显示样式:     当前分类: 材料    当前期刊: Biomaterials Science    加入关注    导出
我的关注
我的收藏
您暂时未登录!
登录
  • Precision gas therapy using intelligent nanomedicine
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-12
    Qianjun He
    更新日期:2017-09-22
  • Targeting ligand-functionalized photothermal scaffolds for cancer cell capture and in-situ ablation
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-21
    Jing Zhang, Jingchao Li, Xiuhui Wang, Naoki Kawazoe, Guoping Chen

    Scaffolds have been explored as a useful carrier to deliver efficient photothermal conversion agents for localized photothermal therapy applications because they can constrain the agents in designated regions. However, cell capture by porous structures cannot discriminate cancer cells and normal cells. In this study, folic acid (FA) as a typical targeting ligand for cancer cells was introduced in the porous photothermal scaffolds. Poly-L-lysine was mixed with gelatin to increase amino side groups for FA incorporation. By changing Poly-L-lysine amount, the number of free amino groups in the scaffolds could be controlled. After reaction with activated FA, composite scaffolds with different FA incorporation amount were prepared. Cell culture results showed that the FA-functionalized photothermal scaffolds could efficiently capture folate-positive cervical cancer cells compared with gelatin scaffold. The capture efficiency increased with the increase of FA amount in the scaffolds. Furthermore, cancer cells in the FA-functionalized photothermal scaffolds can be efficiently killed during near-infrared laser irradiation. The results indicated that the FA-functionalized photothermal scaffolds had good cancer cell capture ability and excellent cancer cells ablation efficacy, which may provide useful information for the design of multifunctional scaffolds with cancer cell capture capacity and photothermal ablation ability.

    更新日期:2017-09-21
  • Engineering highly swellable dual-responsive protein-based injectable hydrogels: The effects of molecular structure and composition in vivo
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-21
    V.H. Giang Phan, Thavasyappan Thambi, Bong Sup Kim, Dai Phu Huynh, Doo Sung Lee

    Stimuli-responsive hydrogels, known as smart hydrogels, are three-dimensional amphiphilic or hydrophilic polymer networks that are able to change their volume or phase, and other properties, including viscosity, structure, and dimension, in response to change in pH, temperature, and magnetic or electric field. Highly swellable, dual-responsive bovine serum albumin (BSA)-based injectable hydrogels are here prepared by the chemical conjugation of pH- and temperature-responsive oligo(sulfamethazine acrylate-co-N-isopropyacrylamide) (oligo(SMA-co-NIPAM)) copolymers on the surface of BSA through carbodiimide-mediated chemistry. The pH- and temperature-responsive oligomer-bearing BSA conjugates show rapid sol-to-gel phase transition properties. Specifically, the free flowing conjugates at high pH (pH 8.4, 23 °C) are transformed to a viscoelastic gel at the physiological condition (pH 7.4, 37 °C). The swelling ratio, gel strength, and pore size of the BSA hydrogel was tuned by altering the conjugation ratio of various lengths and compositions of oligo(SMA-co-NIPAM) copolymers to BSA. Subcutaneously administered BSA conjugate sols into the dorsal region of Sprague-Dawley rats formed an in situ gel. When the oligo(NIPAM) content in the hydrogel was high, the degradation rate of BSA hydrogels was remarkably slow, and two weeks after in vivo administration, the hydrogels with high oligo(NIPAM) had swollen more than 4-fold. An in vivo biodegradation study demonstrated that no necrosis or hemorrhage was observed in the tissues with the hydrogels. The concurrent stimuli-responsivity at the physiological condition and high elasticity suggests that these smart hydrogels may open a new avenue for hydrogel applications.

    更新日期:2017-09-21
  • Novel Poly(Vinyl Alcohol)-Based Amphiphilic Nanogels by Non-Covalent Boric Acid Crosslinking of Polymeric Micelles
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-21
    Hen Moshe, Yuval Davizon, Maya Menaker Raskin, Alejandro Sosnik

    In this work, we report on a new type of poly(vinyl alcohol)-g-poly(N-isopropylacrylamide) (PVA-g-PNiPAAm) amphiphilic nanogel produced by the non-covalent crosslinking of PVA polyol domains in preformed polymeric micelles with boric acid. The nanomaterials showed sizes in the 100-250 nm range (DLS) and a spherical morphology (HR-SEM). We demonstrated that the size of the polymeric micelles could be fine-tuned by changing the concentration (and the aggregation pattern) of the polymeric amphiphile in water. Upon crosslinking, the polymeric micelles turned into physically stable amphiphilic nanogels that displayed size and size distribution similar to the micellar precursor for up to two weeks, even under disfavored conditions of concentration and temperature that, in the case of non-crosslinked counterparts, resulted in fast disassembly. In addition, we show for the first time the feasibility of the spray-drying technology to consolidate the 3D network formed between PVA and boric acid and to produce stable powders that can be reconstituted upon use at any desired concentration. Moreover, the formation of a borated surface conferred the nanogels with good mucoadhesiveness in vitro. Finally, these novel nanomaterials showed optimal cell compatibility in a model of the intestinal epithelium, the Caco2 cell line. Overall results demonstrate the unprecedented versatility of the proposed modular approach and opens completely new horizons in the application of polymeric micelles and other self-assembly polymeric nanomaterials in diagnostics and therapeutics.

