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Acyl Capping Group Identity Effects on α-Helicity: On the Importance of Amide·Water Hydrogen Bonds to α-Helix Stability Biochemistry (IF 2.9) Pub Date : 2024-04-16 Megh R. Bhatt, Himal K. Ganguly, Neal J. Zondlo
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Stereospecific NANOG PEST Stabilization by Pin1 Biochemistry (IF 2.9) Pub Date : 2024-04-15 Josephine C. Ferreon, Hai Minh Ta, Hyosuk Yun, Kyoung-Jae Choi, My Diem Quan, Phoebe S. Tsoi, Choel Kim, Chul Won Lee, Allan Chris M. Ferreon
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Polyethylene Glycol Impacts Conformation and Dynamics of Escherichia coli Prolyl-tRNA Synthetase Via Crowding and Confinement Effects Biochemistry (IF 2.9) Pub Date : 2024-04-12 Jessica Liebau, Bethany F. Laatsch, Joshua Rusnak, Keegan Gunderson, Brianna Finke, Kassandra Bargender, Alex Narkiewicz-Jodko, Katelyn Weeks, Murphi T. Williams, Irina Shulgina, Karin Musier-Forsyth, Sudeep Bhattacharyya, Sanchita Hati
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Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein Biochemistry (IF 2.9) Pub Date : 2024-04-11 Jianjun Cao, Matthew J. Belousoff, Radostin Danev, Arthur Christopoulos, Denise Wootten, Patrick M. Sexton
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Contribution of a C-Terminal Extension to the Substrate Affinity and Oligomeric Stability of Aldehyde Dehydrogenase from Thermus thermophilus HB27 Biochemistry (IF 2.9) Pub Date : 2024-04-11 Wiktoria Brytan, Kim Shortall, Francisco Duarte, Tewfik Soulimane, Luis Padrela
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Substrate Specificities of Variants of Barley (1,3)- and (1,3;1,4)-β-d-Glucanases Resulting from Mutagenesis and Segment Hybridization Biochemistry (IF 2.9) Pub Date : 2024-04-10 Mu-Rong Kao, Jake Parker, Daniel Oehme, Shu-Chieh Chang, Lin-Chen Cheng, Damao Wang, Vaibhav Srivastava, John M. Wagner, Philip J. Harris, Yves S. Y. Hsieh
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4,4-Difluoroproline as a Unique 19F NMR Probe of Proline Conformation Biochemistry (IF 2.9) Pub Date : 2024-04-10 Himal K. Ganguly, Brice A. Ludwig, Caitlin M. Tressler, Megh R. Bhatt, Anil K. Pandey, Caitlin M. Quinn, Shi Bai, Glenn P. A. Yap, Neal J. Zondlo
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Correction to “Structural Elucidation of the Cell-Penetrating Penetratin Peptide in Model Membranes at the Atomic Level: Probing Hydrophobic Interactions in the Blood–Brain Barrier” Biochemistry (IF 2.9) Pub Date : 2024-04-10 Swapna Bera, Rajiv K. Kar, Susanta Mondal, Kalipada Pahan, Anirban Bhunia
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Cyanovirin-N Binding to N-Acetyl-d-glucosamine Requires Carbohydrate-Binding Sites on Two Different Protomers Biochemistry (IF 2.9) Pub Date : 2024-04-09 Irene Maier, Georg Kontaxis, Christian Zimmermann, Christoph Steininger
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Modulation of Electron Transfer Branches by Atrazine and Triazine Herbicides in Photosynthetic Reaction Centers Biochemistry (IF 2.9) Pub Date : 2024-04-08 Gai Nishikawa, Keisuke Saito, Hiroshi Ishikita
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Initial Steps in Methanobactin Biosynthesis: Substrate Binding by the Mixed-Valent Diiron Enzyme MbnBC Biochemistry (IF 2.9) Pub Date : 2024-04-08 Richard J. Jodts, Madeline B. Ho, Reyvin M. Reyes, Yun Ji Park, Peter E. Doan, Amy C. Rosenzweig, Brian M. Hoffman
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Structural, Spectroscopic, and Computational Insights from Canavanine-Bound and Two Catalytically Compromised Variants of the Ethylene-Forming Enzyme Biochemistry (IF 2.9) Pub Date : 2024-04-05 Shramana Chatterjee, Matthias Fellner, JoelA. Rankin, Midhun G. Thomas, Simahudeen Bathir J S Rifayee, Christo Z. Christov, Jian Hu, Robert P. Hausinger
