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On-device phase engineering Nat. Mater. (IF 41.2) Pub Date : 2024-04-25 Xiaowei Liu, Junjie Shan, Tianjun Cao, Liang Zhu, Jiayu Ma, Gang Wang, Zude Shi, Qishuo Yang, Mingyu Ma, Zenglin Liu, Shengnan Yan, Lizheng Wang, Yudi Dai, Junlin Xiong, Fanqiang Chen, Buwei Wang, Chen Pan, Zhenlin Wang, Bin Cheng, Yongmin He, Xin Luo, Junhao Lin, Shi-Jun Liang, Feng Miao
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China's Moon atlas is the most detailed ever made Nature (IF 64.8) Pub Date : 2024-04-25
The Geologic Atlas of the Lunar Globe doubles the resolution of Apollo-era maps and will support the space ambitions of China and other countries.
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‘Shut up and calculate’: how Einstein lost the battle to explain quantum reality Nature (IF 64.8) Pub Date : 2024-04-25
By suppressing questions they considered too ‘philosophical’, post-war physicists created an unquestioning orthodoxy that influences science to this day.
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Algorithm ranks peer reviewers by reputation — but critics warn of bias Nature (IF 64.8) Pub Date : 2024-04-25
There are questions about whether the tool, which could be used by editors to find and shortlist peer reviewers, would disadvantage inexperienced candidates or those in certain locations.
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NATO is boosting AI and climate research as scientific diplomacy remains on ice Nature (IF 64.8) Pub Date : 2024-04-25
As the military alliance created to counter the Soviet Union expands, it is prioritizing studies on how climate change affects security, cyber attacks and election interference.
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Are robots the solution to the crisis in older-person care? Nature (IF 64.8) Pub Date : 2024-04-25
Social robots that promise companionship and stimulation for older people and those with dementia are attracting investment, but some question their benefits.
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Structures of human γδ T cell receptor–CD3 complex Nature (IF 64.8) Pub Date : 2024-04-24 Weizhi Xin, Bangdong Huang, Ximin Chi, Yuehua Liu, Mengjiao Xu, Yuanyuan Zhang, Xu Li, Qiang Su, Qiang Zhou
Gamma delta (γδ) T cells, a unique T cell subgroup, are crucial in various immune responses and immunopathology1-3. The γδ T cell receptor (TCR), generated by γδ T cells, recognizes a diverse range of antigens independently of the major histocompatibility complex2. The γδ TCR associates with CD3 subunits, initiating T cell activation and holding great potential in immunotherapy4. Here, we report the
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How gliding marsupials got their ‘wings’ Nature (IF 64.8) Pub Date : 2024-04-24
Hear the biggest stories from the world of science | 24 April 2024
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Should the Maldives be creating new land? Nature (IF 64.8) Pub Date : 2024-04-24
The Maldives are racing to reclaim vast amounts of land to combat rising sea levels. But many are concerned that these efforts risk harming the paradise they aims to protect
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This giant extinct salmon had tusks like a warthog Nature (IF 64.8) Pub Date : 2024-04-24
Scientists initially thought that the outsized teeth were fangs, giving rise to the ‘sabre-toothed salmon’ nickname.
