-
A method for predicting drugs that can boost the efficacy of immune checkpoint blockade Nat. Immunol. (IF 30.5) Pub Date : 2024-03-18 Yun Xia, Xin Li, Nana Bie, Wen Pan, Ya-Ru Miao, Mei Yang, Yan Gao, Chuang Chen, Hanqing Liu, Lu Gan, An-Yuan Guo
-
Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components Nat. Immunol. (IF 30.5) Pub Date : 2024-03-14 Andrea Mencarelli, Pradeep Bist, Hae Woong Choi, Hanif Javanmard Khameneh, Alessandra Mortellaro, Soman N. Abraham
-
Author Correction: The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila Nat. Immunol. (IF 30.5) Pub Date : 2024-03-15 Safia Deddouche, Nicolas Matt, Aidan Budd, Stefanie Mueller, Cordula Kemp, Delphine Galiana-Arnoux, Catherine Dostert, Christophe Antoniewski, Jules A. Hoffmann, Jean-Luc Imler
-
The power of memory T cells minus antibodies Nat. Immunol. (IF 30.5) Pub Date : 2024-03-15 Thi H. O. Nguyen, Katherine Kedzierska
-
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules Nat. Immunol. (IF 30.5) Pub Date : 2024-03-14 J. Magarian Blander, Yuhua Shi
-
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination Nat. Immunol. (IF 30.5) Pub Date : 2024-03-14 Valeria Fumagalli, Micol Ravà, Davide Marotta, Pietro Di Lucia, Elisa B. Bono, Leonardo Giustini, Federica De Leo, Maura Casalgrandi, Emanuele Monteleone, Violette Mouro, Chiara Malpighi, Chiara Perucchini, Marta Grillo, Sara De Palma, Lorena Donnici, Silvia Marchese, Matteo Conti, Hiromi Muramatsu, Stanley Perlman, Norbert Pardi, Mirela Kuka, Raffaele De Francesco, Marco E. Bianchi, Luca G. Guidotti
-
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis Nat. Immunol. (IF 30.5) Pub Date : 2024-03-07 Xin He, Xiantao Zhang, Bolin Wu, Jieyi Deng, Yongli Zhang, Airu Zhu, Yaochang Yuan, Yingtong Lin, Achun Chen, Jinzhu Feng, Xiumei Wang, Shijian Wu, Yingying Liu, Jie Liu, Yalin Wang, Rong Li, Chaofeng Liang, Quyu Yuan, Yu Liang, Qiannan Fang, Zhihui Xi, Wenjie Li, Liting Liang, Zhenglai Zhang, Hui Tang, Yi Peng, Changwen Ke, Xiancai Ma, Weibin Cai, Ting Pan, Bingfeng Liu, Kai Deng, Jun Chen, Jincun
-
Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression Nat. Immunol. (IF 30.5) Pub Date : 2024-03-06 Kaitlin R. Carroll, Mark Mizrachi, Sean Simmons, Bahtiyar Toz, Czeslawa Kowal, Jeffrey Wingard, Nazila Tehrani, Aida Zarfeshani, Nina Kello, Lara El Khoury, Rachel Weissman-Tsukamoto, Joshua Z. Levin, Bruce T. Volpe, Betty Diamond
-
Learning from cancer mutations Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Nicholas J. Bernard
T cell lymphomas acquire mutations that endow them with advantages to endure the immunosuppressive tumor microenvironment. Researchers have now found a way to turn the tables on cancer by using these mutations to develop more effective chimeric antigen receptor (CAR) T cell therapies. In a study published in Nature, the authors created a barcoded library of mutant genes from T cell malignancies and
-
Complement profile Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Ioana Staicu
Severe COVID-19 has been associated with complement activation, hypercoagulation and vascular injury. In Science, Cervia-Hasler et al. report persistent complement-mediated immunopathology and thromboinflammation in long COVID as well. High-throughput proteomics on serum from 113 SARS-CoV-2-infected individuals (40 of which reported persisting symptoms at 6 months) at acute and 6 months after severe
-
Surface RNAs move neutrophils Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Paula Jáuregui
RNAs have been detected on the outer surface of mammalian cells, including some with glycan modifications known as glycoRNAs; however, the biological function of these surface molecules is unclear. Research now published in Cell shows that on neutrophils these RNAs are required for efficient recruitment, adhesion and transendothelial migration at inflammatory sites in mice. Using extracellular RNase
-
What Jane Jacobs has taught me about neuroimmunology Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Jennifer L. Gommerman
In acknowledgment of Women’s History Month, I have drawn upon timeless concepts from Jane Jacobs’ seminal 1961 book The Death and Life of Great American Cities1 to describe emerging ideas in neuroimmunology and how we may collectively move the field forward.