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Differential Interactions of the Proteasome Inhibitor PI31 with Constitutive and Immuno-20S Proteasomes Biochemistry (IF 2.9) Pub Date : 2024-04-05 Jason Wang, Abbey Kjellgren, George N. DeMartino
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Strong Protection by 4-Hydroxyestrone against Erastin-Induced Ferroptotic Cell Death in Estrogen Receptor-Negative Human Breast Cancer Cells: Evidence for Protein Disulfide Isomerase as a Mechanistic Target for Protection Biochemistry (IF 2.9) Pub Date : 2024-04-03 Hongge Wang, Ming-Jie Hou, Lixi Liao, Peng Li, Tongxiang Chen, Pan Wang, Bao Ting Zhu
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Kinetics of Intermediate Release Enhances P450 11B2-Catalyzed Aldosterone Synthesis Biochemistry (IF 2.9) Pub Date : 2024-04-02 Juan Valentín-Goyco, Sang-Choul Im, Richard J. Auchus
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Glycerol 3-Phosphate Dehydrogenase: Role of the Protein Conformational Change in Activation of a Readily Reversible Enzyme-Catalyzed Hydride Transfer Reaction Biochemistry (IF 2.9) Pub Date : 2024-03-28 Judith R. Cristobal, Rania Hegazy, John P. Richard
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Drug Design: Do Not Forget the Supramolecular Factor Biochemistry (IF 2.9) Pub Date : 2024-03-28 Steven L. Regen
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Poacic Acid, a Plant-Derived Stilbenoid, Augments Cell Wall Chitin Production, but Its Antifungal Activity Is Hindered by This Polysaccharide and by Fungal Essential Metals Biochemistry (IF 2.9) Pub Date : 2024-03-27 Adi Yona, Micha Fridman
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Replication of [AT/TA]25 Microsatellite Sequences by Human DNA Polymerase δ Holoenzymes Is Dependent on dNTP and RPA Levels Biochemistry (IF 2.9) Pub Date : 2024-03-26 Kara G. Pytko, Rachel L. Dannenberg, Kristin A. Eckert, Mark Hedglin
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In Vitro and In Silico Explorations of the Protein Conformational Changes of Corynebacterium glutamicum MshA, a Model Retaining GT-B Glycosyltransferase Biochemistry (IF 2.9) Pub Date : 2024-03-20 Bakar A. Hassan, Jozafina Milicaj, Meka Tyson, Ramesh Karki, Yuk Y. Sham, Patrick A. Frantom, Erika A. Taylor
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Cryo-EM of the Nucleosome Core Particle Bound to Ran-RCC1 Reveals a Dynamic Complex Biochemistry (IF 2.9) Pub Date : 2024-03-19 Shuya Kate Huang, John L. Rubinstein, Lewis E. Kay
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Tryptophan-Centric Bioinformatics Identifies New Lasso Peptide Modifications Biochemistry (IF 2.9) Pub Date : 2024-03-18 Lonnie A. Harris, Hamada Saad, Kyle E. Shelton, Lingyang Zhu, Xiaorui Guo, Douglas A. Mitchell
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AQP4-DARPin1: A Chimeric Antigen Based on Scaffold Protein DARPin for Efficient Detection of AQP4-IgG in NMOSD Biochemistry (IF 2.9) Pub Date : 2024-03-18 Xiaofei Wang, Shubei Ma, Ying Bai, Xinyang Wu, Fangling Ji, Lingyun Jia
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Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization Biochemistry (IF 2.9) Pub Date : 2024-03-15 Prajakta Badve, Katlyn K. Meier
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Structural Motifs at the Telomeres and Their Role in Regulatory Pathways Biochemistry (IF 2.9) Pub Date : 2024-03-14 Abeer F R Alanazi, Gary N Parkinson, Shozeb Haider
