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Correction: Aptamer AS1411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer RSC Med. Chem. (IF 4.1) Pub Date : 2024-04-15 Yuejie Zhu, Xiang Li, Qi Zhang, Xiantao Yang, Xudong Sun, Yi Pan, Xia Yuan, Yuan Ma, Bo Xu, Zhenjun Yang
Correction for ‘Aptamer AS1411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer’ by Yuejie Zhu et al., RSC Med. Chem., 2024, https://doi.org/10.1039/d3md00752a.
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Chiral hydroxymethyl-1H,3H-pyrrolo[1,2-c]thiazoles: the search for selective p53-activating agents for colorectal cancer therapy RSC Med. Chem. (IF 4.1) Pub Date : 2024-04-12 Mees M. Hendrikx, Adelino M. R. Pereira, Ana B. Pereira, Carla S. C. Carvalho, João L. P. Ribeiro, Maria I. L. Soares, Lucília Saraiva, Teresa M. V. D. Pinho e Melo
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Computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy RSC Med. Chem. (IF 4.1) Pub Date : 2024-04-11 Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
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Substituted 4-methylcoumarin inhibitors of SLC26A3 (DRA) for treatment of constipation and hyperoxaluria RSC Med. Chem. (IF 4.1) Pub Date : 2024-04-09 Maria Ahmadi, Livia de Souza Goncalves, Alan S. Verkman, Onur Cil, Marc O. Anderson
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Systematic generation and analysis of counterfactuals for compound activity predictions using multi-task models RSC Med. Chem. (IF 4.1) Pub Date : 2024-04-08 Alec Lamens, Jürgen Bajorath
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Azole-based compounds as potential anti-Acanthamoeba agents RSC Med. Chem. (IF 4.1) Pub Date : 2024-04-03 Balsam Qubais Saeed, Rania Hamdy, Noor Akbar, Sreedevi Edathadan Sajeevan, Naveed Ahmed Khan, Sameh S. M. Soliman
Acanthamoeba castellanii is an opportunistic pathogen with public health implications, largely due to its invasive nature and non-specific symptoms. Our study focuses on the potential of azole compounds, particularly those with triazole scaffolds, as anti-amoebic agents. Out of 10 compounds, compounds T1 and T8 exhibited effective anti-Acanthamoeba activity with MIC50 values of 125.37 and 143.92 μg
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Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-D-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes RSC Med. Chem. (IF 4.1) Pub Date : 2024-04-02 Alex H. Y. Chan, Terence C. S. Ho, Imam Fathoni, Rawia Hamid, Anna K. H. Hirsch, Kevin J. Saliba, Finian J. Leeper
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Design, docking optimization, and evaluation of biotin-PEG4-1,8-naphthalimide as a potent and safe antitumor agent with dual targeting of ferroptosis and DNA RSC Med. Chem. (IF 4.1) Pub Date : 2024-04-02 Qi Wang, Si-Min Liang, Zhi-Chen Mao, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
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Antitubercular activity of 2-mercaptobenzothiazole derivatives targeting Mycobacterium tuberculosis type II NADH dehydrogenase RSC Med. Chem. (IF 4.1) Pub Date : 2024-04-01 Pallavi Saha, Shashikanta Sau, Nitin Pal Kalia, Deepak K. Sharma
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A new class of 7-deazaguanine agents targeting autoimmune diseases: dramatic reduction of synovial fibroblast IL-6 production from human rheumatoid arthritis patients and improved performance against murine experimental autoimmune encephalomyelitis RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-28 Michelle Cotter, Shauna M. Quinn, Ursula Fearon, Sharon Ansboro, Tatsiana Rakovic, John M. Southern, Vincent P. Kelly, Stephen J. Connon
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Discovery of new tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors for reversing multidrug resistance enabled by a synthetic methodology-based library RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-27 Tao Yu, Rong Zeng, Yu Guan, Bin Pan, Hong-Wei Li, Jing Gu, Peng-Fei Zheng, Yan Qian, Qin Ouyang
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Inhibition of bacterial RNA polymerase function and protein–protein interactions: a promising approach for next-generation antibacterial therapeutics RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-26 Jiqing Ye, Cheuk Hei Kan, Xiao Yang, Cong Ma
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Pyrazolopyridine-based kinase inhibitors for anti-cancer targeted therapy RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-25 Pallabi Halder, Anubhav Rai, Vishal Talukdar, Parthasarathi Das, Naga Rajiv Lakkaniga