-
Opening the doors of opportunity Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Noriko Isobe
Breakdown barriers that make you hesitate from challenging yourself, and jump into new fields that interest you.
-
Marching forward in neuroimmunology Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01
As part of Women’s History Month, we are celebrating the contributions of women who stand at the crossroads of immunology and neurobiology.
-
Neuroimmunology, women scientists and dogma Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Robyn S. Klein
Reflecting on the decision to become a neuroimmunologist, and the women mentors who taught me how to challenge dogma in all its forms.
-
Alterations of iron homeostasis as a potential druggable driver of long COVID Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Oriana Marques, Martina U. Muckenthaler
-
Neuroimmunology, the field that welcomed me and made me want to stay Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Irene Salinas
Entering a new scientific field is difficult and daunting. Here I relate my personal journey as a fish immunologist and how neuroimmunologists welcomed me with open arms (and brains), giving me the sense of belonging that we all need as scientists.
-
Unveiling the antitumor function of ID3 in liver macrophages Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Anne-Gaëlle Goubet, Mikaël J. Pittet
-
Success without intervention: keeping the conversation open Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Fabienne Brilot
Since the discoveries of autoantibodies in neurological diseases, women have had a fascinating journey in neuroimmunology. At a time when groundbreaking advances are being made, let’s continue the conversation about women in science.
-
Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19 Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Aimee L. Hanson, Matthew P. Mulè, Hélène Ruffieux, Federica Mescia, Laura Bergamaschi, Victoria S. Pelly, Lorinda Turner, Prasanti Kotagiri, Berthold Göttgens, Christoph Hess, Nicholas Gleadall, John R. Bradley, James A. Nathan, Paul A. Lyons, Hal Drakesmith, Kenneth G. C. Smith
-
Integrating single-cell multi-omics and prior biological knowledge for a functional characterization of the immune system Nat. Immunol. (IF 30.5) Pub Date : 2024-02-27 Philipp Sven Lars Schäfer, Daniel Dimitrov, Eduardo J. Villablanca, Julio Saez-Rodriguez
-
A repair pathway lost in multiple sclerosis provides a new drug opportunity Nat. Immunol. (IF 30.5) Pub Date : 2024-02-26 Lise Torp Jensen, Kathrine E. Attfield, Lars Fugger
-
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology Nat. Immunol. (IF 30.5) Pub Date : 2024-02-26 Mathias Linnerbauer, Lena Lößlein, Oliver Vandrey, Anne Peter, Yanan Han, Thanos Tsaktanis, Emile Wogram, Maria Needhamsen, Lara Kular, Lisa Nagel, Julia Zissler, Marie Andert, Lisa Meszaros, Jannis Hanspach, Finnja Zuber, Ulrike J. Naumann, Martin Diebold, Michael A. Wheeler, Tobias Beyer, Lucy Nirschl, Ana Cirac, Frederik B. Laun, Claudia Günther, Jürgen Winkler, Tobias Bäuerle, Maja Jagodic, Bernhard
-
CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis Nat. Immunol. (IF 30.5) Pub Date : 2024-02-23 Simon Rauber, Hashem Mohammadian, Christian Schmidkonz, Armin Atzinger, Alina Soare, Christoph Treutlein, Samuel Kemble, Christopher B. Mahony, Manuel Geisthoff, Mario R. Angeli, Maria G. Raimondo, Cong Xu, Kai-Ting Yang, Le Lu, Hannah Labinsky, Mina S. A. Saad, Charles A. Gwellem, Jiyang Chang, Kaiyue Huang, Eleni Kampylafka, Johannes Knitza, Rostyslav Bilyy, Jörg H. W. Distler, Megan M. Hanlon, Ursula