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Characterization of a Structurally Distinct ATP-Dependent Reactivating Factor of Adenosylcobalamin-Dependent Lysine 5,6-Aminomutase Biochemistry (IF 2.9) Pub Date : 2024-03-12 Amanda L. Darbyshire, Kirsten R. Wolthers
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Correction to “Non-Steady State Analysis of Enzyme Kinetics in Real Time Elucidates Substrate Association and Dissociation Rates: Demonstration with Analysis of Firefly Luciferase Mutants” Biochemistry (IF 2.9) Pub Date : 2024-03-12 Renee Dale, Yuki Ohmuro-Matsuyama, Hiroshi Ueda, Naohiro Kato
Some of the numerical values presented in Supplemental File S2 were wrong. The corrected Supporting Information is with this Correction. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.biochem.3c00657. Corrected Supplemental File S2 (PDF) Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may
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Structure–Function Analysis of the A1 Subunit of Shiga Toxin 2 with Peptides That Target the P-Stalk Binding Site and Inhibit Activity Biochemistry (IF 2.9) Pub Date : 2024-03-11 Xiao-Ping Li, Michael J. Rudolph, Yang Chen, Nilgun E. Tumer
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RaptGen-Assisted Generation of an RNA/DNA Hybrid Aptamer against SARS-CoV-2 Spike Protein Biochemistry (IF 2.9) Pub Date : 2024-03-08 Tatsuo Adachi, Shigetaka Nakamura, Akiya Michishita, Daiki Kawahara, Mizuki Yamamoto, Michiaki Hamada, Yoshikazu Nakamura
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Glu1022.53-Mediated Early Conformational Changes in the Process of Light-Induced Green Cone Pigment Activation Biochemistry (IF 2.9) Pub Date : 2024-03-08 Takuma Sasaki, Kota Katayama, Hiroo Imai, Hideki Kandori
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Binding and Activation of LRP1-Dependent Cell Signaling in Schwann Cells Using a Peptide Derived from the Hemopexin Domain of MMP-9 Biochemistry (IF 2.9) Pub Date : 2024-03-07 John H. Kim, Aashish Shivkumar, Masaki Norimoto, Sascha Castro Lingl, Christian Seitz, Rommie E. Amaro, Steve L. Gonias, Jerry Yang, Wendy M. Campana
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Assessing Interferon Regulatory Factor 4 Complex Formation: Differential Behavior of Homocomplexes Versus Heterocomplexes Induced by Mutations Biochemistry (IF 2.9) Pub Date : 2024-03-05 Yupeng Li, Setoka Hirano, Katsuya Sato, Masatake Osawa, Hitoshi Nagaoka
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Lipid-Binding Regions within PKC-Related Serine/Threonine Protein Kinase N1 (PKN1) Required for Its Regulation Biochemistry (IF 2.9) Pub Date : 2024-03-05 Jason L. J. Lin, Hanna S. Yuan
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Zα Domain of ADAR1 Binds to an A-Form-like Nucleic Acid Duplex with Low Micromolar Affinity Biochemistry (IF 2.9) Pub Date : 2024-03-04 Parker J. Nichols, Robb Welty, Jeffrey B. Krall, Morkos A. Henen, Quentin Vicens, Beat Vögeli
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Discovery of Red-Shifting Mutations in Firefly Luciferase Using High-Throughput Biochemistry Biochemistry (IF 2.9) Pub Date : 2024-03-04 Clair M. Colee, Nicole M. Oberlag, Marcell Simon, Owen S. Chapman, Lyndsey C. Flanagan, Edison S. Reid-McLaughlin, Jordan A. Gewing-Mullins, Synaida Maiche, Devi F. Patel, Andre R. O. Cavalcanti, Aaron M. Leconte
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A Novel Dual-Fc Bispecific Antibody with Enhanced Fc Effector Function Biochemistry (IF 2.9) Pub Date : 2024-03-01 Fulai Zhou, Yinyin Ben, Hao Jiang, Siwen Tan, Guangmao Mu, Zhengxia Zha, Shuting Dong, Sheng Huang, Yijun Zhou, Ying Jin, Mark L. Chiu
