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Leucine zipper as a bridge for transaminase self-assembly: A fusion enzyme for efficient chiral conversion of d-phenylglycine Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-16 Jiali Liu, Xin Zhang, Zilong Shao, Jingwen Yang, Hongbin Zhang
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Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-16 Ya-Qi Xiao, Jiao Long, Shuang-Shuang Zhang, Yuan-Yuan Zhu, Shuang-Xi Gu
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Discovery of 4-phenyl-1H-indazole derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-16 Chenglong Xu, Zhiqiang Sun, Xuewen Zhang, Qinru Zang, Zichao Yang, Ling Li, Xixiang Yang, Yueyu He, Zeli Ma, Jianjun Chen
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Antioxidant aromatic compounds from Amomum villosum and target prediction of active ingredients Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-16 Junming Liang, Yang Xu, Jinxia Chen, Zhiruo Zhang, Hui Wang, Kexin Liu, Dejuan Sun, Hua Li, Lixia Chen
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Inhibition of TGF-β1/Smad3 signaling by compound 5aa: A potential treatment for idiopathic pulmonary fibrosis Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-16 Baijiao An, Yanhua Fang, Lihan Wang, Wenyan Nie, Mengxuan Wang, Haoran Nie, Chengjun Wu, Ruoyu Wang
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Dried tangerine peel polysaccharide (DTPP) alleviates hepatic steatosis by suppressing TLR4/MD-2-mediated inflammation and endoplasmic reticulum stress Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-16 Lingzhi Wang, Wenxi Li, Yinggang Li, Gengrui Chen, Lijuan Zhao, Wu Li, Shengwei Wang, Chunming Wang, Yanxian Feng, Yibo Zhang
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Improved synthesis and application of an alkyne-functionalized isoprenoid analogue to study the prenylomes of motor neurons, astrocytes and their stem cell progenitors Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-16 Kiall F. Suazo, Vartika Mishra, Sanjay Maity, Shelby A. Auger, Katarzyna Justyna, Alexandru M. Petre, Linda Ottoboni, Jessica Ongaro, Stefania P. Corti, Francesco Lotti, Serge Przedborski, Mark D. Distefano
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Exploring cyclopropylamine containing cyanopyrimidines as LSD1 inhibitors: Design, synthesis, ADMET, MD analysis and anticancer activity profiling Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-16 Khursheed Ahmad Sheikh, Darakhshan Parveen, M. Mumtaz Alam, Faizul Azam, Mohammad Ahmed Khan, Mymoona Akhter, Sharba Tasneem, Meenu, Suhel Parvez, Khalid Imtiyaz, Moshahid A. Rizvi, M. Shaquiquzzaman
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13-Oxyingenol-dodecanoate inhibits the growth of non-small cell lung cancer cells by targeting ULK1 Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-15 Xin-Ye Wang, Yu-Jue Wang, Bo-Wen Guo, Zi-Lin Hou, Gu-Xue Zhang, Zheng Han, Qingbo Liu, Guo-Dong Yao, Shao-Jiang Song
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Design, synthesis, and biological evaluation of cathepsin B cleavage albumin-binding SN38 prodrug in breast cancer Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-14 Yingxin Lu, Ying Huang, Jiyu Jin, Jiahui Yu, Wei Lu, Shulei Zhu
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Synthesis and preclinical evaluation of a novel probe [18F]AlF-NOTA-IPB-GPC3P for PET imaging of GPC3 positive tumor Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-14 Chunwei Mo, Penghui Sun, Haoran Liang, Zihao Chen, Meng Wang, Lilan Fu, Shun Huang, Ganghua Tang
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Dual site reactivity of indole-3-Schiff bases with S/Se/Cl substituted ketenes for stereoselective C-4 substituted indole-β-lactams, biological evaluations, magic chloro effect and molecular docking studies Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-14 Kiran Sharma, Pankaj kumar, Amita Sharma, Shamsher S. Bari, Gaganpreet Bhullar, Subhash C. Sahoo, Aman Bhalla
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Effective α-glycosidase inhibitors based on polyphenolic benzothiazole heterocycles Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-12 Esra Sevimli, Gökçe Seyhan, Didem Akkaya, Suat Sarı, Burak Barut, Baybars Köksoy
