights and poor funding: more than a headache
    Lancet Neurol. (IF 26.284) Pub Date : 2017-08-16
    Cheryl Lai
    更新日期:2017-08-16
  • T cells and Parkinson's disease
    Lancet Neurol. (IF 26.284) Pub Date : 2017-08-11
    R Lee Mosley, Howard E Gendelman
    更新日期:2017-08-12
  • Communication at the borders of consciousness
    Lancet Neurol. (IF 26.284) Pub Date : 2017-08-11
    Anna Kennedy
    更新日期:2017-08-12
  • B vitamins in stroke prevention: time to reconsider
    Lancet Neurol. (IF 26.284) Pub Date : 2017-09-01
    J David Spence, Qilong Yi, Graeme J Hankey
    更新日期:2017-08-10
  • Clinical presentation and management of dyskinetic cerebral palsy
    Lancet Neurol. (IF 26.284) Pub Date : 2017-09-01
    Elegast Monbaliu, Kate Himmelmann, Jean-Pierre Lin, Els Ortibus, Laura Bonouvrié, Hilde Feys, R Jeroen Vermeulen, Bernard Dan
    更新日期:2017-08-10
  • Detection, risk factors, and functional consequences of cerebral microinfarcts
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-14
    Susanne J van Veluw, Andy Y Shih, Eric E Smith, Christopher Chen, Julie A Schneider, Joanna M Wardlaw, Steven M Greenberg, Geert Jan Biessels
    更新日期:2017-08-10
  • Paroxysmal sympathetic hyperactivity: the storm after acute brain injury
    Lancet Neurol. (IF 26.284) Pub Date : 2017-09-01
    Geert Meyfroidt, Ian J Baguley, David K Menon
    更新日期:2017-08-10
  • Intracerebral gene therapy in children with mucopolysaccharidosis type IIIB syndrome: an uncontrolled phase 1/2 clinical trial
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-13
    Marc Tardieu, Michel Zérah, Marie-Lise Gougeon, Jérome Ausseil, Stéphanie de Bournonville, Béatrice Husson, Dimitrios Zafeiriou, Giancarlo Parenti, Philippe Bourget, Béatrice Poirier, Valérie Furlan, Cécile Artaud, Thomas Baugnon, Thomas Roujeau, Ronald G Crystal, Christian Meyer, Kumaran Deiva, Jean-Michel Heard
    更新日期:2017-08-10
  • Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study
    Lancet Neurol. (IF 26.284) Pub Date : 2017-06-19
    Davina J Hensman Moss, Antonio F Pardiñas, Douglas Langbehn, Kitty Lo, Blair R Leavitt, Raymund Roos, Alexandra Durr, Simon Mead, A Coleman, R Dar Santos, J Decolongon, A Sturrock, E Bardinet, C Jauff Ret, D Justo, S Lehericy, C Marelli, K Nigaud, R Valabrègue, SJA van den Bogaard, E M Dumas, J van der Grond, EP t'Hart, C Jurgens, M-N Witjes-Ane, N Arran, J Callaghan, C Stopford, C Frost, R Jones, N Hobbs, N Lahiri, R Ordidge, G Owen, T Pepple, J Read, M Say, E Wild, A Patel, N C Fox, C Gibbard, I Malone, H Crawford, D Whitehead, S Keenan, D M Cash, C Berna, N Bechtel, S Bohlen, A Hoff Man, P Kraus, E Axelson, C Wang, T Acharya, S Lee, W Monaco, C Campbell, S Queller, K Whitlock, C Campbell, M Campbell, E Frajman, C Milchman, A O'Regan, I Labuschagne, J Stout, B Landwehrmeyer, D Craufurd, R Scahill, S Hicks, C Kennard, H Johnson, A Tobin, HD Rosas, R Reilmann, B Borowsky, C Pourchot, S C Andrews, Anne-Catherine Bachoud-Lévi, Anna Rita Bentivoglio, Ida Biunno, Raphael Bonelli, Jean-Marc Burgunder, Stephen Dunnett, Joaquim Ferreira, Olivia Handley, Arvid Heiberg, Torsten Illmann, G. Bernhard Landwehrmeyer, Jamie Levey, Maria A. Ramos-Arroyo, Jørgen Nielsen, Susana Pro Koivisto, Markku Päivärinta, Raymund A.C. Roos, A Rojo Sebastián, Sarah