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High-performance fibre battery with polymer gel electrolyte Nature (IF 64.8) Pub Date : 2024-04-24 Chenhao Lu, Haibo Jiang, Xiangran Cheng, Jiqing He, Yao Long, Yingfan Chang, Xiaocheng Gong, Kun Zhang, Jiaxin Li, Zhengfeng Zhu, Jingxia Wu, Jiajia Wang, Yuanyuan Zheng, Xiang Shi, Lei Ye, Meng Liao, Xuemei Sun, Bingjie Wang, Peining Chen, Yonggang Wang, Huisheng Peng
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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers Nature (IF 64.8) Pub Date : 2024-04-24 Stephane Ferretti, Jacques Hamon, Ruben de Kanter, Clemens Scheufler, Rita Andraos-Rey, Stephanie Barbe, Elisabeth Bechter, Jutta Blank, Vincent Bordas, Ernesta Dammassa, Andrea Decker, Noemi Di Nanni, Marion Dourdoigne, Elena Gavioli, Marc Hattenberger, Alisa Heuser, Christelle Hemmerlin, Jürgen Hinrichs, Grainne Kerr, Laurent Laborde, Isabel Jaco, Eloísa Jiménez Núñez, Hans-Joerg Martus, Cornelia
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Antisense oligonucleotide therapeutic approach for Timothy syndrome Nature (IF 64.8) Pub Date : 2024-04-24 Xiaoyu Chen, Fikri Birey, Min-Yin Li, Omer Revah, Rebecca Levy, Mayuri Vijay Thete, Noah Reis, Konstantin Kaganovsky, Massimo Onesto, Noriaki Sakai, Zuzana Hudacova, Jin Hao, Xiangling Meng, Seiji Nishino, John Huguenard, Sergiu P. Pașca
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Multi-project wafers for flexible thin-film electronics by independent foundries Nature (IF 64.8) Pub Date : 2024-04-24 Hikmet Çeliker, Wim Dehaene, Kris Myny
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Growth of diamond in liquid metal at 1 atm pressure Nature (IF 64.8) Pub Date : 2024-04-24 Yan Gong, Da Luo, Myeonggi Choe, Yongchul Kim, Babu Ram, Mohammad Zafari, Won Kyung Seong, Pavel Bakharev, Meihui Wang, In Kee Park, Seulyi Lee, Tae Joo Shin, Zonghoon Lee, Geunsik Lee, Rodney S. Ruoff
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PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells Nature (IF 64.8) Pub Date : 2024-04-24 Sebastian B. Lacher, Janina Dörr, Gustavo P. de Almeida, Julian Hönninger, Felix Bayerl, Anna Hirschberger, Anna-Marie Pedde, Philippa Meiser, Lukas Ramsauer, Thomas J. Rudolph, Nadine Spranger, Matteo Morotti, Alizee J. Grimm, Sebastian Jarosch, Arman Oner, Lisa Gregor, Stefanie Lesch, Stefanos Michaelides, Luisa Fertig, Daria Briukhovetska, Lina Majed, Sophia Stock, Dirk H. Busch, Veit R. Buchholz
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A high-density and high-confinement tokamak plasma regime for fusion energy Nature (IF 64.8) Pub Date : 2024-04-24 S. Ding, A. M. Garofalo, H. Q. Wang, D. B. Weisberg, Z. Y. Li, X. Jian, D. Eldon, B. S. Victor, A. Marinoni, Q. M. Hu, I. S. Carvalho, T. Odstrčil, L. Wang, A. W. Hyatt, T. H. Osborne, X. Z. Gong, J. P. Qian, J. Huang, J. McClenaghan, C. T. Holcomb, J. M. Hanson
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Single-cell analysis reveals context-dependent, cell-level selection of mtDNA Nature (IF 64.8) Pub Date : 2024-04-24 Anna V. Kotrys, Timothy J. Durham, Xiaoyan A. Guo, Venkata R. Vantaku, Sareh Parangi, Vamsi K. Mootha
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Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase Nature (IF 64.8) Pub Date : 2024-04-24 Kristen A. Baltgalvis, Kelsey N. Lamb, Kent T. Symons, Chu-Chiao Wu, Melissa A. Hoffman, Aaron N. Snead, Xiaodan Song, Thomas Glaza, Shota Kikuchi, Jason C. Green, Donald C. Rogness, Betty Lam, Maria E. Rodriguez-Aguirre, David R. Woody, Christie L. Eissler, Socorro Rodiles, Seth M. Negron, Steffen M. Bernard, Eileen Tran, Jonathan Pollock, Ali Tabatabaei, Victor Contreras, Heather N. Williams, Martha
