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Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology Biomaterials (IF 14.0) Pub Date : 2024-04-16 Da-Yuan Wang, Linzhu Su, Kees Poelstra, David W. Grainger, Henny C. van der Mei, Linqi Shi, Henk J. Busscher
Biomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention
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Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy Biomaterials (IF 14.0) Pub Date : 2024-04-15 Yiliang Yang, Yiwei Peng, Yitian Du, Meng Lin, Jiajia Li, Datong Gao, Zhenzhen Yang, Wei Wang, Yanxia Zhou, Xinru Li, Taiqiang Yan, Xianrong Qi
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Implantable CAR T cell factories enhance solid tumor treatment Biomaterials (IF 14.0) Pub Date : 2024-04-15 Sharda Pandit, Pritha Agarwalla, Feifei Song, Anton Jansson, Gianpietro Dotti, Yevgeny Brudno
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Gram-negative bacteria recognition and photodynamic elimination by Zn-DPA based sensitizers Biomaterials (IF 14.0) Pub Date : 2024-04-15 Zuokai Wang, Shuang Zeng, Yifu Hao, Wenlin Cai, Wen Sun, Jianjun Du, Saran Long, Jiangli Fan, Jingyun Wang, Xiaoqiang Chen, Xiaojun Peng
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NIR-responsive copper nanoliposome composites for cascaded ferrotherapy via ferroptosis actived ICD and IFN-γ released Biomaterials (IF 14.0) Pub Date : 2024-04-15 Junrui Wang, Wenli Zhang, Zhuoyan Xie, Xingyue Wang, Jiangshan Sun, Fei Ran, Weixi Jiang, Yun Liu, Zhigang Wang, Haitao Ran, Dajing Guo
Metallic biomaterials activate tumor ferroptosis by increasing oxidative stress, but their efficacy is severely limited in tumor microenvironment. Although interferon gamma (IFN-γ) can promote tumor ferroptosis sensitivity by inhibiting the antioxidant system and promoting lipid accumulation, this effect limited by the lack of IFN-γ accumulation in tumors. Herein, we report a near-infrared (NIR)-responsive
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Optical controlled and nuclear targeted CECR2 competitor to downregulate CSF-1 for metastatic breast cancer immunotherapy Biomaterials (IF 14.0) Pub Date : 2024-04-12 Yi Cen, Ying Chen, Xinxuan Li, Xiayun Chen, Baixue Yu, Mengyi Yan, Ni Yan, Hong Cheng, Shiying Li
The crosstalk between breast cancer cells and tumor associated macrophages (TAMs) greatly contributes to tumor progression and immunosuppression. In this work, cat eye syndrome chromosome region candidate 2 (CECR2) is identified to overexpress in breast cancer patients, which can recognize v-rel avian reticuloendotheliosis viral oncogene homolog A (RelA) and activate nuclear factor κB (NF-κB) to release
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The orientation of CpG conjugation on aluminum oxyhydroxide nanoparticles determines the immunostimulatory effects of combination adjuvants Biomaterials (IF 14.0) Pub Date : 2024-04-11 Zhihui Liang, Hang Bao, Zhiying Yao, Min Li, Chen Chen, Lei Zhang, Huiyang Wang, Yiyang Guo, Yubin Ma, Xuecheng Yang, Ge Yu, Jiancheng Zhang, Changying Xue, Bingbing Sun, Chuanbin Mao
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Synergistic large segmental bone repair by 3D printed bionic scaffolds and engineered ADSC nanovesicles: Towards an optimized regenerative microenvironment Biomaterials (IF 14.0) Pub Date : 2024-04-08 Wenbin Jiang, Yichen Zhan, Yifan Zhang, Di Sun, Guo Zhang, Zhenxing Wang, Lifeng Chen, Jiaming Sun
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Intranasal delivery of low-dose anti-CD124 antibody enhances treatment of chronic rhinosinusitis with nasal polyps Biomaterials (IF 14.0) Pub Date : 2024-04-06 Jiamin Wu, Natalie Jones, Po-Han Chao, Vanessa Chan, Lukas Hohenwarter, Angeline Wu, Marta Bergamo, Cristina Rodríguez-Rodríguez, Katayoun Saatchi, Alex Liang, Urs O. Häfeli, Zheng Tan, Sarah Hedtrich, Lucas J. Andrew, Shyh-Dar Li