Tabrizi, Wim Vandenberghe, Christine Verellen-Dumoulin, Tereza Uhrova, Jan Wahlström, Jacek Zaremba, Verena Baake, Katrin Barth, Monica Bascuñana Garde, Sabrina Betz, Reineke Bos, Jenny Callaghan, Adrien Come, Leonor Correia Guedes, Daniel Ecker, Ana Maria Finisterra, Ruth Fullam, Mette Gilling, Lena Gustafsson, Olivia J Handley, Carina Hvalstedt, Christine Held, Kerstin Koppers, Claudia Lamanna, Matilde Laurà, Asunción Martínez Descals, Saül Martinez-Horta, Tiago Mestre, Sara Minster, Daniela Monza, Lisanne Mütze, Martin Oehmen, Michael Orth, Hélène Padieu, Laurent Paterski, Nadia Peppa, Susana Pro Koivisto, Martina Di Renzo, Amandine Rialland, Niini Røren, Pavla Šašinková, Erika Timewell, Jenny Townhill, Patricia Trigo Cubillo, Wildson Vieira da Silva, Marleen R van Walsem, Carina Whalstedt, Marie-Noelle Witjes-Ané, Grzegorz Witkowski, Abigail Wright, Daniel Zielonka, Eugeniusz Zielonka, Paola Zinzi, Raphael M. Bonelli, Sabine Lilek, Karen Hecht, Brigitte Herranhof, Anna Holl, Hans-Peter Kapfhammer, Michael Koppitz, Markus Magnet, Nicole Müller, Daniela Otti, Annamaria Painold, Karin Reisinger, Monika Scheibl, Helmut Schöggl, Jasmin Ullah, Eva-Maria Braunwarth, Florian Brugger, Lisa Buratti, Eva-Maria Hametner, Caroline Hepperger, Christiane Holas, Anna Hotter, Anna Hussl, Christoph Müller, Werner Poewe, Klaus Seppi, Fabienne Sprenger, Gregor Wenning, Andrea Boogaerts, Godelinde Calmeyn, Isabelle Delvaux, Dirk Liessens, Nele Somers, Michel Dupuit, Cécile Minet, Dominique van Paemel, Pascale Ribaï, Christine Verellen-Dumoulin, Andrea Boogaerts, Wim Vandenberghe, Dimphna van Reijen, Jirí Klempír, Veronika Majerová, Jan Roth, Irena Stárková, Lena E. Hjermind, Oda Jacobsen, Jørgen E. Nielsen, Ida Unmack Larsen, Tua Vinther-Jensen, Heli Hiivola, Hannele Hyppönen, Kirsti Martikainen, Katri Tuuha, Philippe Allain, Dominique Bonneau, Marie Bost, Bénédicte Gohier, Marie-Anne Guérid, Audrey Olivier, Adriana Prundean, Clarisse Scherer-Gagou, Christophe Verny, Blandine Babiloni, Sabrina Debruxelles, Charlotte Duché, Cyril Goizet, Laetitia Jameau, Danielle Lafoucrière, Umberto Spampinato, Rekha Barthélémy, Christelle De Bruycker, Maryline Cabaret Anne-Sophie Carette, Eric Decorte Luc Defebvre, Marie Delliaux, Arnaud Delval, Alain Destee, Kathy Dujardin, Marie-Hélène Lemaire, Sylvie Manouvrier, Mireille Peter, Lucie Plomhouse, Bernard Sablonnière, Clémence Simonin, Stéphanie Thibault-Tanchou, Isabelle Vuillaume, Marcellin Bellonet, Hassan Berrissoul, Stéphanie Blin, Françoise Courtin, Cécile Duru, Véronique Fasquel, Olivier Godefroy, Pierre Krystkowiak, Béatrice Mantaux, Martine Roussel, Sandrine Wannepain, Jean-Philippe Azulay, Marie Delfini, Alexandre Eusebio, Frédérique Fluchere, Laura Mundler, Mathieu Anheim, Celine Julié, Ouhaid Lagha Boukbiza, Nadine Longato, Gabrielle Rudolf, Christine Tranchant, Marie-Agathe Zimmermann, Christoph Michael Kosinski, Eva Milkereit, Daniela Probst, Kathrin Reetz, Christian Sass, Johannes Schiefer, Christiane Schlangen, Cornelius J. Werner, Harald Gelderblom, Josef Priller, Harald Prüß, Eike Jakob Spruth, Gisa Ellrichmann, Lennard Herrmann, Rainer Hoffmann, Barbara Kaminski, Peter Kotz, Christian Prehn, Carsten Saft, Herwig Lange, Robert Maiwald, Matthias Löhle, Antonia Maass, Simone Schmidt, Cecile