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Anti-cancer activity and mechanism of flurbiprofen organoselenium compound RY-1-92 in non-small cell lung cancer RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-22 Bo Cui, Xianda Cheng, Xin Zhang, Lili Chen, Wenqian Pang, Yue Liu, Zhe Yang, Hui Li, Xianran He, Xiaolong Li, Xiuli Bi
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Carltonine-derived compounds for targeted butyrylcholinesterase inhibition RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-22 Filip Pidany, Jana Kroustkova, Jaroslav Jenco, Katerina Hradiska Breiterova, Lubica Muckova, Lucie Novakova, Jiri Kunes, Jakub Fibigar, Tomas Kucera, Martin Novak, Ales Sorf, Martina Hrabinova, Lenka Pulkrabkova, Jiri Janousek, Ondrej Soukup, Daniel Jun, Jan Korabecny, Lucie Cahlikova
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Helical sulfonyl-γ-AApeptides for the inhibition of HIV-1 fusion and HIF-1α signaling RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-20 Xue Zhao, Heng Liu, Justin C. Zhang, Jianfeng Cai
Synthetic helical peptidic foldamers show promising applications in chemical biology and biomedical sciences by mimicking protein helical segments. Sulfonyl-γ-AApeptide helices developed by our group exhibit good chemodiversity, predictable folding structures, proteolytic resistance, favorable cell permeability, and enhanced bioavailability. Herein, in this minireview, we highlight two recent examples
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Exploiting thiol-functionalized benzosiloxaboroles for achieving diverse substitution patterns – synthesis, characterization and biological evaluation of promising antibacterial agents RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-20 Krzysztof Nowicki, Joanna Krajewska, Tomasz M. Stępniewski, Monika Wielechowska, Patrycja Wińska, Anna Kaczmarczyk, Julia Korpowska, Jana Selent, Paulina H. Marek-Urban, Krzysztof Durka, Krzysztof Woźniak, Agnieszka E. Laudy, Sergiusz Luliński
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Synthesis and biological evaluation of new naphthalimide–thiourea derivatives as potent antimicrobial agents active against multidrug-resistant Staphylococcus aureus and Mycobacterium tuberculosis RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-19 Preeti Rana, Ramulu Parupalli, Abdul Akhir, Deepanshi Saxena, Rahul Maitra, Mohmmad Imran, Pradip Malik, Shaik Mahammad Ghouse, Swanand Vinayak Joshi, Danaboina Srikanth, Y. V. Madhavi, Arunava Dasgupta, Sidharth Chopra, Srinivas Nanduri
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Ebselen analogues with dual human neutrophil elastase (HNE) inhibitory and antiradical activity RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-19 Letizia Crocetti, Francesca Catarzi, Maria Paola Giovannoni, Claudia Vergelli, Gianluca Bartolucci, Marco Pallecchi, Paola Paoli, Patrizia Rossi, Martina Lippi, Igor A. Schepetkin, Mark T. Quinn, Gabriella Guerrini
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In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therapeutic agents for triple negative breast cancer RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-19 Luísa Carvalho, Fábio Pedroso de Lima, Mónica Cerqueira, Ana Silva, Olívia Pontes, Sofia Oliveira-Pinto, Sara Guerreiro, Marta D. Costa, Sara Granja, Patrícia Maciel, Adhemar Longatto-Filho, Fátima Baltazar, Fernanda Proença, Marta Costa
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SETDB1 as a cancer target: challenges and perspectives in drug design RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-19 Haifa Hassanie, André Berndt Penteado, Larissa Costa de Almeida, Raisa Ludmila Calil, Flávio da Silva Emery, Leticia Veras Costa-Lotufo, Gustavo Henrique Goulart Trossini
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Live cell screening to identify RNA-binding small molecule inhibitors of the pre-let-7–Lin28 RNA–protein interaction RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-19 Sydney L. Rosenblum, Dalia M. Soueid, George Giambasu, Steve Vander Roest, Alexander Pasternak, Erin F. DiMauro, Vladimir Simov, Amanda L. Garner
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Coumarin–furo[2,3-d]pyrimidone hybrid molecules targeting human liver cancer cells: synthesis, anticancer effect, EGFR inhibition and molecular docking studies RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-19 Tianshuai Wang, Yumeng Gao, Fengxu Wu, Lun Luo, Junkai Ma, Yanggen Hu