Frequent injections of anti-CD124 monoclonal antibody (αCD124) over long periods of time are used to treat chronic rhinosinusitis with nasal polyps (CRSwNP). Needle-free, intranasal administration (i.n.) of αCD124 is expected to provide advantages of localized delivery, improved efficacy, and enhanced medication adherence. However, delivery barriers such as the mucus and epithelium in the nasal tissue
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Biomimetic and multifunctional nanocomposites for precision fungi theranostics Biomaterials (IF 14.0) Pub Date : 2024-04-04 Li Wang, Yueyue Gui, Kexin Li, Wei Tao, Chao Li, Jin Qiu, Jiehua Ma
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Optimization of lipid nanoparticles for gene editing of the liver via intraduodenal delivery Biomaterials (IF 14.0) Pub Date : 2024-04-04 Yining Zhu, Shuting Sarah Cai, Jingyao Ma, Leonardo Cheng, Christine Wei, Ataes Aggarwal, Wu Han Toh, Charles Shin, Ruochen Shen, Jiayuan Kong, Shuming Alan Mao, Yeh-Hsing Lao, Kam W. Leong, Hai-Quan Mao
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Nitroreductase-responsive nanoparticles for in situ fluorescence imaging and synergistic antibacterial therapy of bacterial keratitis Biomaterials (IF 14.0) Pub Date : 2024-04-03 Jing Xiang, Ruifen Zou, Pin Wang, Xinfangzi Wang, Xuefei He, Fang Liu, Chen Xu, Aiguo Wu
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Microfluidic-based multifunctional microspheres for enhanced oral co-delivery of probiotics and postbiotics Biomaterials (IF 14.0) Pub Date : 2024-04-03 Xinyuan Yang, Weimin Nie, Chong Wang, Zhonglin Fang, Luoran Shang
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Exosome/antimicrobial peptide laden hydrogel wound dressings promote scarless wound healing through miR-21-5p-mediated multiple functions Biomaterials (IF 14.0) Pub Date : 2024-04-02 YuLing Yang, JiaNi Zhang, SiWen Wu, Yu Deng, ShiHan Wang, Li Xie, XiaoPeng Li, Li Yang
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Engineered extracellular vesicle-based gene therapy for the treatment of discogenic back pain Biomaterials (IF 14.0) Pub Date : 2024-04-01 Shirley N. Tang, Ana I. Salazar-Puerta, Mary K. Heimann, Kyle Kuchynsky, María A. Rincon-Benavides, Mia Kordowski, Gilian Gunsch, Lucy Bodine, Khady Diop, Connor Gantt, Safdar Khan, Anna Bratasz, Olga Kokiko-Cochran, Julie Fitzgerald, Damien M. Laudier, Judith A. Hoyland, Benjamin A. Walter, Natalia Higuita-Castro, Devina Purmessur
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Engineering fibronectin-templated multi-component fibrillar extracellular matrices to modulate tissue-specific cell response Biomaterials (IF 14.0) Pub Date : 2024-04-01 Seungkuk Ahn, Akanksha Jain, Krishna Chaitanya Kasuba, Makiko Seimiya, Ryoko Okamoto, Barbara Treutlein, Daniel J. Müller
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Vaso-Lock for sutureless anastomosis in a pig arteriovenous loop model Biomaterials (IF 14.0) Pub Date : 2024-04-01 Xiaowei Li, Emma R. Young, Cameron Martin, Joseph G. Ribaudo, Mohamed Zaghloul, Sophia Roberts, Rodrigo Meade, Batool Arif, William R. Moritz, Sarah Madira, Jonathon B. Schofield, Helen Xun, Caitlin W. Hicks, Sung H. Kang, Mohamed A. Zayed, Justin M. Sacks
A vascular anastomosis is a critical surgical skill that involves connecting blood vessels. Traditional handsewn techniques can be challenging and resource intensive. To address these issues, we have developed a unique sutureless anastomotic device called Vaso-Lock. This intraluminal device connects free vascular ends using anchors to maintain traction and enable a rapid anastomosis. We tested the
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Exosomes based strategies for cardiovascular diseases: Opportunities and challenges Biomaterials (IF 14.0) Pub Date : 2024-03-31 Hang Li, Jun Zhang, Mingyue Tan, Yunfei Yin, Yiyi Song, Yongjian Zhao, Lin Yan, Ning Li, Xianzuo Zhang, Jiaxiang Bai, Tingbo Jiang, Hongxia Li
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Matrix mechanics regulates muscle regeneration by modulating kinesin-1 activity Biomaterials (IF 14.0) Pub Date : 2024-03-29 Wan-Yu Chiang, Helen Wenshin Yu, Ming-Chung Wu, Yi-Man Huang, Yin-Quan Chen, Jong-Wei Lin, Yen-Wenn Liu, Li-Ru You, Arthur Chiou, Jean-Cheng Kuo