    更新日期:2017-09-21
  • Orthogonal enzymatic reactions for rapid crosslinking and dynamic tuning of PEG-peptide hydrogels
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-21
    Matthew Robert Arkenberg, Chien-Chi Lin

    Stiffening of the extracellular matrix is a hallmark in cancer progression, embryonic development, and wound healing. To mimic this dynamic process, our work explored orthogonal enzymatic reactions capable of modulating properties of poly(ethylene glycol) (PEG)-peptide hydrogels. A hepta-mutant bacterial transpeptidase Sortase A (SrtA7M) was used to ligate two PEG-peptide macromers (i.e., PEG-YLPRTG and NH2-GGGG-PEG) into a primary hydrogel network. The hydrogels were dynamically stiffened using mushroom tyrosinase (MT), which oxidized tyrosine residues into di-tyrosine and led to increased matrix stiffness. After confirming the expression and enhanced catalytic activity of SrtA7M, we investigated the cytocompatibility of the enzymatic reaction with a mouse insulinoma cell line, MIN6. In addition, we altered peptide substrate concentrations and evaluated their influence on primary hydrogel network properties and MT-triggered stiffening. Using a pancreatic cancer cell line, COLO-357, the effect of MT-triggered stiffening on spheroid formation was investigated. We found that cell spheroids formed in hydrogels that were exposed to MT were significantly smaller than spheroids formed without MT incubation, suggesting matrix stiffening played a crucial role in the sizes of cancer cell spheroids. Through utilizing highly specific and orthogonal enzymatic reactions, this hydrogel platform permits rapid and mild in situ cell encapsulation, as well as dynamic control of matrix stiffness for investigating the role of matrix stiffening on cell fate processes.

    更新日期:2017-09-21
  • Design and Development of Polysaccharide Hemostatic Materials and Their Hemostatic Mechanism
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-20
    Xiao Yang, Wen Liu, Na Li, Mingshan Wang, Bin Liang, Ihsan Ullah, Agnaldo Luis Neve, Yakai Feng, Hao Chen, Changcan Shi

    The formation of stable blood clots or hemostasis is essential to prevent major blood loss and death from excessive bleeding. However, the body’s own coagulation process is not able to accomplish hemostasis timely without the assistance of hemostatic agents. For developing the novel topical hemostatic agents, tissue adhesives and sealants, it is necessary to understand the coagulation process and hemostasis mechanism of different materials. Among hemostatic materials, polysaccharide is naturally derived polymer having excellent biodegradable and biocompatible properties. This review provides an overview of polysaccharide-based hemostatic materials and agents, including their advantages and drawbacks in the hemostatic application. Furthermore, the polysaccharide-based hemostatic materials with functions of anti-microbial and healing are also introduced.

    更新日期:2017-09-20
  • Nucleobase-modified polyamidoamine-mediated miR-23b delivery to inhibit the proliferation and migration of lung cancer
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-18
    Haobo Han, Jiebing Yang, Yudi Wang, Wenqi Chen, Jiawen Chen, Yan Yang, Quanshun Li

    The nucleobase analogue 2-amino-6-chloropurine was modified on the surface of polyamidoamine (PAMAM) to construct a derivative AP-PAMAM, and then it was used as a gene carrier for miR-23b delivery to achieve the anti-tumor effects. The carrier AP-PAMAM could condense miR-23b into stable nanoparticles with particle size of 97.3 nm (N/P ratio of 50), which was favorable for the cellular uptake of nanoparticles. Compared with PAMAM, AP-PAMAM exhibited obviously enchanced transfection efficiency through the transfection asssy of plasmids pEGFP-N3 and pGL-3. Using human lung adenocarcinoma cell line A549 as a model, AP-PAMAM-mediated miR-23b delivery could achieve stronger anti-proliferative effect than PAMAM/miR-23b. The inhibition of cell proliferation was elucidated to be associated with the apoptotic induction (apoptotic ratio of 23.2%) and S phase arrest owing to the decreased expression level of cyclin D1. Meanwhile, AP-PAMAM-mediated miR-23b delivery could suppress the cell migration and invasion of cancer cells through wound healing and Transwell migration assays. In summary, the PAMAM derivative-mediated miR-23b delivery could be a promising strategy for achieving tumor gene therapy.