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The novel small molecule E0924G dually regulates bone formation and bone resorption through activating the PPARδ signaling pathway to prevent bone loss in ovariectomized rats and senile mice Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-11 Yining Li, Chao Liu, Xiaowan Han, Ren Sheng, Li Bao, Lijuan Lei, Yexiang Wu, Quanjie Li, Yuyan Zhang, Jing Zhang, Weizhi Wang, Yuhao Zhang, Shunwang Li, Chenyin Wang, Xinwei Wei, Jingrui Wang, Zonggen Peng, Yanni Xu, Shuyi Si
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Peroxynitrite-activated fluorescent probe with two reaction triggers for pathological diagnosis and therapeutic evaluation of inflammation Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-09 Feiyan Liu, Manman Li, Weixia Li, Yingjie Ren, Mingliang Zhang, Hui Zhang, Pan Wang, Yali Wu, Kehan Wang, Xiaoyan Wang, Xiaofei Chen, Jinfa Tang
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Synthesis, structural, multitargeted molecular docking analysis of anti-cancer, anti-tubercular, DNA interactions of benzotriazole based macrocyclic ligand Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-09 P. Pon Matheswari, J. Ilavarasi Jeyamalar, Ancy Iruthayaraj, B. Ravindran Durai Nayagam
Biologically important macromolecule 1, 1′, 3, 3′ Bis − [2,3,5,6-Tetramethyl-p-phenylenebis(methylene)] dibenzotriazlinium dibromide hydrate (BTD) was synthesized and characterized using FT-IR, NMR and single-crystal XRD (SCXRD). SCXRD revealed that the compound was crystallized as a monoclinic system and associated through weak intermolecular interactions like H-bonding and π- π stacking interactions
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Discovery of novel thiophene-3-carboxamide derivatives as potential VEGFR-2 inhibitors with anti-angiogenic properties Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-09 Tai Li, Jiawei Wang, Limiao Feng, Qi Zhou, Qian Xie, Yanni Shen, Rongxin Ji, Xiaoping Liu, Yan Wang, Chun Hu
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Development of D-π-A organic dyes for discriminating HSA from BSA and study on dye-HSA interaction Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-09 Hao-Wen Cao, Yan-Song Chen, Jing-Zhi Li, Hai-Wen Chen, Lu-Yu Li, Ze-Kai Li, Ming-Qi Wang
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Discovery of a new class of potent pyrrolo[3,4-c]quinoline-1,3-diones based inhibitors of human dihydroorotate dehydrogenase: Synthesis, pharmacological and toxicological evaluation Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-09 Marina G. Dimitrijević, Cornelia Roschger, Kevin Lang, Andreas Zierer, Milica G. Paunović, Ana D. Obradović, Miloš M. Matić, Marijana Pocrnić, Nives Galić, Andrija Ćirić, Milan D. Joksović
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Rapid identifying of COX-2 inhibitors from turmeric (Curcuma longa) by bioaffinity ultrafiltration coupled with UPLC-Q Exactive-Orbitrap-MS and zebrafish-based in vivo validation Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-09 Zhenwei Lan, Rui Yang, Hu Wang, Xingyang Xue, Yue Sun, Shumei Wang, Ying Zhang, Jiang Meng
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Design, synthesis, docking, and antiviral evaluation of some novel pyrimidinone-based α-aminophosphonates as potent H1N1 and HCoV-229E inhibitors Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-08 Hend A. Hekal, Omar M. Hammad, Nasser R. El-Brollosy, Maha M. Salem, Abdou K. Allayeh
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d-type peptides based fluorescent probes for “turn on” sensing of heparin Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-08 Huan Xu, Xing-Yan Fu, Yong-Xin Bao, Shu-Ya Zhu, Zi Xu, Min Song, Yun-Kun Qi, Zhibo Li, Shan-Shan Du
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Discovery of PXR agonists from Hypericum japonicum: A class of novel nonaromatic acylphloroglucinol-terpenoid adducts Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-08 Haiguo Su, Hangfei Liang, Jianing Tian, Lei Zheng, Huilin Li, Xiao Yang, Sheng Yin, Huichang Bi