Sarcopenia, a prevalent muscle disease characterized by muscle mass and strength reduction, is associated with impaired skeletal muscle regeneration. However, the influence of the biomechanical properties of sarcopenic skeletal muscle on the efficiency of the myogenic program remains unclear. Herein, we established a mouse model of sarcopenia and observed a reduction in stiffness within the sarcopenic
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Bispecific fibrous glue synergistically boosts vascular normalization and antitumor immunity for advanced renal carcinoma therapy Biomaterials (IF 14.0) Pub Date : 2024-03-28 Xiu-Hai Wu, Jia-Qi Wang, Man-Di Wang, Ting Xiao, Yu Wang, Jia-Yuan Niu, Lu Wang, Da-Yong Hou, Bo Fu, Zimo Liu, Hao Wang, Wanhai Xu
Immune checkpoint blockade therapy represented by programmed cell death ligand 1 (PD-L1) inhibitor for advanced renal carcinoma with an objective response rate (ORR) in patients is less than 20%. It is attributed to abundant tumoral vasculature with abnormal structure limiting effector T cell infiltration and drug penetration. We propose a bispecific fibrous glue (BFG) to regulate tumor immune and
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Sentinel lymph node identification using NIR-II ultrabright Raman nanotags on preclinical models Biomaterials (IF 14.0) Pub Date : 2024-03-27 Binge Deng, Yan Wang, Xiangdong Bu, Jin Li, Jingsong Lu, Linley Li Lin, Yaohui Wang, Yao Chen, Jian Ye
Surface-enhanced Raman spectroscopy (SERS) nanotags have garnered much attention as promising bioimaging contrast agent with ultrahigh sensitivity, but their clinical translation faces challenges including biological and laser safety. As breast sentinel lymph node (SLN) imaging agents, SERS nanotags used by local injection and only accumulation in SLNs, which were removed during surgery, greatly reduce
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From hemostasis to proliferation: Accelerating the infected wound healing through a comprehensive repair strategy based on GA/OKGM hydrogel loaded with MXene@TiO2 nanosheets Biomaterials (IF 14.0) Pub Date : 2024-03-27 Xingan Qiu, Linxia Nie, Pei Liu, Xiaojiang Xiong, Fangye Chen, Xuezhe Liu, Pengzhen Bu, Bikun Zhou, Meijun Tan, Fangbiao Zhan, Xiufeng Xiao, Qian Feng, Kaiyong Cai
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A functional 3D full-thickness model for comprehending the interaction between airway epithelium and connective tissue in cystic fibrosis Biomaterials (IF 14.0) Pub Date : 2024-03-26 Claudia Mazio, Laura Sara Scognamiglio, Costantino Casale, Valeria Panzetta, Francesco Urciuolo, Luis J.V. Galietta, Giorgia Imparato, Paolo A. Netti
Patients with cystic fibrosis (CF) experience severe lung disease, including persistent infections, inflammation, and irreversible fibrotic remodeling of the airways. Although therapy with transmembrane conductance regulator (CFTR) protein modulators reached optimal results in terms of CFTR rescue, lung transplant remains the best line of care for patients in an advanced stage of CF. Indeed, chronic
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Overcoming antibiotic resistance caused by genetic mutations of Helicobacter pylori with mucin adhesive polymer-based therapeutics Biomaterials (IF 14.0) Pub Date : 2024-03-25 Byoungjun Lim, Kyoung Sub Kim, Ji Yong Ahn, Kun Na
Herein, we describe the 3′-sialyllactose-polyethyleneimine-chlorine e6 conjugate (3PC), meticulously engineered to effectively target Helicobacter bacteria () within the gastric environment. The composition of 3PC comprises polyethyleneimine, a cationic polymer, 3′-sialyllactose, which exhibits a specific binding affinity for surface proteins, and a photosensitizer capable of generating oxygen radicals