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QM/MM Study of the Catalytic Mechanism and Substrate Specificity of the Aromatic Substrate C-Methyltransferase Fur6 Biochemistry (IF 2.9) Pub Date : 2024-02-29 Fan Zhao, Yoshitaka Moriwaki, Tomohiro Noguchi, Kentaro Shimizu, Tomohisa Kuzuyama, Tohru Terada
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Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of epi-Isozizaene Synthase into α-Bisabolol Synthase Biochemistry (IF 2.9) Pub Date : 2024-02-29 Samuel A. Eaton, David W. Christianson
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Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase Biochemistry (IF 2.9) Pub Date : 2024-02-28 Huiying Li, Christine D. Hardy, Cory T. Reidl, Qing Jing, Fengtian Xue, Maris Cinelli, Richard B. Silverman, Thomas L. Poulos
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Replication Bypass of the N-(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase η Biochemistry (IF 2.9) Pub Date : 2024-02-27 Rachana Tomar, Songlin Li, Martin Egli, Michael P. Stone
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Disruption of an Active Site Network Leads to Activation of C2α-Lactylthiamin Diphosphate on the Antibacterial Target 1-Deoxy-d-xylulose-5-phosphate Synthase Biochemistry (IF 2.9) Pub Date : 2024-02-23 Eucolona M. Toci, Steven L. Austin, Ananya Majumdar, H. Lee Woodcock, Caren L. Freel Meyers
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Pronucleotide Probes Reveal a Diverging Specificity for AMPylation vs UMPylation of Human and Bacterial Nucleotide Transferases Biochemistry (IF 2.9) Pub Date : 2024-02-22 Dietrich Mostert, Wilhelm Andrei Bubeneck, Theresa Rauh, Pavel Kielkowski, Aymelt Itzen, Kirsten Jung, Stephan A. Sieber
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Characterization of the Zinc Uptake Repressor (Zur) from Acinetobacter baumannii Biochemistry (IF 2.9) Pub Date : 2024-02-22 Minyong Kim, My Tra Le, Lixin Fan, Courtney Campbell, Sambuddha Sen, Daiana A. Capdevila, Timothy L. Stemmler, David P. Giedroc
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Biosynthesis of Cytidine Diphosphate-6-d-Glucitol for the Capsular Polysaccharides of Campylobacter jejuni Biochemistry (IF 2.9) Pub Date : 2024-02-22 Manas K. Ghosh, Tamari Narindoshvili, James B. Thoden, Mitchell E. Schumann, Hazel M. Holden, Frank M. Raushel
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Asparagine-85 Stabilizes a Structural Active Site Water Network in CYP121A1 of Mycobacterium tuberculosis Biochemistry (IF 2.9) Pub Date : 2024-02-21 Christopher S. Campomizzi, Patil Pranita Uttamrao, Jack J. Stallone, Thenmalarchelvi Rathinavelan, D. Fernando Estrada
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Biosynthesis of UDP-α-N-Acetyl-d-mannosaminuronic Acid and CMP-β-N-Acetyl-d-neuraminic Acid for the Capsular Polysaccharides of Campylobacter jejuni Biochemistry (IF 2.9) Pub Date : 2024-02-21 Manas K. Ghosh, Frank M. Raushel
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Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3 Biochemistry (IF 2.9) Pub Date : 2024-02-20 Isabella C. Russell, Xin Zhang, Fabian Bumbak, Samantha M. McNeill, Tracy M. Josephs, Michael G. Leeming, George Christopoulos, Hariprasad Venugopal, Maria M. Flocco, Patrick M. Sexton, Denise Wootten, Matthew J. Belousoff
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Structural Insights into the Interaction between the C-Terminal-Deleted BH3-like Motif Peptide of Hepatitis B Virus X Protein and Bcl-xL Biochemistry (IF 2.9) Pub Date : 2024-02-20 Hideki Kusunoki, Taiichi Sakamoto, Naohiro Kobayashi, Toshiyuki Kohno, Kaori Wakamatsu, Takashi Nagata