The design, synthesis and investigation of antitumor activities of some coumarin–furo[2,3-d]pyrimidone hybrid molecules are reported. In vitro, HepG2 cells were used to investigate the cytotoxicity of 6a–n and 10a–n. The results demonstrated that coupling a furopyrimidone scaffold with coumarin through a hydrazide linker can effectively improve their synergistic anticancer activity. The coumarin–furo[2
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Structure-based virtual screening of unbiased and RNA-focused libraries to identify new ligands for the HCV IRES model system RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-18 Elisabeth Kallert, Laura Almena Rodriguez, Jan-Åke Husmann, Kathrin Blatt, Christian Kersten
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A novel BODIPY-based theranostic agent for in vivo fluorescence imaging of cerebral Aβ and ameliorating Aβ-associated disorders in Alzheimer's disease transgenic mice RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-15 Jingjing Zhang, Wenming Ren, Xiaohui Liu, Jingjing Chen, Yuteng Zeng, Huaijiang Xiang, Youhong Hu, Haiyan Zhang
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Discovery of novel SOS1 inhibitors using machine learning RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-15 Lihui Duo, Yi Chen, Qiupei Liu, Zhangyi Ma, Amin Farjudian, Wan Yong Ho, Sze Shin Low, Jianfeng Ren, Jonathan D. Hirst, Hua Xie, Bencan Tang
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Imidazopyrimidine: from a relatively exotic scaffold to an evolving structural motif in drug discovery RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-13 Moumita Ghosh Chowdhury, Vaishnavi Kalmegh, Saumya Kapoor, Vaishnavi Kamble, Amit Shard
Nitrogen-fused heterocycles are of immense importance in modern drug discovery and development. Among them, imidazopyrimidine is a highly versatile scaffold with vast pharmacological utility. These compounds demonstrate a broad spectrum of pharmacological actions, including antiviral, antifungal, anti-inflammatory, and anticancer. Their adaptable structure allows for extensive structural modifications
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Design, synthesis and antimycobacterial activity of imidazo[1,5-a]quinolines and their zinc-complexes RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-12 Michael Marner, Niclas Kulhanek, Johanna Eichberg, Kornelia Hardes, Michael Dal Molin, Jan Rybniker, Michael Kirchner, Till F. Schäberle, Richard Göttlich
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4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-12 Francesca Barbieri, Vincent Carlen, Maria Grazia Martina, Filomena Sannio, Sacha Cancade, Cecilia Perini, Margherita Restori, Emmanuele Crespan, Giovanni Maga, Jean-Denis Docquier, Valeria Cagno, Marco Radi
Respiratory tract infections involving a variety of microorganisms such as viruses, bacteria, and fungi are a prominent cause of morbidity and mortality globally, exacerbating various pre-existing respiratory and non-respiratory conditions. Moreover, the ability of bacteria and viruses to coexist might impact the development and severity of lung infections, promoting bacterial colonization and subsequent
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Enhanced inhibitory activity of compounds containing purine scaffolds compared to protein kinase CK2α considering crystalline water RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-12 Keiji Nishiwaki, Shiori Nakatani, Shinya Nakamura, Kenji Yoshioka, Eri Nakagawa, Masato Tsuyuguchi, Takayoshi Kinoshita, Isao Nakanishi
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Design and synthesis of Meldrum's acid based 7-azaindole anchored 1,2,3-triazole hybrids as anticancer agents RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-11 Murali Krishna Vanga, Rambabu Bhukya, Vishnu Thumma, S. S. S. S. Sudha Ambadipudi, V. Lakshma Nayak, Sai Balaji Andugulapati, Vijjulatha Manga
A series of Meldrum's acid, 7-azaindole and 1,2,3-triazole hybrids were synthesized and evaluated for their in vitro anticancer activity against five different cancer cell lines viz. MCF-7 (breast cancer), HeLa (cervical cancer), DU-145 (prostate cancer), HepG2 (liver cancer) and K562 (myelogenous leukemia cell). Among the series, compound 6b containing a 4-methyl substitution showed potent activity
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Aptamer AS411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-04 Yuejie Zhu, Xiang Li, Qi Zhang, Xiantao Yang, Xudong Sun, Yi Pan, Xia Yuan, Yuan Ma, Bo Xu, Zhenjun Yang
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Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-05 Aliakbar Khalili Yazdi, Sumera Perveen, Cheng Dong, Xiaosheng Song, Aiping Dong, Magdalena M. Szewczyk, Matthew F. Calabrese, Agustin Casimiro-Garcia, Subramanyam Chakrapani, Matthew S. Dowling, Emel Ficici, Jisun Lee, Justin I. Montgomery, Thomas N. O'Connell, Grzegorz J. Skrzypek, Tuan P. Tran, Matthew D. Troutman, Feng Wang, Jennifer A. Young, Jinrong Min, Dalia Barsyte-Lovejoy, Peter J. Brown,