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Design and development of novel self-assembled catechol-modified bile acid conjugates as pH-responsive apical sodium-dependent bile acid transporter targeting nanoparticles Biomaterials (IF 14.0) Pub Date : 2024-03-24 Dong-Nyeong Lee, Seong-Bin Yang, Seho Kweon, Jun-Hyuck Lee, Kyeong-Ju Lee, Yeonsu Ryu, Dong Wook Shin, Young Jun Kim, Yong-Kyu Lee, Jooho Park
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Engineered human osteoarthritic cartilage organoids Biomaterials (IF 14.0) Pub Date : 2024-03-22 Laura Dönges, Atharva Damle, Andrea Mainardi, Thomas Bock, Monica Schönenberger, Ivan Martin, Andrea Barbero
The availability of human cell-based models capturing molecular processes of cartilage degeneration can facilitate development of disease-modifying therapies for osteoarthritis [1], a currently unmet clinical need. Here, by imposing specific inflammatory challenges upon mesenchymal stromal cells at a defined stage of chondrogenesis, we engineered a human organotypic model which recapitulates main OA
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Multi-step strategies for synergistic treatment of urinary tract infections based on D-xylose-decorated antimicrobial peptide carbon dots Biomaterials (IF 14.0) Pub Date : 2024-03-22 Chunhui Miao, Yajie Zhang, Guowen Liu, Jianming Yang, Kaiyuan Yu, Junqiang Lv, Ran Liu, Zhi Yao, Yuanjie Niu, Xiaojuan Wang, Quan Wang
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Biomaterial-mediated intracellular control of macrophages for cell therapy in pro-inflammatory and pro-fibrotic conditions Biomaterials (IF 14.0) Pub Date : 2024-03-22 Tina Tylek, Joanna Wong, Andrew E. Vaughan, Kara L. Spiller
Macrophages are key modulators of all inflammatory diseases and essential for their resolution, making macrophage cell therapy a promising strategy for regenerative medicine. However, since macrophages change rapidly in response to microenvironmental cues, their phenotype must be controlled post-administration. We present a tunable biomaterial-based strategy to control macrophages intracellularly via
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Planar amorphous silicon carbide microelectrode arrays for chronic recording in rat motor cortex Biomaterials (IF 14.0) Pub Date : 2024-03-21 Justin R. Abbott, Eleanor N. Jeakle, Pegah Haghighi, Joshua O. Usoro, Brandon S. Sturgill, Yupeng Wu, Negar Geramifard, Rahul Radhakrishna, Sourav Patnaik, Shido Nakajima, Jordan Hess, Yusef Mehmood, Veda Devata, Gayathri Vijayakumar, Armaan Sood, Teresa Thuc Doan Thai, Komal Dogra, Ana G. Hernandez-Reynoso, Joseph J. Pancrazio, Stuart F. Cogan
Chronic implantation of intracortical microelectrode arrays (MEAs) capable of recording from individual neurons can be used for the development of brain-machine interfaces. However, these devices show reduced recording capabilities under chronic conditions due, at least in part, to the brain's foreign body response (FBR). This creates a need for MEAs that can minimize the FBR to possibly enable long-term
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An all-in-one therapeutic platform for the treatment of resistant Helicobacter pylori infection Biomaterials (IF 14.0) Pub Date : 2024-03-21 Chao Sun, Jia Huang, Xiaoqian Guo, Chenli Zhang, Li Wei, Ka Ioi Wong, Ziyun Yang, Gang Zhao, Min Lu, Weiyan Yao
() infection is a major cause of gastric diseases. Currently, bismuth-based quadruple therapy is widely adopted for eradicating infection. However, this first-line strategy faces several challenges such as drug resistance, intestinal dysbacteriosis, and patients’ poor compliance. To overcome these problems, an all-in-one therapeutic platform (CLA-Bi-ZnO@Lipo) that composed of liposomes loading clarithromycin
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Mammary tissue-derived extracellular matrix hydrogels reveal the role of irradiation in driving a pro-tumor and immunosuppressive microenvironment Biomaterials (IF 14.0) Pub Date : 2024-03-21 Tian Zhu, Steven M. Alves, Arianna Adamo, Xiaona Wen, Kevin C. Corn, Anastasia Shostak, Shereena Johnson, Nicholas D. Shaub, Shannon E. Martello, Benjamin C. Hacker, Antonio D'Amore, Rizia Bardhan, Marjan Rafat