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A magnetar giant flare in the nearby starburst galaxy M82 Nature (IF 64.8) Pub Date : 2024-04-24 Sandro Mereghetti, Michela Rigoselli, Ruben Salvaterra, Dominik Patryk Pacholski, James Craig Rodi, Diego Gotz, Edoardo Arrigoni, Paolo D’Avanzo, Christophe Adami, Angela Bazzano, Enrico Bozzo, Riccardo Brivio, Sergio Campana, Enrico Cappellaro, Jerome Chenevez, Fiore De Luise, Lorenzo Ducci, Paolo Esposito, Carlo Ferrigno, Matteo Ferro, Gian Luca Israel, Emeric Le Floc’h, Antonio Martin-Carrillo,
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Whole-cortex in situ sequencing reveals input-dependent area identity Nature (IF 64.8) Pub Date : 2024-04-24 Xiaoyin Chen, Stephan Fischer, Mara C. P. Rue, Aixin Zhang, Didhiti Mukherjee, Patrick O. Kanold, Jesse Gillis, Anthony M. Zador
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Periportal macrophages protect against commensal-driven liver inflammation Nature (IF 64.8) Pub Date : 2024-04-24 Yu Miyamoto, Junichi Kikuta, Takahiro Matsui, Tetsuo Hasegawa, Kentaro Fujii, Daisuke Okuzaki, Yu-chen Liu, Takuya Yoshioka, Shigeto Seno, Daisuke Motooka, Yutaka Uchida, Erika Yamashita, Shogo Kobayashi, Hidetoshi Eguchi, Eiichi Morii, Karl Tryggvason, Takashi Shichita, Hisako Kayama, Koji Atarashi, Jun Kunisawa, Kenya Honda, Kiyoshi Takeda, Masaru Ishii
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High carrier mobility along the [111] orientation in Cu2O photoelectrodes Nature (IF 64.8) Pub Date : 2024-04-24 Linfeng Pan, Linjie Dai, Oliver J. Burton, Lu Chen, Virgil Andrei, Youcheng Zhang, Dan Ren, Jinshui Cheng, Linxiao Wu, Kyle Frohna, Anna Abfalterer, Terry Chien-Jen Yang, Wenzhe Niu, Meng Xia, Stephan Hofmann, Paul J. Dyson, Erwin Reisner, Henning Sirringhaus, Jingshan Luo, Anders Hagfeldt, Michael Grätzel, Samuel D. Stranks
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Probing entanglement in a 2D hard-core Bose–Hubbard lattice Nature (IF 64.8) Pub Date : 2024-04-24 Amir H. Karamlou, Ilan T. Rosen, Sarah E. Muschinske, Cora N. Barrett, Agustin Di Paolo, Leon Ding, Patrick M. Harrington, Max Hays, Rabindra Das, David K. Kim, Bethany M. Niedzielski, Meghan Schuldt, Kyle Serniak, Mollie E. Schwartz, Jonilyn L. Yoder, Simon Gustavsson, Yariv Yanay, Jeffrey A. Grover, William D. Oliver
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One-dimensional proximity superconductivity in the quantum Hall regime Nature (IF 64.8) Pub Date : 2024-04-24 Julien Barrier, Minsoo Kim, Roshan Krishna Kumar, Na Xin, P. Kumaravadivel, Lee Hague, E. Nguyen, A. I. Berdyugin, Christian Moulsdale, V. V. Enaldiev, J. R. Prance, F. H. L. Koppens, R. V. Gorbachev, K. Watanabe, T. Taniguchi, L. I. Glazman, I. V. Grigorieva, V. I. Fal’ko, A. K. Geim
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Transient loss of Polycomb components induces an epigenetic cancer fate Nature (IF 64.8) Pub Date : 2024-04-24 V. Parreno, V. Loubiere, B. Schuettengruber, L. Fritsch, C. C. Rawal, M. Erokhin, B. Győrffy, D. Normanno, M. Di Stefano, J. Moreaux, N. L. Butova, I. Chiolo, D. Chetverina, A.-M. Martinez, G. Cavalli
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Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo Nature (IF 64.8) Pub Date : 2024-04-24 L. Francisco Lorenzo-Martín, Tania Hübscher, Amber D. Bowler, Nicolas Broguiere, Jakob Langer, Lucie Tillard, Mikhail Nikolaev, Freddy Radtke, Matthias P. Lutolf