    更新日期:2017-09-18
  • Thermo-rheological Responsive Microcapsules for Time-Dependent Controlled Release of Human Mesenchymal Stromal Cells
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-18
    Wing Cheung Mak, Brice Magne, Kwan Yee Cheung, Diana Atanasova, May Griffith

    Human mesenchymal stromal cells (hMSCs) are adult-source cells that have been extensively evaluated for cell-based therapies. hMSCs delivered by intravascular injection have been reported to accumulate at sites of injury to promote tissue repair and can also be employed as vectors for delivery of therapeutic genes. However, the full potential of hMSCs remains limited as the cells are lost after injection due to anoikis and the adverse pathologic environment. Encapsulation of cells has been proposed as a means of increasing cell viability. However, controlling the release of the therapeutic cells over time to target tissue still remains a challenge today. Here, we report the design and development of thermo-rheological responsive hydrogels that allow for precise, time dependent controlled-release of hMSCs. The encapsulated hMSCs retained good viability from 76% to 87% dependent upon the hydrogel compositions. We demonstrated the design of different blended hydrogel composites with modulated strengthen (S parameter) and looseness of hydrogel networks (N parameter) to control the release of hMSCs from the thermos-responsive hydrogel capsules. We further showed the feasibility on controlled-release of encapsulated hMSCs within 3D matrix scaffolds. We reported for the first time by a systematic analysis that there is a direct correlation between the thermo-rheological properties associated with the degradation of the hydrogel composite and the cell release kinetics. This work therefore provides new insights for further development of smart carrier systems for stem cell therapy.

    更新日期:2017-09-18
  • pH and redox dual-sensitive polysaccharide nanoparticles for the efficient delivery of doxorubicin
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-04
    Shengcai Yang, Zhaohui Tang, Dawei Zhang, Mingxiao Deng, Xuesi Chen
    更新日期:2017-09-15
  • Recent developments in the synthesis, properties, and biomedical applications of core/shell superparamagnetic iron oxide nanoparticles with gold
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-30
    Sandip Sabale, Priyanka Kandesar, Vidhya Jadhav, Rachel Komorek, Radha Kishan Motkuri, Xiao-Ying Yu
    更新日期:2017-09-13
  • Precision Gas Therapy by Intelligent Nanomedicines
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-12
    Qianjun He

    Gas therapy is an emerging and promising field owing to unique therapeutic effects of several kinds of gases (NO, CO, H2S and H2) in many major diseases including cancer and cardiovascular diseases, and is also facing the challenges in enhancing gas therapy efficacy and avoiding gas poisoning risk. Here, we have proposed a new concept of precision gas therapy by the nanomedicine strategy to overcome the challenges. In this perspective, we have addressed a series of existing and potential solutions from the view of nanomedicine, and conveyed a collection of opinions about the future expandable researches of precision gas therapy.

    更新日期:2017-09-12
  • Development of drug-loaded polymer microcapsules for treatment of epilepsy
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-07
    Yu Chen, Qi Gu, Zhilian Yue, Jeremy M. Crook, Simon E. Moulton, Mark J. Cook, Gordon G. Wallace
    更新日期:2017-09-12
  • Neural stem cell proliferation and differentiation in the conductive PEDOT-HA/Cs/Gel scaffold for neural tissue engineering
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-29
    Shuping Wang, Shui Guan, Jianqiang Xu, Wenfang Li, Dan Ge, Changkai Sun, Tianqing Liu, Xuehu Ma
    更新日期:2017-09-12
  • Hydration of hydrogels regulates vascularization in vivo
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-07
    Jie Wu, Kunxi Zhang, Xi Yu, Jianxun Ding, Lei Cui, Jingbo Yin

    The key barrier to clinical applications of tissue engineering scaffolds is the limitation of rapid and sufficient vascularization. Adipose-derived stem cells (ASCs), especially multicellular aggregates, exhibited a promising angiogenic activity. Herein, we designed a series of poly(L-glutamic acid) (PLGA)-based hydrogels with tunable hydration to control in situ formation of multicellular spheroids. Oligo(ethylene glycol)s (OEGs) were employed to regulate the hydration of hydrogels. The hydrogel cross-linked with ethylene glycol (OEG1) supported the most excellent adhesion and proliferation of human ASCs in vitro. However, the adherent ASCs were gradually replaced with multicellular spheroids in higher hydration of hydrogels. Moreover, the in situ formation of spheroids was more effective to upregulate hypoxia-adaptive signals (e.g., hypoxia-inducible factor-1α, HIF-1α) and enhance secretion of angiogenic factors (e.g., vascular endothelial growth and factor (VEGF) and fibroblast growth factor 2 (FGF-2)) compared to adherent cells in OEG1 hydrogels. The hydrogel cross-linked with oligo(ethylene glycol)400 (OEG9) carrying spheroids induced a high angiogenic response of host tissue in vivo, resulting in an improved system vascularization, compared to adherent cells in OEG1 hydrogel. These features indicated that the PLGA-based hydrogels were expected to be applied toward bone and fat tissue regeneration.