Radiation therapy (RT) is essential for triple negative breast cancer (TNBC) treatment. However, patients with TNBC continue to experience recurrence after RT. The role of the extracellular matrix (ECM) of irradiated breast tissue in tumor recurrence is still unknown. In this study, we evaluated the structure, molecular composition, and mechanical properties of irradiated murine mammary fat pads (MFPs)
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Membrane-anchoring selenophene viologens for antibacterial photodynamic therapy against periodontitis via restoring subgingival flora and alleviating inflammation Biomaterials (IF 14.0) Pub Date : 2024-03-21 Rui Ding, Xu Liu, Xiaodan Zhao, Qi Sun, Yilong Cheng, Ang Li, Dandan Pei, Gang He
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FAK, vinculin, and talin control mechanosensitive YAP nuclear localization Biomaterials (IF 14.0) Pub Date : 2024-03-20 Elijah N. Holland, Marc A. Fernández-Yagüe, Dennis W. Zhou, Eric B. O'Neill, Ayanna U. Woodfolk, Ana Mora-Boza, Jianping Fu, David D. Schlaepfer, Andrés J. García
Focal adhesions (FAs) are nanoscale complexes containing clustered integrin receptors and intracellular structural and signaling proteins that function as principal sites of mechanotransduction in part via promoting the nuclear translocation and activation of the transcriptional coactivator yes-associated protein (YAP). Knockdown of FA proteins such as focal adhesion kinase (FAK), talin, and vinculin
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A neoteric antibacterial ceria-silver nanozyme for abiotic surfaces Biomaterials (IF 14.0) Pub Date : 2024-03-18 Abinaya Sindu Pugazhendhi, Craig J. Neal, Khoa Minh Ta, Marco Molinari, Udit Kumar, Fei Wei, Elayaraja Kolanthai, Andrew Ady, Christina Drake, Megan Hughes, Shibu Yooseph, Sudipta Seal, Melanie J. Coathup
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Plant mucus-derived microgels: Blood-triggered gelation and strong hemostatic adhesion Biomaterials (IF 14.0) Pub Date : 2024-03-16 Yu Huang, Weichao Hu, Kaige Xu, Ruijue Dan, Shali Tan, Zhenzhen Shu, Xin Li, Hangzong Liu, Chaoqiang Fan, Malcolm Xing, Shiming Yang
Arrest of bleeding usually applies clotting agents to trigger coagulation procedures or adhesives to interrupt blood flow through sealing the vessel; however, the efficiency is compromised. Here, we propose a concept of integration of hemostasis and adhesion via yam mucus's microgels. The mucus microgels exhibit attractive attributes of hydrogel with uniform size and shape. Their shear-thinning, self-healing
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ROS-responsive drug-releasing injectable microgels for ameliorating myocardial infarction Biomaterials (IF 14.0) Pub Date : 2024-03-16 Shuqin Wang, Yuejun Yao, Liang Song, Zihe Zhai, Shifen Li, Zhaolong Wang, Liyin Shen, Yang Zhu, Wenxing Liu, Changyou Gao
Despite of the recent advances in regulatory T cell (Treg) therapy, a limited number of available cells and specificity at the desired tissue site have severely compromised their efficacy. Herein, an injectable drug-releasing (MTK-TK-drug) microgel system in response to stimulation by reactive oxygen species (ROS) was constructed with a coaxial capillary microfluidic system and UV curing. The spherical
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“On/off”-switchable crosslinked PTX-nanoformulation with improved precise delivery for NSCLC brain metastases and restrained adverse reaction over nab-PTX Biomaterials (IF 14.0) Pub Date : 2024-03-14 Shuaijun Li, Caiting Meng, Qian Hao, Ruina Zhou, Luyao Dai, Yucheng Guo, Sitong Zhao, Xin Zhou, Chunju Lou, Ji Xu, Peng Xu, Jinfan Yang, Yifan Ding, Yanni Lv, Shengli Han, Shuai Li, Jing Li, Huafeng Kang, Zhengtao Xiao, Mingqian Tan, Xiaobin Ma, Hao Wu
Non-small cell lung cancer (NSCLC) brain metastases present a significant treatment challenge due to limited drug delivery efficiency and severe adverse reactions. In this study, we address these challenges by designing a “on/off” switchable crosslinked paclitaxel (PTX) nanocarrier, BPM-PD, with novel ultra-pH-sensitive linkages (pH 6.8 to 6.5). BPM-PD demonstrates a distinct “on/off” switchable release