Bosredon, Alexander Storch, Annett Wolz, Martin Wolz, Philipp Capetian, Johann Lambeck, Birgit Zucker, Kai Boelmans, Christos Ganos, Walburgis Heinicke, Ute Hidding, Jan Lewerenz, Alexander Münchau, Michael Orth, Jenny Schmalfeld, Lars Stubbe, Simone Zittel, Gabriele Diercks, Dirk Dressler, Heike Gorzolla, Christoph Schrader, Pawel Tacik, Michael Ribbat, Bernhard Longinus, Katrin Bürk, Jens Carsten Möller, Ida Rissling, Mark Mühlau, Alexander Peinemann, Michael Städtler, Adolf Weindl, Juliane Winkelmann, Cornelia Ziegler, Natalie Bechtel, Heike Beckmann, Stefan Bohlen, Eva Hölzner, Herwig Lange, Ralf Reilmann, Stefanie Rohm, Silke Rumpf, Sigrun Schepers, Natalia Weber, Matthias Dose, Gabriele Leythäuser, Ralf Marquard, Tina Raab, Alexandra Wiedemann, Katrin Barth, Andrea Buck, Julia Connemann, Daniel Ecker, Carolin Geitner, Christine Held, Andrea Kesse, Bernhard Landwehrmeyer, Christina Lang, Jan Lewerenz, Franziska Lezius, Solveig Nepper, Anke Niess, Michael Orth, Ariane Schneider, Daniela Schwenk, Sigurd Süßmuth, Sonja Trautmann, Patrick Weydt, Claudia Cormio, Vittorio Sciruicchio, Claudia Serpino, Marina de Tommaso, Sabina Capellari, Pietro Cortelli, Roberto Galassi, Giovanni Rizzo, Roberto Poda, Cesa Scaglione, Elisabetta Bertini, Elena Ghelli, Andrea Ginestroni, Francesca Massaro, Claudia Mechi, Marco Paganini, Silvia Piacentini, Silvia Pradella, Anna Maria Romoli, Sandro Sorbi, Giovanni Abbruzzese, Monica Bandettini di Poggio, Giovanna Ferrandes, Paola Mandich, Roberta Marchese, Alberto Albanese, Daniela Di Bella, Anna Castaldo, Stefano Di Donato, Cinzia Gellera, Silvia Genitrini, Caterina Mariotti, Daniela Monza, Lorenzo Nanetti, Dominga Paridi, Paola Soliveri, Chiara Tomasello, Giuseppe De Michele, Luigi Di Maio, Marco Massarelli, Silvio Peluso, Alessandro Roca, Cinzia Valeria Russo, Elena Salvatore, Pierpaolo Sorrentino, Enrico Amico, Mariagrazia Favellato, Annamaria Griguoli, Irene Mazzante, Martina Petrollini, Ferdinando Squitieri, Barbara D'Alessio, Chiara Esposito, Rita Bentivoglio, Marina Frontali, Arianna Guidubaldi, Tamara Ialongo, Gioia Jacopini, Carla Piano, Silvia Romano, Francesco Soleti, Maria Spadaro, Paola Zinzi, Monique S.E. van Hout, Marloes E. Verhoeven, Jeroen P.P. van Vugt, A. Marit de Weert, J.J.W. Bolwijn, M. Dekker, B. Kremer, K.L. Leenders, J.C.H. van Oostrom, Simon J.A. van den Bogaard, Reineke Bos, Eve M. Dumas, Ellen P. 't Hart, Raymund A.C. Roos, Berry Kremer, C.C.P. Verstappen, Olaf Aaserud, Jan Frich C, Arvid Heiberg, Marleen R van Walsem, Ragnhild Wehus, Kathrine Bjørgo, Madeleine Fannemel, Per F. Gørvell, Eirin Lorentzen, Susana Pro Koivisto, Lars Retterstøl, Bodil Stokke, Inga Bjørnevoll, Sigrid Botne Sando, Artur Dziadkiewicz, Malgorzata Nowak, Piotr Robowski, Emilia Sitek, Jaroslaw Slawek, Witold Soltan, Michal Szinwelski, Magdalena Blaszcyk, Magdalena Boczarska-Jedynak, Ewelina Ciach-Wysocka, Agnieszka Gorzkowska, Barbara Jasinska-Myga, Gabriela Klodowska-Duda, Gregorz Opala, Daniel Stompel, Krzysztof Banaszkiewicz, Dorota Bocwinska, Kamila Bojakowska-Jaremek, Malgorzata Dec, Malgorzata Krawczyk, Monika Rudzinska, Elzbieta Szczygiel, Andrzej Szczudlik, Anna Wasielewska, Magdalena Wójcik, Anna Bryl, Anna Ciesielska, Aneta Klimberg, Jerzy Marcinkowski, Husam Samara, Justyna Sempolowicz, Daniel