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Molecular determinants and signaling effects of PKA RIα phase separation Mol. Cell (IF 16.0) Pub Date : 2024-03-26 Julia C. Hardy, Emily H. Pool, Jessica G.H. Bruystens, Xin Zhou, Qingrong Li, Daojia R. Zhou, Max Palay, Gerald Tan, Lisa Chen, Jaclyn L.C. Choi, Ha Neul Lee, Stefan Strack, Dong Wang, Susan S. Taylor, Sohum Mehta, Jin Zhang
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The splicing regulators RBM5 and RBM10 are subunits of the U2 snRNP engaged with intron branch sites on chromatin Mol. Cell (IF 16.0) Pub Date : 2024-03-26 Andrey Damianov, Chia-Ho Lin, Jeffrey Huang, Lin Zhou, Yasaman Jami-Alahmadi, Parham Peyda, James Wohlschlegel, Douglas L. Black
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Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice Mol. Cell (IF 16.0) Pub Date : 2024-03-22 Oleksandra Sirozh, Anabel Saez-Mas, Bomi Jung, Laura Sanchez-Burgos, Eduardo Zarzuela, Sara Rodrigo-Perez, Ivan Ventoso, Vanesa Lafarga, Oscar Fernandez-Capetillo
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Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis Mol. Cell (IF 16.0) Pub Date : 2024-03-22 Erica M. Hildebrand, Kirill Polovnikov, Bastiaan Dekker, Yu Liu, Denis L. Lafontaine, A. Nicole Fox, Ying Li, Sergey V. Venev, Leonid A. Mirny, Job Dekker
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Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape Mol. Cell (IF 16.0) Pub Date : 2024-03-22 Prajwal C. Boddu, Abhishek K. Gupta, Rahul Roy, Bárbara De La Peña Avalos, Anne Olazabal-Herrero, Nils Neuenkirchen, Joshua T. Zimmer, Namrata S. Chandhok, Darren King, Yasuhito Nannya, Seishi Ogawa, Haifan Lin, Matthew D. Simon, Eloise Dray, Gary M. Kupfer, Amit Verma, Karla M. Neugebauer, Manoj M. Pillai
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A SIFI odyssey: Silencing the stress response amid mitochondrial import blockade to safeguard cell survival Mol. Cell (IF 16.0) Pub Date : 2024-03-21 Yuleika G. Martinez Castillo, Chantell S. Evans
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How transcription factor binding controls transcriptional bursting dynamics: A single-molecule view Mol. Cell (IF 16.0) Pub Date : 2024-03-21 Shasha Chong, Shawn Yoshida
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Integrating the response to stressed mitochondria Mol. Cell (IF 16.0) Pub Date : 2024-03-21 Elliot Dine, Richard J. Youle
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Meet the authors: Jayoung Ku, Keonyong Lee, and Yoosik Kim Mol. Cell (IF 16.0) Pub Date : 2024-03-21 Jayoung Ku, Keonyong Lee, Yoosik Kim
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ERMA (TMEM94) is a P-type ATPase transporter for Mg2+ uptake in the endoplasmic reticulum Mol. Cell (IF 16.0) Pub Date : 2024-03-20 Neelanjan Vishnu, Manigandan Venkatesan, Travis R. Madaris, Mridula K. Venkateswaran, Kristen Stanley, Karthik Ramachandran, Adhishree Chidambaram, Abitha K. Madesh, Wenli Yang, Jyotsna Nair, Melanie Narkunan, Tharani Muthukumar, Varsha Karanam, Leroy C. Joseph, Amy Le, Ayodeji Osidele, M. Imran Aslam, John P. Morrow, May C. Malicdan, Peter B. Stathopulos, Muniswamy Madesh
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A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53 Mol. Cell (IF 16.0) Pub Date : 2024-03-19 Guy Zoltsman, Thi Lieu Dang, Miriam Kuchersky, Ofrah Faust, Micael S. Silva, Tal Ilani, Anne S. Wentink, Bernd Bukau, Rina Rosenzweig
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Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1 Mol. Cell (IF 16.0) Pub Date : 2024-03-18 Tristen Wright, Meghan E. Turnis, Christy R. Grace, Xiao Li, Lauren A. Brakefield, Yong-Dong Wang, Haiyan Xu, Ewa Kaminska, Leslie K. Climer, Tresor O. Mukiza, Chi-Lun Chang, Tudor Moldoveanu, Joseph T. Opferman
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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH Mol. Cell (IF 16.0) Pub Date : 2024-03-18 Pinki Gahlot, Bojana Kravic, Giulia Rota, Johannes van den Boom, Sophie Levantovsky, Nina Schulze, Elena Maspero, Simona Polo, Christian Behrends, Hemmo Meyer