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Valleytronics in bulk MoS2 with a topologic optical field Nature (IF 64.8) Pub Date : 2024-04-24 Igor Tyulnev, Álvaro Jiménez-Galán, Julita Poborska, Lenard Vamos, Philip St. J. Russell, Francesco Tani, Olga Smirnova, Misha Ivanov, Rui E. F. Silva, Jens Biegert
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Regioselective hydroformylation of propene catalysed by rhodium-zeolite Nature (IF 64.8) Pub Date : 2024-04-24 Xiangjie Zhang, Tao Yan, Huaming Hou, Junqing Yin, Hongliu Wan, Xiaodong Sun, Qing Zhang, Fanfei Sun, Yao Wei, Mei Dong, Weibin Fan, Jianguo Wang, Yujie Sun, Xiong Zhou, Kai Wu, Yong Yang, Yongwang Li, Zhi Cao
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Mechanism of single-stranded DNA annealing by RAD52–RPA complex Nature (IF 64.8) Pub Date : 2024-04-24 Chih-Chao Liang, Luke A. Greenhough, Laura Masino, Sarah Maslen, Ilirjana Bajrami, Marcel Tuppi, Mark Skehel, Ian A. Taylor, Stephen C. West
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Dearomatization drives complexity generation in freshwater organic matter Nature (IF 64.8) Pub Date : 2024-04-24 Siyu Li, Mourad Harir, David Bastviken, Philippe Schmitt-Kopplin, Michael Gonsior, Alex Enrich-Prast, Juliana Valle, Norbert Hertkorn
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Emx2 underlies the development and evolution of marsupial gliding membranes Nature (IF 64.8) Pub Date : 2024-04-24 Jorge A. Moreno, Olga Dudchenko, Charles Y. Feigin, Sarah A. Mereby, Zhuoxin Chen, Raul Ramos, Axel A. Almet, Harsha Sen, Benjamin J. Brack, Matthew R. Johnson, Sha Li, Wei Wang, Jenna M. Gaska, Alexander Ploss, David Weisz, Arina D. Omer, Weijie Yao, Zane Colaric, Parwinder Kaur, Judy St. Leger, Qing Nie, Alexandria Mena, Joseph P. Flanagan, Greta Keller, Thomas Sanger, Bruce Ostrow, Maksim V. Plikus
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Phylogenomics and the rise of the angiosperms Nature (IF 64.8) Pub Date : 2024-04-24 Alexandre R. Zuntini, Tom Carruthers, Olivier Maurin, Paul C. Bailey, Kevin Leempoel, Grace E. Brewer, Niroshini Epitawalage, Elaine Françoso, Berta Gallego-Paramo, Catherine McGinnie, Raquel Negrão, Shyamali R. Roy, Lalita Simpson, Eduardo Toledo Romero, Vanessa M. A. Barber, Laura Botigué, James J. Clarkson, Robyn S. Cowan, Steven Dodsworth, Matthew G. Johnson, Jan T. Kim, Lisa Pokorny, Norman J
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Optical clocks at sea Nature (IF 64.8) Pub Date : 2024-04-24 Jonathan D. Roslund, Arman Cingöz, William D. Lunden, Guthrie B. Partridge, Abijith S. Kowligy, Frank Roller, Daniel B. Sheredy, Gunnar E. Skulason, Joe P. Song, Jamil R. Abo-Shaeer, Martin M. Boyd
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PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function Nature (IF 64.8) Pub Date : 2024-04-24 Matteo Morotti, Alizee J. Grimm, Helen Carrasco Hope, Marion Arnaud, Mathieu Desbuisson, Nicolas Rayroux, David Barras, Maria Masid, Baptiste Murgues, Bovannak S. Chap, Marco Ongaro, Ioanna A. Rota, Catherine Ronet, Aspram Minasyan, Johanna Chiffelle, Sebastian B. Lacher, Sara Bobisse, Clément Murgues, Eleonora Ghisoni, Khaoula Ouchen, Ribal Bou Mjahed, Fabrizio Benedetti, Naoill Abdellaoui, Riccardo