    更新日期:2017-09-07
  • Peptides, polypeptides and peptide–polymer hybrids as nucleic acid carriers
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-07
    Marya Ahmed
    更新日期:2017-09-07
  • Development of drug-loaded polymer microcapsules for treatment of epilepsy
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-07
    Yu Chen, Qi Gu, Zhilian Yue, Jeremy M Crook, Simon Moulton, Mark Cook, Gordon G. Wallace

    Despite significant progress in developing new drugs for seizure control, epilepsy still affects 1% of the global population and is drug-resistant in more than 30% of cases. To improve the therapeutic efficacy of epilepsy medication, a promising approach is to deliver anti-epilepsy drugs directly to affected brain areas using local drug delivery systems. The drug delivery systems must meet a number of criteria, including high drug loading efficiency, biodegradability, neuro-cytocompatibility and predictable drug release profiles. Here we report the development of fibre- and sphere-based microcapsules that exhibit controllable uniform morphologies and drug release profiles as predicted by mathematical modelling. Importantly, both forms of fabricated microcapsules are compatible with human brain derived neural stem cells and their differentiation to neurons and supporting neuroglia, indicating clinical compliance for neural transplantation and therapeutic drug delivery.

    更新日期:2017-09-07
  • 3D printed poly(ε-caprolactone) scaffolds modified with hydroxyapatite and poly(propylene fumarate) and their effects on the healing of rabbit femur defects
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-22
    Senem Buyuksungur, Tugba Endogan Tanir, Arda Buyuksungur, Ezgi Irem Bektas, Gamze Torun Kose, Deniz Yucel, Tahsin Beyzadeoglu, Engin Cetinkaya, Cagri Yenigun, Ergin Tönük, Vasif Hasirci, Nesrin Hasirci
    更新日期:2017-09-07
  • Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-28
    A. E. Pentecost, C. E. Witherel, Y. Gogotsi, K. L. Spiller
    更新日期:2017-09-06
  • pH and redox dual-sensitive polysaccharide nanoparticles for efficient delivery of doxorubicin
    Biomater. Sci. (IF 4.21) Pub Date : 2017-09-04
    Shengcai Yang, Zhaohui Tang, Dawei Zhang, Mingxiao Deng, Xuesi Chen

    pH and redox dual-sensitive biodegradable polysaccharide, succinic acid decorated dextran-g-phenylalanine ethyl ester-g-cysteine ethyl ester (Dex-SA-L-Phe-L-Cys), were synthesized to load doxorubicin hydrochloride (DOX•HCl). The DOX-loaded nanoparticles, which were prepared in aqueous solution and free of organic solvent, could spontaneously self-assemble into uniform size. When loading DOX•HCl, mercapto Dex-SA-L-Phe-L-Cys was oxidized into crosslinked disulfide linkage to form pH and redox dual-sensitive nanoparticles (DOX-S-NPs). The amphiphilic polymer loaded DOX•HCl into core through electrostatic and hydrophobic interactions, meanwhile the crosslinked disulfide bond could stabilize the drug loaded nanoparticles. As a control with similar polymer structure, succinic acid decorated dextran-g-phenylalanine ethyl ester (Dex-SA-L-Phe) was prepared to obtain pH-sensitive DOX-loaded micelles (DOX-N-NPs). The controlled pH and redox-dependent release profiles of DOX-S-NPs in vitro were certified in different releasing mediums. Furthermore, the cellular uptake of DOX-S-NPs were comparable with free DOX•HCl, determined by confocal laser scanning microscopy (CLSM) and flow cytometry. Cytotoxicity assay in vitro showed that the DOX-S-NPs and free DOX•HCl were similar in inhibiting the proliferation of non-small cell lung carcinoma A549 and breast cancer MCF-7 cell lines. DOX-S-NPs displayed similar antitumor efficiency compared with free DOX•HCl, but lower toxicity in body weight. These dual-sensitive DOX-S-NPs provided a useful strategy for anti-tumor therapy.

    更新日期:2017-09-04
  • Recent development in synthesis, properties, and biomedical applications of core/shell superparamagnetic iron oxide nanoparticles with gold
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-30
    Sandip R. Sabale, Priyanka Kandesar, Vidhya Jadhav, Rachel Komorek, Radha Kishan Motkuri, Xiao-Ying Yu

    In the last decade, magnetic nanoparticles (MNPs), especially superparamagnetic iron oxide nanoparticles (SPIONs), have immensely promoted the advancement of diagnostics and theranostics in the biomedical field. Unique properties of SPIONs-core and the functional gold (Au)-shell in consortium (SPIONS/Au core/shell or CS), have a wide range of biomedical applications including but not limited to magnetic resonance imaging (MRI), dual modality MRI/computed tomography (CT), photo-induced and magnetic fluid hyperthermia (MFH), drug delivery, biosensors, and bio-separation. Researchers have made much effort to develop the synthesis strategies for size control and surface modifications to achieve the desired properties of these CSs for applications in in vitro and in vivo studies. This review highlights recent development in the synthesis and biomedical applications of SPIONs/Au CSs including γ-Fe2O3/Au (maghemite), Fe3O4/Au (magnetite), and MFe2O4/Au (M=divalent metal ions) in the past seven years. More importantly, current trends of SPIONs/Au in relation to the biochemical industry are surveyed. Finally, we outline the developmental need of SPIONs/Au with a perspective in material synthesis and their novel applications in disease diagnosis and treatment in the near future.