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A kinetic dichotomy between mitochondrial and nuclear gene expression processes Mol. Cell (IF 16.0) Pub Date : 2024-03-18 Erik McShane, Mary Couvillion, Robert Ietswaart, Gyan Prakash, Brendan M. Smalec, Iliana Soto, Autum R. Baxter-Koenigs, Karine Choquet, L. Stirling Churchman
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Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency Mol. Cell (IF 16.0) Pub Date : 2024-03-14 David Lando, Xiaoyan Ma, Yang Cao, Aleksandra Jartseva, Tim J. Stevens, Wayne Boucher, Nicola Reynolds, Bertille Montibus, Dominic Hall, Andreas Lackner, Ramy Ragheb, Martin Leeb, Brian D. Hendrich, Ernest D. Laue
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A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice Mol. Cell (IF 16.0) Pub Date : 2024-03-12 Xiaoding Ma, Jianli Yin, Longliang Qiao, Hang Wan, Xingwan Liu, Yang Zhou, Jiali Wu, Lingxue Niu, Min Wu, Xinyi Wang, Haifeng Ye
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Imprinted X chromosome inactivation at the gamete-to-embryo transition Mol. Cell (IF 16.0) Pub Date : 2024-03-07 Chunyao Wei, Barry Kesner, Hao Yin, Jeannie T. Lee
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H2AK119ub1 differentially fine-tunes gene expression by modulating canonical PRC1- and H1-dependent chromatin compaction Mol. Cell (IF 16.0) Pub Date : 2024-03-07 Jicheng Zhao, Jie Lan, Min Wang, Cuifang Liu, Zheng Fang, Aoqun Song, Tiantian Zhang, Liang Wang, Bing Zhu, Ping Chen, Juan Yu, Guohong Li
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CDK-independent role of D-type cyclins in regulating DNA mismatch repair Mol. Cell (IF 16.0) Pub Date : 2024-03-07 Gergely Rona, Bearach Miwatani-Minter, Qingyue Zhang, Hailey V. Goldberg, Marc A. Kerzhnerman, Jesse B. Howard, Daniele Simoneschi, Ethan Lane, John W. Hobbs, Elizabeth Sassani, Andrew A. Wang, Sarah Keegan, Daniel J. Laverty, Cortt G. Piett, Lorinc S. Pongor, Miranda Li Xu, Joshua Andrade, Anish Thomas, Piotr Sicinski, Manor Askenazi, Beatrix Ueberheide, David Fenyö, Zachary D. Nagel, Michele Pagano
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Dissection of a CTCF topological boundary uncovers principles of enhancer-oncogene regulation Mol. Cell (IF 16.0) Pub Date : 2024-03-06 Kyung Lock Kim, Gilbert J. Rahme, Viraat Y. Goel, Chadi A. El Farran, Anders S. Hansen, Bradley E. Bernstein
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Alternative splicing decouples local from global PRC2 activity Mol. Cell (IF 16.0) Pub Date : 2024-03-06 Niccolò Arecco, Ivano Mocavini, Enrique Blanco, Cecilia Ballaré, Elina Libman, Sophie Bonnal, Manuel Irimia, Luciano Di Croce
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Sister chromatid cohesion halts DNA loop expansion Mol. Cell (IF 16.0) Pub Date : 2024-03-06 Nathalie Bastié, Christophe Chapard, Axel Cournac, Sanae Nejmi, Henri Mboumba, Olivier Gadal, Agnès Thierry, Frederic Beckouët, Romain Koszul
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Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease Mol. Cell (IF 16.0) Pub Date : 2024-03-05 Kwamina Nyame, Andy Hims, Aya Aburous, Nouf N. Laqtom, Wentao Dong, Uche N. Medoh, Julia C. Heiby, Jian Xiong, Alessandro Ori, Monther Abu-Remaileh
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Structural atlas of human primary microRNAs generated by SHAPE-MaP Mol. Cell (IF 16.0) Pub Date : 2024-03-05 S. Chan Baek, Boseon Kim, Harim Jang, Kijun Kim, Il-Soo Park, Dal-Hee Min, V. Narry Kim
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Structure of the multi-subunit chloroplast RNA polymerase Mol. Cell (IF 16.0) Pub Date : 2024-02-29 Paula F.V. do Prado, Frederik M. Ahrens, Monique Liebers, Noah Ditz, Hans-Peter Braun, Thomas Pfannschmidt, Hauke S. Hillen
Chloroplasts contain a dedicated genome that encodes subunits of the photosynthesis machinery. Transcription of photosynthesis genes is predominantly carried out by a plastid-encoded RNA polymerase (PEP), a nearly 1 MDa complex composed of core subunits with homology to eubacterial RNA polymerases (RNAPs) and at least 12 additional chloroplast-specific PEP-associated proteins (PAPs). However, the architecture