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Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection Biomaterials (IF 14.0) Pub Date : 2024-03-14 Menglin Sun, Jiameng Wang, Xiaobo Huang, Ruiqiang Hang, Peide Han, Jiqiang Guo, Xiaohong Yao, Paul K. Chu, Xiangyu Zhang
The poor efficiency of US-responsive coatings on implants restricts their practical application. Immunotherapy that stimulates immune cells to enhance their antibacterial activity is expected to synergize with sonodynamic therapy for treating implant infection effectively and safely. Herein, US-responsive hybrid coatings composed of the oxygen-deficient BaTiO nanorod arrays and -arginine (BaTiO/LA)
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MDSC-targeting gold nanoparticles enhance PD-1 tumor immunotherapy by inhibiting NLRP3 inflammasomes Biomaterials (IF 14.0) Pub Date : 2024-03-13 Yangyang Zhu, Pin Chen, Bochuan Hu, Suqin Zhong, Kai Yan, Yu Wu, Shanshan Li, Yinyin Yang, Zexin Xu, Yutong Lu, Ying Ouyang, Hui Bao, Weiguang Gu, Longping Wen, Yunjiao Zhang
Myeloid-derived suppressor cells (MDSCs) play a crucial role in the immune escape mechanisms that limit the efficacy of immunotherapeutic strategies. In the tumor microenvironment, NLRP3 inflammasome-driven Interleukin-1β (IL-1β) production serves to dampen antitumor immune responses, promoting tumor growth, progression, and immunosuppression. In this study, we revealed that gold nanoparticles (Au
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Magnetic natural lipid nanoparticles for oral treatment of colorectal cancer through potentiated antitumor immunity and microbiota metabolite regulation Biomaterials (IF 14.0) Pub Date : 2024-03-11 Baoyi Li, Menghang Zu, Aodi Jiang, Yingui Cao, Jiaxue Wu, Mohammad-Ali Shahbazi, Xiaoxiao Shi, Rui L. Reis, Subhas C. Kundu, Bo Xiao
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Perfusable adipose decellularized extracellular matrix biological scaffold co-recellularized with adipose-derived stem cells and L6 promotes functional skeletal muscle regeneration following volumetric muscle loss Biomaterials (IF 14.0) Pub Date : 2024-03-11 Wei Liang, Meng Han, Guan Li, Wanwen Dang, Huiting Wu, Xiaoyu Meng, Yonghuan Zhen, Weibo Lin, Rigele Ao, Xiaoqing Hu, Yang An
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Progress in the development of piezoelectric biomaterials for tissue remodeling Biomaterials (IF 14.0) Pub Date : 2024-03-11 Amit Nain, Srishti Chakraborty, Snigdha Roy Barman, Pratik Gavit, Sushma Indrakumar, Akhilesh Agrawal, Zong-Hong Lin, Kaushik Chatterjee
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Degradation-controlled tissue extracellular sponge for rapid hemostasis and wound repair after kidney injury Biomaterials (IF 14.0) Pub Date : 2024-03-11 Jae Yun Kim, Tugce Sen, Jae Yeon Lee, Dong-Woo Cho
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Modeling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathogenicity Biomaterials (IF 14.0) Pub Date : 2024-03-09 Tim Kaden, Raquel Alonso-Roman, Parastoo Akbarimoghaddam, Alexander S. Mosig, Katja Graf, Martin Raasch, Bianca Hoffmann, Marc T. Figge, Bernhard Hube, Mark S. Gresnigt
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Local delivery of stem cell spheroids with protein/polyphenol self-assembling armor to improve myocardial infarction treatment via immunoprotection and immunoregulation Biomaterials (IF 14.0) Pub Date : 2024-03-08 Chuanfeng An, Fei Shao, Canling Long, Yujie Zhang, Wen Nie, Rui Zeng, Zhenzhen Dou, Yuan Zhao, Yuanyuan Lin, Shiying Zhang, Lijun Zhang, Changle Ren, Yang Zhang, Guangqian Zhou, Huanan Wang, Jia Liu
Stem cell therapies have shown great potential for treating myocardial infarction (MI) but are limited by low cell survival and compromised functionality due to the harsh microenvironment at the disease site. Here, we presented a Mesenchymal stem cell (MSC) spheroid-based strategy for MI treatment by introducing a protein/polyphenol self-assembling armor coating on the surface of cell spheroids, which