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N-Containing triterpenoid saponins from Mussaenda densiflora and identification of heinsiagenin A as a potent immunosuppressant Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-06 Xiuying Du, Dilinaer Litifu, Wenlong Yuan, Zhongxian Chen, Zhenhua Chen, Rujun Zhang, Jianping Zuo, Zemin Lin, Weimin Zhao
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Design, selective synthesis and biological activities evaluation of novel thiazol-2-ylbenzamide and thiazole-2-ylbenzimidoyl chloride derivatives Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-06 Zonghan Xu, Xiang Cheng, Hongyun Cui, Linmin Cao, Yaping Song, Xihao Chang, Dandan Wang, Xianhai Lv
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Design, synthesis, in silico and biological evaluation of new indole based oxadiazole derivatives targeting estrogen receptor alpha Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-05 Kamalpreet Kaur, Harkomal Verma, Prabhakar Gangwar, Kailash Jangid, Monisha Dhiman, Vinod Kumar, Vikas Jaitak
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Structure-guided design of novel biphenyl-quinazoline derivatives as potent non-nucleoside reverse transcriptase inhibitors featuring improved anti-resistance, selectivity, and solubility Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-05 Jin-Si Wang, Ke-Xin Zhao, Kun Zhang, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen
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Antimicrobial macrozones interact with biological macromolecules via two-site binding mode of action: Fluorimetric, NMR and docking studies Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-05 Tomislav Jednačak, Ivana Mikulandra, Kristina Smokrović, Andrea Hloušek-Kasun, Monika Kapustić, Kristina Delaš, Ivo Piantanida, Marta Jurković, Branimir Bertoša, Klaus Zangger, Predrag Novak
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Natural anti-neuroinflammatory inhibitors in vitro and in vivo from Aglaia odorata Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-04 Qianqian Yin, Gang Chen, Danyang Mu, Yuxin Yang, Jinle Hao, Bin Lin, Di Zhou, Yue Hou, Ning Li
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Design and synthesis of novel imidazole-chalcone derivatives as microtubule protein polymerization inhibitors to treat cervical cancer and reverse cisplatin resistance Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-04 Zhengye Liu, Zheng Yang, Mourboul Ablise
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Dimeric peptoids as antibacterial agents Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-03 Ghayah Bahatheg, Rajesh Kuppusamy, Muhammad Yasir, Samara Bridge, Shyam K. Mishra, Charles G. Cranfield, David StC. Black, Mark Willcox, Naresh Kumar
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Advances in the discovery of activin receptor-like kinase 5 (ALK5) inhibitors Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-03 Mai A. Mansour, Ghaneya S. Hassan, Rabah A.T. Serya, Maiy Y. Jaballah, Khaled A.M. Abouzid
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Chaetoxylariones A–G: undescribed chromone-derived polyketides from co-culture of Chaetomium virescens and Xylaria grammica enabled via the molecular networking strategy Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-03 Sitian Zhang, Lianghu Gu, Yongtong Lin, Hanxiao Zeng, Nanjin Ding, Jiangchun Wei, Xiaoxia Gu, Chang Liu, Weiguang Sun, Yuan Zhou, Yonghui Zhang, Zhengxi Hu
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Novel partially reversible NDM-1 inhibitors based on the naturally occurring houttuynin Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-03 Lifang Wang, Yaowen Liang, Pan Luo, Manna Huang, Yiqian Wan
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Bioisosteric replacement strategy leads to novel DNA gyrase B inhibitors with improved potencies and properties Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-03 Wenjie Xue, Xueping Zuo, Xueqi Zhao, Xiaomin Wang, Xiangyu Zhang, Jie Xia, Maosheng Cheng, Huali Yang