Zielonka, Anna Gogol, Piotr Janik, Hubert Kwiecinski, Zygmunt Jamrozik, Jakub Antczak, Katarzyna Jachinska, Wioletta Krysa, Maryla Rakowicz, Przemyslaw Richter, Rafal Rola, Danuta Ryglewicz, Halina Sienkiewicz-Jarosz, Iwona Stepniak, Anna Sulek, Grzegorz Witkowski, Jacek Zaremba, Elzbieta Zdzienicka, Karolina Zieora-Jakutowicz, Joaquim J Ferreira, Miguel Coelho, Leonor Correia Guedes, Tiago Mendes, Tiago Mestre, Anabela Valadas, Carlos Andrade, Miguel Gago, Carolina Garrett, Maria Rosália Guerra, Carmen Durán Herrera, Patrocinio Moreno Garcia, Miquel Aguilar Barbera, Dolors Badenes Guia, Laura Casas Hernanz, Judit López Catena, Pilar Quiléz Ferrer, Ana Rojo Sebastián, Gemma Tome Carruesco, Jordi Bas, Núria Busquets, Matilde Calopa, Misericordia Floriach Robert, Celia Mareca Viladrich, Jesús Miguel Ruiz Idiago, Antonio Villa Riballo, Esther Cubo, Cecilia Gil Polo, Natividad Mariscal, Perez Jessica Rivadeneyra, Francisco Barrero, Blas Morales, María Fenollar, Rocío García-Ramos García, Paloma Ortega, Clara Villanueva, Javier Alegre, Mónica Bascuñana, Juan Garcia Caldentey, Marta Fatás Ventura, Guillermo García Ribas, Justo García de Yébenes, José Luis López-Sendón Moreno, Patricia Trigo Cubillo, Javier Alegre, Fernando Alonso Frech, Justo García de Yébenes, Pedro J García Ruíz, Asunción Martínez-Descals, Rosa Guerrero, María José Saiz Artiga, Vicenta Sánchez, María Fuensanta Noguera Perea, Lorenza Fortuna, Salvadora Manzanares, Gema Reinante, María Martirio Antequera Torres, Laura Vivancos Moreau, Sonia González González, Luis Menéndez Guisasola, Carlos Salvador, Esther Suaréz San Martín, Inés Legarda Ramirez, Aranzazú Gorospe, Mónica Rodriguez Lopera, Penelope Navas Arques, María José Torres Rodríguez, Barbara Vives Pastor, Itziar Gaston, Maria Dolores Martinez-Jaurrieta, Maria A. Ramos-Arroyo, Jose Manuel Garcia Moreno, Carolina Mendez Lucena, Fatima Damas, Hermoso Eva Pacheco Cortegana, José Chacón Peña, Luis Redondo, Fátima Carrillo, María Teresa Cáceres, Pablo Mir, María José Lama Suarez, Laura Vargas-González, Maria E. Bosca, Francisco Castera Brugada, Juan Andres Burguera, Anabel Campos, Garcia Carmen Peiró Vilaplana, Peter Berglund, Radu Constantinescu, Gunnel Fredlund, Ulrika Høsterey-Ugander, Petra Linnsand, Liselotte Neleborn-Lingefjärd, Jan Wahlström, Magnus Wentzel, Ghada Loutfi, Carina Olofsson, Eva-Lena Stattin, Laila Westman, Birgitta Wikström, Jean-Marc Burgunder, Yanik Stebler, Alain Kaelin, Irene Romero, Michael Schüpbach, Sabine Weber Zaugg, Maria Hauer, Roman Gonzenbach, Hans H. Jung, Violeta Mihaylova, Jens Petersen, Roisin Jack, Kirsty Matheson, Zosia Miedzybrodzka, Daniela Rae, Sheila A Simpson, Fiona Summers, Alexandra Ure, Vivien Vaughan, Shahbana Akhtar, Jenny Crooks, Adrienne Curtis, Jenny de Souza, John Piedad, Hugh Rickards, Jan Wright, Elizabeth Coulthard, Louise Gethin, Beverley Hayward, Kasia Sieradzan, Abigail Wright, Matthew Armstrong, Roger A. Barker, Deidre O'Keefe, Anna Di Pietro, Kate Fisher, Anna Goodman, Susan Hill, Ann Kershaw, Sarah Mason, Nicole Paterson, Lucy Raymond, Rachel Swain, Natalie Valle Guzman, Monica Busse, Cynthia Butcher, Jenny Callaghan, Stephen Dunnett, Catherine Clenaghan, Ruth Fullam, Olivia Handley, Sarah Hunt, Lesley Jones, Una Jones, Hanan Khalil, Sara