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Network of large pedigrees reveals social practices of Avar communities Nature (IF 64.8) Pub Date : 2024-04-24 Guido Alberto Gnecchi-Ruscone, Zsófia Rácz, Levente Samu, Tamás Szeniczey, Norbert Faragó, Corina Knipper, Ronny Friedrich, Denisa Zlámalová, Luca Traverso, Salvatore Liccardo, Sandra Wabnitz, Divyaratan Popli, Ke Wang, Rita Radzeviciute, Bence Gulyás, István Koncz, Csilla Balogh, Gabriella M. Lezsák, Viktor Mácsai, Magdalena M. E. Bunbury, Olga Spekker, Petrus le Roux, Anna Szécsényi-Nagy, Balázs
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Mini-colon and brain 'organoids' shed light on cancer and other diseases Nature (IF 64.8) Pub Date : 2024-04-24
Tiny 3D structures made from human stem cells sometimes offer insights that animal models cannot.
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Atomic clock keeps ultra-precise time aboard a rocking naval ship Nature (IF 64.8) Pub Date : 2024-04-24
The best timepieces tend to be fragile, but a device based on iodine threads the needle between precision and practicality.
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Robust optical clocks promise stable timing in a portable package Nature (IF 64.8) Pub Date : 2024-04-24 Bonnie L. S. Marlow, Jonathan Hirschauer
At-sea testing of three compact optical clocks.
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Targeting RNA opens therapeutic avenues for Timothy syndrome Nature (IF 64.8) Pub Date : 2024-04-24 Silvia Velasco
Genetic therapy for Timothy syndrome tested in organoid models.
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Plastic pollution: three numbers that support a crackdown Nature (IF 64.8) Pub Date : 2024-04-24
As negotiators haggle over a global treaty to curb plastics pollution, a flood of data outlines how a treaty could make a difference.
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Bioengineered ‘mini-colons’ shed light on cancer progression Nature (IF 64.8) Pub Date : 2024-04-24 Nicolò Riggi, Felipe de Sousa e Melo
Experimental system to examine tumour formation over space and time.
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Ancient DNA traces family lines and political shifts in the Avar empire Nature (IF 64.8) Pub Date : 2024-04-24 Lara M. Cassidy
Social structure of a medieval civilization revealed by ancient DNA.
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Galaxy found napping in the primordial Universe Nature (IF 64.8) Pub Date : 2024-04-24 Jacqueline Antwi-Danso
JWST reveals distant quenched galaxy.
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Retractions are part of science, but misconduct isn’t — lessons from a superconductivity lab Nature (IF 64.8) Pub Date : 2024-04-24
Journals, funders and institutions that employ researchers all want to produce or disseminate rigorous scientific knowledge — and all can learn lessons from misconduct cases.
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Tumours form without genetic mutations Nature (IF 64.8) Pub Date : 2024-04-24 Anne-Kathrin Classen
Temporarily disrupting epigenetic silencing causes flies to grow tumours.
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DNA from ancient graves reveals the culture of a mysterious nomadic people Nature (IF 64.8) Pub Date : 2024-04-24
Hundreds of genomes shed light on the marriage habits and social norms of the Avar people of central Europe.
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Marsupial genomes reveal how a skin membrane for gliding evolved Nature (IF 64.8) Pub Date : 2024-04-24 Darío G. Lupiáñez
Finding the gene that enabled some marsupial species to glide.