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Corrigendum to “Selective binding of C-6OH sulfated hyaluronic acid to the angiogenic isoform of VEGF165” [Biomaterials 77(2016) 130–138] Biomaterials (IF 14.0) Pub Date : 2024-02-28 Dong-Kwon Lim, Ryan G. Wylie, Robert S. Langer, Daniel S. Kohane
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An ATPase-Mimicking MXene nanozyme pharmacologically breaks the ironclad defense system for ferroptosis cancer therapy Biomaterials (IF 14.0) Pub Date : 2024-02-27 Huan Wang, Xinchen Liu, Xiangyu Yan, Yong Du, Fang Pu, Jinsong Ren, Xiaogang Qu
Anticancer nanomedicines used for ferroptosis therapy generally rely on the direct delivery of Fenton catalysts to drive lipid peroxidation in cancer cells. However, the therapeutic efficacy is limited by the ferroptosis resistance caused by the intracellular anti-ferroptotic signals. Herein, we report the intrinsic ATPase-mimicking activity of a vanadium carbide MXene nanozyme (PVCMs) to pharmacologically
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Ultrasound-augmented enzyodynamic-Ca2+ overload synergetic tumor nanotherapy Biomaterials (IF 14.0) Pub Date : 2024-02-26 Meiqi Chang, Lu Zhang, Tingting Zhang, Yanqiu Duan, Wei Feng, Shaoling Yang, Yu Chen, Zeyu Wang
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Cuproptotic nanoinducer-driven proteotoxic stress potentiates cancer immunotherapy by activating the mtDNA–cGAS–STING signaling Biomaterials (IF 14.0) Pub Date : 2024-02-26 Xinying Yu, Bei Li, Jie Yan, Wenxi Li, Hao Tian, Guohao Wang, Songtao Zhou, Yunlu Dai
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Multichannel-optical imaging for in vivo evaluating the safety and therapeutic efficacy of stem cells in tumor model in terms of cell tropism, proliferation and NF-κB activity Biomaterials (IF 14.0) Pub Date : 2024-02-23 Dehua Huang, Xue Yang, Zhao Peng, Hongqiang Yin, Yongyang Liu, Yejun Zhang, Chunyan Li, Guangcun Chen, Qiangbin Wang
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Development of pluripotent stem cell-derived epidermal organoids that generate effective extracellular vesicles in skin regeneration Biomaterials (IF 14.0) Pub Date : 2024-02-23 Sojung Kwak, Cho Lok Song, Jinhyuk Lee, Sungyeon Kim, Seungyoon Nam, Young-Jun Park, Jungwoon Lee
Cellular skin substitutes such as epidermal constructs have been developed for various applications, including wound healing and skin regeneration. These cellular models are mostly derived from primary cells such as keratinocytes and fibroblasts in a two-dimensional (2D) state, and further development of three-dimensional (3D) cultured organoids is needed to provide insight into the epidermal phenotype
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Honeycomb-inspired ZIF-sealed interface enhances osseointegration via anti-infection and osteoimmunomodulation Biomaterials (IF 14.0) Pub Date : 2024-02-21 Jiale Dong, Wei Zhou, Xianli Hu, Jiaxiang Bai, Siming Zhang, Xianzuo Zhang, Lei Yu, Peng Yang, Lingtong Kong, Mingkai Liu, Xifu Shang, Zheng Su, Dechun Geng, Chen Zhu
Implant-associated infections (IAIs) pose a significant threat to orthopedic surgeries. Bacteria colonizing the surface of implants disrupt bone formation-related cells and interfere with the osteoimmune system, resulting in an impaired immune microenvironment and osteogenesis disorders. Inspired by nature, a zeolitic imidazolate framework (ZIF)-sealed smart drug delivery system on Ti substrates (ZSTG)
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Mild magnetic hyperthermia-activated immuno-responses for primary bladder cancer therapy Biomaterials (IF 14.0) Pub Date : 2024-02-21 Fenggang Qi, Qunqun Bao, Ping Hu, Yuedong Guo, Yang Yan, Xudong Yao, Jianlin Shi