    更新日期:2017-08-30
  • Understanding the metal mediated assembly and hydrogel formation of a β-hairpin peptide
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-24
    Luis M. De Leon-Rodriguez, Yacine Hemar, Alok K. Mitra, Margaret A. Brimble
    更新日期:2017-08-30
  • Neural stem cells proliferation and differentiation in the conductive PEDOT-HA/Cs/Gel scaffold for neural tissue engineering
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-29
    Shuping Wang, Shui Guan, Jianqiang Xu, Wenfang Li, Dan Ge, Changkai Sun, Tianqing Liu, Xuehu Ma

    Engineering scaffolds with excellent electro-activity are increasingly important to tissue engineering and regenerative medicine. Herein, conductive poly(3,4-ethylenedioxythiophene) doped with hyaluronic acid (PEDOT-HA) nanoparticles were firstly synthesized via chemical oxidant polymerization. Three-dimension (3D) PEDOT-HA/Cs/Gel scaffold was then developed by introducing PEDOT-HA nanoparticles into the chitosan/gelatin (Cs/Gel) matrix. HA, as a bridge, not only was used as a dopant, but also combined PEDOT into the Cs/Gel via chemical crosslinking. The PEDOT-HA/Cs/Gel scaffold was used as a conductive substrate for neural stem cells (NSCs) culture in vitro. The results demonstrated PEDOT-HA/Cs/Gel scaffold had excellent biocompatibility for NSCs proliferation and differentiation. 3D confocal fluorescence images showed cells attached on the channel surface of Cs/Gel and PEDOT-HA/Cs/Gel scaffold with normal neuronal morphology. Compared to Cs/Gel scaffold, PEDOT-HA/Cs/Gel scaffold not only promoted NSCs proliferation with up-regulated expression of Ki67, but also enhanced NSC differentiation into neurons and astrocytes with up-regulated expression of β tubulin-III and GFAP, respectively. It is expected that this electro-active and bio-active PEDOT-HA/Cs/Gel scaffold will be used as a conductive platform to regulate NSCs behaviors for neural tissue engineering.

    更新日期:2017-08-29
  • Gd3+-Functionalized gold nanoclusters for fluorescence–magnetic resonance bimodal imaging
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-15
    Guohai Liang, Lifu Xiao
    更新日期:2017-08-29
  • Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-28
    Amanda E Pentecost, Claire E Witherel, Yury Gogotsi, Kara L Spiller

    Chronic inflammatory disorders such as rheumatoid arthritis are characterized by excessive pro-inflammatory or “M1” activation of macrophages, the primary cells of the innate immune system. Current treatments include delivery of glucocorticoids (e.g. dexamethasone - Dex), which reduce pro-inflammatory M1 behaviour in macrophages. However, these treatments have many off-target effects on cells other than macrophages, resulting in broad immunosuppression. To limit such side effects, drug-incorporated nano- and microparticles may be used to selectively target macrophages via phagocytosis, because of their roles as highly effective phagocytes in the body. In this study, surface-modified nanodiamond (ND) was explored as a platform for the delivery of dexamethasone to macrophages because of ND’s rich surface chemistry, which contributes to ND’s high potential as a versatile drug delivery platform. After finding that octadecylamine-functionalized nanodiamond (ND-ODA) enhanced adsorption of Dex compared to carboxylated ND, the effects of Dex, ND-ODA, and Dex-adsorbed ND-ODA on primary human macrophage gene expression were characterized. Surprisingly, even in the absence of Dex, ND-ODA had strong anti-inflammatory effects, as determined by multiplex gene expression via NanoString and by protein secretion analysis via ELISA. ND-ODA also inhibited expression of M2a markers yet increased the expression of M2c markers and phagocytic receptors. Interestingly, the adsorption of Dex to ND-ODA further increased some anti-inflammatory effects, but abrogated the effect on phagocytic receptors, compared to its individual components. Overall, the ability of ND-ODA to promote anti-inflammatory and pro-phagocytic behaviour in macrophages, even in the absence of loaded drugs, suggests its potential for use as an anti-inflammatory therapeutic to directly target macrophages through phagocytosis.

    更新日期:2017-08-28
  • Understanding the Metal Mediated Assembly and Hydrogel Formation of a β-Hairpin Peptide
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-24
    Luis Manuel M De Leon Rodriguez, Yacine Hemar, Alok Mitra, Margaret A Brimble

    We report the design and characterization of a peptide that assembles as β-hairpins and forms hydrogels under physiological conditions. These hydrogels formed both in the absence and presence of several metal ions and displayed characteristic sheer-thinning properties. In particular, in the presence of Zn2+, we observed a novel hydrogel that proceeded via an inter/intra molecular metal-coordination mechanism-inter-molecular assembly that was previously reported instead to promote amyloid type aggregates.