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Progress in small-molecule inhibitors targeting PD-L1 RSC Med. Chem. (IF 4.1) Pub Date : 2024-03-04 Jindan Xu, Yuanfang Kong, Pengbo Zhu, Mingyan Du, Xuan Liang, Yan Tong, Xiaofei Li, Chunhong Dong
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Synthesis and structure–activity relationship of novel thiazole aminoguanidines against MRSA and Escherichia coli RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-29 Ping Yang, Hui-Zhong Liu, Ying-Si Wang, Hong Qi, Ling-Ling Wang, Bei-Bei Wang, Xiao-Bao Xie
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The medicinal chemistry evolution of antibody–drug conjugates RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-28 Adrian D. Hobson
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New azole derivatives linked to indole/indoline moieties combined with FLC against drug-resistant Candida albicans RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-28 Yunhong Shen, Min Pan, Hui Gao, Yi Zhang, Ruirui Wang, Jun Li, Zewei Mao
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A colorimetric assay adapted to fragment screening revealing aurones and chalcones as new arginase inhibitors RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-28 Jason Muller, Luca Marchisio, Rym Attia, Andy Zedet, Robin Maradan, Maxence Vallet, Alison Aebischer, Dominique Harakat, François Senejoux, Christophe Ramseyer, Sarah Foley, Bruno Cardey, Corine Girard, Marc Pudlo
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Design, synthesis, and evaluation of novel ferrostatin derivatives for the prevention of HG-induced VEC ferroptosis RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-28 Xin-Xin Wang, Run-Jie Wang, Hua-Long Ji, Xiao-Yu Liu, Nai-Yu Zhang, Kai-Ming Wang, Kai Chen, Ping-Ping Liu, Ning Meng, Cheng-Shi Jiang
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Recognition of arylmethylidene derivatives of imidazothiazolotriazinones as novel tubulin polymerization inhibitors RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-28 Alexei N. Izmest'ev, Elena V. Svirshchevskaya, Sergey B. Akopov, Angelina N. Kravchenko, Galina A. Gazieva
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Nitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-26 Joana R. L. Ribeiro, Nikoletta Szemerédi, Bruno M. F. Gonçalves, Gabriella Spengler, Carlos A. M. Afonso, Maria-José U. Ferreira
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Correction: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody–drug conjugate properties RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-22 Adrian D. Hobson, Haizhong Zhu, Wei Qiu, Russell A. Judge, Kenton Longenecker
Correction for ‘Minimising the payload solvent exposed hydrophobic surface area optimises the antibody–drug conjugate properties’ by Adrian D. Hobson et al., RSC Med. Chem., 2024, https://doi.org/10.1039/d3md00540b.
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Unusual Ni⋯Ni interaction in Ni(II) complexes as potential inhibitors for the development of new anti-SARS-CoV-2 Omicron drugs RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-20 Simranjeet Singh, Mukesh Choudhary
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Synthesis and bioactivity of psilocybin analogues containing a stable carbon–phosphorus bond RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-21 Marthe Vandevelde, Andreas Simoens, Bavo Vandekerckhove, Christian Stevens
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1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-21 Robin van der Straat, Rosalie Draijer, Ewa Surmiak, Roberto Butera, Lennart Land, Katarzyna Magiera-Mularz, Bogdan Musielak, Jacek Plewka, Tad A. Holak, Alexander Dömling
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Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-20 Mihaela-Liliana Ţînţaş, Ludovic Peauger, Anaïs Barré, Cyril Papamicaël, Thierry Besson, Jana Sopkovà-de Oliveira Santos, Vincent Gembus, Vincent Levacher
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Design, synthesis, in vitro and in silico evaluation of indole-based tetrazole derivatives as putative anti-breast cancer agents RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-19 Kamalpreet Kaur, Harkomal Verma, Prabhakar Gangwar, Monisha Dhiman, Vikas Jaitak