-
A mechanism for BCG vaccine cross-protection against pulmonary viral infections Nat. Immunol. (IF 30.5) Pub Date : 2024-02-21
-
A nasal vaccine elicits protective CD8+ T cell immunity against antigen shifted SARS-CoV-2 virus Nat. Immunol. (IF 30.5) Pub Date : 2024-02-20
-
Adipose Treg cells in charge of metabolism Nat. Immunol. (IF 30.5) Pub Date : 2024-02-14 Melanie Grusdat, Dirk Brenner
-
Reactivating antitumor immunity by inhibiting JMJD1C Nat. Immunol. (IF 30.5) Pub Date : 2024-02-14 Xuezheng Wang, Keji Zhao
-
IL-23 stabilizes an effector Treg cell program in the tumor microenvironment Nat. Immunol. (IF 30.5) Pub Date : 2024-02-14 Tobias Wertheimer, Pascale Zwicky, Lukas Rindlisbacher, Colin Sparano, Marijne Vermeer, Bruno Marcel Silva de Melo, Claudia Haftmann, Tamina Rückert, Aakriti Sethi, Stefanie Schärli, Anna Huber, Florian Ingelfinger, Caroline Xu, Daehong Kim, Philipp Häne, André Fonseca da Silva, Andreas Muschaweckh, Nicolas Nunez, Sinduya Krishnarajah, Natalie Köhler, Robert Zeiser, Mohamed Oukka, Thomas Korn, Sonia
-
Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity Nat. Immunol. (IF 30.5) Pub Date : 2024-02-14 Xuehui Long, Sulin Zhang, Yuliang Wang, Jingjing Chen, Yanlai Lu, Hui Hou, Bichun Lin, Xutong Li, Chang Shen, Ruirui Yang, Huamin Zhu, Rongrong Cui, Duanhua Cao, Geng Chen, Dan Wang, Yun Chen, Sulan Zhai, Zhiqin Zeng, Shusheng Wu, Mengting Lou, Junhong Chen, Jian Zou, Mingyue Zheng, Jun Qin, Xiaoming Wang
-
Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism Nat. Immunol. (IF 30.5) Pub Date : 2024-02-14 Santiago Valle Torres, Kevin Man, Tarek Elmzzahi, Darya Malko, David Chisanga, Yang Liao, Melanie Prout, Caitlin A. Abbott, Adelynn Tang, Jian Wu, Matthias Becker, Teisha Mason, Vanessa Haynes, Carlson Tsui, Mehrnoush Hadaddzadeh Shakiba, Doaa Hamada, Kara Britt, Joanna R. Groom, Shaun R. McColl, Wei Shi, Matthew J. Watt, Graham Le Gros, Bhupinder Pal, Marc Beyer, Ajithkumar Vasanthakumar, Axel Kallies
-
A new step in understanding mouse cDC ontogeny Nat. Immunol. (IF 30.5) Pub Date : 2024-02-13 Charles-Antoine Dutertre
-
Distinct ontogenetic lineages dictate cDC2 heterogeneity Nat. Immunol. (IF 30.5) Pub Date : 2024-02-13 Carlos M. Minutti, Cécile Piot, Mariana Pereira da Costa, Probir Chakravarty, Neil Rogers, Hector Huerga Encabo, Ana Cardoso, Jane Loong, Gilles Bessou, Cyrille Mionnet, Jean Langhorne, Dominique Bonnet, Marc Dalod, Elena Tomasello, Caetano Reis e Sousa
-
Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection Nat. Immunol. (IF 30.5) Pub Date : 2024-02-09 Baoling Ying, Tamarand L. Darling, Pritesh Desai, Chieh-Yu Liang, Igor P. Dmitriev, Nadia Soudani, Traci Bricker, Elena A. Kashentseva, Houda Harastani, Saravanan Raju, Meizi Liu, Aaron G. Schmidt, David T. Curiel, Adrianus C. M. Boon, Michael S. Diamond
-
Mapping brain–immune interactions in ischemic stroke Nat. Immunol. (IF 30.5) Pub Date : 2024-02-02 Danye Jiang, Louise McCullough
-
Working towards diversity in the immunology research community Nat. Immunol. (IF 30.5) Pub Date : 2024-02-01
Many immunologists strongly support the drive for inclusion and diversity in the workplace, but factors beyond their control are making this an ever more difficult goal.