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Smart composite scaffold to synchronize magnetic hyperthermia and chemotherapy for efficient breast cancer therapy Biomaterials (IF 14.0) Pub Date : 2024-02-20 Rui Sun, Huajian Chen, Man Wang, Toru Yoshitomi, Masaki Takeguchi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
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Multi-functional dual-layer nanofibrous membrane for prevention of postoperative pancreatic leakage Biomaterials (IF 14.0) Pub Date : 2024-02-19 Prayas Chakma Shanto, Md Abdullah Al Fahad, Hae Il Jung, Myeongki Park, Hyeyoung Kim, Sang Ho Bae, Byong-Taek Lee
Postoperative pancreatic leakage due to pancreatitis in patients is a life-threatening surgical complication. The majority of commercial barriers are unable to meet the demands for pancreatic leakage due to poor adhesiveness, toxicity, and inability to degrade. In this study, we fabricated mitomycin-c and thrombin-loaded multifunctional dual-layer nanofibrous membrane with a combination of alginate
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Small-diameter vascular graft composing of core-shell structured micro-nanofibers loaded with heparin and VEGF for endothelialization and prevention of neointimal hyperplasia Biomaterials (IF 14.0) Pub Date : 2024-02-14 Md Abdullah Al Fahad, Hyun-Yong Lee, Seongsu Park, Minji Choi, Prayas Chakma Shanto, Myeongki Park, Sang Ho Bae, Byong-Taek Lee
Despite the significant progress made in recent years, clinical issues with small-diameter vascular grafts related to low mechanical strength, thrombosis, intimal hyperplasia, and insufficient endothelialization remain unresolved. This study aims to design and fabricate a core-shell fibrous small-diameter vascular graft by co-axial electrospinning process, which will mechanically and biologically meet
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Injectable pathological microenvironment-responsive anti-inflammatory hydrogels for ameliorating intervertebral disc degeneration Biomaterials (IF 14.0) Pub Date : 2024-02-13 Lei Liu, Wantao Wang, Lin Huang, Yiwen Xian, Wenzheng Ma, Jinghao Fan, Yixi Li, Hongmei Liu, Zhaomin Zheng, Decheng Wu
Chronic local inflammation and resulting cellular dysfunction of nucleus pulposus (NP) cells are important pathogenic factors of intervertebral disc degeneration (IDD). Injectable pathological microenvironment-responsive hydrogels hold significant potential for treating IDD by adapting to dynamic microenvironment of IDD. Herein, we proposed an injectable gelatin-based hydrogel drug delivery system
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Patient-derived tumor spheroid-induced angiogenesis preclinical platform for exploring therapeutic vulnerabilities in cancer Biomaterials (IF 14.0) Pub Date : 2024-02-12 Jihoon Ko, Sujin Hyung, You Jeong Heo, Sangmin Jung, Seung Tae Kim, Se Hoon Park, Jung Yong Hong, Sung Hee Lim, Kyoung-Mee Kim, Sanghee Yoo, Noo Li Jeon, Jeeyun Lee
This study addresses the demand for research models that can support patient-treatment decisions and clarify the complexities of a tumor microenvironment by developing an advanced non-animal preclinical cancer model. Based on patient-derived tumor spheroids (PDTS), the proposed model reconstructs the tumor microenvironment with emphasis on tumor spheroid-driven angiogenesis. The resulting microfluidic
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Corrigendum to “On-site fabrication of bi-layered adhesive mesenchymal stromal cell dressings for the treatment of heart failure” [Biomaterials 209 (2019) 41–53] Biomaterials (IF 14.0) Pub Date : 2024-02-09 Kazuya Kobayashi, Yuki Ichihara, Nobuhiko Sato, Nobuyoshi Umeda, Laura Fields, Masafumi Fukumitsu, Yoshiyuki Tago, Tomoya Ito, Satoshi Kainuma, Mihai Podaru, Fiona Lewis-McDougall, Kenichi Yamahara, Rakesh Uppal, Ken Suzuki
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Corrigendum to “Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure” [Biomaterials 154 (2018) 12–23] Biomaterials (IF 14.0) Pub Date : 2024-02-09 Yuki Ichihara, Masahiro Kaneko, Kenichi Yamahara, Marinos Koulouroudias, Nobuhiko Sato, Rakesh Uppal, Kenji Yamazaki, Satoshi Saito, Ken Suzuki