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Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology Mol. Cell (IF 16.0) Pub Date : 2024-02-29 Gayathri Muthukumar, Taylor A. Stevens, Alison J. Inglis, Theodore K. Esantsi, Reuben A. Saunders, Fabian Schulte, Rebecca M. Voorhees, Alina Guna, Jonathan S. Weissman
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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis Mol. Cell (IF 16.0) Pub Date : 2024-02-28 Kaiwen Bao, Yanhui Ma, Yuan Li, Xilin Shen, Jiao Zhao, Shanshan Tian, Chunyong Zhang, Can Liang, Ziyan Zhao, Ying Yang, Kai Zhang, Na Yang, Fei-long Meng, Jihui Hao, Jie Yang, Tao Liu, Zhi Yao, Ding Ai, Lei Shi
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The proteomic landscape of genotoxic stress-induced micronuclei Mol. Cell (IF 16.0) Pub Date : 2024-02-28 Kate M. MacDonald, Shahbaz Khan, Brian Lin, Rose Hurren, Aaron D. Schimmer, Thomas Kislinger, Shane M. Harding
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Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing Mol. Cell (IF 16.0) Pub Date : 2024-02-23 Bonnie G. Su, Seychelle M. Vos
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Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation Mol. Cell (IF 16.0) Pub Date : 2024-02-23 Hao Li, Zhejian Ji, Joao A. Paulo, Steven P. Gygi, Tom A. Rapoport
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Discovery of cytosine deaminases enables base-resolution methylome mapping using a single enzyme Mol. Cell (IF 16.0) Pub Date : 2024-02-22 Romualdas Vaisvila, Sean R. Johnson, Bo Yan, Nan Dai, Billal M. Bourkia, Minyong Chen, Ivan R. Corrêa, Erbay Yigit, Zhiyi Sun
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Single-molecule tracking reveals the functional allocation, in vivo interactions, and spatial organization of universal transcription factor NusG Mol. Cell (IF 16.0) Pub Date : 2024-02-21 Hafez El Sayyed, Oliver J. Pambos, Mathew Stracy, Max E. Gottesman, Achillefs N. Kapanidis
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Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo Mol. Cell (IF 16.0) Pub Date : 2024-02-21 Jimmy K. Guo, Mario R. Blanco, Ward G. Walkup IV, Grant Bonesteele, Carl R. Urbinati, Abhik K. Banerjee, Amy Chow, Olivia Ettlin, Mackenzie Strehle, Parham Peyda, Enrique Amaya, Vickie Trinh, Mitchell Guttman
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Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting Mol. Cell (IF 16.0) Pub Date : 2024-02-20 Jerry Li, Nicholas Purser, Joanna Liwocha, Daniel C. Scott, Holly A. Byers, Barbara Steigenberger, Spencer Hill, Ishita Tripathi-Giesgen, Trent Hinkle, Fynn M. Hansen, J. Rajan Prabu, Senthil K. Radhakrishnan, Donald S. Kirkpatrick, Kurt M. Reichermeier, Brenda A. Schulman, Gary Kleiger
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UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity Mol. Cell (IF 16.0) Pub Date : 2024-02-19 Chuan He, Xixin Xing, Hsin-Yi Chen, Minling Gao, Jie Shi, Bolin Xiang, Xiangling Xiao, Yishuang Sun, Haisheng Yu, Gaoshan Xu, Yingmeng Yao, Zuosong Xie, Yujie Xing, Bugi Ratno Budiarto, Shih-Yu Chen, Yang Gao, Yu-Ru Lee, Jinfang Zhang
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Transcription factor exchange enables prolonged transcriptional bursts Mol. Cell (IF 16.0) Pub Date : 2024-02-19 Wim Pomp, Joseph V.W. Meeussen, Tineke L. Lenstra
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Protein language models-assisted optimization of a uracil-N-glycosylase variant enables programmable T-to-G and T-to-C base editing Mol. Cell (IF 16.0) Pub Date : 2024-02-19 Yan He, Xibin Zhou, Chong Chang, Ge Chen, Weikuan Liu, Geng Li, Xiaoqi Fan, Mingsun Sun, Chensi Miao, Qianyue Huang, Yunqing Ma, Fajie Yuan, Xing Chang
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Meet the authors: Nico Wahl, Georg Dechant, and Galina Apostolova Mol. Cell (IF 16.0) Pub Date : 2024-02-15 Nico Wahl, Georg Dechant, Galina Apostolova