Minster, Michael Owen, Kathleen Price, Anne Rosser, Jenny Townhill, Maureen Edwards, Carrie Ho, Teresa Hughes, Marie McGill, Pauline Pearson, Mary Porteous, Paul Smith, Peter Brockie, Jillian Foster, Nicola Johns, Sue McKenzie, Jean Rothery, Gareth Thomas, Shona Yates, Liz Burrows, Carol Chu, Amy Fletcher, Deena Gallantrae, Stephanie Hamer, Alison Harding, Stefan Klöppel, Alison Kraus, Fiona Laver, Monica Lewis, Mandy Longthorpe, Ivana Markova, Ashok Raman, Nicola Robertson, Mark Silva, Aileen Thomson, Sue Wild, Pam Yardumian, Carol Chu, Carole Evans, Deena Gallentrae, Stephanie Hamer, Alison Kraus, Ivana Markova, Ashok Raman, Carol Chu, Stephanie Hamer, Emma Hobson, Stuart Jamieson, Alison Kraus, Ivana Markova, Ashok Raman, Hannah Musgrave, Liz Rowett, Jean Toscano, Sue Wild, Pam Yardumian, Colin Bourne, Jackie Clapton, Carole Clayton, Heather Dipple, Dawn Freire-Patino, Janet Grant, Diana Gross, Caroline Hallam, Julia Middleton, Ann Murch, Catherine Thompson, Sundus Alusi, Rhys Davies, Kevin Foy, Emily Gerrans, Louise Pate, Thomasin Andrews, Andrew Dougherty, Charlotte Golding, Fred Kavalier, Hana Laing, Alison Lashwood, Dene Robertson, Deborah Ruddy, Alastair Santhouse, Anna Whaite, Thomasin Andrews, Stefania Bruno, Karen Doherty, Charlotte Golding, Salman Haider, Davina Hensman, Nayana Lahiri, Monica Lewis, Marianne Novak, Aakta Patel, Nicola Robertson, Elisabeth Rosser, Sarah Tabrizi, Rachel Taylor, Thomas Warner, Edward Wild, Natalie Arran, Judith Bek, Jenny Callaghan, David Craufurd, Ruth Fullam, Marianne Hare, Liz Howard, Susan Huson, Liz Johnson, Mary Jones, Helen Murphy, Emma Oughton, Lucy Partington-Jones, Dawn Rogers, Andrea Sollom, Julie Snowden, Cheryl Stopford, Jennifer Thompson, Iris Trender-Gerhard, Nichola Verstraelen, Leann Westmoreland, Richard Armstrong, Kathryn Dixon, Andrea H Nemeth, Gill Siuda, Ruth Valentine, David Harrison, Max Hughes, Andrew Parkinson, Beverley Soltysiak, Oliver Bandmann, Alyson Bradbury, Paul Gill, Helen Fairtlough, Kay Fillingham, Isabella Foustanos, Mbombe Kazoka, Kirsty O'Donovan, Nadia Peppa, Cat Taylor, Katherine Tidswell, Oliver Quarrell, Jean-Marc Burgunder, Puay Ngoh Lau, Emmanul Pica, Louis Tan, Peter Holmans, Lesley Jones, Sarah J Tabrizi
    更新日期:2017-08-10
  • Safety and efficacy of dual-lead thalamic deep brain stimulation for patients with treatment-refractory multiple sclerosis tremor: a single-centre, randomised, single-blind, pilot trial
    Lancet Neurol. (IF 26.284) Pub Date : 2017-06-19
    Seth F Oliveria, Ramon L Rodriguez, Dawn Bowers, Daniel Kantor, Justin D Hilliard, Erin H Monari, Bonnie M Scott, Michael S Okun, Kelly D Foote
    更新日期:2017-08-10
  • Celebrating life in a Death Cafe
    Lancet Neurol. (IF 26.284) Pub Date : 2017-06-21
    Jules Morgan
    更新日期:2017-08-10
  • Dementia: a carer's insight
    Lancet Neurol. (IF 26.284) Pub Date : 2017-05-16
    Christina Wayman
    更新日期:2017-08-10
  • Neurons and architecture: from the inside out
    Lancet Neurol. (IF 26.284) Pub Date : 2017-05-10
    Jules Morgan
    更新日期:2017-08-10
  • Seth Oliveria
    Lancet Neurol. (IF 26.284) Pub Date : 2017-09-01
    更新日期:2017-08-10
  • The first report of Alzheimer's disease
    Lancet Neurol. (IF 26.284) Pub Date : 2017-09-01
    Emmanuel Drouin, Guillaume Drouin