    更新日期:2017-08-24
  • Functionalized lignin biomaterials for enhancing optical properties and cellular interactions of dyes
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-14
    Anthony N. Cauley, James N. Wilson
    更新日期:2017-08-23
  • Surface-modified polymers for cardiac tissue engineering
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-03
    Ambigapathi Moorthi, Yu-Chang Tyan, Tze-Wen Chung
    更新日期:2017-08-23
  • Recent advances in biomaterials for the treatment of diabetic foot ulcers
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-15
    Lisa N. Kasiewicz, Kathryn A. Whitehead
    更新日期:2017-08-22
  • Nanocellulosic materials as bioinks for 3D bioprinting
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-14
    Carmen C. Piras, Susana Fernández-Prieto, Wim M. De Borggraeve
    更新日期:2017-08-22
  • Alginate-based hydrogels functionalised at the nanoscale using layer-by-layer assembly for potential cartilage repair
    Biomater. Sci. (IF 4.21) Pub Date : 2017-07-18
    P. Gentile, C. Ghione, A. M. Ferreira, A. Crawford, P. V. Hatton
    更新日期:2017-08-22
  • Cyclodextrin-based biological stimuli-responsive carriers for smart and precision medicine
    Biomater. Sci. (IF 4.21) Pub Date : 2017-07-10
    Rongqiang Liao, Pin Lv, Qian Wang, Jiaoni Zheng, Bing Feng, Bo Yang
    更新日期:2017-08-22
  • Tripartite polyionic complex (PIC) micelles as non-viral vectors for mesenchymal stem cell siRNA transfection
    Biomater. Sci. (IF 4.21) Pub Date : 2017-07-07
    Sophie Raisin, Marie Morille, Claire Bony, Danièle Noël, Jean-Marie Devoisselle, Emmanuel Belamie
    更新日期:2017-08-22
  • Cationic folate-mediated liposomal delivery of bis-arylidene oxindole induces efficient melanoma tumor regression
    Biomater. Sci. (IF 4.21) Pub Date : 2017-07-03
    Chandra Kumar Elechalawar, Kathyayani Sridharan, Abhishek Pal, Mohammed Tanveer Ahmed, Mohammed Yousuf, Susanta Sekhar Adhikari, Rajkumar Banerjee
    更新日期:2017-08-22
  • Synthesis of controlled, high-molecular weight poly(L-glutamic acid) brush polymers
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-30
    Ryan Baumgartner, Diane Kuai, Jianjun Cheng
    更新日期:2017-08-22
  • 更新日期:2017-08-22
  • Gemcitabine–camptothecin conjugates: a hybrid prodrug for controlled drug release and synergistic therapeutics
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-23
    Meili Hou, Peng Xue, Yong-E. Gao, Xiaoqian Ma, Shuang Bai, Yuejun Kang, Zhigang Xu
    更新日期:2017-08-22
  • 3D printed porous ceramic scaffolds for bone tissue engineering: a review
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-23
    Yu Wen, Sun Xun, Meng Haoye, Sun Baichuan, Chen Peng, Liu Xuejian, Zhang Kaihong, Yang Xuan, Peng Jiang, Lu Shibi
    更新日期:2017-08-22
  • Iodine-131-labeled, transferrin-capped polypyrrole nanoparticles for tumor-targeted synergistic photothermal-radioisotope therapy
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-21
    Xuejiao Song, Chao Liang, Liangzhu Feng, Kai Yang, Zhuang Liu
    更新日期:2017-08-22
  • Fibroblast fate regulation by time dependent TGF-β1 and IL-10 stimulation in biomimetic 3D matrices
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-20
    Jiranuwat Sapudom, Xiancheng Wu, Marina Chkolnikov, Michael Ansorge, Ulf Anderegg, Tilo Pompe
    更新日期:2017-08-22
  • Design, preparation and performance of a novel drug-eluting stent with multiple layer coatings
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-20
    Tingzhang Hu, Song Lin, Ruolin Du, Meiling Fu, Qiong Rao, Tieying Yin, Yan Huang, Guixue Wang
    更新日期:2017-08-22
  • Impact of the biomolecular corona on the structure of PEGylated liposomes
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-19
    Luca Digiacomo, Daniela Pozzi, Heinz Amenitsch, Giulio Caracciolo
    更新日期:2017-08-22
  • Novel fibrous collagen-based cream accelerates fibroblast growth for wound healing applications: in vitro and in vivo evaluation
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-19
    Sivalingam Udhayakumar, Krishnakumar Gopal Shankar, Sampath Sowndarya, Chellan Rose
    更新日期:2017-08-22
  • Anti-oxidant and immune-modulatory properties of sulfated alginate derivatives on human chondrocytes and macrophages
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-16
    Anne Kerschenmeyer, Øystein Arlov, Vera Malheiro, Matthias Steinwachs, Markus Rottmar, Katharina Maniura-Weber, Gemma Palazzolo, Marcy Zenobi-Wong
    更新日期:2017-08-22
  • Carbon dots for tracking and promoting the osteogenic differentiation of mesenchymal stem cells
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-14
    Dan Shao, Mengmeng Lu, Duo Xu, Xiao Zheng, Yue Pan, Yubin Song, Jinying Xu, Mingqiang Li, Ming Zhang, Jing Li, Guangfan Chi, Li Chen, Bai Yang
    更新日期:2017-08-22
  • MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrin
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-13
    Bo Wu, Xiao-Qi Li, Tong Huang, Shu-Ting Lu, Bing Wan, Ru-Fang Liao, Yu-Shuang Li, Aju Baidya, Qing-Yun Long, Hai-Bo Xu
    更新日期:2017-08-22
  • Bilayered nanofibrous 3D hierarchy as skin rudiment by emulsion electrospinning for burn wound management
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-13
    Pallabi Pal, Prabhash Dadhich, Pavan Kumar Srivas, Bodhisatwa Das, Dhrubajyoti Maulik, Santanu Dhara
    更新日期:2017-08-22
  • Bioinspired onion epithelium-like structure promotes the maturation of cardiomyocytes derived from human pluripotent stem cells
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-12
    Cong Xu, Li Wang, Yue Yu, Fangchao Yin, Xiaoqing Zhang, Lei Jiang, Jianhua Qin
    更新日期:2017-08-22
  • ε-Polylysine-based thermo-responsive adsorbents for immunoglobulin adsorption–desorption under mild conditions
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-08
    Masashi Maruyama, Keisuke Shibuya
    更新日期:2017-08-22
  • A collagen telopeptide binding peptide shows potential in aiding collagen bundle formation and fibril orientation
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-08
    Wenyu Yang, Lin Li, Guanghao Su, Zhe Zhang, Yiting Cao, Xuemin Li, Yanping Shi, Qiqing Zhang
    更新日期:2017-08-22
  • Synchronization of excitable cardiac cultures of different origin
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-07
    N. N. Agladze, O. V. Halaidych, V. A. Tsvelaya, T. Bruegmann, C. Kilgus, P. Sasse, K. I. Agladze
    更新日期:2017-08-22
  • Keratin: dissolution, extraction and biomedical application
    Biomater. Sci. (IF 4.21) Pub Date : 2017-05-31
    Amin Shavandi, Tiago H. Silva, Adnan A. Bekhit, Alaa El-Din A. Bekhit
    更新日期:2017-08-22
  • 3D Printed Poly(ε-caprolactone) Scaffolds Modified with Hydroxyapatite and Poly(propylene fumarate) and Effects on Healing of Rabbit Femur Defects
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-22
    Senem Büyüksungur, Tuğba Endoğan Tanır, Arda Buyuksungur, Ezgi İrem Bektaş, Gamze Torun Köse, Deniz Yücel, Tahsin Beyzadeoğlu, Engin Çetinkaya, Çağrı Yenigün, Ergin Tönük, Vasif Hasirci, Nesrin Hasirci