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Transcription complexes recruit a chaperone to perform cotranscriptional processing of tRNA Mol. Cell (IF 16.0) Pub Date : 2024-02-15 Nayef Jarrous, Dhivakar Mani
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Peptidyl-tRNA hydrolase as a key player in the liberation of truncated nascent chains from the ribosomal subunit Mol. Cell (IF 16.0) Pub Date : 2024-02-15 Marina V. Rodnina
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SLC25A39 links mitochondrial GSH sensing with iron metabolism Mol. Cell (IF 16.0) Pub Date : 2024-02-15 Xiong Chen, Boyi Gan
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C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line Mol. Cell (IF 16.0) Pub Date : 2024-02-14 Ansgar Zoch, Gabriela Konieczny, Tania Auchynnikava, Birgit Stallmeyer, Nadja Rotte, Madeleine Heep, Rebecca V. Berrens, Martina Schito, Yuka Kabayama, Theresa Schöpp, Sabine Kliesch, Brendan Houston, Liina Nagirnaja, Moira K. O’Bryan, Kenneth I. Aston, Donald F. Conrad, Juri Rappsilber, Robin C. Allshire, Atlanta G. Cook, Frank Tüttelmann, Dónal O’Carroll
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Specialized replication mechanisms maintain genome stability at human centromeres Mol. Cell (IF 16.0) Pub Date : 2024-02-14 Andrea Scelfo, Annapaola Angrisani, Marco Grillo, Bethany M. Barnes, Francesc Muyas, Carolin M. Sauer, Chin Wei Brian Leung, Marie Dumont, Marine Grison, David Mazaud, Mickaël Garnier, Laetitia Guintini, Louisa Nelson, Fumiko Esashi, Isidro Cortés-Ciriano, Stephen S. Taylor, Jérôme Déjardin, Therese Wilhelm, Daniele Fachinetti
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The HRI branch of the integrated stress response selectively triggers mitophagy Mol. Cell (IF 16.0) Pub Date : 2024-02-09 Yogaditya Chakrabarty, Zheng Yang, Hsiuchen Chen, David C. Chan
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Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells Mol. Cell (IF 16.0) Pub Date : 2024-02-09 Juliette Fedry, Joana Silva, Mihajlo Vanevic, Stanley Fronik, Yves Mechulam, Emmanuelle Schmitt, Amédée des Georges, William James Faller, Friedrich Förster
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Persistence of backtracking by human RNA polymerase II Mol. Cell (IF 16.0) Pub Date : 2024-02-09 Kevin B. Yang, Aviram Rasouly, Vitaly Epshtein, Criseyda Martinez, Thao Nguyen, Ilya Shamovsky, Evgeny Nudler
RNA polymerase II (RNA Pol II) can backtrack during transcription elongation, exposing the 3′ end of nascent RNA. Nascent RNA sequencing can approximate the location of backtracking events that are quickly resolved; however, the extent and genome-wide distribution of more persistent backtracking are unknown. Consequently, we developed a method to directly sequence the extruded, “backtracked” 3′ RNA
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Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91 Mol. Cell (IF 16.0) Pub Date : 2024-02-06 Aslihan Shenol, Michael Lückmann, Mette Trauelsen, Matteo Lambrughi, Matteo Tiberti, Elena Papaleo, Thomas M. Frimurer, Thue W. Schwartz
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The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs Mol. Cell (IF 16.0) Pub Date : 2024-02-06 Shu Yang, Chun-Yuan Ting, Mary A. Lilly
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Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils Mol. Cell (IF 16.0) Pub Date : 2024-01-30 Kristian Jeppsson, Biswajit Pradhan, Takashi Sutani, Toyonori Sakata, Miki Umeda Igarashi, Davide Giorgio Berta, Takaharu Kanno, Ryuichiro Nakato, Katsuhiko Shirahige, Eugene Kim, Camilla Björkegren
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IκBζ is a dual-use coactivator of NF-κB and POU transcription factors Mol. Cell (IF 16.0) Pub Date : 2024-02-02 Aktan Alpsoy, Xiaoli S. Wu, Sujay Pal, Olaf Klingbeil, Pramod Kumar, Osama El Demerdash, Benan Nalbant, Christopher R. Vakoc