    Alois Alzheimer (1864-1915), a German psychiatrist and neuropathologist, was the first to describe the clinical and pathological features of a then unrecognised brain disease. In 1895, Alzheimer described “arteriosclerotic brain atrophy”.1 This notion was important for differentiating arterosclerotic dementia from general paralysis since, in those days, syphilis was considered to be the most common form of presenile dementia.

    更新日期:2017-08-10
  • Marc Tardieu: the interface man
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-13
    Adrian Burton
    更新日期:2017-08-10
  • Training non-physicians as neurosurgeons in sub-Saharan Africa
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-05
    Adrian Burton
    更新日期:2017-08-10
  • Corrections
    Lancet Neurol. (IF 26.284) Pub Date : 2017-09-01

    Saft C. Identifying modifiers of Huntington's disease progression. Lancet Neurol 2017; 16: 679–80—In reference 6 of this linked comment, the first author was incorrect. This correction has been made in the online version as of Aug 8, 2017 and is correct in the print version.

    更新日期:2017-08-10
  • Corrections
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-14

    Byrne LM, Rodrigues FB, Blennow K, et al. Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis. Lancet Neurol 2017; 16: 601–09—In figure 5C, the legend for the x-axis should have been “NfL concentration in plasma (pg/mL)” These corrections have been made to the online version as of July 14, 2017.

    更新日期:2017-08-10
  • Corrections
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-13

    Liu G, Locascio JJ, Corvol J-C, et al. Prediction of cognition in Parkinson's disease with a clinical–genetic score: a longitudinal analysis of nine cohorts. Lancet Neurol 2017; 16: 620–29—In this Article, the author list should have said “for the HBS, CamPaIGN, PICNICS, PROPARK, PSG, DIGPD, and PDBP investigators”. The appendix has also been replaced. These corrections have been made to the online version as of July 13, 2017.

    更新日期:2017-08-10
  • Corrections
    Lancet Neurol. (IF 26.284) Pub Date : 2017-06-28

    Hensman Moss DJ, Pardiñas AF, Langbehn D, et al. Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study. Lancet Neurol 2017; published online June 19. http://dx.doi.org/10.1016/S1474-4422(17)30161-8—In the appendix of this article, some of the members of the Track Investigator list were not listed. This correction has been made in the online version as of June 28, 2017.

    更新日期:2017-08-10
  • Low risk of ischaemic stroke in hyperhomocysteinaemia
    Lancet Neurol. (IF 26.284) Pub Date : 2017-09-01
    Josef Finsterer

    Whether elevated serum homocysteine concentrations (ie, hyperhomocysteinaemia) are a risk factor for ischaemic stroke and if normalising hyperhomocysteinaemia might reduce stroke risk are controversial issues. Hyperhomocysteinaemia can be primary (ie, hereditary) or secondary (ie, due to vitamin B12 deficiency, diabetes, etc). The effect of both primary and secondary hyperhomocysteinaemia on putative stroke risk is debated. One study1 has shown that hyperhomocysteinaemia is an independent risk factor for ischaemic stroke, whereas other studies have reached different conclusions.