-
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells Nat. Immunol. (IF 30.5) Pub Date : 2024-01-26 Nathan L. Board, Zhe Yuan, Fengting Wu, Milica Moskovljevic, Meghana Ravi, Srona Sengupta, Sung Soo Mun, Francesco R. Simonetti, Jun Lai, Pablo Tebas, Kenneth Lynn, Rebecca Hoh, Steven G. Deeks, Janet D. Siliciano, Luis J. Montaner, Robert F. Siliciano
-
Carnosine helps cancer cells to evade immune surveillance by regulating intracellular pH Nat. Immunol. (IF 30.5) Pub Date : 2024-01-25
-
CD8+ TRM cells in perpetual motion Nat. Immunol. (IF 30.5) Pub Date : 2024-01-23 Laurie A. Dempsey
T cell motility in tissues is thought to be directed by chemokine gradients and integrin-dependent adhesive interactions within the stromal environment. In Science Immunology, Ruef et al. identify a new form of chemoattractant-independent immune surveillance by tissue-resident CD8+ T memory (TRM) cells that reside in exocrine gland tissues. TRM cells in exocrine glands expressed more F-actin and non-muscle
-
CTLA-4 nanobody stops colitis Nat. Immunol. (IF 30.5) Pub Date : 2024-01-23 Nicholas J. Bernard
Colitis is a common adverse effect of cancer therapy with checkpoint inhibitors, including those that target CTLA-4 signaling, and perturbations of the intestinal microbiome have been implicated in this pathology. Normal laboratory mice have not shed much light on this pathology as they are resistant to checkpoint-driven colitis, possibly owing to their restricted diet and microbiome. Research now
-
Mucosal boosting Nat. Immunol. (IF 30.5) Pub Date : 2024-01-23 Ioana Staicu
Intramuscular immunization with mRNA or adenovirus vector-based vaccines does not induce mucosal immunity or complete protection against SARS-CoV-2 variants. In Nature, McMahan et al. show that intratracheal boosting with a bivalent adenovirus-based SARS-CoV-2 vaccine (Ad26) induces humoral and cellular immunity in the respiratory mucosa and near complete protection against a SARS-CoV-2 BQ.1.1 challenge
-
JAK1 hits a nerve Nat. Immunol. (IF 30.5) Pub Date : 2024-01-23 Stephanie Houston
Individuals with germline JAK1 gain-of-function (GoF) variants develop atopic dermatitis and asthma. In Cell, Tamari et al. investigated the mechanism by which JAK1 signaling contributes to allergic inflammation, and identified a role for neuronal JAK1 in regulating neuropeptide expression in the vagal ganglia, which can suppress pathogenic ILC2 responses in the lung. Mice expressing the mutant human
-
When ceramides meet immune senescence, a GIMAP5 connection Nat. Immunol. (IF 30.5) Pub Date : 2024-01-23 Atrayee Gope, Claudio Mauro
-
Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria Nat. Immunol. (IF 30.5) Pub Date : 2024-01-23 Jingwei Ma, Liang Tang, Yaoyao Tan, Jingxuan Xiao, Keke Wei, Xin Zhang, Yuan Ma, Shuai Tong, Jie Chen, Nannan Zhou, Li Yang, Zhang Lei, Yonggang Li, Jiadi Lv, Junwei Liu, Huafeng Zhang, Ke Tang, Yi Zhang, Bo Huang
-
Three cytokine pairs modulate sepsis effects at the organism level Nat. Immunol. (IF 30.5) Pub Date : 2024-01-16
-
The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+ T cell fates Nat. Immunol. (IF 30.5) Pub Date : 2024-01-18 Xin Zhao, Wei Hu, Sung Rye Park, Shaoqi Zhu, Shengen Shawn Hu, Chongzhi Zang, Weiqun Peng, Qiang Shan, Hai-Hui Xue
-
Releasing the TLE3 break to put TCM cells on a fast track Nat. Immunol. (IF 30.5) Pub Date : 2024-01-18 Jian Shen, Siying Lin, Weiguo Cui
-
Building a next-generation, two-component protein subunit vaccine against monkeypox virus Nat. Immunol. (IF 30.5) Pub Date : 2024-01-18
-
Metabolic waypoints during T cell differentiation Nat. Immunol. (IF 30.5) Pub Date : 2024-01-18 Drew Wilfahrt, Greg M. Delgoffe
-