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Alternative polyadenylation determines the functional landscape of inverted Alu repeats Mol. Cell (IF 16.0) Pub Date : 2024-02-02 Jayoung Ku, Keonyong Lee, Doyeong Ku, Sujin Kim, Jongbin Lee, Hyunwoo Bang, Namwook Kim, Hyunsu Do, Hyeonjung Lee, Chunghun Lim, Jinju Han, Young-suk Lee, Yoosik Kim
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Structural basis for plasmid restriction by SMC JET nuclease Mol. Cell (IF 16.0) Pub Date : 2024-02-02 Florian Roisné-Hamelin, Hon Wing Liu, Michael Taschner, Yan Li, Stephan Gruber
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Out with the old, in with the new: Pioneer transcription factors as activators and repressors of lineage specification genes Mol. Cell (IF 16.0) Pub Date : 2024-02-01 Yang Liu, Paul A. Wade
In this issue of Molecular Cell, Matsui et al.1 examine lineage determination by pioneer transcription factors, finding that they control cell fate in cooperation with PRDM family members by repressing alternative-lineage and precocious gene expression through establishment of bivalent enhancers.
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Meet the authors: Vasty Osei Amponsa and Kylie J. Walters Mol. Cell (IF 16.0) Pub Date : 2024-02-01 Vasty Osei Amponsa, Kylie J. Walters
We talk to Vasty Osei Amponsa and Kylie J. Walters about their paper “hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50”, their journeys across continents leading them to the NCI, and how Kylie tries to foster curiosity and a sense of belonging in her lab.
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AlphaFold: Research accelerator and hypothesis generator Mol. Cell (IF 16.0) Pub Date : 2024-02-01 Elizabeth A. Campbell, Helen Walden, Johannes C. Walter, Arun K. Shukla, Martin Beck, Lori A. Passmore, H. Eric Xu
To celebrate the 50th anniversary of Cell Press and the Cell focus issue on structural biology, we discussed with scientists working across diverse fields how AlphaFold has changed their research and brought structural biology to the masses.
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DNA repair, gap suppression, or fork protection: BRCA2 needs a break! Mol. Cell (IF 16.0) Pub Date : 2024-02-01 Diego Dibitetto, Sven Rottenberg
In this issue of Molecular Cell, Lim et al.1 reveal new insights into the distinct roles of BRCA2 in coping with DNA breaks, highlighting homologous recombination as the pivotal function that affects tumorigenesis and therapy response.
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BREACHing new grounds in fragile X syndrome: Trinucleotide expansion linked to genome-wide heterochromatin domains and genome misfolding Mol. Cell (IF 16.0) Pub Date : 2024-02-01 Edda G. Schulz
In a recent study in Cell, Malachowski et al.1 show that the trinucleotide expansion in the FMR1 gene underlying fragile X syndrome triggers formation of large heterochromatin domains across the genome, resulting in the repression of synaptic genes housed within these domains.
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CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs Mol. Cell (IF 16.0) Pub Date : 2024-01-30 Rachel Anderson, Michael R. Das, Yeonji Chang, Kelsey Farenhem, Cameron O. Schmitz, Ankur Jain
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COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells Mol. Cell (IF 16.0) Pub Date : 2024-01-30 Ludovic Pelosi, Laura Morbiato, Arthur Burgardt, Fiorella Tonello, Abigail K. Bartlett, Rachel M. Guerra, Katayoun Kazemzadeh Ferizhendi, Maria Andrea Desbats, Bérengère Rascalou, Marco Marchi, Luis Vázquez-Fonseca, Caterina Agosto, Giuseppe Zanotti, Morgane Roger-Margueritat, María Alcázar-Fabra, Laura García-Corzo, Ana Sánchez-Cuesta, Plácido Navas, Gloria Brea-Calvo, Eva Trevisson, Fabien Pierrel
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Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute Mol. Cell (IF 16.0) Pub Date : 2024-01-30 Longyu Wang, Wanping Chen, Chendi Zhang, Xiaochen Xie, Fuyong Huang, Miaomiao Chen, Wuxiang Mao, Na Yu, Qiang Wei, Lixin Ma, Zhuang Li