    A large variety of approaches has been used to treat large and irregular shaped bone defects with less than optimal success due to material or design issues. In the recent years patient specific constructs prepared by additive manufacturing provided a solution to the need for shaping implants to fit irregular defects in the surgery theater. In this study, cylindrical disks of poly(ε-caprolactone) (PCL) was printed by fused deposition modeling and modified with nanohydroxyapatite (HAp) and poly(propylene fumarate) (PPF) to create a mechanically strong implant with well-defined pore size and porosity, controllable surface hydrophilicity (with PPF) and osteoconductivity (with HAp). Cytotoxicity, irritation and inflammation tests demonstrated that the scaffolds were biocompatible. PCL/HAp and PCL/HAp/PPF scaffolds were implanted in the femurs of rabbits with and without seeding with Rabbit Bone Marrow Stem Cells (BMSC) and examined after 4 and 8 weeks with micro-CT, mechanically and histologically. BMSC seeded PCL/HAp/PPF scaffolds showed improved tissue regeneration as determined by bone mineral density and micro-CT. Compressive and tension stiffness values (394 and 463 N/mm) were significantly higher than that of the healthy rabbit femur (316 and 392 N/mm, respectively) after 8 weeks of implantation. These 3D implants have great potential for patient-specific bone defect treatments.