BCG immunization induces CX3CR1hi effector memory T cells to provide cross-protection via IFN-γ-mediated trained immunity Nat. Immunol. (IF 30.5) Pub Date : 2024-01-15 Kim A. Tran, Erwan Pernet, Mina Sadeghi, Jeffrey Downey, Julia Chronopoulos, Elizabeth Lapshina, Oscar Tsai, Eva Kaufmann, Jun Ding, Maziar Divangahi
-
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2 Nat. Immunol. (IF 30.5) Pub Date : 2024-01-11 Kailin Yin, Michael J. Peluso, Xiaoyu Luo, Reuben Thomas, Min-Gyoung Shin, Jason Neidleman, Alicer Andrew, Kyrlia C. Young, Tongcui Ma, Rebecca Hoh, Khamal Anglin, Beatrice Huang, Urania Argueta, Monica Lopez, Daisy Valdivieso, Kofi Asare, Tyler-Marie Deveau, Sadie E. Munter, Rania Ibrahim, Ludger Ständker, Scott Lu, Sarah A. Goldberg, Sulggi A. Lee, Kara L. Lynch, J. Daniel Kelly, Jeffrey N. Martin
-
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states Nat. Immunol. (IF 30.5) Pub Date : 2024-01-10 Derrick Callahan, Shuchi Smita, Stephen Joachim, Kenneth Hoehn, Steven Kleinstein, Florian Weisel, Maria Chikina, Mark Shlomchik
-
Breaking NGF–TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection Nat. Immunol. (IF 30.5) Pub Date : 2024-01-09 Tao Yin, Guoping Wang, Liuyang Wang, Poorva Mudgal, Ergang Wang, Christopher C. Pan, Peter B. Alexander, Haiyang Wu, Chengjie Cao, Yaosi Liang, Lianmei Tan, De Huang, Mengyang Chong, Rui Chen, Bryan Jian Wei Lim, Kun Xiang, Wei Xue, Lixin Wan, Hailan Hu, Yuin-Han Loh, Xiao-Fan Wang, Qi-Jing Li
-
Tissues of origin matter to plasma cell longevity Nat. Immunol. (IF 30.5) Pub Date : 2024-01-08 Wataru Ise, Tomohiro Kurosaki
-
A pairwise cytokine code explains the organism-wide response to sepsis Nat. Immunol. (IF 30.5) Pub Date : 2024-01-08 Michihiro Takahama, Ashwini Patil, Gabriella Richey, Denis Cipurko, Katherine Johnson, Peter Carbonetto, Madison Plaster, Surya Pandey, Katerina Cheronis, Tatsuki Ueda, Adam Gruenbaum, Tadafumi Kawamoto, Matthew Stephens, Nicolas Chevrier
-
Rational design of a ‘two-in-one’ immunogen DAM drives potent immune response against monkeypox virus Nat. Immunol. (IF 30.5) Pub Date : 2024-01-05 Han Wang, Peng Yin, Tingting Zheng, Lanju Qin, Shihua Li, Pu Han, Xiao Qu, Jun Wen, Haoyi Ding, Jiahao Wu, Tianxiang Kong, Zhengrong Gao, Songtao Hu, Xin Zhao, Xiangyu Cao, Min Fang, Jianxun Qi, Jianzhong Jeff Xi, Kai Duan, Xiaoming Yang, Zhuobing Zhang, Qihui Wang, Wenjie Tan, George Fu Gao
-
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice Nat. Immunol. (IF 30.5) Pub Date : 2024-01-04 Anastasia du Halgouet, Kerstin Bruder, Nina Peltokangas, Aurélie Darbois, David Obwegs, Marion Salou, Robert Thimme, Maike Hofmann, Olivier Lantz, Sagar
-
Baseline immune characteristics linked to pneumococcal vaccine responsiveness in older adults Nat. Immunol. (IF 30.5) Pub Date : 2024-01-05
-
Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults Nat. Immunol. (IF 30.5) Pub Date : 2024-01-05 Sathyabaarathi Ravichandran, Fernando Erra-Diaz, Onur E. Karakaslar, Radu Marches, Lisa Kenyon-Pesce, Robert Rossi, Damien Chaussabel, Djamel Nehar-Belaid, David C. LaFon, Virginia Pascual, Karolina Palucka, Silke Paust, Moon H. Nahm, George A. Kuchel, Jacques Banchereau, Duygu Ucar
-
IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development Nat. Immunol. (IF 30.5) Pub Date : 2024-01-05 Wilford Goh, Harrison Sudholz, Momeneh Foroutan, Sebastian Scheer, Aline Pfefferle, Rebecca B. Delconte, Xiangpeng Meng, Zihan Shen, Robert Hennessey, Isabella Y. Kong, Iona S. Schuster, Christopher E. Andoniou, Melissa J. Davis, Soroor Hediyeh-Zadeh, Fernando Souza-Fonseca-Guimaraes, Ian A. Parish, Paul Beavis, Daniel Thiele, Michael Chopin, Mariapia A. Degli-Esposti, Joe Cursons, Axel Kallies, Jai