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Daily briefing: Visual clutter skews our time perception Nature (IF 64.8) Pub Date : 2024-04-23
Our ability to track time is skewed by what we are looking at. Plus, NASA has reestablished clear communication with Voyager 1 and why we aren’t ready for the next big volcano eruption.
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Tailoring cobalt spinel oxide with site-specific single atom incorporation for high-performance electrocatalysis Energy Environ. Sci. (IF 32.5) Pub Date : 2024-04-25 Taeghwan Hyeon, Kangjae Lee, Jaehyuk Shim, Hyunsoo Ji, Jungho Kim, Hyeon Seok Lee, Heejong Shin, Megalamane S. Bootharaju, Kug-Seung Lee, Wonjae Ko, Jaewoo Lee, Kang Kim, Seungwoo Yoo, Sungeun Heo, Jaeyune Ryu, Seoin Back, Byoung-Hoon Lee, Yung-Eun Sung
Universal incorporation of metals into cobalt spinel oxide (CSO) has emerged as a versatile and promising strategy to enhance catalytic performance. However, the uncontrolled reactivity of early transition metal and metalloid precursors with water has presented a significant challenge in achieving atomic-scale metal incorporation within CSO. This study presents a groundbreaking approach for the atomic-scale
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Advancements and strategic approaches in catenane synthesis Chem. Soc. Rev. (IF 46.2) Pub Date : 2024-04-25 Qing Chen, Kelong Zhu
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A Mitochondrial-Targeted Activity-Based Sensing Probe for Ratiometric Imaging of Formaldehyde Reveals Key Regulators of the Mitochondrial One-Carbon Pool Chem. Sci. (IF 8.4) Pub Date : 2024-04-25 Chris Chang, Logan Tenney, Vanha N Pham, Thomas F. Brewer
Formaldehyde (FA) is both a highly reactive environmental genotoxin and an endogenously produced metabolite that functions as a signaling molecule and one-carbon (1C) store to regulate 1C metabolism and epigenetics in the cell. Owing to its signal-stress duality, cells have evolved multiple clearance mechanisms to maintain FA homeostasis, acting to avoid the established genotoxicity of FA while also
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Improving Electron Transportation and Operational Lifetime of Full Color Organic Light Emitting Diode Through “Weak hydrogen bonding cage” Structure Chem. Sci. (IF 8.4) Pub Date : 2024-04-25 Huayi Zhou, Tengyue Li, Mingliang Xie, Yannan Zhou, Qikun Sun, Shitong Zhang, Yujian Zhang, Wenjun Yang, Shanfeng Xue
Efficient electron-transporting materials (ETMs) are critical to achieving excellent performance of organic light-emitting diodes (OLEDs), yet developing such materials remains a major long-term challenge, particularly ETMs with high electron mobilities (μeles). Herein, we report a short conjugated ETM molecule (PICN) with a dipolar phenanthroimidazole group, which exhibits an electron mobility of
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Structural elucidation of HIV-1 G-quadruplexes in cellular environment and their ligand binding using responsive 19F-labeled nucleoside probes Chem. Sci. (IF 8.4) Pub Date : 2024-04-25 Sarupa Roy, Priyasha Majee, Sruthi Sudhakar, Satyajit Mishra, Jeet Kalia, P. I. Pradeepkumar, Seergazhi G Srivatsan
Understanding structure and recognition of highly conserved regulatory segments of the integrated viral DNA genome that forms unique topologies can greatly aid devise novel therapeutic strategies to counter chronic infections. In this study, we configured a probe system using highly environment-sensitive nucleoside analogs, 5-fluoro-2'-deoxyuridine (FdU) and 5-fluorobenzofuran-2'-deoxyuridine (FBFdU)
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Photochemical and Biological Dual-effects Enhance the Inhibition of Photosensitizer for Tumour Growth Chem. Sci. (IF 8.4) Pub Date : 2024-04-25 Hua Zhang, Huiyu Niu, Yang Liu, Yafu Wang, Yonggang Yang, Ge Wang, Tony D. James, Jonathan L. Sessler