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Application of tobramycin benzyl ether as an antibiotic adjuvant capable of sensitizing multidrug-resistant Gram-negative bacteria to rifampicin RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Danzel Marie Ramirez, Shiv Dhiman, Ayan Mukherjee, Ruwani Wimalasekara, Frank Schweizer
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In vitro biological evaluation and in silico studies of linear diarylheptanoids from Curcuma aromatica Salisb. as urease inhibitors RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Tho Huu Le, Dung Ngoc Phuong Ho, Hai Xuan Nguyen, Truong Nhat Van Do, Mai Thanh Thi Nguyen, Lam K. Huynh, Nhan Trung Nguyen
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AiZynth impact on medicinal chemistry practice at AstraZeneca RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Jason D. Shields, Rachel Howells, Gillian Lamont, Yin Leilei, Andrew Madin, Christopher E. Reimann, Hadi Rezaei, Tristan Reuillon, Bryony Smith, Clare Thomson, Yuting Zheng, Robert E. Ziegler
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Deconvoluting low yield from weak potency in direct-to-biology workflows with machine learning RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-15 William McCorkindale, Mihajlo Filep, Nir London, Alpha A. Lee, Emma King-Smith
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Design, synthesis and biological evaluation of rhein–piperazine–furanone hybrids as potential anticancer agents RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-13 Yu He, Si-Si Zhang, Meng-Xue Wei
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Correction: Design and synthesis of eugenol/isoeugenol glycoconjugates and other analogues as antifungal agents against Aspergillus fumigatus RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-12 Lakshmi Goswami, Lovely Gupta, Sayantan Paul, Maansi Vermani, Pooja Vijayaraghavan, Asish K. Bhattacharya
Correction for ‘Design and synthesis of eugenol/isoeugenol glycoconjugates and other analogues as antifungal agents against Aspergillus fumigatus’ by Lakshmi Goswami et al., RSC Med. Chem., 2022, 13, 955–962, https://doi.org/10.1039/D2MD00138A.
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Stereoselective synthesis and antiproliferative activity of allo-gibberic acid-based 1,3-aminoalcohol regioisomers RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-12 Zein Alabdeen Khdar, Tam Minh Le, Zsuzsanna Schelz, István Zupkó, Zsolt Szakonyi
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Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-12 Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland, Sridhar Sreeramulu, Franziska Kinnen, Christian Richter, Charis Georgiou, Vladyslav Yadrykhinsky, Edgar Specker, Kristaps Jaudzems, Tanja Miletić, Robert Harmel, Phil Gribbon, Harald Schwalbe, Ruth Brenk, Aigars Jirgensons, Andrea Zaliani, Jordi Mestres
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Discovery of a new pyrido[2,3-d]pyridazine-2,8-dione derivative as a potential anti-inflammatory agent through COX-1/COX-2 dual inhibition RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-08 Fernanda A. Rosa, Davana S. Gonçalves, Karlos E. Pianoski, Michael J. V. da Silva, Franciele Q. Ames, Rafael P. Aguiar, Hélito Volpato, Danielle Lazarin-Bidóia, Celso V. Nakamura, Ciomar A. Bersani-Amado
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Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-06 Norhan A. Abdelrahman, Ahmed A. Al-Karmalawy, Maiy Y. Jaballah, Galal Yahya, Marwa Sharaky, Khaled A. M. Abouzid
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Design, synthesis and biological evaluation of novel morpholinopyrimidine-5-carbonitrile derivatives as dual PI3K/mTOR inhibitors RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-02 Ghada S. Rady, Moshira A. El Deeb, Marwa T. M. Sarg, Azza T. Taher, Amira A. Helwa
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Glucosamine substituted sulfonylureas: IRS–PI3K–PKC–AKT–GLUT4 insulin signalling pathway intriguing agent RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-01 Ghadeer A. R. Y. Suaifan, Bayan Alkhawaja, Mayadah B. Shehadeh, Mridula Sharmaa, Chan Hor Kuan, Patrick Nwabueze Okechukwu
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Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of Plasmodial cysteine protease inhibitors for the treatment of malaria RSC Med. Chem. (IF 4.1) Pub Date : 2024-02-01 Hari Madhav, G. Srinivas Reddy, Zeba Rizvi, Ehtesham Jameel, Tarosh S. Patel, Abdur Rahman, Vikas Yadav, Sadaf Fatima, Fatima Heyat, Kavita Pal, Amisha Minju-OP, Naidu Subbarao, Souvik Bhattacharjee, Bharat C. Dixit, Puran Singh Sijwali, Nasimul Hoda