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Synthesis, physicochemical characterization, and investigation of anti-inflammatory activity of water-soluble PEGylated 1,2,4-Triazoles Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-03 Sin-Min Li, Wei-Zheng Zeng, Cheng-Yen Chung, Naoto Uramaru, Guan-Jhong Huang, Fung Fuh Wong
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Identification of benzo[b]thiophene-1,1-dioxide derivatives as novel PHGDH covalent inhibitors Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-03 Xin-Yu Cao, Xinge Li, Feng Wang, Yichen Duan, Xingmei Wu, Guo-Qiang Lin, Meiyu Geng, Min Huang, Ping Tian, Shuai Tang, Dingding Gao
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Dual inhibition of oxidative phosphorylation and glycolysis to enhance cancer therapy Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-02 Xi Sheng, Meng-Meng Wang, Guan-Dong Zhang, Yan Su, Hong-Bao Fang, Zheng-Hong Yu, Zhi Su
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Ferroptosis inducers: A new frontier in cancer therapy Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-02 Wenjing Ma, Naiyuan Hu, Wenqian Xu, Linxi Zhao, Chutong Tian, Ken-ichiro Kamei
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Discovery of a novel small-molecule activator of SIRT3 that inhibits cell proliferation and migration by apoptosis and autophagy-dependent cell death pathways in colorectal cancer Bioorgan. Chem. (IF 5.1) Pub Date : 2024-04-02 Yi Mou, Yanmei Chen, Zhichao Fan, Liansong Ye, Bing Hu, Bo Han, Guan Wang
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PI3Kδ and mTOR dual inhibitors: Design, synthesis and anticancer evaluation of 3-substituted aminomethylquinoline analogues Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-30 Digambar Yevale, Nishith Teraiya, Twinkle Lalwani, Mayur Dalasaniya, Khushal Kapadiya, Rakesh Kumar Ameta, Chetan B. Sangani, Yong-Tao Duan
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Discovery of novel quinolin-2-one derivatives as potential GSK-3β inhibitors for treatment of Alzheimer’s disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-30 Esraa Abdo Moustafa, Heba Abdelrasheed Allam, Marwa A. Fouad, Ahmed M. El Kerdawy, Nahed Nasser Eid El-Sayed, Christoph Wagner, Hatem A. Abdel-Aziz, Manal Abdel Fattah Ezzat
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Discovery of two non-UDP-mimic inhibitors of O-GlcNAc transferase by screening a DNA-encoded library Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-29 Cyril Balsollier, Simon Bijkerk, Arjan de Smit, Kevin van Eekelen, Krištof Bozovičar, Dirk Husstege, Tihomir Tomašič, Marko Anderluh, Roland J. Pieters
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Synthesis and pharmacodynamic evaluation of Dihydropteridone derivatives against PDCoV in vivo and in vitro Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-29 Kai Sun, Zhongmou Zhang, Jiani Xing, Shouye Ma, Yongzhuang Ge, Lu Xia, Xiaoqiong Diao, Yonghong Li, Zhanyong Wei, Zhenya Wang
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A novel natural Syk inhibitor suppresses IgE-mediated mast cell activation and passive cutaneous anaphylaxis Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-29 Lele Wang, Yuzhen Fang, Yuqing Ma, Zixi Zhao, Ruonan Ma, Yanling Zhang, Yanjiang Qiao, Xing Wang, Yuxin Zhang
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Discovery of novel co-degradation CK1α and CDK7/9 PROTACs with p53 activation for treating acute myeloid leukemia Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-28 Kai Wang, Meixu Jiang, Huimin Liu, Chen Meng, Mengyuan Li, Haibin Lu
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Discovery of a novel class of rosmarinic acid derivatives as antibacterial agents: Synthesis, structure-activity relationship and mechanism of action Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-28 Yong Wang, Zhiguang Liang, Yihui Cao, Cheung-Hin Hung, Ruolan Du, Alan Siu-Lun Leung, Pui-Kin So, Pak-Ho Chan, Wing-Leung Wong, Yun-Chung Leung, Kwok-Yin Wong
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Discovery and development of novel 10,12-disubstituted aloperine derivatives against HCoV-OC43 by targeting allosteric site of host TMPRSS2 Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-27 Runze Meng, Xiuli Zhong, Yue Gong, Yulong Shi, Jiayu Li, Zhiyun Wu, Qionglu Duan, Xintong Zhang, Yuheng Mei, Jingyang Zhu, Zonggen Peng, Yinghong Li, Danqing Song