    更新日期:2017-08-22
  • Clot-entrapped blood cells in synergy with human mesenchymal stem cells create a pro-angiogenic healing response
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-15
    Melanie A. Burkhardt, Isabel Gerber, Cameron Moshfegh, Miriam S. Lucas, Jasmin Waser, Maximilian Y. Emmert, Simon P. Hoerstrup, Falko Schlottig, Viola Vogel
    更新日期:2017-08-15
  • Gd3+-functionalized gold nanoclusters for fluorescence-magnetic resonance bimodal imaging
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-15
    Liang Guohai, Lifu Xiao

    Multimodal imaging that aims to advance imaging by strategically combining existing technologies with uniquely designed probes has attracted great interest in recent years. In this work, Gd3+-functionalized gold nanoclusters were prepared with a straightforward and scalable approach by using proteins as templates. The impact of the synthesis approach on the conjugation efficiency of Gd chelators to protein, as well as fluorescence quantum yield of gold nanoclusters was carefully studied. The effect of protein size on the relaxivity of the probes was also investigated. By using the optimal conditions, dual function probes with intense red fluorescence emission and longitudinal relaxivity as high as 9.7 mM-1s-1 could be obtained. The probes were applied for cell staining and in vivo contrast-enhanced magnetic resonance imaging (MRI). The MR images showed that the dual function probes circulated freely in the blood pool without undesirable accumulation in the liver and spleen. Meanwhile, the material could be removed from the body through renal clearance, making it attractive for practical multimodal imaging.

    更新日期:2017-08-15
  • Recent advances in biomaterials for the treatment of diabetic foot ulcers
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-15
    Lisa N. Kasiewicz, Kathryn A. Whitehead

    Diabetes mellitus is one of the most challenging epidemics facing the world today, with over 300 million patients affected worldwide. A significant complication associated with diabetes is hyperglycemia, which impairs wound healing. The rise in the diabetic patient population in recent years has precipitated an increase in the incidence and prevalence of chronic diabetic wounds, most commonly the diabetic foot ulcer. Although foot ulcers are difficult to treat due to their complicated pathology, outcomes have improved with the development of increasingly sophisticated biomaterials that accelerate healing. In this review, we describe recently developed biomaterials that elicit healing through cell-material interactions and/or the sustained delivery of drugs. These tunable therapeutic systems increase angiogenesis, collagen deposition, cell proliferation, and growth factors concentrations, while decreasing inflammation and enzymatic degradation of the extracellular matrix. As the field of biomaterials for wound healing continues to mature, we expect to witness a broader range of clinical options that will speed healing times and improve patient quality of life.

    更新日期:2017-08-15
  • Nanocellulosic materials as bioinks for 3D bioprinting
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-14
    Carmen Piras, Susana Fernández-Prieto, Wim M De Borggraeve

    3D bioprinting is a new developing technology with lots of promise in tissue engineering and regenerative medicine. Being biocompatible, biodegradable, renewable and cost-effective, cellulosic nanomaterials have recently captured the attention of researchers due to their applicability as inks for 3D bioprinting. Although a number of cellulose-based bioinks have been reported, the potential of cellulose nanofibrils and nanocrystals has not been fully explored yet. This minireview aims at highlighting the use of nanocellulosic materials for 3D bioprinting as an emerging, promising, new research field.

    更新日期:2017-08-14
  • Functionalized Lignin Biomaterials for Enhancing Optical Properties and Cellular Interactions of Dyes
    Biomater. Sci. (IF 4.21) Pub Date : 2017-08-14
    Anthony Nolan Cauley, James N. Wilson

    We report a library of functionalized lignins and demonstrate their utility as nanocontainers for organic dyes in biologically relevant applications. Kraft lignin was modified via SN2 reaction at the phenolic -OH group utilizing a mild base, potassium carbonate, and various alkyl halides, several bearing additional functionalities, with dimethylsulfoxide as solvent. The resulting phenoxy ethers were characterized by 1H-NMR and IR spectroscopy, as well as DLS and SEM to evaluate their morphology and supramolecular organization. Lignin modified with long-chain hydrocarbon tails was found to effectively encapsulate DiD, a cyanine dye, decrease aggregation, enhance optical transitions and exert a photoprotective effect. The dye-lignin assemblies were also examined as imaging agents, via confocal microscopy, and found to accumulate intracellularly with no leaching of the dye to hydrophobic subcellular components observed. Lignin functionalized with short chain carboxylic acids effectively interacts with ligands directed at the norepinephrine transporter (NET), suggesting applications in sequestration of neuroactive compounds.

    更新日期:2017-08-14
  • In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels
    Biomater. Sci. (IF 4.21) Pub Date : 2017-07-04
    Iman Noshadi, Seonki Hong, Kelly E. Sullivan, Ehsan Shirzaei Sani, Roberto Portillo-Lara, Ali Tamayol, Su Ryon Shin, Albert E. Gao, Whitney L. Stoppel, Lauren D. Black III, Ali Khademhosseini, Nasim Annabi
    更新日期:2017-08-14
  • Dispersible oxygen microsensors map oxygen gradients in three-dimensional cell cultures
    Biomater. Sci. (IF 4.21) Pub Date : 2017-06-12
    Sasha Cai Lesher-Pérez, Ge-Ah Kim, Chuan-hsien Kuo, Brendan M. Leung, Sanda Mong, Taisuke Kojima, Christopher Moraes, M. D. Thouless, Gary D. Luker, Shuichi Takayama
    更新日期:2017-08-14
  • 更新日期:2017-08-04
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
所有期刊列表A-Z