    更新日期:2017-08-10
  • Intracerebral gene therapy for mucopolysaccharidosis type IIIB syndrome
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-13
    Kim Hemsley, Adeline Lau

    The devastating paediatric-onset lysosomal storage disorder mucopolysaccharidosis type III syndrome (also known as Sanfilippo syndrome), has been viewed as untreatable. Rapidly progressing neurological impairments lead to death, typically in the second decade of life. In The Lancet Neurology, Marc Tardieu and colleagues1 report the outcomes of a phase 1/2 clinical trial of intracerebral gene therapy with a recombinant adenoassociated viral vector serotype 2/5 encoding human α-N-acetylglucosaminidase (NAGLU) in four young children (age 20–53 months) with mucopolysaccharidosis type IIIB syndrome.

    更新日期:2017-08-10
  • Identifying modifiers of Huntington's disease progression
    Lancet Neurol. (IF 26.284) Pub Date : 2017-06-19
    Carsten Saft

    Researchers are now harvesting the first fruits of their labour from nearly two decades of tremendous efforts to track progression of Huntington's disease in the manifest and premanifest phases. Large observational studies such as PREDICT-HD,1 COHORT,2 REGISTRY,3 and TRACK-HD4 have aimed to find objective measures of disease progression and learn about the course of the disease. The work to measure disease progression is ongoing. The global, observational study ENROLL-HD5 is currently recruiting and is intended to become the largest study of Huntington's disease.

    更新日期:2017-08-10
  • Multiple sclerosis tremor: are technical advances enough?
    Lancet Neurol. (IF 26.284) Pub Date : 2017-06-19
    Derrick Soh, Alfonso Fasano

    Tremor is the most common disorder in patients with multiple sclerosis and greatly contributes to the disability of these patients. This tremor rarely presents with the high-frequency action component seen in primary tremor disorders; rather, it is the combination of several features, particularly cerebellar ones. Therefore, drugs are rarely effective, whereas surgery can provide variable results depending on the severity of the underlying ataxia. In The Lancet Neurology, Seth Oliveria and colleagues1 report the findings from their single centre, single-blind, prospective, randomised pilot trial of dual-lead thalamic deep brain stimulation (DBS) in 12 patients with treatment-refractory tremor caused by multiple sclerosis.

    更新日期:2017-08-10
  • Pointing the way to primary prevention of dementia
    Lancet Neurol. (IF 26.284) Pub Date : 2017-09-01
    The Lancet Neurology
    更新日期:2017-08-10
  • Eric Reiman: aiming to prevent Alzheimer's disease
    Lancet Neurol. (IF 26.284) Pub Date : 2017-06-30
    Tony Kirby
    更新日期:2017-08-10
  • Keeping an open mind in neurological practice
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-03
    Ava Easton
    更新日期:2017-08-10
  • Perspectives on time
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-03
    Jonathan Blott
    更新日期:2017-08-10
  • Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-03
    Morten Gersel Stokholm, Alex Iranzo, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina Bacher Svendsen, Alicia Garrido, Dolores Vilas, Per Borghammer, Joan Santamaria, Arne Møller, Carles Gaig, David J Brooks, Eduardo Tolosa, Nicola Pavese
    更新日期:2017-08-10
  • Imaging neuroinflammation to monitor α-synucleinopathy
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-03
    Yasuomi Ouchi

    Neuroinflammation in neurodegenerative diseases generally refers to a chronic immune response in the CNS, in which innate immune cells such as microglia and astrocytes are responsible for robust inflammatory responses and neuronal death. However, each neurodegenerative disease also has a preclinical period, during which potentially harmful inflammatory events might already be happening. With the advent of disease-modifying drugs, early detection of abnormal signals from the brain milieu during the preclinical phase is important because diagnostic symptoms, once developed, are so relentless that few therapeutic countermeasures are left for clinicians to use.

    更新日期:2017-08-10
  • The Rhythms of Thought
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-05
    Robert Stirrups
    更新日期:2017-08-10
  • James Crichton-Browne
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-05
    Ray Cavanaugh
    更新日期:2017-08-10
  • Conversations with a neuroscientist
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-11
    Cheryl Lai
    更新日期:2017-08-10
  • An outsider's journey in brain science
    Lancet Neurol. (IF 26.284) Pub Date : 2017-07-11
    Isabel Lokody
    更新日期:2017-08-10
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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