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The Biochemical Impact of Extracting an Embedded Adenylate Kinase Domain Using Circular Permutation Biochemistry (IF 2.9) Pub Date : 2024-02-15 Tom Coleman, John Shin, Jonathan J. Silberg, Yousif Shamoo, Joshua T. Atkinson
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Using Vibrio natriegens for High-Yield Production of Challenging Expression Targets and for Protein Perdeuteration Biochemistry (IF 2.9) Pub Date : 2024-02-15 Natalia Mojica, Flore Kersten, Mateu Montserrat-Canals, G. Robb Huhn III, Abelone M. Tislevoll, Gabriele Cordara, Ken Teter, Ute Krengel
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Hydrogen/Deuterium Exchange Mass Spectrometry Provides Insights into the Role of Drosophila Testis-Specific Myosin VI Light Chain AndroCaM Biochemistry (IF 2.9) Pub Date : 2024-02-15 Jing Li, Prashant N. Jethva, Henry W. Rohrs, Saketh Chemuru, Kathryn Miller, Michael L. Gross, Kathleen M. Beckingham
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Correction to “β-Hairpin Alignment Alters Oligomer Formation in Aβ-Derived Peptides” Biochemistry (IF 2.9) Pub Date : 2024-02-15 Sarah M. Ruttenberg, Adam G. Kreutzer, Nicholas L. Truex, James S. Nowick
Due to an oversight on our part, we did not properly acknowledge the Advanced Light Source Beamline that allowed the X-ray crystallographic structure determination in this manuscript. The Acknowledgments section has been rewritten as below to reflect this oversight. We thank the Advanced Light Source for allowing the acquisition of crystallographic data. Beamline 5.0.2 of the Advanced Light Source
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Biological Evaluation of Antibody-Drug Conjugates Produced by Tag-Free Lipoate Ligase A Modification Biochemistry (IF 2.9) Pub Date : 2024-02-13 Shunsuke Yamazaki, Kenichiro Ito, Tsubasa Aoki, Naoko Arashida, Tomohiro Watanabe, Tomohiro Fujii, Yutaka Matsuda
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Myomerger Induces Membrane Hemifusion and Regulates Fusion Pore Expansion Biochemistry (IF 2.9) Pub Date : 2024-02-13 Ary Lautaro Di Bartolo, Marcelo Caparotta, Luis Mariano Polo, Diego Masone
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Discrete Acyltransferases and Thioesterases in Iso-Migrastatin and Lactimidomycin Biosynthesis Biochemistry (IF 2.9) Pub Date : 2024-02-12 Andrew D. Steele, Hui Jiang, Guohui Pan, Si-Kyu Lim, Edward Kalkreuter, Thomas Kwong, Jianhua Ju, Scott Rajski, Ben Shen
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Investigating the Cytosolic Delivery of Proteins by Lipid Nanoparticles Using the Chloroalkane Penetration Assay Biochemistry (IF 2.9) Pub Date : 2024-02-09 Jing Wang, Shiying Zhang, Yamin Li, Qiaobing Xu, Joshua A. Kritzer
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Stable RNA G-Quadruplex in the 5′-UTR of Human cIAP1 mRNA Promotes Translation in an IRES-Independent Manner Biochemistry (IF 2.9) Pub Date : 2024-02-09 Aditya Singha Roy, Subhabrata Majumder, Partha Saha
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The RNA-Binding Domain of hnRNP U Extends beyond the RGG/RG Motifs Biochemistry (IF 2.9) Pub Date : 2024-02-08 Otto A. Kletzien, Deborah S. Wuttke, Robert T. Batey
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The Impact of Second-Shell Nucleotides on Ligand Specificity in Cyclic Dinucleotide Riboswitches Biochemistry (IF 2.9) Pub Date : 2024-02-08 Kathryn M. Barth, David A. Hiller, Scott A. Strobel
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BRD4354 Is a Potent Covalent Inhibitor against the SARS-CoV-2 Main Protease Biochemistry (IF 2.9) Pub Date : 2024-02-08 Yan J. Sheng, Syuan-Ting A. Kuo, Tingyuan Yang, Hanyuan E. Zhang, David H. Russell, Xin Yan, Shiqing Xu, Wenshe R. Liu, Carol A. Fierke