Photosensitizers typically rely on a singular photochemical reaction to generate reactive oxygen species, which can then inhibit or eradicate lesions. However, photosensitizers often exhibit limited therapeutic efficiency due to their reliance on a single photochemical effect. Herein, we propose a new strategy that integrates the photochemical effect (Type-I photochemical effect) with a biological
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The Development of Cage Phosphine ‘DalPhos’ Ligands to Enable Nickel-Catalyzed Cross-Couplings of (Hetero)aryl Electrophiles Chem. Sci. (IF 8.4) Pub Date : 2024-04-25 Kathleen M Morrison, Mark Stradiotto
Nickel-catalyzed cross-couplings of (hetero)aryl electrophiles with a diversity of nucleophiles (nitrogen, oxygen, carbon, and other) have evolved into competitive alternatives to well-established palladium- and copper-based protocols for the synthesis of (hetero)aryl products, including (hetero)anilines and (hetero)aryl ethers. A survey of the literature reveals that the use of cage phosphine (CgP)
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Insights into mechanistic interpretation of crystalline-state reddish phosphorescence of non-planar π-conjugated organoboron compounds Chem. Sci. (IF 8.4) Pub Date : 2024-04-25 Yohei Adachi, Maho Kurihara, Kohei Yamada, Fuka Arai, Yuto Hattori, Keita Yamana, Riku Kawasaki, Joji Ohshita
Metal-free room-temperature phosphorescent (RTP) materials are attracting attention in such applications as organic light-emitting diodes and bioimaging. However, the chemical structures of RTP materials reported thus far are mostly predominantly based on π-conjugated systems incorporating heavy atoms such as bromine atoms or carbonyl groups, resulting in limited structural diversity. On the other
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Azole reagents enabled ligation of peptide acyl pyrazoles for chemical protein synthesis Chem. Sci. (IF 8.4) Pub Date : 2024-04-25 Peisi Liao, Chunmao He
Native chemical ligation (NCL) has been playing an increasingly important role in chemical protein synthesis (CPS), more efficient ligation methods that circumvent the requirement of peptidyl thioester and thiol additive—which allow the following desulfurization or refolding in one pot—are urgently needed for the synthesis of more complex protein targets and in large quantities. Herein, we discover
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Metal-free Platforms for Molecular Thin Films as High-performance Supercapacitors Chem. Sci. (IF 8.4) Pub Date : 2024-04-25 Ritu Gupta, Ankur Malik, Kusum Kumari, Saurabh Kumar Singh, Vincent Vivier, Prakash Chandra Mondal
Controlling chemical functionalization and achieving stable electrode-molecule interfaces for high-performance electrochemical energy storage applications remains a challenging task. Herein, we present a simple, controllable, scalable, and versatile electrochemical modification approach of graphite rods (GR) extracted from low-cost Eveready cells that were covalently modified with anthracene oligomers
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Directed Evolution of Escherichia coli Surface-displayed Vitreoscilla Hemoglobin as an Artificial Metalloenzyme for the Synthesis of 5-Imino-1,2,4-thiadiazoles Chem. Sci. (IF 8.4) Pub Date : 2024-04-25 Yaning Xu, Fengxi Li, Hanqing Xie, Yuyang Liu, Weiwei Han, Junhao Wu, Lei Cheng, Chunyu Wang, Zhengqiang Li, Lei Wang
Artificial metalloenzymes (ArMs) are constructed by anchoring organometallic catalysts to an evolvable protein scaffold. They present the advantages of both components and exhibit considerable potential for the in vivo catalysis of new-to-nature reactions. Herein, Escherichia coli surface-displayed Vitreoscilla hemoglobin (VHbSD-Co) that anchored the cobalt porphyrin cofactor instead of the original