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Targeted genetic and small molecule disruption of N-Ras CaaX cleavage alters its localization and oncogenic potential Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-27 Emily R. Hildebrandt, Shaneela A. Hussain, Michelle A. Sieburg, Rajani Ravishankar, Nadeem Asad, Sangram Gore, Takahiro Ito, James L. Hougland, Timothy M. Dore, Walter K. Schmidt
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New meroterpenoids and polyketides from the endophytic fungus Paraphaeosphaeria sp. C-XB-J-1 and their anti-inflammatory and SARS-CoV-2 Mpro inhibitory activities Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-27 Qi Li, Peng-Yun Yang, Chao Peng, Xing-Jie Zhang, Yun-Tao Jiang, Yan-Ping Li, Lu Gao
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The new N2, N4-diphenylpyridine-2,4-diamine deuterated derivatives as EGFR inhibitors to overcome C797S-mediated resistance Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-26 Jiadai Liu, Wenyan Nie, Haoran Nie, Han Yao, Yuanyuan Ren, Longcai Cao, Jiaqi Qiu, Mengxuan Wang, Xingshu Li, Baijiao An, Xian Jia
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Induction of breast cancer cell apoptosis by novel thiouracil-fused heterocyclic compounds through boosting of Bax/Bcl-2 ratio and DFT study Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-26 Eman Mansour, Ahmed A. Abd-Rabou, Mohamed A. El-Atawy, Hoda A. Ahmed, Ahmed F. El-Farargy, Heba K. Abd El-Mawgoud
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Structure–activity relationship and biofilm formation-related gene targets of oleanolic acid-type saponins from Pulsatilla chinensis against Candida albicans Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-25 Junfeng Tan, Zengguang Zhang, Dan Zheng, Yu Mu, Bixuan Cao, Junwei Yang, Li Han, Xueshi Huang
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The design, synthesis and bioactivity evaluation of novel androgen receptor degraders based on hydrophobic tagging Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-24 Ying Sun, Huating Wang, Yaru Li, Zhaoxiang Li, Zhihui Mao, Mengyao Zhang, Yixian Shao, Jiaqi Ye, Dan Li, Lihong Shan
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Design, synthesis and Anti-Plasmodial activity of Mortiamide-Lugdunin conjugates Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-24 Nattamon Trirattanaporn, Roonglawan Rattanajak, Kanchana Dokladda, Sumalee Kamchonwongpaisan, Panumart Thongyoo
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Discovery of cinnamylaldehyde-derived mono-carbonyl curcumin analogs as anti-gastric cancer agents via suppression of STAT3 and AKT pathway Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-24 Xi Chen, Peiqin Zhang, Huating Zhang, Xueqiang Ma, Ye Zhang, Yajie Wu, Kaiwen Jin, Jiabing Wang, Jianzhang Wu
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Design and application of a novel “turn-on” fluorescent probe for imaging sulfite in living cells and inflammation models Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-24 Kun Yao, Hua Liu, Binbin Fang, Congyang Xia, Lingmin Gu, Lin Fang, Haohao Zhu, Jie Pan, Guofu Zhang
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Discovery of sesquiterpenoids from an actinomycete Crossiella cryophila through genome mining and heterologous expression Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-22 Qian Yang, Jupeng Tian, Shungen Chen, Ziyi Yang, Zengyuan Wang, Hui-Min Xu, Liao-Bin Dong
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Accurate detection depression cell model with a dual-locked fluorescence probe in response to noradrenaline and HClO Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-22 Xinyi Xiong, Jianwen Qiu, Shaofei Fu, Biaofeng Gu, Chunli Zhong, Lan Zhao, Yong Gao
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Arylacryl amides: Design, synthesis and the protection against cisplatin-induced acute kidney injury via TLR4/STING/NF-κB pathway Bioorgan. Chem. (IF 5.1) Pub Date : 2024-03-21 Xiaoming Wu, Long Zhou, Ziyun Li, Kuanrong Rong, Shan Gao, Yun Chen, Jiawei Zuo, Wenjian Tang